This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] See more...

Aliases for TEX11 Gene

Aliases for TEX11 Gene

  • Testis Expressed 11 2 3 5
  • Testis Expressed Sequence 11 2 3
  • Testis-Expressed Protein 11 3 4
  • MZIP4 2 3
  • Spo22 2 3
  • TSGA3 2 3
  • TGC1 2 3
  • ZIP4 2 3
  • Testis-Expressed Sequence 11 Protein 3
  • SPGFX2 3
  • TEX11 5

External Ids for TEX11 Gene

Previous GeneCards Identifiers for TEX11 Gene

  • GC0XM065926
  • GC0XM067226
  • GC0XM067982
  • GC0XM068615
  • GC0XM069531
  • GC0XM069665
  • GC0XM069748
  • GC0XM063570
  • GC0XM070528

Summaries for TEX11 Gene

Entrez Gene Summary for TEX11 Gene

  • This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEX11 Gene

TEX11 (Testis Expressed 11) is a Protein Coding gene. Diseases associated with TEX11 include Spermatogenic Failure, X-Linked, 2 and Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation.

UniProtKB/Swiss-Prot Summary for TEX11 Gene

  • Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEX11 Gene

Genomics for TEX11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TEX11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ070908 Promoter 0.8 EPDnew 600.7 0.0 0 0.1 CTCF ZNF512 MGA CBX3 NFE2 ZNF316 MYC EHMT2 CREM ZBTB33 TEX11 ENSG00000213747 lnc-FOXO4-5 DLG3
GH0XJ071191 Enhancer 0.5 FANTOM5 Ensembl 1.8 -282.9 -282870 1.6 ZBTB40 NANOG GJB1 TEX11 ENSG00000228427 LOC107985688 lnc-NLGN3-2 NLGN3
GH0XJ070929 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 -21.9 -21869 2.8 ZSCAN4 POLR2A SCRT2 SIN3A TAF1 GTF2F1 TBP L3MBTL2 ZNF473 SLC7A3 GCNA MED12 IL2RG CXorf65 lnc-FOXO4-1 TEX11
GH0XJ070922 Enhancer 0.6 Ensembl ENCODE 0.4 -14.4 -14422 0.5 ZNF316 ZSCAN5C MAFF MAFK MAFG EMSY SLC7A3 lnc-FOXO4-1 TEX11
GH0XJ070921 Enhancer 0.5 Ensembl ENCODE 0.4 -13.4 -13408 1.3 POLR2A SPI1 SLC7A3 lnc-FOXO4-1 TEX11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEX11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEX11

Top Transcription factor binding sites by QIAGEN in the TEX11 gene promoter:
  • AREB6
  • Brachyury
  • FOXC1
  • FOXD3
  • FOXJ2
  • FOXJ2 (long isoform)
  • Nkx6-1
  • NRSF form 2
  • POU2F1
  • POU2F1a

Genomic Locations for TEX11 Gene

Genomic Locations for TEX11 Gene
chrX:70,511,227-70,908,731
(GRCh38/hg38)
Size:
397,505 bases
Orientation:
Minus strand
chrX:69,748,790-70,128,581
(GRCh37/hg19)
Size:
379,792 bases
Orientation:
Minus strand

Genomic View for TEX11 Gene

Genes around TEX11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX11 Gene

Proteins for TEX11 Gene

  • Protein details for TEX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYF3-TEX11_HUMAN
    Recommended name:
    Testis-expressed protein 11
    Protein Accession:
    Q8IYF3
    Secondary Accessions:
    • A8K8V6
    • Q5JQQ8
    • Q96LZ4
    • Q96M47
    • Q9BXU6

    Protein attributes for TEX11 Gene

    Size:
    940 amino acids
    Molecular mass:
    107889 Da
    Quaternary structure:
    • Interacts with SYCP2. Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (By similarity). Interacts with SHOC1 (PubMed:29742103).
    SequenceCaution:
    • Sequence=AAK31973.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TEX11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEX11 Gene

Post-translational modifications for TEX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEX11 Gene

Domains & Families for TEX11 Gene

Gene Families for TEX11 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TEX11 Gene

Suggested Antigen Peptide Sequences for TEX11 Gene

GenScript: Design optimal peptide antigens:
  • Testis expressed 11 (B1ALL0_HUMAN)
  • Testis expressed 11 (Q5JQR1_HUMAN)
  • Testis-expressed sequence 11 protein (TEX11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IYF3

UniProtKB/Swiss-Prot:

TEX11_HUMAN :
  • Belongs to the SPO22 family.
Family:
  • Belongs to the SPO22 family.
genes like me logo Genes that share domains with TEX11: view

Function for TEX11 Gene

Molecular function for TEX11 Gene

UniProtKB/Swiss-Prot Function:
Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.

Phenotypes From GWAS Catalog for TEX11 Gene

Gene Ontology (GO) - Molecular Function for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TEX11: view
genes like me logo Genes that share phenotypes with TEX11: view

Human Phenotype Ontology for TEX11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TEX11 Gene

MGI Knock Outs for TEX11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX11

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TEX11 Gene

Localization for TEX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX11 Gene

Chromosome. Note=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes. {ECO:0000250 UniProtKB:Q14AT2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX11 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IEA --
GO:0000795 colocalizes_with synaptonemal complex ISS --
GO:0000801 central element IBA 21873635
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with TEX11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEX11 Gene

Pathways & Interactions for TEX11 Gene

PathCards logo

SuperPathways for TEX11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IEA --
GO:0006311 meiotic gene conversion ISS --
GO:0007060 male meiosis chromosome segregation IBA 21873635
GO:0007130 synaptonemal complex assembly IBA 21873635
GO:0007131 reciprocal meiotic recombination IBA,ISS --
genes like me logo Genes that share ontologies with TEX11: view

No data available for Pathways by source and SIGNOR curated interactions for TEX11 Gene

Drugs & Compounds for TEX11 Gene

No Compound Related Data Available

Transcripts for TEX11 Gene

mRNA/cDNA for TEX11 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX11

Alternative Splicing Database (ASD) splice patterns (SP) for TEX11 Gene

No ASD Table

Relevant External Links for TEX11 Gene

GeneLoc Exon Structure for
TEX11

Expression for TEX11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX11 Gene

This gene is overexpressed in Testis (x25.0) and Pancreas (x21.7).

Protein differential expression in normal tissues from HIPED for TEX11 Gene

This gene is overexpressed in Bone (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEX11 Gene



Protein tissue co-expression partners for TEX11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEX11

SOURCE GeneReport for Unigene cluster for TEX11 Gene:

Hs.121776

mRNA Expression by UniProt/SwissProt for TEX11 Gene:

Q8IYF3-TEX11_HUMAN
Tissue specificity: Testis-specific. Not expressed in adult ovaries.

Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX11 Gene

Germ Layers:
  • mesoderm
Systems:
  • reproductive
Regions:
Pelvis:
  • ovary
  • testicle
genes like me logo Genes that share expression patterns with TEX11: view

No data available for Evidence on tissue expression from TISSUES for TEX11 Gene

Orthologs for TEX11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TEX11 30 31
  • 99.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TEX11 30 31
  • 84.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TEX11 30 31
  • 79.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tex11 30 17 31
  • 74.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tex11 30
  • 73.67 (n)
Oppossum
(Monodelphis domestica)
Mammalia TEX11 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TEX11 30 31
  • 63 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TEX11 31
  • 49 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tex11 30
  • 56.74 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC797197 30
  • 56.16 (n)
TEX11 31
  • 47 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToOne
Species where no ortholog for TEX11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TEX11 Gene

ENSEMBL:
Gene Tree for TEX11 (if available)
TreeFam:
Gene Tree for TEX11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEX11: view image

Paralogs for TEX11 Gene

No data available for Paralogs for TEX11 Gene

Variants for TEX11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEX11 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
723016 Benign: not provided 70,853,150(-) G/A SYNONYMOUS_VARIANT
739815 Benign: not provided 70,873,305(-) A/T SYNONYMOUS_VARIANT
742077 Likely Benign: not provided 70,554,643(-) G/T INTRON_VARIANT
743695 Likely Benign: not provided 70,629,739(-) A/G INTRON_VARIANT
754071 Benign: not provided 70,853,132(-) T/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TEX11 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEX11 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv1629284 CNV insertion 17803354
esv2667978 CNV deletion 23128226
esv2740210 CNV deletion 23290073
esv2740211 CNV deletion 23290073
esv33082 CNV loss 17666407
esv3558956 CNV deletion 23714750
esv3558958 CNV deletion 23714750
esv3574038 CNV loss 25503493
esv3574039 CNV loss 25503493
nsv1073946 CNV deletion 25765185
nsv1076712 CNV duplication 25765185
nsv1119345 CNV duplication 24896259
nsv1128539 CNV deletion 24896259
nsv1129341 OTHER inversion 24896259
nsv1139408 CNV deletion 24896259
nsv425085 CNV deletion 16902084
nsv473008 CNV novel sequence insertion 20440878
nsv475135 CNV novel sequence insertion 20440878
nsv475250 CNV novel sequence insertion 20440878
nsv507968 OTHER sequence alteration 20534489
nsv510931 OTHER complex 20534489
nsv517078 CNV gain 19592680

Variation tolerance for TEX11 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX11 Gene

Human Gene Mutation Database (HGMD)
TEX11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX11 Gene

Disorders for TEX11 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TEX11 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TEX11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TEX11_HUMAN
  • Spermatogenic failure, X-linked, 2 (SPGFX2) [MIM:309120]: An infertility disorder caused by spermatogenesis defects. It is characterized by mixed testicular atrophy and azoospermia with meiotic arrest. {ECO:0000269 PubMed:25970010, ECO:0000269 PubMed:28718531}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TEX11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TEX11: view

No data available for Genatlas for TEX11 Gene

Publications for TEX11 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang PJ … Page DC (Nature genetics 2001) 2 3 4
  2. SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis. (PMID: 29742103) Guiraldelli MF … Pezza RJ (PLoS genetics 2018) 3 4
  3. X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men. (PMID: 25970010) Yatsenko AN … Tüttelmann F (The New England journal of medicine 2015) 3 4
  4. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston KI … Carrell DT (Human reproduction (Oxford, England) 2010) 3 41
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for TEX11 Gene

  • Signalway Proteins for TEX11

Sources for TEX11 Gene