Aliases for TEX10 Gene

Aliases for TEX10 Gene

  • Testis Expressed 10 2 3 5
  • Testis-Expressed Protein 10 3 4
  • Testis Expressed Gene 10 2 3
  • BA208F1.2 2 3
  • Ipi1 2 3
  • Testis-Expressed Sequence 10 Protein 3
  • Testis Expressed Sequence 10 2
  • FLJ20287 2
  • TEX10 5

External Ids for TEX10 Gene

Previous GeneCards Identifiers for TEX10 Gene

  • GC09M098445
  • GC09M100143
  • GC09M102104
  • GC09M103064
  • GC09M072663

Summaries for TEX10 Gene

GeneCards Summary for TEX10 Gene

TEX10 (Testis Expressed 10) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is RMDN3.

UniProtKB/Swiss-Prot Summary for TEX10 Gene

  • Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).

Gene Wiki entry for TEX10 Gene

Additional gene information for TEX10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEX10 Gene

Genomics for TEX10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TEX10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEX10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEX10

Top Transcription factor binding sites by QIAGEN in the TEX10 gene promoter:
  • C/EBPalpha
  • CUTL1
  • HOXA3
  • LCR-F1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for TEX10 Gene

Genomic Locations for TEX10 Gene
chr9:100,302,075-100,352,942
(GRCh38/hg38)
Size:
50,868 bases
Orientation:
Minus strand
chr9:103,064,357-103,115,259
(GRCh37/hg19)
Size:
50,903 bases
Orientation:
Minus strand

Genomic View for TEX10 Gene

Genes around TEX10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEX10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEX10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEX10 Gene

Proteins for TEX10 Gene

  • Protein details for TEX10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXF1-TEX10_HUMAN
    Recommended name:
    Testis-expressed protein 10
    Protein Accession:
    Q9NXF1
    Secondary Accessions:
    • B4DYV2
    • Q5T722
    • Q5T723
    • Q8NCN8
    • Q8TDY0

    Protein attributes for TEX10 Gene

    Size:
    929 amino acids
    Molecular mass:
    105674 Da
    Quaternary structure:
    • Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome particles (PubMed:21326211).

    Alternative splice isoforms for TEX10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEX10 Gene

Post-translational modifications for TEX10 Gene

  • Ubiquitination at Lys197
  • Modification sites at PhosphoSitePlus

Other Protein References for TEX10 Gene

No data available for DME Specific Peptides for TEX10 Gene

Domains & Families for TEX10 Gene

Gene Families for TEX10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TEX10 Gene

InterPro:
Blocks:
  • HEAT repeat
ProtoNet:

Suggested Antigen Peptide Sequences for TEX10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57815 (B4DYV2_HUMAN)
  • cDNA FLJ50387 (B7Z9D5_HUMAN)
  • Testis-expressed sequence 10 protein (TEX10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NXF1

UniProtKB/Swiss-Prot:

TEX10_HUMAN :
  • Belongs to the IPI1/TEX10 family.
Family:
  • Belongs to the IPI1/TEX10 family.
genes like me logo Genes that share domains with TEX10: view

Function for TEX10 Gene

Molecular function for TEX10 Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).

Phenotypes From GWAS Catalog for TEX10 Gene

Gene Ontology (GO) - Molecular Function for TEX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21326211
genes like me logo Genes that share ontologies with TEX10: view
genes like me logo Genes that share phenotypes with TEX10: view

Animal Models for TEX10 Gene

MGI Knock Outs for TEX10:
  • Tex10 Tex10<tm1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for TEX10 Gene

miRTarBase miRNAs that target TEX10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEX10 Gene

Localization for TEX10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEX10 Gene

Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250 UniProtKB:Q3URQ0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEX10 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TEX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with TEX10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEX10 Gene

Pathways & Interactions for TEX10 Gene

genes like me logo Genes that share pathways with TEX10: view

Gene Ontology (GO) - Biological Process for TEX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with TEX10: view

No data available for SIGNOR curated interactions for TEX10 Gene

Drugs & Compounds for TEX10 Gene

(1) Drugs for TEX10 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
duloxetine Approved Pharma Antagonist 0
genes like me logo Genes that share compounds with TEX10: view

Transcripts for TEX10 Gene

mRNA/cDNA for TEX10 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEX10

Alternative Splicing Database (ASD) splice patterns (SP) for TEX10 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for TEX10 Gene

GeneLoc Exon Structure for
TEX10

Expression for TEX10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEX10 Gene

Protein differential expression in normal tissues from HIPED for TEX10 Gene

This gene is overexpressed in Fetal gut (10.5), Fetal testis (8.0), and Fetal ovary (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TEX10 Gene



Protein tissue co-expression partners for TEX10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEX10

SOURCE GeneReport for Unigene cluster for TEX10 Gene:

Hs.494648

Evidence on tissue expression from TISSUES for TEX10 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TEX10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEX10 Gene

Orthologs for TEX10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEX10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TEX10 30 31
  • 99.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TEX10 30 31
  • 94.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TEX10 30 31
  • 92.53 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tex10 30 17 31
  • 88.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tex10 30
  • 88.86 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TEX10 31
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TEX10 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TEX10 30 31
  • 73.05 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TEX10 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tex10 30
  • 62.06 (n)
Str.6381 30
Zebrafish
(Danio rerio)
Actinopterygii tex10 30 31
  • 53.02 (n)
OneToOne
Dr.10172 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG1575 31
  • 26 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.579 31
  • 37 (a)
OneToMany
-- 31
  • 26 (a)
OneToMany
Species where no ortholog for TEX10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TEX10 Gene

ENSEMBL:
Gene Tree for TEX10 (if available)
TreeFam:
Gene Tree for TEX10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEX10: view image

Paralogs for TEX10 Gene

Paralogs for TEX10 Gene

genes like me logo Genes that share paralogs with TEX10: view

Variants for TEX10 Gene

Additional dbSNP identifiers (rs#s) for TEX10 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEX10 Gene

Variant ID Type Subtype PubMed ID
nsv507523 OTHER sequence alteration 20534489

Variation tolerance for TEX10 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEX10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEX10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEX10 Gene

Disorders for TEX10 Gene

No disorders were found for TEX10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEX10 Gene

Publications for TEX10 Gene

  1. The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex. (PMID: 21326211) Finkbeiner E … Muller S (The EMBO journal 2011) 2 3 4
  2. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. (PMID: 22872859) Fanis P … van Dijk TB (Molecular & cellular proteomics : MCP 2012) 3 4
  3. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y … Roeder RG (Cell 2005) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for TEX10 Gene

Sources for TEX10 Gene