Aliases for TEX15 Gene
External Ids for TEX15 Gene
Previous GeneCards Identifiers for TEX15 Gene
This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutations in this gene are associated with nonobstructive azoospermia. [provided by RefSeq, Apr 2017]
GeneCards Summary for TEX15 Gene
TEX15 (Testis Expressed 15, Meiosis And Synapsis Associated) is a Protein Coding gene. Diseases associated with TEX15 include Spermatogenic Failure 25 and Spermatogenic Failure 1. Among its related pathways are Meiosis and Cell Cycle, Mitotic.
UniProtKB/Swiss-Prot Summary for TEX15 Gene
Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair.