Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed diff... See more...

Aliases for TESMIN Gene

Aliases for TESMIN Gene

  • Testis Expressed Metallothionein Like Protein 2 3 5
  • Metallothionein-Like 5, Testis-Specific (Tesmin) 2 3
  • Testis-Specific Metallothionein-Like Protein 3 4
  • CXC Domain Containing 2 2 3
  • CXCDC2 2 3
  • Tesmin 3 4
  • MTL5 3 4
  • Metallothionein-Like 5, Testis-Specific 4
  • TESMIN 5
  • MTLT 3

External Ids for TESMIN Gene

Previous HGNC Symbols for TESMIN Gene

  • MTL5

Summaries for TESMIN Gene

Entrez Gene Summary for TESMIN Gene

  • Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation and are involved in spermatogenesis. This gene encodes a metallothionein-like protein which has been shown to be expressed differentially in mouse testis and ovary. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TESMIN Gene

TESMIN (Testis Expressed Metallothionein Like Protein) is a Protein Coding gene. An important paralog of this gene is LIN54.

UniProtKB/Swiss-Prot Summary for TESMIN Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TESMIN Gene

Genomics for TESMIN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TESMIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J068748 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 264.7 +0.8 784 3.6 SP1 MYC POLR2A ZIC2 NONO CTCF SMAD5 ETS1 CHD2 BHLHE40 TESMIN HSALNG0085256 lnc-CPT1A-1 GAL
GH11J068854 Promoter/Enhancer 1.7 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.3 -105.3 -105308 3.8 NCOR1 IKZF1 ZNF592 CEBPA ATF3 ZSCAN16 ZIC2 YY1 MXD4 CEBPB HSALNG0085263 HSALNG0085264 IGHMBP2 LINC02701 LTO1 KMT5B TESMIN MRPL21 CPT1A lnc-IGHMBP2-2
GH11J068658 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 16.9 +92.4 92363 1.6 ZNF600 ZNF580 NFIC ZIC2 BHLHE40 FEZF1 ZNF341 ZNF610 ZNF843 RAD21 TESMIN GAL PPP6R3 HSALNG0085246 RF00017-875
GH11J068869 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -118.7 -118737 1.4 IKZF1 KLF9 MNT CTCF NBN TAL1 TEAD3 PRDM10 RAD21 SMARCA4 LINC02701 HSALNG0085267 HSALNG0085268 IGHMBP2 MRPL21 TESMIN MRGPRF MRGPRF-AS1 CPT1A
GH11J068689 Enhancer 0.7 Ensembl ENCODE 22.7 +61.1 61137 1.5 CTCF MAFF ZNF316 MAFK PTBP1 MAFG GATA2 RAD21 NFXL1 EMSY LOC107984343 TESMIN HSALNG0085252 GAL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TESMIN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TESMIN

Genomic Locations for TESMIN Gene

Latest Assembly
chr11:68,706,674-68,751,564
(GRCh38/hg38)
Size:
44,891 bases
Orientation:
Minus strand

Previous Assembly
chr11:68,474,908-68,518,988
(GRCh37/hg19 by Entrez Gene)
Size:
44,081 bases
Orientation:
Minus strand

chr11:68,474,908-68,519,032
(GRCh37/hg19 by Ensembl)
Size:
44,125 bases
Orientation:
Minus strand

Genomic View for TESMIN Gene

Genes around TESMIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESMIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESMIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESMIN Gene

Proteins for TESMIN Gene

  • Protein details for TESMIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4I5-MTL5_HUMAN
    Recommended name:
    Tesmin
    Protein Accession:
    Q9Y4I5
    Secondary Accessions:
    • A8K8J3
    • Q4G182
    • Q6P2E2
    • Q8NCC8

    Protein attributes for TESMIN Gene

    Size:
    508 amino acids
    Molecular mass:
    55025 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD24668.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for TESMIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TESMIN Gene

Post-translational modifications for TESMIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TESMIN Gene

Domains & Families for TESMIN Gene

Gene Families for TESMIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TESMIN Gene

Suggested Antigen Peptide Sequences for TESMIN Gene

GenScript: Design optimal peptide antigens:
  • Testis-specific metallothionein-like protein (MTL5_HUMAN)
  • MTL5 protein (Q6PHY4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4I5

UniProtKB/Swiss-Prot:

MTL5_HUMAN :
  • Belongs to the lin-54 family.
Family:
  • Belongs to the lin-54 family.
genes like me logo Genes that share domains with TESMIN: view

Function for TESMIN Gene

Molecular function for TESMIN Gene

UniProtKB/Swiss-Prot Function:
May have a role in spermatogenesis.

Phenotypes From GWAS Catalog for TESMIN Gene

Gene Ontology (GO) - Molecular Function for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0046872 metal ion binding NAS 10191092
genes like me logo Genes that share ontologies with TESMIN: view
genes like me logo Genes that share phenotypes with TESMIN: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TESMIN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESMIN Gene

Localization for TESMIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESMIN Gene

Cytoplasm. Nucleus. Note=Predominantly localized to the cytoplasm. Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc. {ECO:0000250 UniProtKB:Q9WTJ6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TESMIN gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with TESMIN: view

Pathways & Interactions for TESMIN Gene

PathCards logo

SuperPathways for TESMIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for TESMIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006875 cellular metal ion homeostasis NAS 10191092
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis NAS 10191092
GO:0010038 response to metal ion NAS 10191092
genes like me logo Genes that share ontologies with TESMIN: view

No data available for Pathways by source and SIGNOR curated interactions for TESMIN Gene

Drugs & Compounds for TESMIN Gene

(2) Drugs for TESMIN Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Carrier, binder 276
Silver Approved, Investigational Pharma Target, binder 0
genes like me logo Genes that share compounds with TESMIN: view

Transcripts for TESMIN Gene

mRNA/cDNA for TESMIN Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TESMIN

Alternative Splicing Database (ASD) splice patterns (SP) for TESMIN Gene

No ASD Table

Relevant External Links for TESMIN Gene

GeneLoc Exon Structure for
TESMIN

Expression for TESMIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TESMIN

mRNA Expression by UniProt/SwissProt for TESMIN Gene:

Q9Y4I5-MTL5_HUMAN
Tissue specificity: Expressed specifically in testis.

Evidence on tissue expression from TISSUES for TESMIN Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TESMIN: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TESMIN Gene

Orthologs for TESMIN Gene

This gene was present in the common ancestor of animals.

Orthologs for TESMIN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MTL5 29 30
  • 99.21 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MTL5 29
  • 84.48 (n)
Dog
(Canis familiaris)
Mammalia MTL5 29 30
  • 83.66 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mtl5 29 30
  • 73.35 (n)
OneToOne
Tesmin 16
Rat
(Rattus norvegicus)
Mammalia Mtl5 29
  • 72.86 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MTL5 30
  • 69 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MTL5 30
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MTL5 29 30
  • 65.4 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MTL5 30
  • 61 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii MTL5 30
  • 24 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5658 29
Fruit Fly
(Drosophila melanogaster)
Insecta mip120 30
  • 11 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea lin-54 30
  • 23 (a)
OneToMany
Species where no ortholog for TESMIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TESMIN Gene

ENSEMBL:
Gene Tree for TESMIN (if available)
TreeFam:
Gene Tree for TESMIN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TESMIN: view image
Alliance of Genome Resources:
Additional Orthologs for TESMIN

Paralogs for TESMIN Gene

Paralogs for TESMIN Gene

genes like me logo Genes that share paralogs with TESMIN: view

Variants for TESMIN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TESMIN Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs12365708 -- p.Cys223Arg
rs35773957 -- p.Val260Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TESMIN Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TESMIN Gene

Variant ID Type Subtype PubMed ID
dgv670n106 CNV deletion 24896259
esv2744665 CNV deletion 23290073
esv2744666 CNV deletion 23290073
nsv1070468 CNV deletion 25765185
nsv509422 CNV insertion 20534489

Variation tolerance for TESMIN Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TESMIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TESMIN
Leiden Open Variation Database (LOVD)
TESMIN

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESMIN Gene

Disorders for TESMIN Gene

Additional Disease Information for TESMIN

No disorders were found for TESMIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESMIN Gene

Publications for TESMIN Gene

  1. A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. (PMID: 10191092) Sugihara T … Mitsui Y (Genomics 1999) 3 4 22
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  5. Extracellular HIV-1 viral protein R affects astrocytic glyceraldehyde 3-phosphate dehydrogenase activity and neuronal survival. (PMID: 23728617) Ferrucci A … Wigdahl B (Journal of neurovirology 2013) 3

Products for TESMIN Gene

Sources for TESMIN Gene