Aliases for TESPA1 Gene
External Ids for TESPA1 Gene
Previous HGNC Symbols for TESPA1 Gene
Previous GeneCards Identifiers for TESPA1 Gene
GeneCards Summary for TESPA1 Gene
TESPA1 (Thymocyte Expressed, Positive Selection Associated 1) is a Protein Coding gene. Diseases associated with TESPA1 include Pancreatic Squamous Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is ITPRID2.
UniProtKB/Swiss-Prot Summary for TESPA1 Gene
Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.