This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutati... See more...

Aliases for TEX15 Gene

Aliases for TEX15 Gene

  • Testis Expressed 15, Meiosis And Synapsis Associated 2 3 5
  • Cancer/Testis Antigen 42 2 3 4
  • CT42 2 3 4
  • Testis-Expressed Protein 15 3 4
  • Testis-Expressed Sequence 15 Protein 3
  • Testis Expressed Sequence 15 2
  • Testis Expressed 15 2
  • SPGF25 3
  • TEX15 5

External Ids for TEX15 Gene

Previous GeneCards Identifiers for TEX15 Gene

  • GC08M030510
  • GC08M031141
  • GC08M030545
  • GC08M030746
  • GC08M029235
  • GC08M030689

Summaries for TEX15 Gene

Entrez Gene Summary for TEX15 Gene

  • This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutations in this gene are associated with nonobstructive azoospermia. [provided by RefSeq, Apr 2017]

GeneCards Summary for TEX15 Gene

TEX15 (Testis Expressed 15, Meiosis And Synapsis Associated) is a Protein Coding gene. Diseases associated with TEX15 include Spermatogenic Failure 25 and Spermatogenic Failure 1. Among its related pathways are Meiosis and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot Summary for TEX15 Gene

  • Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEX15 Gene

Genomics for TEX15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TEX15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J030911 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.7 730 2.2 RNF2 PRDM10 ZNF512 IKZF1 JUND PRDM1 MTA2 ZIC2 ZNF24 PATZ1 GTF2E2 TEX15 lnc-TEX15-1 PPP2CB lnc-WRN-2 RF00017-6941
GH08J030862 Enhancer 0.3 Ensembl 12.3 +49.9 49907 1 PRDM6 SMARCA4 PPP2CB TEX15 piR-32214-639 RF00017-6942 lnc-TEX15-1 RF00017-6941
GH08J031049 Enhancer 0.6 FANTOM5 Ensembl 1.9 -137.1 -137093 1.4 ATF2 ZBTB33 SP7 TEX15 PURG WRN RF00017-6943 NRG1
GH08J030919 Enhancer 0.9 Ensembl ENCODE 0.4 -5.6 -5600 1.6 CTCF TEAD4 STAT3 REST RAD21 SP1 TRIM22 RUNX3 BCLAF1 ZBTB48 PPP2CB ENSG00000253961 ENSG00000253204 TEX15 lnc-TEX15-1 PURG RF00017-6941
GH08J030922 Enhancer 0.8 Ensembl 0.4 -11.1 -11093 3 ATF7 PRDM10 ZNF629 DPF2 CEBPA ZNF140 ZXDB FOXA2 ZNF580 ZNF266 WRN GTF2E2 PURG PPP2CB RPS15AP24 ENSG00000253961 ENSG00000272375 ENSG00000253204 TEX15 piR-43106-191
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEX15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEX15

Top Transcription factor binding sites by QIAGEN in the TEX15 gene promoter:
  • AML1a
  • IRF-2
  • IRF-7A
  • NF-kappaB1
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for TEX15 Gene

Genomic Locations for TEX15 Gene
chr8:30,831,544-30,913,008
(GRCh38/hg38)
Size:
81,465 bases
Orientation:
Minus strand
chr8:30,689,060-30,748,122
(GRCh37/hg19)
Size:
59,063 bases
Orientation:
Minus strand

Genomic View for TEX15 Gene

Genes around TEX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX15 Gene

Proteins for TEX15 Gene

  • Protein details for TEX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXT5-TEX15_HUMAN
    Recommended name:
    Testis-expressed protein 15
    Protein Accession:
    Q9BXT5

    Protein attributes for TEX15 Gene

    Size:
    2789 amino acids
    Molecular mass:
    315336 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEX15 Gene

Post-translational modifications for TEX15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEX15 Gene

Domains & Families for TEX15 Gene

Gene Families for TEX15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEX15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEX15 Gene

GenScript: Design optimal peptide antigens:
  • TEX15 protein (A5D8W7_HUMAN)
  • Testis expressed 15 (B2RU27_HUMAN)
  • Testis expressed sequence 15, isoform CRA_a (D3DSV6_HUMAN)
  • Cancer/testis antigen 42 (TEX15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BXT5

UniProtKB/Swiss-Prot:

TEX15_HUMAN :
  • Belongs to the TEX15 family.
Family:
  • Belongs to the TEX15 family.
genes like me logo Genes that share domains with TEX15: view

Function for TEX15 Gene

Molecular function for TEX15 Gene

UniProtKB/Swiss-Prot Function:
Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair.

Phenotypes From GWAS Catalog for TEX15 Gene

genes like me logo Genes that share phenotypes with TEX15: view

Human Phenotype Ontology for TEX15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TEX15 Gene

MGI Knock Outs for TEX15:

Animal Model Products

CRISPR Products

miRNA for TEX15 Gene

miRTarBase miRNAs that target TEX15

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TEX15 Gene

Localization for TEX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX15 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX15 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TEX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TEX15: view

Pathways & Interactions for TEX15 Gene

PathCards logo

SuperPathways for TEX15 Gene

SuperPathway Contained pathways
1 Meiosis
.73
2 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with TEX15: view

Pathways by source for TEX15 Gene

3 Reactome pathways for TEX15 Gene

Gene Ontology (GO) - Biological Process for TEX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007129 synapsis IEA --
GO:0007140 male meiotic nuclear division IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with TEX15: view

No data available for SIGNOR curated interactions for TEX15 Gene

Drugs & Compounds for TEX15 Gene

No Compound Related Data Available

Transcripts for TEX15 Gene

mRNA/cDNA for TEX15 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX15

Alternative Splicing Database (ASD) splice patterns (SP) for TEX15 Gene

No ASD Table

Relevant External Links for TEX15 Gene

GeneLoc Exon Structure for
TEX15

Expression for TEX15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX15 Gene

This gene is overexpressed in Testis (x23.2) and Uterus (x11.0).

Protein differential expression in normal tissues from HIPED for TEX15 Gene

This gene is overexpressed in Heart (32.1) and Liver, secretome (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEX15 Gene



Protein tissue co-expression partners for TEX15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEX15

SOURCE GeneReport for Unigene cluster for TEX15 Gene:

Hs.458316

mRNA Expression by UniProt/SwissProt for TEX15 Gene:

Q9BXT5-TEX15_HUMAN
Tissue specificity: Expressed in testis, predominantly in germ cells (PubMed:11279525, PubMed:26199321). Low expression, if any, in ovary (PubMed:11279525, PubMed:26199321). Also expressed in several cancers (PubMed:12704671).
genes like me logo Genes that share expression patterns with TEX15: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX15 Gene

Orthologs for TEX15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TEX15 30 31
  • 99.26 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TEX15 30 31
  • 82.29 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TEX15 30 31
  • 78.59 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tex15 30 17 31
  • 73.46 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tex15 30
  • 69.92 (n)
Oppossum
(Monodelphis domestica)
Mammalia TEX15 31
  • 35 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TEX15 31
  • 35 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tex15 31
  • 15 (a)
OneToOne
Species where no ortholog for TEX15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TEX15 Gene

ENSEMBL:
Gene Tree for TEX15 (if available)
TreeFam:
Gene Tree for TEX15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEX15: view image

Paralogs for TEX15 Gene

No data available for Paralogs for TEX15 Gene

Variants for TEX15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEX15 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
684768 Likely Benign: not provided 30,837,061(-) C/T MISSENSE_VARIANT
708791 Likely Benign: not provided 30,846,604(-) G/A MISSENSE_VARIANT
712060 Likely Benign: not provided 30,845,222(-) C/T MISSENSE_VARIANT
712693 Benign: not provided 30,842,870(-) C/T MISSENSE_VARIANT
712695 Benign: not provided 30,844,192(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TEX15 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEX15 Gene

Variant ID Type Subtype PubMed ID
nsv519692 CNV gain 19592680

Variation tolerance for TEX15 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.67; 95.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX15 Gene

Human Gene Mutation Database (HGMD)
TEX15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX15 Gene

Disorders for TEX15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TEX15 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TEX15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TEX15_HUMAN
  • Spermatogenic failure 25 (SPGF25) [MIM:617960]: An autosomal recessive infertility disorder caused by spermatogenesis defects that result in severe oligozoospermia or azoospermia. {ECO:0000269 PubMed:26199321, ECO:0000269 PubMed:28303806, ECO:0000269 PubMed:28355598}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TEX15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TEX15: view

No data available for Genatlas for TEX15 Gene

Publications for TEX15 Gene

  1. Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family. (PMID: 26199321) Okutman O … Viville S (Human molecular genetics 2015) 2 3 4
  2. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang PJ … Page DC (Nature genetics 2001) 2 3 4
  3. Case study of a patient with cryptozoospermia associated with a recessive TEX15 nonsense mutation. (PMID: 28303806) Wang X … Gao ZL (Asian journal of andrology 2018) 3 4
  4. Two Novel TEX15 Mutations in a Family with Nonobstructive Azoospermia. (PMID: 28355598) Colombo R … Bini M (Gynecologic and obstetric investigation 2017) 3 4
  5. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston KI … Carrell DT (Human reproduction (Oxford, England) 2010) 3 41

Products for TEX15 Gene

Sources for TEX15 Gene