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This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
TESK2 (Testis Associated Actin Remodelling Kinase 2) is a Protein Coding gene. Among its related pathways are Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TESK1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004672 | protein kinase activity | TAS | 10512679 |
GO:0004674 | protein serine/threonine kinase activity | IBA,ISS | -- |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | -- |
GO:0004713 | protein tyrosine kinase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,ISS | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
GO:0016604 | nuclear body | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Focal Adhesion |
.61
|
Symbol | External ID(s) | Details |
---|---|---|
HSP90AB1 | ||
PAK6 | ||
ABI1 | ||
BRDT | ||
C8orf44-SGK3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | ISS | -- |
GO:0007283 | spermatogenesis | IEA,ISS | -- |
GO:0016310 | phosphorylation | IEA | -- |
GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | -- |
GO:0030036 | actin cytoskeleton organization | IEA,ISS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||
SP2: | - | ||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TESK2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TESK2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TESK2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tesk2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tesk2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | TESK2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TESK2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TESK2 31 |
|
OneToOne | |
LOC100858275 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | TESK2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tesk2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tesk2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | cdi 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | Y52D5A.2 31 |
|
ManyToMany | |
T25B9.5 31 |
|
ManyToMany | |||
Y69E1A.3 31 |
|
ManyToMany | |||
kin-21 31 |
|
ManyToMany | |||
K09B11.5 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1428512439 | A breast infiltrating ductal carcinoma sample | p.Gly11Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2663522 | CNV | deletion | 23128226 |
esv2669051 | CNV | deletion | 23128226 |
esv2747796 | CNV | deletion | 23290073 |
esv2750837 | CNV | loss | 17911159 |
esv3585905 | CNV | loss | 21293372 |
esv3585906 | CNV | loss | 21293372 |
esv3585907 | CNV | loss | 21293372 |
esv3893512 | CNV | gain | 25118596 |
nsv1126996 | CNV | deletion | 24896259 |
nsv1145341 | CNV | deletion | 24896259 |
nsv829726 | CNV | loss | 17160897 |
nsv945919 | CNV | duplication | 23825009 |
No disorders were found for TESK2 Gene.