Aliases for TEX14 Gene
External Ids for TEX14 Gene
Previous GeneCards Identifiers for TEX14 Gene
The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
GeneCards Summary for TEX14 Gene
TEX14 (Testis Expressed 14, Intercellular Bridge Forming Factor) is a Protein Coding gene. Diseases associated with TEX14 include Spermatogenic Failure 23 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
UniProtKB/Swiss-Prot Summary for TEX14 Gene
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).