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Aliases for TEX11 Gene

Aliases for TEX11 Gene

  • Testis Expressed 11 2 3 5
  • Testis Expressed Sequence 11 2 3
  • Testis-Expressed Sequence 11 Protein 3
  • Testis-Expressed Protein 11 3
  • SPGFX2 3
  • TSGA3 3
  • TGC1 3

External Ids for TEX11 Gene

Previous GeneCards Identifiers for TEX11 Gene

  • GC0XM065926
  • GC0XM067226
  • GC0XM067982
  • GC0XM068615
  • GC0XM069531
  • GC0XM069665
  • GC0XM069748
  • GC0XM063570

Summaries for TEX11 Gene

Entrez Gene Summary for TEX11 Gene

  • This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEX11 Gene

TEX11 (Testis Expressed 11) is a Protein Coding gene. Diseases associated with TEX11 include Spermatogenic Failure, X-Linked, 2 and Azoospermia.

UniProtKB/Swiss-Prot for TEX11 Gene

  • Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity).

Additional gene information for TEX11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX11 Gene

Genomics for TEX11 Gene

GeneHancer (GH) Regulatory Elements for TEX11 Gene

Promoters and enhancers for TEX11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI070908 Promoter 0.9 EPDnew 550.8 0.0 0 0.1 CTCF ATF1 L3MBTL2 ZNF316 SMARCA4 GMEB1 ZNF512 NFE2 ZBTB33 EMSY TEX11 GC0XP070858
GH0XI071191 Enhancer 0.3 FANTOM5 1.8 -282.6 -282637 0.3 ZBTB40 GJB1 TEX11 ENSG00000228427 NLGN3
GH0XI070930 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 0.3 -22.3 -22285 1.4 ZNF473 L3MBTL2 POLR2A SCRT2 ZSCAN4 SIN3A SLC7A3 GCNA CXorf65 TEX11
GH0XI070922 Enhancer 0.5 ENCODE 0.4 -14.4 -14402 0.5 MAFF ZNF316 ZSCAN5C MAFG MAFK EMSY SLC7A3 TEX11
GH0XI070921 Enhancer 0.3 ENCODE 0.4 -13.4 -13408 1.3 SPI1 SLC7A3 TEX11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TEX11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEX11 gene promoter:

Genomic Locations for TEX11 Gene

Genomic Locations for TEX11 Gene
383,171 bases
Minus strand

Genomic View for TEX11 Gene

Genes around TEX11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX11 Gene

Proteins for TEX11 Gene

  • Protein details for TEX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-expressed protein 11
    Protein Accession:
    Secondary Accessions:
    • A8K8V6
    • Q5JQQ8
    • Q96LZ4
    • Q96M47
    • Q9BXU6

    Protein attributes for TEX11 Gene

    940 amino acids
    Molecular mass:
    107889 Da
    Quaternary structure:
    • Interacts with SYCP2. Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (By similarity).
    • Sequence=AAK31973.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI39958.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI40155.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI41496.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TEX11 Gene


neXtProt entry for TEX11 Gene

Post-translational modifications for TEX11 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TEX11 Gene

Domains & Families for TEX11 Gene

Gene Families for TEX11 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TEX11 Gene

Suggested Antigen Peptide Sequences for TEX11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPO22 family.
  • Belongs to the SPO22 family.
genes like me logo Genes that share domains with TEX11: view

Function for TEX11 Gene

Molecular function for TEX11 Gene

UniProtKB/Swiss-Prot Function:
Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity).

Phenotypes From GWAS Catalog for TEX11 Gene

Gene Ontology (GO) - Molecular Function for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TEX11: view
genes like me logo Genes that share phenotypes with TEX11: view

Human Phenotype Ontology for TEX11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TEX11 Gene

MGI Knock Outs for TEX11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TEX11 Gene

Localization for TEX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX11 Gene

Chromosome. Note=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX11 gene
Compartment Confidence
nucleus 3
mitochondrion 2
extracellular 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IEA --
GO:0000795 colocalizes_with synaptonemal complex ISS --
GO:0000801 central element IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with TEX11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEX11 Gene

Pathways & Interactions for TEX11 Gene

SuperPathways for TEX11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IEA --
GO:0006311 meiotic gene conversion ISS --
GO:0007060 male meiosis chromosome segregation IEA --
GO:0007130 synaptonemal complex assembly IEA --
GO:0007131 reciprocal meiotic recombination ISS --
genes like me logo Genes that share ontologies with TEX11: view

No data available for Pathways by source and SIGNOR curated interactions for TEX11 Gene

Drugs & Compounds for TEX11 Gene

No Compound Related Data Available

Transcripts for TEX11 Gene

mRNA/cDNA for TEX11 Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TEX11 Gene

Testis expressed 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX11 Gene

No ASD Table

Relevant External Links for TEX11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TEX11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX11 Gene

This gene is overexpressed in Testis (x25.0) and Pancreas (x21.7).

Protein differential expression in normal tissues from HIPED for TEX11 Gene

This gene is overexpressed in Bone (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TEX11 Gene

Protein tissue co-expression partners for TEX11 Gene

NURSA nuclear receptor signaling pathways regulating expression of TEX11 Gene:


SOURCE GeneReport for Unigene cluster for TEX11 Gene:


mRNA Expression by UniProt/SwissProt for TEX11 Gene:

Tissue specificity: Testis-specific. Not expressed in adult ovaries.

Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX11 Gene

Germ Layers:
  • mesoderm
  • reproductive
  • ovary
  • testicle
genes like me logo Genes that share expression patterns with TEX11: view

Primer Products

No data available for Evidence on tissue expression from TISSUES for TEX11 Gene

Orthologs for TEX11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEX11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TEX11 33 34
  • 99.1 (n)
(Canis familiaris)
Mammalia TEX11 33 34
  • 84.46 (n)
(Bos Taurus)
Mammalia TEX11 33 34
  • 79.79 (n)
(Mus musculus)
Mammalia Tex11 33 16 34
  • 74.23 (n)
(Rattus norvegicus)
Mammalia Tex11 33
  • 73.67 (n)
(Monodelphis domestica)
Mammalia TEX11 34
  • 49 (a)
(Gallus gallus)
Aves TEX11 33 34
  • 63 (n)
(Anolis carolinensis)
Reptilia TEX11 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tex11 33
  • 56.74 (n)
(Danio rerio)
Actinopterygii LOC797197 33
  • 56.16 (n)
TEX11 34
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for TEX11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEX11 Gene

Gene Tree for TEX11 (if available)
Gene Tree for TEX11 (if available)

Paralogs for TEX11 Gene

No data available for Paralogs for TEX11 Gene

Variants for TEX11 Gene

Sequence variations from dbSNP and Humsavar for TEX11 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs140984555 pathogenic, Spermatogenic failure, X-linked, 2, Spermatogenic failure, X-linked, 2 (SPGFX2) [MIM:309120] 70,605,421(-) C/T coding_sequence_variant, missense_variant
rs143246552 pathogenic, Spermatogenic failure, X-linked, 2, Spermatogenic failure, X-linked, 2 (SPGFX2) [MIM:309120] 70,853,093(-) T/C coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs147088100 pathogenic, Spermatogenic failure, X-linked, 2 70,853,248(-) G/A coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant
rs1000010705 -- 70,803,780(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000012498 -- 70,696,624(-) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TEX11 Gene

Variant ID Type Subtype PubMed ID
nsv517078 CNV gain 19592680
nsv510931 OTHER complex 20534489
nsv507968 OTHER sequence alteration 20534489
nsv475250 CNV novel sequence insertion 20440878
nsv475135 CNV novel sequence insertion 20440878
nsv473008 CNV novel sequence insertion 20440878
nsv425085 CNV deletion 16902084
nsv1139408 CNV deletion 24896259
nsv1129341 OTHER inversion 24896259
nsv1128539 CNV deletion 24896259
nsv1119345 CNV duplication 24896259
nsv1076712 CNV duplication 25765185
nsv1073946 CNV deletion 25765185
esv3574039 CNV loss 25503493
esv3574038 CNV loss 25503493
esv3558958 CNV deletion 23714750
esv3558956 CNV deletion 23714750
esv33082 CNV loss 17666407
esv2740211 CNV deletion 23290073
esv2740210 CNV deletion 23290073
esv2667978 CNV deletion 23128226
esv1629284 CNV insertion 17803354
esv1584074 OTHER inversion 17803354

Variation tolerance for TEX11 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX11 Gene

Disorders for TEX11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TEX11 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure, x-linked, 2
  • spgfx2
  • spermatogenic failure
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search TEX11 in MalaCards View complete list of genes associated with diseases


  • Spermatogenic failure, X-linked, 2 (SPGFX2) [MIM:309120]: An infertility disorder caused by spermatogenesis defects. It is characterized by mixed testicular atrophy and azoospermia with meiotic arrest. {ECO:0000269 PubMed:25970010}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TEX11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TEX11: view

No data available for Genatlas for TEX11 Gene

Publications for TEX11 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang PJ … Page DC (Nature genetics 2001) 2 3 4 58
  2. X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men. (PMID: 25970010) Yatsenko AN … Tüttelmann F (The New England journal of medicine 2015) 3 4 58
  3. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston KI … Carrell DT (Human reproduction (Oxford, England) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary. (PMID: 28364521) Rosario R … Anderson RA (Molecular human reproduction 2017) 3 58

Products for TEX11 Gene

Sources for TEX11 Gene

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