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Aliases for TESK2 Gene

Aliases for TESK2 Gene

  • Testis Associated Actin Remodelling Kinase 2 2 3
  • Testis-Specific Kinase 2 2 3 5
  • Testicular Protein Kinase 2 3 4
  • Dual Specificity Testis-Specific Protein Kinase 2 3
  • EC 2.7.12.1 4

External Ids for TESK2 Gene

Previous GeneCards Identifiers for TESK2 Gene

  • GC01M045536
  • GC01M044809
  • GC01M045239
  • GC01M045222
  • GC01M045478
  • GC01M045582
  • GC01M045809
  • GC01M043921

Summaries for TESK2 Gene

Entrez Gene Summary for TESK2 Gene

  • This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for TESK2 Gene

TESK2 (Testis Associated Actin Remodelling Kinase 2) is a Protein Coding gene. Among its related pathways are Focal Adhesion. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TESK1.

UniProtKB/Swiss-Prot for TESK2 Gene

  • Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at Ser-3. May play an important role in spermatogenesis.

Gene Wiki entry for TESK2 Gene

Additional gene information for TESK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESK2 Gene

Genomics for TESK2 Gene

GeneHancer (GH) Regulatory Elements for TESK2 Gene

Promoters and enhancers for TESK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J045489 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 433 2.2 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TESK2 CCDC163 NSUN4 PRDX1 LRRC41 TOE1 IPP GPBP1L1 KIF2C ZSWIM5
GH01J045493 Enhancer 0.7 ENCODE 650.7 -2.0 -1962 0.2 CTCF RB1 ARNT ARID4B EBF1 YBX1 RAD21 CC2D1A ARID2 ZNF143 TESK2 PIR33787
GH01J045496 Promoter 0.5 EPDnew 650.4 -5.3 -5316 0.1 TESK2 PIR33787 CCDC163
GH01J045334 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 11.3 +153.1 153069 7.9 MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 TOE1 MUTYH GPBP1L1 LRRC41 RPL7AP16 HECTD3 PRDX1 MMACHC NASP CCDC163
GH01J045409 Enhancer 1.3 FANTOM5 Ensembl ENCODE 13 +80.1 80051 3.8 HDAC1 ZBTB40 ZNF766 FOS ATF7 RUNX3 CREM ZEB2 SP1 ZNF217 PRDX1 TESK2 HMGB1P48 MMACHC CCDC163 IPP PPIAP36 PIR46302
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TESK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TESK2 gene promoter:
  • ARP-1
  • C/EBPbeta
  • MZF-1
  • E47
  • CBF(2)
  • NF-Y
  • Msx-1
  • SRF (504 AA)
  • SRF
  • ZID

Genomic Locations for TESK2 Gene

Genomic Locations for TESK2 Gene
chr1:45,343,883-45,491,342
(GRCh38/hg38)
Size:
147,460 bases
Orientation:
Minus strand
chr1:45,809,555-45,956,872
(GRCh37/hg19)
Size:
147,318 bases
Orientation:
Minus strand

Genomic View for TESK2 Gene

Genes around TESK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESK2 Gene

Proteins for TESK2 Gene

  • Protein details for TESK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S53-TESK2_HUMAN
    Recommended name:
    Dual specificity testis-specific protein kinase 2
    Protein Accession:
    Q96S53
    Secondary Accessions:
    • Q5T422
    • Q5T423
    • Q8N520
    • Q9Y3Q6

    Protein attributes for TESK2 Gene

    Size:
    571 amino acids
    Molecular mass:
    63639 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TESK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TESK2 Gene

Post-translational modifications for TESK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TESK2 Gene

Domains & Families for TESK2 Gene

Gene Families for TESK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q96S53

UniProtKB/Swiss-Prot:

TESK2_HUMAN :
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TESK2: view

Function for TESK2 Gene

Molecular function for TESK2 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at Ser-3. May play an important role in spermatogenesis.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation on Ser-219.
GENATLAS Biochemistry:
testis specific protein kinase 2,expressed in testis and prostate,involved in spermatogenesis

Enzyme Numbers (IUBMB) for TESK2 Gene

Phenotypes From GWAS Catalog for TESK2 Gene

Gene Ontology (GO) - Molecular Function for TESK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10512679
GO:0004674 protein serine/threonine kinase activity IBA,ISS --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004871 obsolete signal transducer activity IBA --
genes like me logo Genes that share ontologies with TESK2: view
genes like me logo Genes that share phenotypes with TESK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TESK2

Clone Products

  • Addgene plasmids for TESK2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESK2 Gene

Localization for TESK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TESK2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TESK2 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TESK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IBA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with TESK2: view

Pathways & Interactions for TESK2 Gene

SuperPathways for TESK2 Gene

SuperPathway Contained pathways
1 Focal Adhesion
genes like me logo Genes that share pathways with TESK2: view

Pathways by source for TESK2 Gene

1 BioSystems pathway for TESK2 Gene

SIGNOR curated interactions for TESK2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TESK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0007283 spermatogenesis IEA,ISS --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0030036 actin cytoskeleton organization IEA,ISS --
genes like me logo Genes that share ontologies with TESK2: view

Drugs & Compounds for TESK2 Gene

(2) Drugs for TESK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
Manganese Approved Nutra 37
genes like me logo Genes that share compounds with TESK2: view

Transcripts for TESK2 Gene

Unigene Clusters for TESK2 Gene

Testis-specific kinase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for TESK2

Alternative Splicing Database (ASD) splice patterns (SP) for TESK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - -
SP2: -
SP3:

Relevant External Links for TESK2 Gene

GeneLoc Exon Structure for
TESK2
ECgene alternative splicing isoforms for
TESK2

Expression for TESK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TESK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TESK2 Gene

This gene is overexpressed in Blymphocyte (31.0), Testis (18.2), and Prostate (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TESK2 Gene



Protein tissue co-expression partners for TESK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TESK2 Gene:

TESK2

SOURCE GeneReport for Unigene cluster for TESK2 Gene:

Hs.591499

mRNA Expression by UniProt/SwissProt for TESK2 Gene:

Q96S53-TESK2_HUMAN
Tissue specificity: Predominantly expressed in testis and prostate. Found predominantly in non-germinal Sertoli cells.

Evidence on tissue expression from TISSUES for TESK2 Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TESK2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TESK2 Gene

Orthologs for TESK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TESK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TESK2 34 33
  • 99.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TESK2 34 33
  • 90.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TESK2 34 33
  • 90.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tesk2 16 34 33
  • 86.43 (n)
rat
(Rattus norvegicus)
Mammalia Tesk2 33
  • 86.2 (n)
oppossum
(Monodelphis domestica)
Mammalia TESK2 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TESK2 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TESK2 34
  • 76 (a)
OneToOne
LOC100858275 33
  • 71.85 (n)
lizard
(Anolis carolinensis)
Reptilia TESK2 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tesk2 33
  • 69.59 (n)
zebrafish
(Danio rerio)
Actinopterygii tesk2 34 33
  • 66.86 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cdi 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y52D5A.2 34
  • 18 (a)
ManyToMany
T25B9.5 34
  • 18 (a)
ManyToMany
Y69E1A.3 34
  • 17 (a)
ManyToMany
kin-21 34
  • 16 (a)
ManyToMany
K09B11.5 34
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToMany
Species where no ortholog for TESK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TESK2 Gene

ENSEMBL:
Gene Tree for TESK2 (if available)
TreeFam:
Gene Tree for TESK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TESK2: view image

Paralogs for TESK2 Gene

Paralogs for TESK2 Gene

(13) SIMAP similar genes for TESK2 Gene using alignment to 4 proteins:

  • TESK2_HUMAN
  • B4DYL6_HUMAN
  • D3DPZ7_HUMAN
  • F5GWP9_HUMAN
genes like me logo Genes that share paralogs with TESK2: view

Variants for TESK2 Gene

Sequence variations from dbSNP and Humsavar for TESK2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_041214 A breast infiltrating ductal carcinoma sample p.Gly11Ala
rs1000009900 -- 45,382,529(-) A/G intron_variant
rs1000047057 -- 45,394,163(-) C/T intron_variant
rs1000056021 -- 45,382,227(-) T/C intron_variant
rs1000076558 -- 45,380,833(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TESK2 Gene

Variant ID Type Subtype PubMed ID
esv2663522 CNV deletion 23128226
esv2669051 CNV deletion 23128226
esv2747796 CNV deletion 23290073
esv2750837 CNV loss 17911159
esv3585905 CNV loss 21293372
esv3585906 CNV loss 21293372
esv3585907 CNV loss 21293372
esv3893512 CNV gain 25118596
nsv1126996 CNV deletion 24896259
nsv1145341 CNV deletion 24896259
nsv829726 CNV loss 17160897
nsv945919 CNV duplication 23825009

Variation tolerance for TESK2 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TESK2 Gene

Human Gene Mutation Database (HGMD)
TESK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TESK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESK2 Gene

Disorders for TESK2 Gene

Additional Disease Information for TESK2

No disorders were found for TESK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TESK2 Gene

Publications for TESK2 Gene

  1. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. (PMID: 11418599) Toshima J … Mizuno K (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. (PMID: 10512679) Røsok O … Aasheim HC (Genomics 1999) 2 3 4 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TESK2 Gene

  • Addgene plasmids for TESK2

Sources for TESK2 Gene

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