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The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011] See more...
Aliases for TEX14 Gene
Aliases for TEX14 Gene
External Ids for TEX14 Gene
- HGNC: 11737
- Entrez Gene: 56155
- Ensembl: ENSG00000121101
- OMIM: 605792
- UniProtKB: Q8IWB6
Previous GeneCards Identifiers for TEX14 Gene
- GC17M056378
- GC17M059115
- GC17M056976
- GC17M057108
- GC17M053989
- GC17M056634
- GC17M051994
Summaries for TEX14 Gene
-
The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
GeneCards Summary for TEX14 Gene
TEX14 (Testis Expressed 14, Intercellular Bridge Forming Factor) is a Protein Coding gene. Diseases associated with TEX14 include Spermatogenic Failure 23 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
UniProtKB/Swiss-Prot Summary for TEX14 Gene
-
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).
Additional gene information for TEX14 Gene
- HGNC(11737)
- Entrez Gene(56155)
- Ensembl(ENSG00000121101)
- OMIM(605792)
- UniProtKB(Q8IWB6)
- Open Targets Platform(ENSG00000121101)
- Search for TEX14 at DataMed
- Search for TEX14 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEX14 Gene
Genomics for TEX14 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TEX14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TEX14 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEX14
- Top Transcription factor binding sites by QIAGEN in the TEX14 gene promoter:
-
- E47
- IRF-7A
- POU2F1
- POU2F1a
- SREBP-1a
- SREBP-1b
- SREBP-1c
- Tal-1beta
Genomic Locations for TEX14 Gene
Genomic Locations for TEX14 Gene
- chr17:58,556,678-58,692,055
- (GRCh38/hg38)
- Size:
- 135,378 bases
- Orientation:
- Minus strand
- chr17:56,634,038-56,769,416
- (GRCh37/hg19)
- Size:
- 135,379 bases
- Orientation:
- Minus strand
Genomic View for TEX14 Gene
Genes around TEX14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by HGNC
- 17q22 by Entrez Gene
- 17q22 by Ensembl
TEX14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TEX14 Gene
Proteins for TEX14 Gene
-
Protein details for TEX14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IWB6-TEX14_HUMAN
- Recommended name:
- Inactive serine/threonine-protein kinase TEX14
- Protein Accession:
- Q8IWB6
- A6NH19
- Q7RTP3
- Q8ND97
- Q9BXT9
Protein attributes for TEX14 Gene
- Size:
- 1497 amino acids
- Molecular mass:
- 167901 Da
- Quaternary structure:
-
- Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101 (By similarity).
- SequenceCaution:
-
- Sequence=AAK31980.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for TEX14 Gene
Post-translational modifications for TEX14 Gene
- Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TEX14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TEX14
-
Abcam antibodies for TEX14
- Invitrogen Antibodies for TEX14 (AFLGC-TEX14)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TEX14
Protein Products
-
OriGene Purified Proteins for TEX14
- Search Origene for MassSpec and Protein Over-expression Lysates for TEX14
- Origene Custom Protein Services for TEX14
- Novus Biologicals proteins for TEX14
-
Abcam proteins for TEX14
No data available for DME Specific Peptides for TEX14 Gene
Domains & Families for TEX14 Gene
Gene Families for TEX14 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
- Transporters
Protein Domains for TEX14 Gene
- InterPro:
- Blocks:
-
- Ankyrin repeat signature
- ProtoNet:
Suggested Antigen Peptide Sequences for TEX14 Gene
- GenScript: Design optimal peptide antigens:
-
- Testis-expressed sequence 14 (TEX14_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8IWB6UniProtKB/Swiss-Prot:
TEX14_HUMAN :- The protein kinase domain is predicted to be catalytically inactive.
- Belongs to the protein kinase superfamily.
- Domain:
-
- The protein kinase domain is predicted to be catalytically inactive.
- The GPPX3Y motif mediates interaction with CEP55.
- Family:
-
- Belongs to the protein kinase superfamily.
Function for TEX14 Gene
Molecular function for TEX14 Gene
- UniProtKB/Swiss-Prot Function:
- Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).
Phenotypes From GWAS Catalog for TEX14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 20176808 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0019901 | protein kinase binding | IPI | 22405274 |
Phenotypes for TEX14 Gene
- MGI mutant phenotypes for TEX14:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TEX14:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Moderately decreased NFAT1-GFP nuclear translocation
- shRNA abundance <= 25%
- Decreased cell migration
- Increased transferrin (TF) endocytosis
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Increased cell death in HCC-1954 cells
- Increased cell death in HCT116 cells
- Decreased cell proliferation
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, increased cell spreading
Animal Models for TEX14 Gene
- MGI Knock Outs for TEX14:
-
- Tex14 Tex14<tm1Zuk>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TEX14 - Select products 50% OFF >
- * TEX14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TEX14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TEX14
-
Santa Cruz Biotechnology (SCBT) CRISPR for TEX14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TEX14
- Browse OriGene Inhibitory RNA Products For TEX14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX14
Clone Products
- Applied Biological Materials (abm): Clones for TEX14 - Select products 50% OFF >
- * TEX14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TEX14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TEX14
Cell Line Products
-
Horizon Cell Lines for TEX14
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TEX14 Gene
Localization for TEX14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TEX14 Gene
- Cytoplasm. Midbody. Chromosome, centromere, kinetochore. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 2 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
- Cell Junctions (2)
- Cytosol (2)
- Plasma membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IBA,ISS | -- |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005623 | cell | ISS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for TEX14 Gene
Interacting Proteins for TEX14 Gene
Selected Interacting proteins:
Q8IWB6-TEX14_HUMAN
ENSP00000240361
for TEX14 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TEX14
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007094 | mitotic spindle assembly checkpoint | IEA,ISS | -- |
| GO:0007140 | male meiotic nuclear division | IEA,ISS | -- |
| GO:0008608 | attachment of spindle microtubules to kinetochore | IEA,ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for TEX14 Gene
Transcripts for TEX14 Gene
mRNA/cDNA for TEX14 Gene
- 3 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000240361 4911 nts (view in UCSC)
- ENST00000349033 4773 nts (view in UCSC)
- ENST00000389934 4927 nts (view in UCSC)
- ENST00000581147 676 nts (view in UCSC)
- ENST00000582740 4834 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TEX14 - Select products 50% OFF >
- * TEX14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TEX14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TEX14
-
Santa Cruz Biotechnology (SCBT) CRISPR for TEX14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TEX14
- Browse OriGene Inhibitory RNA Products For TEX14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX14
Clone Products
- Applied Biological Materials (abm): Clones for TEX14 - Select products 50% OFF >
- * TEX14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TEX14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TEX14
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for TEX14 Gene
- GeneLoc Exon Structure for
- TEX14
Expression for TEX14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad
- Primary Spermatocyte Seminiferous Tubules
- XX Germ Cells Ovigerous Cord
- XY Germ Cells Testis Cord
- Primordial germ-like cells(West JA et. al. 2006)
- Inner Cell Mass (Early Embryonic Tissues)
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Granulosa Cells Primary Follicle
- XX Germ Cells Ovigerous Cord
-
Testis (Reproductive System)
- Primary Spermatocyte Seminiferous Tubules
- XY Germ Cells Testis Cord
- Seminiferous Tubules
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Germ Cells (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for TEX14 Gene
This gene is overexpressed in Testis (x27.2).
This gene is overexpressed in Testis (31.9), Serum (14.5), Fetal Brain (10.3), and Ovary (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEX14 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEX14
SOURCE GeneReport for Unigene cluster for TEX14 Gene:
Hs.390221mRNA Expression by UniProt/SwissProt for TEX14 Gene:
Q8IWB6-TEX14_HUMAN
Tissue specificity:
Expression restricted to testis.
Evidence on tissue expression from TISSUES for TEX14 Gene
- Nervous system(3)
Primer Products
-
OriGene qPCR primer pairs for TEX14
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX14 Gene
Orthologs for TEX14 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TEX14 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TEX14 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TEX14 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tex14 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tex14 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TEX14 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TEX14 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TEX14 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TEX14 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | TEX14 31 |
|
OneToOne |
- Species where no ortholog for TEX14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TEX14 Gene
- ENSEMBL:
- Gene Tree for TEX14 (if available)
- TreeFam:
- Gene Tree for TEX14 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TEX14: view image
Paralogs for TEX14 Gene
Pseudogenes.org Pseudogenes for TEX14 Gene
No data available for Paralogs for TEX14 Gene
Variants for TEX14 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEX14 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 635288 | Pathogenic: SPERMATOGENIC FAILURE 23 | 58,623,010(-) | C/A | MISSENSE_VARIANT | |
| 684771 | Benign: not provided | 58,616,233(-) | G/C | MISSENSE_VARIANT | |
| 708130 | Likely Benign: not provided | 58,613,423(-) | G/A | NONSENSE | |
| 718159 | Benign: not provided | 58,615,264(-) | G/A | SYNONYMOUS_VARIANT | |
| 723442 | Benign: not provided | 58,622,858(-) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2657166 | CNV | deletion | 23128226 |
| esv2661744 | CNV | deletion | 23128226 |
| esv2671957 | CNV | deletion | 23128226 |
| esv2758698 | CNV | gain | 17122850 |
| esv3582847 | CNV | loss | 25503493 |
| esv3582848 | CNV | loss | 25503493 |
| esv3640889 | CNV | loss | 21293372 |
| esv3640891 | CNV | loss | 21293372 |
| nsv1066945 | CNV | loss | 25217958 |
| nsv1138560 | CNV | deletion | 24896259 |
| nsv1152637 | CNV | insertion | 26484159 |
| nsv428347 | CNV | gain | 18775914 |
| nsv457863 | CNV | loss | 19166990 |
| nsv477144 | CNV | novel sequence insertion | 20440878 |
| nsv515871 | CNV | loss | 19592680 |
| nsv575801 | CNV | loss | 21841781 |
| nsv833498 | CNV | loss | 17160897 |
| nsv962346 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.01;
60.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TEX14 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX14 Gene
Disorders for TEX14 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spermatogenic failure 23 |
|
|
| male infertility with azoospermia or oligozoospermia due to single gene mutation |
|
|
| azoospermia |
|
|
| hemochromatosis, type 1 |
|
|
| fanconi anemia, complementation group a |
|
|
Search TEX14 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TEX14_HUMAN- Spermatogenic failure 23 (SPGF23) [MIM:617707]: An infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia. {ECO:0000269 PubMed:28206990}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for TEX14
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for TEX14 Gene
Publications for TEX14 Gene
- Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. (PMID: 12711554) Wu MH … Matzuk MM (Gene expression patterns : GEP 2003) 2 3 4
- An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang PJ … Page DC (Nature genetics 2001) 2 3 4
- Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells. (PMID: 26392564) Kim HJ … Lee HH (Proceedings of the National Academy of Sciences of the United States of America 2015) 2 3
- Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint. (PMID: 22405274) Mondal G … Couch FJ (Molecular cell 2012) 3 4
- TEX14 interacts with CEP55 to block cell abscission. (PMID: 20176808) Iwamori T … Matzuk MM (Molecular and cellular biology 2010) 3 4
ExternalLinks
Products for TEX14 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TEX14
- Search Origene for MassSpec and Protein Over-expression Lysates for TEX14
- Origene Custom Protein Services for TEX14
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TEX14
- Browse OriGene Inhibitory RNA Products For TEX14
- OriGene qPCR primer pairs for TEX14
- OriGene CRISPR knockouts for TEX14
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TEX14
- Sino Biological Human cDNA Clone for TEX14
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TEX14
- Novus Biologicals proteins for TEX14
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TEX14
- Abcam proteins for TEX14
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for TEX14 (AFLGC-TEX14)
- VectorBuilder Custom and pre-made DNA vectors for TEX14 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TEX14 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TEX14 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TEX14 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TEX14
- antibodies-online: Show 5 available TEX14 Antibodies ranked by validation data
- Compare Top TEX14 Antibodies
- antibodies-online: Search results for available TEX14 related products ranked by validation data
- antibodies-online: Show 3 available TEX14 Proteins ranked by validation data
- Compare Top TEX14 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TEX14
- Search Santa Cruz Biotechnology (SCBT) for TEX14 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TEX14
- Horizon Cell Lines for TEX14
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TEX14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TEX14
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TEX14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX14
Sources for TEX14 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB