Aliases for TEX261 Gene

Aliases for TEX261 Gene

  • Testis Expressed 261 2 3 5
  • Testis Expressed Sequence 261 2 3
  • Protein TEX261 3 4
  • TEG-261 3

External Ids for TEX261 Gene

Previous GeneCards Identifiers for TEX261 Gene

  • GC02M071126
  • GC02M071187
  • GC02M071124
  • GC02M071174
  • GC02M070949
  • GC02M071215
  • GC02M071216
  • GC02M071217
  • GC02M071218
  • GC02M071221

Summaries for TEX261 Gene

GeneCards Summary for TEX261 Gene

TEX261 (Testis Expressed 261) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include COPII adaptor activity. An important paralog of this gene is ENSG00000258881.

Additional gene information for TEX261 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEX261 Gene

Genomics for TEX261 Gene

GeneHancer (GH) Regulatory Elements for TEX261 Gene

Promoters and enhancers for TEX261 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J070993 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 773.7 +0.3 319 3.1 ZNF24 SP1 ZBTB40 CTCF RBPJ POLR2A NR2F1 HCFC1 ELF3 ZFX TEX261 ATP6V1B1-AS1 ENSG00000228384 ENSG00000258881 ZNF638 MPHOSPH10 CLEC4F ANKRD53 ADD2
GH02J070987 Promoter 0.3 EPDnew 750.4 +7.0 7016 0.1 lnc-MCEE-2 piR-54803 piR-48408 TEX261 VAX2 ATP6V1B1-AS1 ENSG00000258881
GH02J070989 Promoter 0.3 EPDnew 750.4 +5.0 5048 0.1 lnc-MCEE-2 TEX261 ATP6V1B1-AS1 ENSG00000228384 ENSG00000258881
GH02J070080 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 50.2 +908.5 908482 11.6 SIN3A ZBTB40 ZBTB6 LCORL FOXA1 MLX RBPJ SMARCE1 POLR2A TCF7L2 PCBP1 TIA1 TEX261 PCBP1-AS1 ANKRD53 CLEC4F C2orf42 MXD1 PCYOX1 CD207
GH02J070246 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 41.3 +747.2 747172 4.6 GTF3C2 SIN3A ZNF24 ZBTB40 MLX RBPJ POLR2A CTBP1 NR2F1 NR2F6 TIA1 C2orf42 TRG-CCC2-1 lnc-C2orf42-4 TEX261 CLEC4F MPHOSPH10 ANKRD53 FAM136A AAK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEX261 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEX261 gene promoter:
  • AML1a
  • c-Ets-1
  • CREB
  • Egr-2
  • FOXD1
  • GATA-1
  • p300
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for TEX261 Gene

Genomic Locations for TEX261 Gene
chr2:70,985,938-70,994,873
(GRCh38/hg38)
Size:
8,936 bases
Orientation:
Minus strand
chr2:71,213,068-71,222,075
(GRCh37/hg19)
Size:
9,008 bases
Orientation:
Minus strand

Genomic View for TEX261 Gene

Genes around TEX261 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX261 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX261 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX261 Gene

Proteins for TEX261 Gene

  • Protein details for TEX261 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWH6-TX261_HUMAN
    Recommended name:
    Protein TEX261
    Protein Accession:
    Q6UWH6
    Secondary Accessions:
    • A1A587
    • D6W5G9
    • Q8WUJ5

    Protein attributes for TEX261 Gene

    Size:
    196 amino acids
    Molecular mass:
    22538 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEX261 Gene

Post-translational modifications for TEX261 Gene

No Post-translational modifications

Other Protein References for TEX261 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEX261 Gene

Domains & Families for TEX261 Gene

Gene Families for TEX261 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TEX261 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEX261 Gene

GenScript: Design optimal peptide antigens:
  • Protein TEX261 (TX261_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UWH6

UniProtKB/Swiss-Prot:

TX261_HUMAN :
  • Belongs to the SVP26 family.
Family:
  • Belongs to the SVP26 family.
genes like me logo Genes that share domains with TEX261: view

Function for TEX261 Gene

Phenotypes From GWAS Catalog for TEX261 Gene

Gene Ontology (GO) - Molecular Function for TEX261 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097020 COPII adaptor activity IBA,IEA 21873635
genes like me logo Genes that share ontologies with TEX261: view
genes like me logo Genes that share phenotypes with TEX261: view

Animal Model Products

CRISPR Products

miRNA for TEX261 Gene

miRTarBase miRNAs that target TEX261

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX261

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TEX261 Gene

Localization for TEX261 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX261 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX261 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
golgi apparatus 3
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TEX261 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030134 COPII-coated ER to Golgi transport vesicle IBA 21873635
GO:0030173 integral component of Golgi membrane IBA 21873635
GO:0030176 integral component of endoplasmic reticulum membrane IBA 21873635
genes like me logo Genes that share ontologies with TEX261: view

Pathways & Interactions for TEX261 Gene

PathCards logo

SuperPathways for TEX261 Gene

No Data Available

Interacting Proteins for TEX261 Gene

Gene Ontology (GO) - Biological Process for TEX261 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA,IEA 21873635
GO:0043065 positive regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with TEX261: view

No data available for Pathways by source and SIGNOR curated interactions for TEX261 Gene

Drugs & Compounds for TEX261 Gene

No Compound Related Data Available

Transcripts for TEX261 Gene

mRNA/cDNA for TEX261 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX261

Alternative Splicing Database (ASD) splice patterns (SP) for TEX261 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for TEX261 Gene

GeneLoc Exon Structure for
TEX261
ECgene alternative splicing isoforms for
TEX261

Expression for TEX261 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEX261 Gene

Protein differential expression in normal tissues from HIPED for TEX261 Gene

This gene is overexpressed in Ovary (36.0), Prostate (24.0), and Liver (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEX261 Gene



Protein tissue co-expression partners for TEX261 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEX261 Gene:

TEX261

SOURCE GeneReport for Unigene cluster for TEX261 Gene:

Hs.516087

Evidence on tissue expression from TISSUES for TEX261 Gene

  • Nervous system(4)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with TEX261: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX261 Gene

Orthologs for TEX261 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TEX261 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX261 33 32
  • 99.83 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 94 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TEX261 33 32
  • 93.45 (n)
OneToMany
dog
(Canis familiaris)
Mammalia TEX261 32
  • 92.95 (n)
-- 33
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tex261 17 33 32
  • 91.5 (n)
rat
(Rattus norvegicus)
Mammalia Tex261 32
  • 91.5 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tex261 32
  • 77.38 (n)
Str.2834 32
African clawed frog
(Xenopus laevis)
Amphibia tex261-prov 32
zebrafish
(Danio rerio)
Actinopterygii tex261 33 32
  • 76.19 (n)
OneToMany
wufb72a06 32
fruit fly
(Drosophila melanogaster)
Insecta CG3500 33 32
  • 56.89 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011456 32
  • 54.39 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR127W 32
  • 49.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SVP26 35 33 32
  • 49.8 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09295g 32
  • 48.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 57 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00778 32
  • 53.76 (n)
Species where no ortholog for TEX261 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX261 Gene

ENSEMBL:
Gene Tree for TEX261 (if available)
TreeFam:
Gene Tree for TEX261 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEX261: view image

Paralogs for TEX261 Gene

Paralogs for TEX261 Gene

genes like me logo Genes that share paralogs with TEX261: view

Variants for TEX261 Gene

Sequence variations from dbSNP and Humsavar for TEX261 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000116130 -- 70,986,052(-) C/T 3_prime_UTR_variant
rs1000188860 -- 70,985,812(-) G/A downstream_transcript_variant
rs1000270866 -- 70,992,923(-) T/C intron_variant
rs1000680628 -- 70,990,995(-) C/T intron_variant
rs1000746407 -- 70,992,602(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TEX261 Gene

Variant ID Type Subtype PubMed ID
esv2666405 CNV deletion 23128226
esv27910 CNV gain 19812545
esv3591215 CNV loss 21293372
nsv1013232 CNV gain 25217958
nsv1146915 OTHER inversion 26484159
nsv517881 CNV loss 19592680

Variation tolerance for TEX261 Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX261 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX261

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX261 Gene

Disorders for TEX261 Gene

Additional Disease Information for TEX261

No disorders were found for TEX261 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX261 Gene

Publications for TEX261 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56
  3. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. (PMID: 9464256) López-Fernández LA … del Mazo J (Biochemical and biophysical research communications 1998) 2 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56

Products for TEX261 Gene

Sources for TEX261 Gene