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This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protei... See more...
Aliases for TESK2 Gene
Aliases for TESK2 Gene
External Ids for TESK2 Gene
- HGNC: 11732
- Entrez Gene: 10420
- Ensembl: ENSG00000070759
- OMIM: 604746
- UniProtKB: Q96S53
Previous GeneCards Identifiers for TESK2 Gene
- GC01M045536
- GC01M044809
- GC01M045239
- GC01M045222
- GC01M045478
- GC01M045582
- GC01M045809
- GC01M043921
Summaries for TESK2 Gene
-
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for TESK2 Gene
TESK2 (Testis Associated Actin Remodelling Kinase 2) is a Protein Coding gene. Among its related pathways are Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TESK1.
UniProtKB/Swiss-Prot Summary for TESK2 Gene
-
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TESK2 Gene
Genomics for TESK2 Gene
GeneHancer (GH) Regulatory Elements for TESK2 Gene
Promoters and enhancers for TESK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TESK2 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TESK2
- Top Transcription factor binding sites by QIAGEN in the TESK2 gene promoter:
-
- ARP-1
- C/EBPbeta
- CBF(2)
- E47
- Msx-1
- MZF-1
- NF-Y
- SRF
- SRF (504 AA)
- ZID
Genomic Locations for TESK2 Gene
Genomic Locations for TESK2 Gene
- chr1:45,343,883-45,491,342
- (GRCh38/hg38)
- Size:
- 147,460 bases
- Orientation:
- Minus strand
- chr1:45,809,555-45,956,872
- (GRCh37/hg19)
- Size:
- 147,318 bases
- Orientation:
- Minus strand
Genomic View for TESK2 Gene
Genes around TESK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.1 by HGNC
- 1p34.1 by Entrez Gene
- 1p34.1 by Ensembl
TESK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TESK2 Gene
Proteins for TESK2 Gene
-
Protein details for TESK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96S53-TESK2_HUMAN
- Recommended name:
- Dual specificity testis-specific protein kinase 2
- Protein Accession:
- Q96S53
- Q5T422
- Q5T423
- Q8N520
- Q9Y3Q6
Protein attributes for TESK2 Gene
- Size:
- 571 amino acids
- Molecular mass:
- 63639 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
- No Data Available
Protein Expression for TESK2 Gene
Post-translational modifications for TESK2 Gene
Other Protein References for TESK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ TESK2 Antibody
- Creative Diagnostics Anti-TESK2 (aa 329-571) polyclonal antibody
- Creative Biolabs Recombinant Mouse anti-Human TESK2 Monoclonal antibody (EML1078)
-
Custom Antibody ServicesOriGene Antibodies for TESK2
- Novus Biologicals Antibodies for TESK2
- Invitrogen Antibodies for TESK2 (AFLGC-TESK2)
-
Biorbyt antibodies for TESK2
-
Boster Bio Antibodies for TESK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TESK2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TESK2
- Origene Custom Protein Services for TESK2
-
Abcam proteins for TESK2
No data available for DME Specific Peptides for TESK2 Gene
Domains & Families for TESK2 Gene
Gene Families for TESK2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TESK2 Gene
- Blocks:
-
- Tyrosine protein kinase, active site
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TESK2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58888, highly similar to Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (B4DYL6_HUMAN)
- Testis-specific kinase 2, isoform CRA_a (D3DPZ7_HUMAN)
- cDNA FLJ14667 fis, clone NT2RP2003164, highly similar to Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Q5T422_HUMAN)
- Testicular protein kinase 2 (TESK2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96S53UniProtKB/Swiss-Prot:
TESK2_HUMAN :- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
- Family:
-
- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Function for TESK2 Gene
Molecular function for TESK2 Gene
- UniProtKB/Swiss-Prot Function:
- Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by autophosphorylation on Ser-219.
- GENATLAS Biochemistry:
- testis specific protein kinase 2,expressed in testis and prostate,involved in spermatogenesis
Enzyme Numbers (IUBMB) for TESK2 Gene
Phenotypes From GWAS Catalog for TESK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | TAS | 10512679 |
| GO:0004674 | protein serine/threonine kinase activity | IBA,ISS | -- |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 22939624 |
Phenotypes for TESK2 Gene
- GenomeRNAi human phenotypes for TESK2:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Dynamic nuclei (hole, folded or small irregular)
- Strongly decreased NFAT1-GFP nuclear translocation
- Increased cell death HMECs cells
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
- Decreased ionizing radiation sensitivity
- Decreased Salmonella enterica Typhimurium invasion
- Decreased cell migration
- Decreased viability
- Increased cell viability after pRB stimulation
- no effect
- Increased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Decreased centriole number
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Increased simian virus 40 (SV40) infection
- Transferrin accumulation in the perinuclear area
- Lamellipodia cells
Animal Model Products
-
Taconic Biosciences Mouse Models for TESK2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TESK2 - Select products 50% OFF >
- * TESK2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TESK2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for TESK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TESK2
- genomics-online: gRNA clones - Search for available TESK2 gRNA products
- Overview of 128 available TESK2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for TESK2
miRNA for TESK2 Gene
- miRTarBase miRNAs that target TESK2
-
- hsa-mir-9-5p (MIRT021469)
- hsa-mir-21-5p (MIRT031008)
- hsa-mir-93-3p (MIRT038778)
- hsa-mir-6836-3p (MIRT488210)
- hsa-mir-539-3p (MIRT488211)
- hsa-mir-485-3p (MIRT488212)
- hsa-mir-6791-3p (MIRT488213)
- hsa-mir-6829-3p (MIRT488214)
- hsa-mir-6778-3p (MIRT488215)
- hsa-mir-1304-3p (MIRT488216)
- hsa-mir-1247-5p (MIRT488217)
- hsa-mir-6890-3p (MIRT488218)
- hsa-mir-4672 (MIRT512861)
- hsa-mir-6744-3p (MIRT512862)
- hsa-mir-4757-5p (MIRT512863)
- hsa-mir-6882-3p (MIRT512864)
- hsa-mir-6768-5p (MIRT512865)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TESK2
- Browse OriGene Inhibitory RNA Products For TESK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TESK2
- genomics-online: shRNA clones - Search for available TESK2 shRNA products
- Overview of 128 available TESK2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for TESK2 - Select products 50% OFF >
- * TESK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TESK2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for TESK2
- Addgene plasmids for TESK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TESK2
- genomics-online: cdna clones - Search for available TESK2 CDNA products
- Overview of 128 available TESK2 gene related products
- orf clones - Search for available TESK2 ORF products
- Overview of 128 available TESK2 gene related products
Cell Line Products
-
Horizon Cell Lines for TESK2
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESK2 Gene
Localization for TESK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TESK2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,ISS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA,IEA | 21873635 |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for TESK2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Focal Adhesion |
.62
|
|
Pathways by source for TESK2 Gene
1 BioSystems pathway for TESK2 Gene
Interacting Proteins for TESK2 Gene
Selected Interacting proteins:
Q96S53-TESK2_HUMAN
ENSP00000361158
for TESK2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TESK2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | ISS | -- |
| GO:0007283 | spermatogenesis | ISS,IEA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | -- |
| GO:0030036 | actin cytoskeleton organization | ISS,IEA | -- |
Transcripts for TESK2 Gene
mRNA/cDNA for TESK2 Gene
- 2 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000372084 2600 bps (ENST00000372084.5)
- ENST00000372086 3071 bps (ENST00000372086.4)
- ENST00000486676 3019 bps (ENST00000486676.5)
- ENST00000493974 428 bps (ENST00000493974.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TESK2 - Select products 50% OFF >
- * TESK2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * TESK2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for TESK2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TESK2
- genomics-online: gRNA clones - Search for available TESK2 gRNA products
- Overview of 128 available TESK2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for TESK2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TESK2
- Browse OriGene Inhibitory RNA Products For TESK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TESK2
- genomics-online: shRNA clones - Search for available TESK2 shRNA products
- Overview of 128 available TESK2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for TESK2 - Select products 50% OFF >
- * TESK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * TESK2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for TESK2
- Addgene plasmids for TESK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TESK2
- genomics-online: cdna clones - Search for available TESK2 CDNA products
- Overview of 128 available TESK2 gene related products
- orf clones - Search for available TESK2 ORF products
- Overview of 128 available TESK2 gene related products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: |
Relevant External Links for TESK2 Gene
- GeneLoc Exon Structure for
- TESK2
Expression for TESK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Thymus (Hematopoietic System)
This gene is overexpressed in Blymphocyte (31.0), Testis (18.2), and Prostate (18.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TESK2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TESK2
SOURCE GeneReport for Unigene cluster for TESK2 Gene:
Hs.591499mRNA Expression by UniProt/SwissProt for TESK2 Gene:
Q96S53-TESK2_HUMAN
Tissue specificity:
Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells.
Evidence on tissue expression from TISSUES for TESK2 Gene
- Nervous system(4.4)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for TESK2
-
OriGene qPCR primer pairs and template standards for TESK2
- genomics-online: primer clones - Search for available TESK2 Primer products
- Overview of 128 available TESK2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TESK2 Gene
Orthologs for TESK2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TESK2 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TESK2 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TESK2 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tesk2 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tesk2 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TESK2 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TESK2 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TESK2 31 |
|
OneToOne | |
| LOC100858275 30 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | TESK2 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tesk2 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tesk2 31 30 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | cdi 31 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y52D5A.2 31 |
|
ManyToMany | |
| T25B9.5 31 |
|
ManyToMany | |||
| Y69E1A.3 31 |
|
ManyToMany | |||
| kin-21 31 |
|
ManyToMany | |||
| K09B11.5 31 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for TESK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for TESK2 Gene
- ENSEMBL:
- Gene Tree for TESK2 (if available)
- TreeFam:
- Gene Tree for TESK2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TESK2: view image
Paralogs for TESK2 Gene
Paralogs for TESK2 Gene
(13) SIMAP similar genes for TESK2 Gene using alignment to 4 proteins:
- TESK2_HUMAN
- B4DYL6_HUMAN
- D3DPZ7_HUMAN
- F5GWP9_HUMAN
Variants for TESK2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TESK2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1428512439 | A breast infiltrating ductal carcinoma sample | p.Gly11Ala |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2663522 | CNV | deletion | 23128226 |
| esv2669051 | CNV | deletion | 23128226 |
| esv2747796 | CNV | deletion | 23290073 |
| esv2750837 | CNV | loss | 17911159 |
| esv3585905 | CNV | loss | 21293372 |
| esv3585906 | CNV | loss | 21293372 |
| esv3585907 | CNV | loss | 21293372 |
| esv3893512 | CNV | gain | 25118596 |
| nsv1126996 | CNV | deletion | 24896259 |
| nsv1145341 | CNV | deletion | 24896259 |
| nsv829726 | CNV | loss | 17160897 |
| nsv945919 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.13;
51.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TESK2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESK2 Gene
Disorders for TESK2 Gene
Additional Disease Information for TESK2
No disorders were found for TESK2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESK2 Gene
Publications for TESK2 Gene
- Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. (PMID: 11418599) Toshima J … Mizuno K (The Journal of biological chemistry 2001) 2 3 4 23 54
- Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. (PMID: 10512679) Røsok O … Aasheim HC (Genomics 1999) 2 3 4 23 54
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
ExternalLinks
Products for TESK2 Gene
- Custom Antibody ServicesOriGene Antibodies for TESK2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for TESK2
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for TESK2
- Browse OriGene Inhibitory RNA Products For TESK2
- OriGene qPCR primer pairs for TESK2
- OriGene qPCR primer pairs and template standards for TESK2
- OriGene CRISPR knockouts for TESK2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for TESK2
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for TESK2
- Novus Biologicals proteins and lysates for TESK2
- Browse Antibodies
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- Abcam proteins for TESK2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for TESK2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for TESK2 (AFLGC-TESK2)
- Addgene plasmids for TESK2
- antibodies-online: Show 19 available TESK2 Antibodies ranked by validation data
- Compare Top TESK2 Antibodies
- antibodies-online: Search results for available TESK2 related products ranked by validation data
- antibodies-online: Show 8 available TESK2 Proteins ranked by validation data
- Compare Top TESK2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TESK2
- Search Santa Cruz Biotechnology (SCBT) for TESK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TESK2
- Horizon Cell Lines for TESK2
- genomics-online: cdna clones - Search for available TESK2 CDNA products
- Overview of 128 available TESK2 gene related products
- orf clones - Search for available TESK2 ORF products
- Overview of 128 available TESK2 gene related products
- genomics-online: gRNA clones - Search for available TESK2 gRNA products
- Overview of 128 available TESK2 gene related products
- genomics-online: primer clones - Search for available TESK2 Primer products
- Overview of 128 available TESK2 gene related products
- genomics-online: shRNA clones - Search for available TESK2 shRNA products
- Overview of 128 available TESK2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TESK2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TESK2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TESK2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TESK2
- Boster Bio Antibodies for TESK2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for TESK2
Sources for TESK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource