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Aliases for TEX28 Gene

Aliases for TEX28 Gene

  • Testis Expressed 28 2 3 5
  • CXorf2 3 4
  • Chromosome X Open Reading Frame 2 2
  • Testis-Specific Protein TEX28 3
  • TEX28 TEX28P1 TEX28P2 4
  • TEX28P1 3
  • TEX28P2 3
  • MRX99 3
  • FTEX 3

External Ids for TEX28 Gene

Previous HGNC Symbols for TEX28 Gene

  • CXorf2

Previous GeneCards Identifiers for TEX28 Gene

  • GC0XM153154
  • GC0XM153498
  • GC0XM142075

Summaries for TEX28 Gene

GeneCards Summary for TEX28 Gene

TEX28 (Testis Expressed 28) is a Protein Coding gene. Diseases associated with TEX28 include Colorblindness, Partial, Protan Series and Blue Cone Monochromacy. An important paralog of this gene is TMCC1.

Additional gene information for TEX28 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX28 Gene

Genomics for TEX28 Gene

GeneHancer (GH) Regulatory Elements for TEX28 Gene

Promoters and enhancers for TEX28 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI154296 Promoter 0.8 EPDnew 550.8 +0.2 180 0.1 BHLHE40 MNT ZBTB33 SETDB1 TEX28 TKTL1
GH0XI154295 Promoter 0.6 EPDnew 550.8 +0.7 724 0.1 ZBTB33 TEX28 TKTL1 OPN1MW3
GH0XI154292 Promoter 0.5 EPDnew 550.8 +3.3 3253 0.1 TEX28 TKTL1 OPN1MW3
GH0XI154540 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE 1.3 -246.5 -246485 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 IKBKG FAM3A F8A1 F8A2 GAB3 MECP2 MPP1 EMD DNASE1L1 IRAK1
GH0XI154038 Enhancer 1.3 FANTOM5 Ensembl ENCODE 1.8 +252.5 252549 9.2 CTCF ZSCAN4 ZNF133 MAX EBF1 CEBPG FEZF1 ZIC2 RAD21 TEAD3 TMEM187 HCFC1 HCFC1-AS1 IKBKG ABCD1 DNASE1L1 MECP2 FAM50A ATP6AP1 EMD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TEX28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEX28 gene promoter:

Genomic Locations for TEX28 Gene

Genomic Locations for TEX28 Gene
chrX:154,271,265-154,295,853
(GRCh38/hg38)
Size:
24,589 bases
Orientation:
Minus strand
chrX:153,498,930-153,523,796
(GRCh37/hg19)

Genomic View for TEX28 Gene

Genes around TEX28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX28 Gene

Proteins for TEX28 Gene

  • Protein details for TEX28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15482-TEX28_HUMAN
    Recommended name:
    Testis-specific protein TEX28
    Protein Accession:
    O15482
    Secondary Accessions:
    • B1B1E8
    • D3DWW5

    Protein attributes for TEX28 Gene

    Size:
    410 amino acids
    Molecular mass:
    46131 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEX28 Gene

Post-translational modifications for TEX28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX28 Gene

No data available for DME Specific Peptides for TEX28 Gene

Domains & Families for TEX28 Gene

Gene Families for TEX28 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TEX28 Gene

Suggested Antigen Peptide Sequences for TEX28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15482

UniProtKB/Swiss-Prot:

TEX28_HUMAN :
  • Belongs to the TEX28 family.
Family:
  • Belongs to the TEX28 family.
genes like me logo Genes that share domains with TEX28: view

Function for TEX28 Gene

Phenotypes From GWAS Catalog for TEX28 Gene

Gene Ontology (GO) - Molecular Function for TEX28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TEX28: view
genes like me logo Genes that share phenotypes with TEX28: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEX28 Gene

Localization for TEX28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX28 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX28 gene
Compartment Confidence
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TEX28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TEX28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEX28 Gene

Pathways & Interactions for TEX28 Gene

SuperPathways for TEX28 Gene

No Data Available

Interacting Proteins for TEX28 Gene

Selected Interacting proteins: O15482-TEX28_HUMAN for TEX28 Gene via IID

Gene Ontology (GO) - Biological Process for TEX28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TEX28: view

No data available for Pathways by source and SIGNOR curated interactions for TEX28 Gene

Drugs & Compounds for TEX28 Gene

No Compound Related Data Available

Transcripts for TEX28 Gene

mRNA/cDNA for TEX28 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEX28 Gene

Testis expressed 28:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX28 Gene

No ASD Table

Relevant External Links for TEX28 Gene

GeneLoc Exon Structure for
TEX28
ECgene alternative splicing isoforms for
TEX28

Expression for TEX28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEX28 Gene

mRNA differential expression in normal tissues according to GTEx for TEX28 Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for TEX28 Gene

This gene is overexpressed in Serum (46.1), Amniocyte (13.6), and Plasma (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEX28 Gene



Protein tissue co-expression partners for TEX28 Gene

NURSA nuclear receptor signaling pathways regulating expression of TEX28 Gene:

TEX28

SOURCE GeneReport for Unigene cluster for TEX28 Gene:

Hs.672606

mRNA Expression by UniProt/SwissProt for TEX28 Gene:

O15482-TEX28_HUMAN
Tissue specificity: Testis specific.

Evidence on tissue expression from TISSUES for TEX28 Gene

  • Intestine(2.9)
genes like me logo Genes that share expression patterns with TEX28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX28 Gene

Orthologs for TEX28 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TEX28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX28 33
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia TEX28 33
  • 76.94 (n)
cow
(Bos Taurus)
Mammalia TEX28 33
  • 74.77 (n)
mouse
(Mus musculus)
Mammalia Tex28 33 16
  • 72.99 (n)
rat
(Rattus norvegicus)
Mammalia Tex28 33
  • 72.11 (n)
Species where no ortholog for TEX28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEX28 Gene

ENSEMBL:
Gene Tree for TEX28 (if available)
TreeFam:
Gene Tree for TEX28 (if available)

Paralogs for TEX28 Gene

Paralogs for TEX28 Gene

(5) SIMAP similar genes for TEX28 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TEX28 Gene

genes like me logo Genes that share paralogs with TEX28: view

Variants for TEX28 Gene

Sequence variations from dbSNP and Humsavar for TEX28 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002196738 -- 154,297,288(-) C/T upstream_transcript_variant
rs1002425912 -- 154,296,798(-) T/C upstream_transcript_variant
rs1002915230 -- 154,295,264(-) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1004768784 -- 154,296,215(-) G/A upstream_transcript_variant
rs1008905043 -- 154,296,454(-) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TEX28 Gene

Variant ID Type Subtype PubMed ID
esv27518 CNV gain+loss 19812545
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv1075344 CNV deletion 25765185
nsv519042 CNV gain 19592680
nsv7161 CNV deletion 18451855

Additional Variant Information for TEX28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX28

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TEX28 Gene

Disorders for TEX28 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TEX28 Gene - From: DISEASES

Disorder Aliases PubMed IDs
colorblindness, partial, protan series
  • cbp
blue cone monochromacy
  • bcm
red-green color blindness
  • colorblindness, partial, deutan series
achromatopsia
  • achm
- elite association - COSMIC cancer census association via MalaCards
Search TEX28 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEX28

genes like me logo Genes that share disorders with TEX28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEX28 Gene

Publications for TEX28 Gene

  1. An insertion/deletion TEX28 polymorphism and its application to analysis of red/green visual pigment gene arrays. (PMID: 15378397) Ueyama H … Yamade S (Journal of human genetics 2004) 2 3 22 58
  2. Identification of a gene within the tandem array of red and green color pigment genes. (PMID: 9268643) Hanna MC … Kirkness EF (Genomics 1997) 2 3 4 58
  3. Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies. (PMID: 19098318) Metlapally R … Young TL (Investigative ophthalmology & visual science 2009) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TEX28 Gene

Sources for TEX28 Gene

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