Aliases for TEX19 Gene

Aliases for TEX19 Gene

  • Testis Expressed 19 2 3 5
  • Testis-Expressed Protein 19 3 4
  • Testis-Expressed Sequence 19 Protein 3

External Ids for TEX19 Gene

Previous GeneCards Identifiers for TEX19 Gene

  • GC17P077911
  • GC17P080317
  • GC17P075715

Summaries for TEX19 Gene

GeneCards Summary for TEX19 Gene

TEX19 (Testis Expressed 19) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for TEX19 Gene

  • Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172).

Additional gene information for TEX19 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEX19 Gene

Genomics for TEX19 Gene

GeneHancer (GH) Regulatory Elements for TEX19 Gene

Promoters and enhancers for TEX19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J082358 Promoter/Enhancer 1.2 EPDnew ENCODE 515.3 -0.1 -139 0.4 MYC TOE1 ZBTB7A DEAF1 ZNF316 SMC3 ZBTB17 MAFF CREB3L1 NKRF TEX19 lnc-SECTM1-1 ENSG00000260011
GH17J082359 Enhancer 0.7 ENCODE 513.1 -0.6 -567 0.2 TOE1 SMC3 ZBTB17 CREB3L1 CTCF MNT ZNF395 TFDP1 SCRT1 RAD21 TEX19 lnc-SECTM1-1
GH17J082361 Promoter 0.6 Ensembl 500.7 -1.1 -1146 0.6 ZBTB17 CTCF ZNF366 PRDM10 RAD21 TEX19 lnc-SECTM1-1
GH17J082291 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 25.5 -60.6 -60614 14.7 EP300 HNRNPK FOXK2 ZBTB40 ZNF217 CTCF TCF12 SIN3A NRF1 POLR2G CSNK1D ENSG00000260563 FAAP100 ENSG00000262652 NARF-IT1 ARL2BPP9 DUS1L OGFOD3 TEX19 HEXD
GH17J082332 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.3 -25.1 -25103 4.1 NRF1 NCOR1 ZIC2 ZBTB10 POLR2A ZNF263 ZBTB11 ZNF423 ZBTB26 TOE1 SECTM1 HSALNG0119414 TEX19 ENSG00000263321 ENSG00000260011 MAFG CSNK1D SLC16A3 lnc-SECTM1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEX19 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEX19

Top Transcription factor binding sites by QIAGEN in the TEX19 gene promoter:
  • aMEF-2
  • Bach2
  • E47
  • HNF-4alpha1
  • HNF-4alpha2
  • ITF-2
  • MEF-2A
  • PPAR-alpha
  • Tal-1
  • Tal-1beta

Genomic Locations for TEX19 Gene

Genomic Locations for TEX19 Gene
chr17:82,359,247-82,363,776
(GRCh38/hg38)
Size:
4,530 bases
Orientation:
Plus strand
chr17:80,317,123-80,321,652
(GRCh37/hg19)
Size:
4,530 bases
Orientation:
Plus strand

Genomic View for TEX19 Gene

Genes around TEX19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX19 Gene

Proteins for TEX19 Gene

  • Protein details for TEX19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA77-TEX19_HUMAN
    Recommended name:
    Testis-expressed protein 19
    Protein Accession:
    Q8NA77

    Protein attributes for TEX19 Gene

    Size:
    164 amino acids
    Molecular mass:
    18469 Da
    Quaternary structure:
    • Interacts with UBR2; does not lead to TEX19 degradation and stabilizes it. Interacts with piRNA-associated proteins DDX4, EDC4, MAEL, PIWIL1, PIWIL2, RANBP9 and TDRD6 (By similarity). Interacts with L1RE1 (PubMed:28806172).

neXtProt entry for TEX19 Gene

Post-translational modifications for TEX19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEX19 Gene

Domains & Families for TEX19 Gene

Gene Families for TEX19 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEX19 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEX19 Gene

GenScript: Design optimal peptide antigens:
  • Testis-expressed sequence 19 protein (TEX19_HUMAN)
genes like me logo Genes that share domains with TEX19: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEX19 Gene

Function for TEX19 Gene

Molecular function for TEX19 Gene

UniProtKB/Swiss-Prot Function:
Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172).
UniProtKB/Swiss-Prot Induction:
Down-regulated by gonadotropin suppression sufficient to cause marked suppression of spermatogenesis and additionally progestogen treatment.

Phenotypes From GWAS Catalog for TEX19 Gene

Gene Ontology (GO) - Molecular Function for TEX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28806172
GO:0034584 piRNA binding ISS --
genes like me logo Genes that share ontologies with TEX19: view
genes like me logo Genes that share phenotypes with TEX19: view

Animal Models for TEX19 Gene

MGI Knock Outs for TEX19:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TEX19 Gene

Localization for TEX19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX19 Gene

Cytoplasm. Note=Was initially reported to localize in the nucleus. However, it was later shown to localize in cytoplasm only. Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q99MV2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX19 gene
Compartment Confidence
nucleus 4
extracellular 1
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TEX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with TEX19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEX19 Gene

Pathways & Interactions for TEX19 Gene

PathCards logo

SuperPathways for TEX19 Gene

No Data Available

Interacting Proteins for TEX19 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000331500 Q8NA77-TEX19_HUMAN for TEX19 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for TEX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development IBA 21873635
GO:0007131 reciprocal meiotic recombination ISS --
GO:0007140 male meiotic nuclear division ISS --
GO:0007283 spermatogenesis IBA,ISS --
GO:0008584 male gonad development IBA 21873635
genes like me logo Genes that share ontologies with TEX19: view

No data available for Pathways by source and SIGNOR curated interactions for TEX19 Gene

Drugs & Compounds for TEX19 Gene

No Compound Related Data Available

Transcripts for TEX19 Gene

mRNA/cDNA for TEX19 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX19 Gene

No ASD Table

Relevant External Links for TEX19 Gene

GeneLoc Exon Structure for
TEX19

Expression for TEX19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEX19 Gene

mRNA differential expression in normal tissues according to GTEx for TEX19 Gene

This gene is overexpressed in Testis (x50.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEX19

SOURCE GeneReport for Unigene cluster for TEX19 Gene:

Hs.231897

mRNA Expression by UniProt/SwissProt for TEX19 Gene:

Q8NA77-TEX19_HUMAN
Tissue specificity: Expressed in testis. Expressed in undifferentiated embryonic stem cells.

Evidence on tissue expression from TISSUES for TEX19 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TEX19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX19 Gene

Orthologs for TEX19 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TEX19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX19 31 30
  • 99.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100299732 30
  • 79.14 (n)
-- 31
  • 34 (a)
OneToMany
-- 31
  • 33 (a)
OneToMany
-- 31
  • 32 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tex19.2 30
  • 70.3 (n)
mouse
(Mus musculus)
Mammalia Tex19.2 17 31 30
  • 70.14 (n)
Tex19.1 31
  • 24 (a)
OneToMany
Species where no ortholog for TEX19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEX19 Gene

ENSEMBL:
Gene Tree for TEX19 (if available)
TreeFam:
Gene Tree for TEX19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEX19: view image

Paralogs for TEX19 Gene

No data available for Paralogs for TEX19 Gene

Variants for TEX19 Gene

Additional dbSNP identifiers (rs#s) for TEX19 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEX19 Gene

Variant ID Type Subtype PubMed ID
dgv5802n54 CNV gain 21841781
dgv5803n54 CNV gain 21841781
dgv5804n54 CNV gain+loss 21841781
esv1367803 CNV insertion 17803354
esv2162612 CNV deletion 18987734
esv21913 CNV gain+loss 19812545
esv2716489 CNV deletion 23290073
esv2716490 CNV deletion 23290073
esv2760445 CNV gain 21179565
esv2762577 CNV gain+loss 21179565
esv3641421 CNV gain 21293372
nsv1059334 CNV gain 25217958
nsv1067194 CNV gain 25217958
nsv112382 CNV deletion 16902084
nsv1132878 CNV insertion 24896259
nsv428351 CNV gain 18775914
nsv469561 CNV loss 16826518
nsv576207 CNV gain 21841781
nsv821135 CNV deletion 20802225
nsv833572 CNV loss 17160897
nsv833573 CNV loss 17160897
nsv952394 CNV deletion 24416366

Variation tolerance for TEX19 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX19

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEX19 Gene

Disorders for TEX19 Gene

Additional Disease Information for TEX19

No disorders were found for TEX19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX19 Gene

Publications for TEX19 Gene

  1. Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line. (PMID: 18096721) Kuntz S … Viville S (Stem cells (Dayton, Ohio) 2008) 2 3 4 54
  2. Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells. (PMID: 28806172) MacLennan M … Adams IR (eLife 2017) 3 4 54
  3. The mammalian-specific Tex19.1 gene plays an essential role in spermatogenesis and placenta-supported development. (PMID: 23674551) Tarabay Y … Viville S (Human reproduction (Oxford, England) 2013) 2 3 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis. (PMID: 28446200) Planells-Palop V … McFarlane RJ (Molecular cancer 2017) 3 54

Products for TEX19 Gene

Sources for TEX19 Gene