Aliases for TEX2 Gene

Aliases for TEX2 Gene

  • Testis Expressed 2 2 3 5
  • Transmembrane Protein 96 2 3 4
  • Testis Expressed Sequence 2 2 3
  • Testis-Expressed Protein 2 3 4
  • TMEM96 3 4
  • Testis-Expressed Sequence 2 Protein 3
  • KIAA1738 4
  • HT008 3

External Ids for TEX2 Gene

Previous GeneCards Identifiers for TEX2 Gene

  • GC17M059579
  • GC17M062224
  • GC17M057594

Summaries for TEX2 Gene

GeneCards Summary for TEX2 Gene

TEX2 (Testis Expressed 2) is a Protein Coding gene. Diseases associated with TEX2 include Wernicke-Korsakoff Syndrome.

Additional gene information for TEX2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEX2 Gene

Genomics for TEX2 Gene

GeneHancer (GH) Regulatory Elements for TEX2 Gene

Promoters and enhancers for TEX2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J064259 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 507.3 +0.7 702 6.3 ZNF217 SIN3A TCF12 POLR2G SP1 PHF8 ZFX REST POLR2A ZBTB26 TEX2 FTSJ3 POLG2 CEP95 DDX42 SLC16A6P1 SMARCD2 DDX5 PLEKHM1P1 ENSG00000265982
GH17J064229 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 516.8 +31.9 31943 3.3 JUND CTBP1 NFYB NCOR1 CTCF NFIC TRIM24 FOS USF1 NFE2 TEX2 CEP95 POLG2 SLC16A6P1 ENSG00000265982 DDX42 PLEKHM1P1 DDX5 FTSJ3 PRR29
GH17J064213 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19.3 +46.5 46471 6.7 EP300 FOXK2 CTCF POLR2G USF1 NCOR1 ZFX ZIC2 REST KDM6A TEX2 CSHL1 GH1 KPNA2P3 ENSG00000265298 HSALNG0118082 piR-38579-023
GH17J064173 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 18 +85.9 85940 7.4 FOXK2 NCOR1 JUND REST KDM6A ZBTB25 SKI TEAD1 ZKSCAN8 MXI1 TEX2 ERN1 DDX5 ICAM2 LIMD2 HSALNG0118082 lnc-ERN1-3
GH17J064239 Enhancer 1.2 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 19.2 +22.2 22192 2.4 JUND FOS REST MXI1 OSR2 CTCF NR2F2 ZBTB17 RBBP5 POLR2A TEX2 piR-38579-023
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEX2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEX2

Top Transcription factor binding sites by QIAGEN in the TEX2 gene promoter:
  • AML1a
  • ATF-2
  • CP2
  • HNF-4alpha1
  • Ik-3
  • Meis-1
  • Meis-1a
  • Meis-1b
  • SRF
  • SRF (504 AA)

Genomic Locations for TEX2 Gene

Genomic Locations for TEX2 Gene
116,097 bases
Minus strand
116,075 bases
Minus strand

Genomic View for TEX2 Gene

Genes around TEX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX2 Gene

Proteins for TEX2 Gene

  • Protein details for TEX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-expressed protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6AHZ5
    • Q8N3L0
    • Q9C0C5

    Protein attributes for TEX2 Gene

    1127 amino acids
    Molecular mass:
    125303 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TEX2 Gene


neXtProt entry for TEX2 Gene

Post-translational modifications for TEX2 Gene

  • Glycosylation at Asn330
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TEX2 Gene

Domains & Families for TEX2 Gene

Gene Families for TEX2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TEX2 Gene

  • Pleckstrin-like

Suggested Antigen Peptide Sequences for TEX2 Gene

GenScript: Design optimal peptide antigens:
  • TEX2 protein (Q2YDX6_HUMAN)
  • TEX2 protein (Q7L166_HUMAN)
  • Testis-expressed sequence 2 protein (TEX2_HUMAN)
genes like me logo Genes that share domains with TEX2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEX2 Gene

Function for TEX2 Gene

Phenotypes From GWAS Catalog for TEX2 Gene

Gene Ontology (GO) - Molecular Function for TEX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008289 lipid binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with TEX2: view
genes like me logo Genes that share phenotypes with TEX2: view

Animal Model Products

CRISPR Products

miRNA for TEX2 Gene

miRTarBase miRNAs that target TEX2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TEX2 Gene

Localization for TEX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX2 gene
Compartment Confidence
plasma membrane 3
nucleus 3
endoplasmic reticulum 3
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TEX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 16449791
genes like me logo Genes that share ontologies with TEX2: view

Pathways & Interactions for TEX2 Gene

PathCards logo

SuperPathways for TEX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process NAS 16449791
GO:0006869 lipid transport IEA --
GO:0007165 signal transduction NAS 16449791
genes like me logo Genes that share ontologies with TEX2: view

No data available for Pathways by source and SIGNOR curated interactions for TEX2 Gene

Drugs & Compounds for TEX2 Gene

No Compound Related Data Available

Transcripts for TEX2 Gene

mRNA/cDNA for TEX2 Gene

20 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX2

Alternative Splicing Database (ASD) splice patterns (SP) for TEX2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: -
SP5: - -
SP6: -
SP7: - - - -
SP8: - - -

Relevant External Links for TEX2 Gene

GeneLoc Exon Structure for

Expression for TEX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEX2 Gene

Protein differential expression in normal tissues from HIPED for TEX2 Gene

This gene is overexpressed in Pancreas (19.0), Plasma (12.5), Breast (8.9), and Lung (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TEX2 Gene

Protein tissue co-expression partners for TEX2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEX2

SOURCE GeneReport for Unigene cluster for TEX2 Gene:


Evidence on tissue expression from TISSUES for TEX2 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with TEX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX2 Gene

Orthologs for TEX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TEX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TEX2 31 30
  • 99.53 (n)
(Canis familiaris)
Mammalia TEX2 31 30
  • 91.47 (n)
(Bos Taurus)
Mammalia TEX2 31 30
  • 89.12 (n)
(Rattus norvegicus)
Mammalia Tex2 30
  • 87.62 (n)
(Mus musculus)
Mammalia Tex2 17 31 30
  • 87.28 (n)
(Monodelphis domestica)
Mammalia TEX2 31
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 81 (a)
-- 31
  • 73 (a)
(Gallus gallus)
Aves TEX2 31 30
  • 74.11 (n)
(Anolis carolinensis)
Reptilia TEX2 31
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tex2.2 30
  • 67.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24580 30
(Danio rerio)
Actinopterygii tex2 31 30
  • 63.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43783 31
  • 21 (a)
(Caenorhabditis elegans)
Secernentea F55C12.5 31
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NVJ2 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7607 31
  • 40 (a)
Species where no ortholog for TEX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEX2 Gene

Gene Tree for TEX2 (if available)
Gene Tree for TEX2 (if available)
Evolutionary constrained regions (ECRs) for TEX2: view image

Paralogs for TEX2 Gene

(1) SIMAP similar genes for TEX2 Gene using alignment to 6 proteins:

  • Q7L166_HUMAN
genes like me logo Genes that share paralogs with TEX2: view

No data available for Paralogs for TEX2 Gene

Variants for TEX2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEX2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs28605685 - p.Thr158Ile

Additional dbSNP identifiers (rs#s) for TEX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEX2 Gene

Variant ID Type Subtype PubMed ID
esv2716103 CNV deletion 23290073
esv3554643 CNV deletion 23714750
esv3641026 CNV loss 21293372
nsv1066968 CNV gain 25217958
nsv1123138 CNV deletion 24896259
nsv2117 CNV deletion 18451855
nsv483108 CNV loss 15286789
nsv509666 CNV insertion 20534489
nsv511058 OTHER complex 20534489
nsv524852 CNV gain 19592680
nsv833512 CNV gain+loss 17160897
nsv833513 CNV loss 17160897

Variation tolerance for TEX2 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX2 Gene

Disorders for TEX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TEX2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
wernicke-korsakoff syndrome
  • transketolase defect
- elite association - COSMIC cancer census association via MalaCards
Search TEX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEX2

genes like me logo Genes that share disorders with TEX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEX2 Gene

Publications for TEX2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  4. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for TEX2 Gene

Sources for TEX2 Gene