Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed diff... See more...

Aliases for TESMIN Gene

Aliases for TESMIN Gene

  • Testis Expressed Metallothionein Like Protein 2 3 5
  • Metallothionein-Like 5, Testis-Specific (Tesmin) 2 3
  • Testis-Specific Metallothionein-Like Protein 3 4
  • CXC Domain Containing 2 2 3
  • Tesmin 3 4
  • MTL5 3 4
  • Metallothionein-Like 5, Testis-Specific 4
  • CXCDC2 3
  • MTLT 3

External Ids for TESMIN Gene

Previous HGNC Symbols for TESMIN Gene

  • MTL5

Summaries for TESMIN Gene

Entrez Gene Summary for TESMIN Gene

  • Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TESMIN Gene

TESMIN (Testis Expressed Metallothionein Like Protein) is a Protein Coding gene. An important paralog of this gene is LIN54.

UniProtKB/Swiss-Prot Summary for TESMIN Gene

Additional gene information for TESMIN Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TESMIN Gene

Genomics for TESMIN Gene

GeneHancer (GH) Regulatory Elements for TESMIN Gene

Promoters and enhancers for TESMIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J068748 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 764.6 +1.0 983 3.2 SP1 POLR2A MYC L3MBTL2 MAX MNT ZNF148 GTF2F1 ZFX ZNF639 TESMIN lnc-CPT1A-1
GH11J069635 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -890.8 -890849 13.6 SIN3A CTCF ZBTB6 RBPJ POLR2A TCF7L2 USF2 NR2F6 MIXL1 NFYC CCND1 LTO1 PPFIA1 FADD IGHMBP2 TESMIN TPCN2 ANO1 lnc-ORAOV1-5
GH11J068210 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 +537.8 537773 6.1 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF RBPJ POLR2A TCF7L2 HCFC1 KMT5B lnc-C11orf24-1 lnc-LRP5-5 PPP6R3 ENSG00000255031 CLCF1 CORO1B ENSG00000260808 RPS6KB2 TPCN2
GH11J068902 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.7 -152.6 -152607 3.5 SIN3A ZNF24 SP1 ZBTB40 GATA3 SIX5 RBPJ POLR2A CTBP1 ATF1 IGHMBP2 MRPL21 lnc-MRPL21-1 LTO1 KMT5B PPP6R3 ENSG00000260808 MRGPRF TPCN2 MRGPRF-AS1
GH11J068854 Promoter/Enhancer 1.7 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.3 -105.3 -105308 3.8 LCORL FOXA1 MLX RBPJ NR2F1 NR2F6 ATF1 CREB1 MIXL1 HLF IGHMBP2 LINC02701 TESMIN MRPL21 CPT1A piR-32677-080
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TESMIN on UCSC Golden Path with GeneCards custom track

Genomic Locations for TESMIN Gene

Genomic Locations for TESMIN Gene
chr11:68,706,674-68,751,564
(GRCh38/hg38)
Size:
44,891 bases
Orientation:
Minus strand
chr11:68,474,908-68,519,032
(GRCh37/hg19)
Size:
44,125 bases
Orientation:
Minus strand

Genomic View for TESMIN Gene

Genes around TESMIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESMIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESMIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESMIN Gene

Proteins for TESMIN Gene

  • Protein details for TESMIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4I5-MTL5_HUMAN
    Recommended name:
    Tesmin
    Protein Accession:
    Q9Y4I5
    Secondary Accessions:
    • A8K8J3
    • Q4G182
    • Q6P2E2
    • Q8NCC8

    Protein attributes for TESMIN Gene

    Size:
    508 amino acids
    Molecular mass:
    55025 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD24668.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for TESMIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TESMIN Gene

Post-translational modifications for TESMIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TESMIN Gene

No data available for DME Specific Peptides for TESMIN Gene

Domains & Families for TESMIN Gene

Gene Families for TESMIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TESMIN Gene

Suggested Antigen Peptide Sequences for TESMIN Gene

GenScript: Design optimal peptide antigens:
  • Testis-specific metallothionein-like protein (MTL5_HUMAN)
  • MTL5 protein (Q6PHY4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4I5

UniProtKB/Swiss-Prot:

MTL5_HUMAN :
  • Belongs to the lin-54 family.
Family:
  • Belongs to the lin-54 family.
genes like me logo Genes that share domains with TESMIN: view

Function for TESMIN Gene

Molecular function for TESMIN Gene

UniProtKB/Swiss-Prot Function:
May have a role in spermatogenesis.

Phenotypes From GWAS Catalog for TESMIN Gene

Gene Ontology (GO) - Molecular Function for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding NAS 10191092
genes like me logo Genes that share ontologies with TESMIN: view
genes like me logo Genes that share phenotypes with TESMIN: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESMIN Gene

Localization for TESMIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESMIN Gene

Cytoplasm. Nucleus. Note=Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc. {ECO:0000250 UniProtKB:Q9WTJ6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TESMIN gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TESMIN: view

Pathways & Interactions for TESMIN Gene

PathCards logo

SuperPathways for TESMIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006875 cellular metal ion homeostasis NAS 10191092
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis NAS 10191092
GO:0010038 response to metal ion NAS 10191092
genes like me logo Genes that share ontologies with TESMIN: view

No data available for Pathways by source and SIGNOR curated interactions for TESMIN Gene

Drugs & Compounds for TESMIN Gene

(2) Drugs for TESMIN Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Carrier, binder 227
Silver Approved, Investigational Pharma Target, binder 0
genes like me logo Genes that share compounds with TESMIN: view

Transcripts for TESMIN Gene

mRNA/cDNA for TESMIN Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TESMIN Gene

No ASD Table

Relevant External Links for TESMIN Gene

GeneLoc Exon Structure for
TESMIN
ECgene alternative splicing isoforms for
TESMIN

Expression for TESMIN Gene

NURSA nuclear receptor signaling pathways regulating expression of TESMIN Gene:

TESMIN

mRNA Expression by UniProt/SwissProt for TESMIN Gene:

Q9Y4I5-MTL5_HUMAN
Tissue specificity: Expressed specifically in testis.

Evidence on tissue expression from TISSUES for TESMIN Gene

  • Nervous system(4.2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TESMIN Gene

Orthologs for TESMIN Gene

This gene was present in the common ancestor of animals.

Orthologs for TESMIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTL5 33 32
  • 99.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MTL5 32
  • 84.48 (n)
dog
(Canis familiaris)
Mammalia MTL5 33 32
  • 83.66 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mtl5 33 32
  • 73.35 (n)
OneToOne
Tesmin 17
rat
(Rattus norvegicus)
Mammalia Mtl5 32
  • 72.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MTL5 33
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTL5 33
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTL5 33 32
  • 65.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTL5 33
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MTL5 33
  • 24 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5658 32
fruit fly
(Drosophila melanogaster)
Insecta mip120 33
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-54 33
  • 23 (a)
OneToMany
Species where no ortholog for TESMIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TESMIN Gene

ENSEMBL:
Gene Tree for TESMIN (if available)
TreeFam:
Gene Tree for TESMIN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TESMIN: view image

Paralogs for TESMIN Gene

Paralogs for TESMIN Gene

genes like me logo Genes that share paralogs with TESMIN: view

Variants for TESMIN Gene

Sequence variations from dbSNP and Humsavar for TESMIN Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000026241 -- 68,708,204(-) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000035724 -- 68,745,480(-) G/A intron_variant
rs1000040954 -- 68,712,052(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000100605 -- 68,737,150(-) C/T 3_prime_UTR_variant, intron_variant
rs1000160741 -- 68,742,889(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TESMIN Gene

Variant ID Type Subtype PubMed ID
dgv670n106 CNV deletion 24896259
esv2744665 CNV deletion 23290073
esv2744666 CNV deletion 23290073
nsv1070468 CNV deletion 25765185
nsv509422 CNV insertion 20534489

Variation tolerance for TESMIN Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TESMIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TESMIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESMIN Gene

Disorders for TESMIN Gene

Additional Disease Information for TESMIN

No disorders were found for TESMIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESMIN Gene

Publications for TESMIN Gene

  1. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. (PMID: 10191092) Sugihara T … Mitsui Y (Genomics 1999) 3 4 23 56
  2. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 56
  3. Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A … Wigdahl B (Journal of neurovirology 2013) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C … Mann M (Science (New York, N.Y.) 2009) 4 56

Products for TESMIN Gene

  • Biorbyt antibodies for TESMIN

Sources for TESMIN Gene