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The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
TEX14 (Testis Expressed 14, Intercellular Bridge Forming Factor) is a Protein Coding gene. Diseases associated with TEX14 include Spermatogenic Failure 23 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 20176808 |
GO:0005524 | ATP binding | IEA | -- |
GO:0019901 | protein kinase binding | IPI | 22405274 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000776 | kinetochore | IBA,ISS | -- |
GO:0000777 | condensed chromosome kinetochore | IEA | -- |
GO:0005623 | cell | ISS | -- |
GO:0005694 | chromosome | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0007049 | cell cycle | IEA | -- |
GO:0007094 | mitotic spindle assembly checkpoint | IEA,ISS | -- |
GO:0007140 | male meiotic nuclear division | IEA,ISS | -- |
GO:0008608 | attachment of spindle microtubules to kinetochore | IEA,ISS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: |
ExUns: | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TEX14 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TEX14 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TEX14 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tex14 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tex14 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TEX14 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TEX14 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TEX14 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TEX14 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | TEX14 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
635288 | Pathogenic: SPERMATOGENIC FAILURE 23 | 58,623,010(-) | C/A | MISSENSE_VARIANT | |
684771 | Benign: not provided | 58,616,233(-) | G/C | MISSENSE_VARIANT | |
708130 | Likely Benign: not provided | 58,613,423(-) | G/A | NONSENSE | |
718159 | Benign: not provided | 58,615,264(-) | G/A | SYNONYMOUS_VARIANT | |
723442 | Benign: not provided | 58,622,858(-) | G/A | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2657166 | CNV | deletion | 23128226 |
esv2661744 | CNV | deletion | 23128226 |
esv2671957 | CNV | deletion | 23128226 |
esv2758698 | CNV | gain | 17122850 |
esv3582847 | CNV | loss | 25503493 |
esv3582848 | CNV | loss | 25503493 |
esv3640889 | CNV | loss | 21293372 |
esv3640891 | CNV | loss | 21293372 |
nsv1066945 | CNV | loss | 25217958 |
nsv1138560 | CNV | deletion | 24896259 |
nsv1152637 | CNV | insertion | 26484159 |
nsv428347 | CNV | gain | 18775914 |
nsv457863 | CNV | loss | 19166990 |
nsv477144 | CNV | novel sequence insertion | 20440878 |
nsv515871 | CNV | loss | 19592680 |
nsv575801 | CNV | loss | 21841781 |
nsv833498 | CNV | loss | 17160897 |
nsv962346 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
spermatogenic failure 23 |
|
|
male infertility with azoospermia or oligozoospermia due to single gene mutation |
|
|
azoospermia |
|
|
hemochromatosis, type 1 |
|
|
fanconi anemia, complementation group a |
|
|