TEX14 Gene (Protein Coding)

Testis Expressed 14, Intercellular Bridge Forming Factor

GC17M058556
GIFtS:
40
The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011] See more...

Aliases for TEX14 Gene

Aliases for TEX14 Gene

  • Testis Expressed 14, Intercellular Bridge Forming Factor 2 3 5
  • Inactive Serine/Threonine-Protein Kinase TEX14 3 4
  • Testis-Expressed Sequence 14 Protein 3 4
  • Protein Kinase-Like Protein SgK307 3 4
  • Cancer/Testis Antigen 113 2 3
  • Sugen Kinase 307 3 4
  • Testis-Expressed Sequence 14 4
  • Testis Expressed Sequence 14 2
  • Testis-Expressed Protein 14 3
  • Testis Expressed 14 2
  • SPGF23 3
  • SGK307 4
  • CT113 3

External Ids for TEX14 Gene

Previous GeneCards Identifiers for TEX14 Gene

  • GC17M056378
  • GC17M059115
  • GC17M056976
  • GC17M057108
  • GC17M053989
  • GC17M056634
  • GC17M051994

Summaries for TEX14 Gene

Entrez Gene Summary for TEX14 Gene

  • The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

GeneCards Summary for TEX14 Gene

TEX14 (Testis Expressed 14, Intercellular Bridge Forming Factor) is a Protein Coding gene. Diseases associated with TEX14 include Spermatogenic Failure 23 and Fanconi Anemia, Complementation Group O. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot Summary for TEX14 Gene

  • Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).

Additional gene information for TEX14 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEX14 Gene

Genomics for TEX14 Gene

GeneHancer (GH) Regulatory Elements for TEX14 Gene

Promoters and enhancers for TEX14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEX14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEX14 gene promoter:
  • E47
  • IRF-7A
  • POU2F1
  • POU2F1a
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Tal-1beta

Genomic Locations for TEX14 Gene

Genomic Locations for TEX14 Gene
chr17:58,556,677-58,692,079
(GRCh38/hg38)
Size:
135,403 bases
Orientation:
Minus strand
chr17:56,634,038-56,769,416
(GRCh37/hg19)
Size:
135,379 bases
Orientation:
Minus strand

Genomic View for TEX14 Gene

Genes around TEX14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX14 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TEX14 Gene

Proteins for TEX14 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TEX14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWB6-TEX14_HUMAN
    Recommended name:
    Inactive serine/threonine-protein kinase TEX14
    Protein Accession:
    Q8IWB6
    Secondary Accessions:
    • A6NH19
    • Q7RTP3
    • Q8ND97
    • Q9BXT9

    Protein attributes for TEX14 Gene

    Size:
    1497 amino acids
    Molecular mass:
    167901 Da
    Quaternary structure:
    • Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101 (By similarity).
    SequenceCaution:
    • Sequence=AAK31980.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TEX14 Gene

    Alternative splice isoforms for TEX14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEX14 Gene

Protein Expression for TEX14 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TEX14 Gene

  • Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEX14 Gene

Domains & Families for TEX14 Gene

Gene Families for TEX14 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Transporters

Protein Domains for TEX14 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEX14 Gene

GenScript: Design optimal peptide antigens:
  • Testis-expressed sequence 14 (TEX14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IWB6

UniProtKB/Swiss-Prot:

TEX14_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • The GPPX3Y motif mediates interaction with CEP55.
Family:
  • Belongs to the protein kinase superfamily.
genes like me logo Genes that share domains with TEX14: view

Function for TEX14 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TEX14 Gene

UniProtKB/Swiss-Prot Function:
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).

Phenotypes From GWAS Catalog for TEX14 Gene

Gene Ontology (GO) - Molecular Function for TEX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 20176808
GO:0005524 ATP binding IEA --
GO:0019901 protein kinase binding IPI 22405274
genes like me logo Genes that share ontologies with TEX14: view
genes like me logo Genes that share phenotypes with TEX14: view

Human Phenotype Ontology for TEX14 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TEX14 Gene

MGI Knock Outs for TEX14:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TEX14 Gene

Localization for TEX14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX14 Gene

Cytoplasm. Midbody. Chromosome, centromere, kinetochore. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX14 gene
Compartment Confidence
extracellular 4
plasma membrane 1
mitochondrion 1
nucleus 1
endosome 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TEX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore ISS,IBA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005623 cell ISS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with TEX14: view

Pathways & Interactions for TEX14 Gene

PathCards logo

SuperPathways for TEX14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEX14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007094 mitotic spindle assembly checkpoint ISS,IEA --
GO:0007140 male meiotic nuclear division IEA,ISS --
GO:0008608 attachment of spindle microtubules to kinetochore IEA,ISS --
genes like me logo Genes that share ontologies with TEX14: view

No data available for Pathways by source and SIGNOR curated interactions for TEX14 Gene

Drugs & Compounds for TEX14 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TEX14 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TEX14 Gene

(3) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a ·
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - - - - - - -
SP5:
SP6:

ExUns: 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for TEX14 Gene

GeneLoc Exon Structure for
TEX14
ECgene alternative splicing isoforms for
TEX14

Expression for TEX14 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEX14 Gene

mRNA expression in normal human tissues for TEX14 Gene
mRNA expression by GTEx for TEX14 GenemRNA expression by BioGPS for TEX14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX14 Gene

This gene is overexpressed in Testis (x27.2).

Protein differential expression in normal tissues from HIPED for TEX14 Gene

This gene is overexpressed in Testis (31.9), Serum (14.5), Fetal Brain (10.3), and Ovary (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEX14 Gene



Protein tissue co-expression partners for TEX14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEX14 Gene:

TEX14

SOURCE GeneReport for Unigene cluster for TEX14 Gene:

Hs.390221

mRNA Expression by UniProt/SwissProt for TEX14 Gene:

Q8IWB6-TEX14_HUMAN
Tissue specificity: Expression restricted to testis.

Evidence on tissue expression from TISSUES for TEX14 Gene

  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with TEX14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX14 Gene

Orthologs for TEX14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TEX14 33 32
  • 99.22 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia TEX14 33 32
  • 84.66 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia TEX14 33 32
  • 83.45 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tex14 32
  • 79.18 (n)
mouse
(Mus musculus)
 Mammalia Tex14 17 33 32
  • 78.27 (n)
oppossum
(Monodelphis domestica)
 Mammalia TEX14 33
  • 53 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TEX14 33
  • 48 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TEX14 33 32
  • 55.1 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TEX14 33
  • 65 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii TEX14 33
  • 45 (a)
 OneToOne
Species where no ortholog for TEX14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX14 Gene

ENSEMBL:
Gene Tree for TEX14 (if available)
TreeFam:
Gene Tree for TEX14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEX14: view image

Paralogs for TEX14 Gene

Pseudogenes.org Pseudogenes for TEX14 Gene

genes like me logo Genes that share paralogs with TEX14: view

No data available for Paralogs for TEX14 Gene

Variants for TEX14 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for TEX14 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000113630 uncertain-significance, Hereditary cancer-predisposing syndrome, Fanconi anemia, complementation group O 58,692,732(-) C/T upstream_transcript_variant
rs1057517641 likely-pathogenic, Fanconi anemia, complementation group O, Breast-ovarian cancer, familial 3 58,692,790(-) T/G upstream_transcript_variant
rs1060502587 uncertain-significance, Fanconi anemia, complementation group O, Hereditary cancer-predisposing syndrome 58,692,725(-) G/A/C upstream_transcript_variant
rs1060502593 uncertain-significance, Fanconi anemia, complementation group O 58,692,687(-) T/G upstream_transcript_variant
rs1060502603 uncertain-significance, Fanconi anemia, complementation group O 58,692,680(-) G/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TEX14 Gene

Variant ID Type Subtype PubMed ID
esv2657166 CNV deletion 23128226
esv2661744 CNV deletion 23128226
esv2671957 CNV deletion 23128226
esv2758698 CNV gain 17122850
esv3582847 CNV loss 25503493
esv3582848 CNV loss 25503493
esv3640889 CNV loss 21293372
esv3640891 CNV loss 21293372
nsv1066945 CNV loss 25217958
nsv1138560 CNV deletion 24896259
nsv1152637 CNV insertion 26484159
nsv428347 CNV gain 18775914
nsv457863 CNV loss 19166990
nsv477144 CNV novel sequence insertion 20440878
nsv515871 CNV loss 19592680
nsv575801 CNV loss 21841781
nsv833498 CNV loss 17160897
nsv962346 CNV duplication 23825009

Variation tolerance for TEX14 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX14 Gene

Human Gene Mutation Database (HGMD)
TEX14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX14 Gene

Disorders for TEX14 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TEX14 Gene - From: HGMD, OMIM, ClinVar, GTR, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 23
  • spgf23
fanconi anemia, complementation group o
  • fanco
breast-ovarian cancer, familial 3
  • breast-ovarian cancer, familial, susceptibility to, 3
- elite association - COSMIC cancer census association via MalaCards
Search TEX14 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TEX14_HUMAN
  • Spermatogenic failure 23 (SPGF23) [MIM:617707]: An infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia. {ECO:0000269 PubMed:28206990}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TEX14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TEX14: view

No data available for Genatlas for TEX14 Gene

Publications for TEX14 Gene

  1. Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. (PMID: 12711554) Wu MH … Matzuk MM (Gene expression patterns : GEP 2003) 2 3 4 56
  2. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang PJ … Page DC (Nature genetics 2001) 2 3 4 56
  3. Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells. (PMID: 26392564) Kim HJ … Lee HH (Proceedings of the National Academy of Sciences of the United States of America 2015) 2 3 56
  4. Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. (PMID: 22405274) Mondal G … Couch FJ (Molecular cell 2012) 3 4 56
  5. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston KI … Carrell DT (Human reproduction (Oxford, England) 2010) 3 43 56

ExternalLinks

View latest publications for TEX14 gene in Mastermind

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