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Aliases for TEX12 Gene

Aliases for TEX12 Gene

  • Testis Expressed 12 2 3 5
  • Testis Expressed Sequence 12 2

External Ids for TEX12 Gene

Previous GeneCards Identifiers for TEX12 Gene

  • GC11U990274
  • GC11P113550
  • GC11P112071
  • GC11P111575
  • GC11P111543
  • GC11P112038
  • GC11P107962

Summaries for TEX12 Gene

Entrez Gene Summary for TEX12 Gene

  • This gene is similar to a mouse gene that is expressed in the testis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEX12 Gene

TEX12 (Testis Expressed 12) is a Protein Coding gene. Among its related pathways are Meiosis and Cell Cycle, Mitotic.

Additional gene information for TEX12 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX12 Gene

Genomics for TEX12 Gene

GeneHancer (GH) Regulatory Elements for TEX12 Gene

Promoters and enhancers for TEX12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I112167 Promoter 0.7 EPDnew 550.8 0.0 -19 0.1 MITF USF1 ZBTB33 TEX12 BCO2 IL18 ENSG00000254638 ENSG00000255292
GH11I112289 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 9.4 +124.7 124671 4.8 ATF1 ARNT SIN3A FEZF1 GLIS2 ZNF207 ZNF143 KLF7 SP5 MXD4 LOC283140 RNU6-44P ENSG00000255292 TEX12 NKAPD1 PIH1D2 BCO2 GC11M112270 GC11P112339
GH11I112119 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.3 -46.5 -46501 3.1 PKNOX1 JUN JUNB CEBPB EP300 MAFF JUND POLR2A FOS PRDM1 IL18 TIMM8B ENSG00000255292 SDHD TEX12 BCO2 LOC101928847 ALG9
GH11I112128 Enhancer 0.9 Ensembl ENCODE 11.3 -38.3 -38290 2.2 KLF1 NFIB JUN KLF17 FOSL1 GATA3 ZBTB48 PRDM10 FOSL2 FOS BCO2 IL18 TEX12 ENSG00000255292 ENSG00000254638 SDHD TIMM8B PIH1D2 NKAPD1 CRYAB
GH11I112240 Enhancer 0.9 ENCODE dbSUPER 10.1 +74.1 74074 2.1 SOX13 TFAP4 FOXA2 MAX ETS1 TEAD3 CTBP1 GATA3 RCOR1 ATF7 TEX12 ENSG00000255292 RNU6-44P BCO2 RPS6P16 LOC100132686 PTS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TEX12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEX12 gene promoter:

Genomic Locations for TEX12 Gene

Genomic Locations for TEX12 Gene
5,188 bases
Plus strand

Genomic View for TEX12 Gene

Genes around TEX12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX12 Gene

Proteins for TEX12 Gene

  • Protein details for TEX12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-expressed protein 12
    Protein Accession:
    Secondary Accessions:
    • A6NDL9
    • B0YIX3

    Protein attributes for TEX12 Gene

    123 amino acids
    Molecular mass:
    14107 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEX12 Gene

Post-translational modifications for TEX12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEX12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEX12 Gene

Domains & Families for TEX12 Gene

Gene Families for TEX12 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEX12 Gene


Suggested Antigen Peptide Sequences for TEX12 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TEX12: view

No data available for UniProtKB/Swiss-Prot for TEX12 Gene

Function for TEX12 Gene

Phenotypes for TEX12 Gene

genes like me logo Genes that share phenotypes with TEX12: view

Animal Models for TEX12 Gene

MGI Knock Outs for TEX12:

miRNA for TEX12 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEX12 Gene

Localization for TEX12 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX12 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for TEX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex IEA --
GO:0000801 central element IEA,IBA --
genes like me logo Genes that share ontologies with TEX12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TEX12 Gene

Pathways & Interactions for TEX12 Gene

SuperPathways for TEX12 Gene

SuperPathway Contained pathways
1 Meiosis
2 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with TEX12: view

Pathways by source for TEX12 Gene

3 Reactome pathways for TEX12 Gene

Interacting Proteins for TEX12 Gene

Gene Ontology (GO) - Biological Process for TEX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000711 meiotic DNA repair synthesis IEA --
GO:0007130 synaptonemal complex assembly IEA,IBA --
genes like me logo Genes that share ontologies with TEX12: view

No data available for SIGNOR curated interactions for TEX12 Gene

Drugs & Compounds for TEX12 Gene

No Compound Related Data Available

Transcripts for TEX12 Gene

mRNA/cDNA for TEX12 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1371) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEX12 Gene

Testis expressed 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX12 Gene

No ASD Table

Relevant External Links for TEX12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TEX12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEX12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX12 Gene

This gene is overexpressed in Testis (x21.7).

Protein differential expression in normal tissues from HIPED for TEX12 Gene

This gene is overexpressed in Fetal ovary (49.1) and Ovary (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEX12 Gene

Protein tissue co-expression partners for TEX12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEX12 Gene:


SOURCE GeneReport for Unigene cluster for TEX12 Gene:


mRNA Expression by UniProt/SwissProt for TEX12 Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with TEX12: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX12 Gene

Orthologs for TEX12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TEX12 33 34
  • 100 (n)
(Canis familiaris)
Mammalia TEX12 33 34
  • 91.33 (n)
(Bos Taurus)
Mammalia TEX12 33 34
  • 89.97 (n)
(Mus musculus)
Mammalia Tex12 33 16 34
  • 86.45 (n)
(Rattus norvegicus)
Mammalia Tex12 33
  • 85.91 (n)
(Monodelphis domestica)
Mammalia TEX12 34
  • 64 (a)
(Gallus gallus)
Aves TEX12 33
  • 58.4 (n)
Species where no ortholog for TEX12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEX12 Gene

Gene Tree for TEX12 (if available)
Gene Tree for TEX12 (if available)

Paralogs for TEX12 Gene

No data available for Paralogs for TEX12 Gene

Variants for TEX12 Gene

Sequence variations from dbSNP and Humsavar for TEX12 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000638355 -- 112,172,351(+) TTTTTTTT/TTTTTTT 3_prime_UTR_variant
rs1000974740 -- 112,172,244(+) T/C 3_prime_UTR_variant
rs1000987659 -- 112,172,046(+) T/C 3_prime_UTR_variant
rs1001115507 -- 112,165,457(+) C/T upstream_transcript_variant
rs1001346612 -- 112,166,485(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TEX12 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV deletion 23290073
nsv519192 CNV gain 19592680

Variation tolerance for TEX12 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX12 Gene

Disorders for TEX12 Gene

Additional Disease Information for TEX12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TEX12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX12 Gene

Publications for TEX12 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang PJ … Page DC (Nature genetics 2001) 2 3 4 58
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults. (PMID: 24182552) Matteini AM … Walston JD (Cytokine 2014) 3 58
  5. Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly. (PMID: 22870393) Davies OR … Pellegrini L (Open biology 2012) 3 58

Products for TEX12 Gene

Sources for TEX12 Gene

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