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Aliases for TEX101 Gene

Aliases for TEX101 Gene

  • Testis Expressed 101 2 3 5
  • Spermatogenesis-Related Gene Protein 3 4
  • Scleroderma-Associated Autoantigen 3 4
  • Spermatogenesis Associated 44 2 3
  • Testis Expressed Sequence 101 2 3
  • Cell Surface Receptor NYD-SP8 3 4
  • Cancer/Testis Antigen 131 2 3
  • SGRG 3 4
  • Testis-Expressed Sequence 101 Protein 3
  • Testis-Specific Protein TES101RP 3
  • Testis-Expressed Protein 101 3
  • TES101RP 3
  • GTPR867 3
  • NYD-SP8 3
  • PRO1884 3
  • SPATA44 3
  • CT131 3

External Ids for TEX101 Gene

Previous GeneCards Identifiers for TEX101 Gene

  • GC00U920630
  • GC19P048585
  • GC19P043892
  • GC19P040326

Summaries for TEX101 Gene

GeneCards Summary for TEX101 Gene

TEX101 (Testis Expressed 101) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is CD177.

UniProtKB/Swiss-Prot for TEX101 Gene

  • Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity).

Additional gene information for TEX101 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEX101 Gene

Genomics for TEX101 Gene

GeneHancer (GH) Regulatory Elements for TEX101 Gene

Promoters and enhancers for TEX101 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043414 Promoter 0.7 EPDnew 550.3 +26.3 26261 0.1 L3MBTL2 NRF1 TEX101 GC19M043399
GH19I043406 Promoter 0.5 EPDnew 550.4 +17.5 17525 0.1 TEX101 GC19M043399
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2 +391.3 391291 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I043673 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.7 +286.2 286239 3 PKNOX1 ATF1 ZNF133 SIN3A YBX1 ZNF2 ZBTB7B ZNF48 ZNF121 ZNF143 ZNF225 ZNF283 ZNF45 PLAUR ZNF180 ZNF226 ZNF112 ZNF234 ZNF223 ZNF224
GH19I043762 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.4 +377.4 377367 6.6 HDGF PKNOX1 SMAD1 SIN3A ZNF2 IRF4 ZNF766 ZNF207 ZNF143 FOS ZNF180 ZNF45 PLAUR XRCC1 ZNF155 ZNF234 ZNF225 SMG9 ZNF224 ZNF230
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TEX101 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEX101 gene promoter:

Genomic Locations for TEX101 Gene

Genomic Locations for TEX101 Gene
chr19:43,388,611-43,418,615
(GRCh38/hg38)
Size:
30,005 bases
Orientation:
Plus strand
chr19:43,892,763-43,922,767
(GRCh37/hg19)

Genomic View for TEX101 Gene

Genes around TEX101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX101 Gene

Proteins for TEX101 Gene

  • Protein details for TEX101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY14-TX101_HUMAN
    Recommended name:
    Testis-expressed protein 101
    Protein Accession:
    Q9BY14
    Secondary Accessions:
    • Q7L5R2
    • Q9BPY7

    Protein attributes for TEX101 Gene

    Size:
    249 amino acids
    Molecular mass:
    26667 Da
    Quaternary structure:
    • Interacts with VAMP3. Interacts with LY6K. Interacts with DPEP3; co-localized on the cell surface of spermatocytes, spermatids, and testicular spermatozoa, co-localized only in cytoplasmic droplets of caput and corpus epididymal sperm. Interacts with ADAM5.

    Alternative splice isoforms for TEX101 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEX101 Gene

Post-translational modifications for TEX101 Gene

  • N-glycosylated; by high mannose and/or biantennary complex and/or certain types of hybrid oligosaccharides; possesses different oligosaccharides chains according to its subcellular localization in the testis.
  • Sheds from membrane raft by ACE and released from the cell surface of epididymal sperm while it passes through the caput epididymis leading to disappearance of TEX101 on spermatozoa; is essential to produce fertile spermatozoa.
  • Glycosylation at isoforms=245 and isoforms=2159

Other Protein References for TEX101 Gene

No data available for DME Specific Peptides for TEX101 Gene

Domains & Families for TEX101 Gene

Gene Families for TEX101 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TEX101 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TEX101 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TEX101: view

No data available for UniProtKB/Swiss-Prot for TEX101 Gene

Function for TEX101 Gene

Molecular function for TEX101 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity).

Phenotypes From GWAS Catalog for TEX101 Gene

genes like me logo Genes that share phenotypes with TEX101: view

Animal Models for TEX101 Gene

MGI Knock Outs for TEX101:

Animal Model Products

miRNA for TEX101 Gene

miRTarBase miRNAs that target TEX101

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEX101 Gene

Localization for TEX101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX101 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted. Cytoplasmic vesicle. Note=Located on plasma membrane of spermatocytes, round and elongated spermatids, and testicular spermatozoa. {ECO:0000250 UniProtKB:Q9JMI7}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX101 gene
Compartment Confidence
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for TEX101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with TEX101: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEX101 Gene

Pathways & Interactions for TEX101 Gene

genes like me logo Genes that share pathways with TEX101: view

Interacting Proteins for TEX101 Gene

Selected Interacting proteins: Q9BY14-TX101_HUMAN for TEX101 Gene via IID

Gene Ontology (GO) - Biological Process for TEX101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0007339 binding of sperm to zona pellucida ISS --
GO:0009566 fertilization ISS --
GO:0097722 sperm motility ISS --
GO:1901317 regulation of flagellated sperm motility ISS --
genes like me logo Genes that share ontologies with TEX101: view

No data available for SIGNOR curated interactions for TEX101 Gene

Drugs & Compounds for TEX101 Gene

No Compound Related Data Available

Transcripts for TEX101 Gene

Unigene Clusters for TEX101 Gene

Testis expressed 101:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEX101 Gene

No ASD Table

Relevant External Links for TEX101 Gene

GeneLoc Exon Structure for
TEX101
ECgene alternative splicing isoforms for
TEX101

Expression for TEX101 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEX101 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEX101 Gene

This gene is overexpressed in Testis (x49.0).

Protein differential expression in normal tissues from HIPED for TEX101 Gene

This gene is overexpressed in Testis (52.6) and Ovary (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEX101 Gene



Protein tissue co-expression partners for TEX101 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEX101 Gene:

TEX101

SOURCE GeneReport for Unigene cluster for TEX101 Gene:

Hs.97978

mRNA Expression by UniProt/SwissProt for TEX101 Gene:

Q9BY14-TX101_HUMAN
Tissue specificity: Detected in testis and spermatogonia. Not detected in spermatocytes. Detected in blood leukocytes.

Evidence on tissue expression from TISSUES for TEX101 Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with TEX101: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX101 Gene

Orthologs for TEX101 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TEX101 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX101 33 34
  • 99 (n)
dog
(Canis familiaris)
Mammalia TEX101 33 34
  • 72.62 (n)
cow
(Bos Taurus)
Mammalia TEX101 33 34
  • 69.99 (n)
mouse
(Mus musculus)
Mammalia Tex101 33 16 34
  • 67.1 (n)
rat
(Rattus norvegicus)
Mammalia Tex101 33
  • 64.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 33 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7403 33
Species where no ortholog for TEX101 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEX101 Gene

ENSEMBL:
Gene Tree for TEX101 (if available)
TreeFam:
Gene Tree for TEX101 (if available)

Paralogs for TEX101 Gene

Paralogs for TEX101 Gene

(1) SIMAP similar genes for TEX101 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TEX101 Gene

genes like me logo Genes that share paralogs with TEX101: view

Variants for TEX101 Gene

Sequence variations from dbSNP and Humsavar for TEX101 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000071900 -- 43,417,084(+) T/G intron_variant
rs1000120078 -- 43,415,304(+) T/C intron_variant
rs1000179265 -- 43,388,045(+) C/T upstream_transcript_variant
rs1000196499 -- 43,404,772(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000206295 -- 43,393,140(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TEX101 Gene

Variant ID Type Subtype PubMed ID
nsv960848 CNV duplication 23825009
nsv579851 CNV loss 21841781
nsv579850 CNV gain 21841781
nsv520852 CNV gain+loss 19592680
nsv509744 CNV insertion 20534489
nsv478444 CNV novel sequence insertion 20440878
nsv469666 CNV loss 16826518
nsv1060280 CNV gain 25217958
nsv1057949 CNV loss 25217958
nsv1057657 CNV gain 25217958
esv3644466 CNV gain 21293372
esv3644465 CNV gain 21293372
esv3583431 CNV loss 25503493
esv2758763 CNV gain+loss 17122850
esv1342569 CNV deletion 17803354
dgv3604n100 CNV loss 25217958
dgv3603n100 CNV gain 25217958

Variation tolerance for TEX101 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX101 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEX101 Gene

Disorders for TEX101 Gene

Additional Disease Information for TEX101

No disorders were found for TEX101 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX101 Gene

Publications for TEX101 Gene

  1. A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis. (PMID: 16516155) Teng X … Kong X (Biochemical and biophysical research communications 2006) 2 3 4 58
  2. TEX101 is shed from the surface of sperm located in the caput epididymidis of the mouse. (PMID: 16388701) Takayama T … Takizawa T (Zygote (Cambridge, England) 2005) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. (PMID: 27098205) Loughner CL … Swamynathan SK (Human genomics 2016) 3 58

Products for TEX101 Gene

Sources for TEX101 Gene

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