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Aliases for TESK1 Gene

Aliases for TESK1 Gene

  • Testis-Specific Kinase 1 2 3 5
  • Testicular Protein Kinase 1 4
  • Testis-Specific Kinase-1 2
  • Testis Specific Kinase-1 2
  • EC 2.7.12.1 4

External Ids for TESK1 Gene

Previous GeneCards Identifiers for TESK1 Gene

  • GC09P035917
  • GC09P035774
  • GC09P035595
  • GC09P035561

Summaries for TESK1 Gene

Entrez Gene Summary for TESK1 Gene

  • This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for TESK1 Gene

TESK1 (Testis-Specific Kinase 1) is a Protein Coding gene. Diseases associated with TESK1 include Wilson-Turner X-Linked Mental Retardation Syndrome. Among its related pathways are ERK Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TESK2.

UniProtKB/Swiss-Prot for TESK1 Gene

  • Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).

Gene Wiki entry for TESK1 Gene

Additional gene information for TESK1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TESK1 Gene

Genomics for TESK1 Gene

GeneHancer (GH) Regulatory Elements for TESK1 Gene

Promoters and enhancers for TESK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I035602 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 550.8 -0.6 -647 3.6 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 E2F8 ZNF143 GC09M035603 TESK1 CD72 ENSG00000231393 LOC101926948 CCDC107 RN7SL22P ARHGEF39 VCP RUSC2
GH09I035608 Enhancer 0.4 ENCODE 0.8 +4.2 4177 2.4 ATF7 ATF2 MIR4667 CCDC107 RN7SL22P ARHGEF39 SIT1 FAM166B CA9 CREB3 TLN1 GBA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TESK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TESK1 gene promoter:

Genomic Locations for TESK1 Gene

Genomic Locations for TESK1 Gene
chr9:35,605,284-35,610,041
(GRCh38/hg38)
Size:
4,758 bases
Orientation:
Plus strand
chr9:35,605,281-35,610,038
(GRCh37/hg19)

Genomic View for TESK1 Gene

Genes around TESK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESK1 Gene

Proteins for TESK1 Gene

  • Protein details for TESK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15569-TESK1_HUMAN
    Recommended name:
    Dual specificity testis-specific protein kinase 1
    Protein Accession:
    Q15569
    Secondary Accessions:
    • Q8IXZ8

    Protein attributes for TESK1 Gene

    Size:
    626 amino acids
    Molecular mass:
    67684 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with TAOK2; leading to inhibit TAOK2 activity. Interacts with SPRED1; leading to inhibit activity (By similarity). Interacts with SPRY4.

neXtProt entry for TESK1 Gene

Post-translational modifications for TESK1 Gene

Other Protein References for TESK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TESK1 Gene

Domains & Families for TESK1 Gene

Gene Families for TESK1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TESK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15569

UniProtKB/Swiss-Prot:

TESK1_HUMAN :
  • The extracatalytic C-terminal part is highly rich in proline residues.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • The extracatalytic C-terminal part is highly rich in proline residues.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TESK1: view

Function for TESK1 Gene

Molecular function for TESK1 Gene

GENATLAS Biochemistry:
testis specific protein kinase 1,putatively involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation on Ser-220. Kinase activity is inhibited by SPRED1 (By similarity).
UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).

Enzyme Numbers (IUBMB) for TESK1 Gene

Gene Ontology (GO) - Molecular Function for TESK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IBA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004871 signal transducer activity IBA --
genes like me logo Genes that share ontologies with TESK1: view
genes like me logo Genes that share phenotypes with TESK1: view

Animal Model Products

miRNA for TESK1 Gene

Clone Products

  • Addgene plasmids for TESK1

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESK1 Gene

Localization for TESK1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TESK1 gene
Compartment Confidence
cytosol 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TESK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0031410 colocalizes_with cytoplasmic vesicle IEA,ISS 18216281
genes like me logo Genes that share ontologies with TESK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TESK1 Gene

Pathways & Interactions for TESK1 Gene

genes like me logo Genes that share pathways with TESK1: view

Pathways by source for TESK1 Gene

SIGNOR curated interactions for TESK1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TESK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007283 spermatogenesis IEA --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0031953 negative regulation of protein autophosphorylation ISS 18216281
genes like me logo Genes that share ontologies with TESK1: view

Drugs & Compounds for TESK1 Gene

(7) Drugs for TESK1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
Manganese Approved Nutra 37
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for TESK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TESK1: view

Transcripts for TESK1 Gene

Unigene Clusters for TESK1 Gene

Testis-specific kinase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for TESK1

Alternative Splicing Database (ASD) splice patterns (SP) for TESK1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: -
SP2: -
SP3: -

Relevant External Links for TESK1 Gene

GeneLoc Exon Structure for
TESK1
ECgene alternative splicing isoforms for
TESK1

Expression for TESK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TESK1 Gene

Protein differential expression in normal tissues from HIPED for TESK1 Gene

This gene is overexpressed in Pancreas (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TESK1 Gene



Protein tissue co-expression partners for TESK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TESK1 Gene:

TESK1

SOURCE GeneReport for Unigene cluster for TESK1 Gene:

Hs.708096

Evidence on tissue expression from TISSUES for TESK1 Gene

  • Nervous system(4.6)
  • Eye(4)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with TESK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TESK1 Gene

Orthologs for TESK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TESK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TESK1 33 34
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia TESK1 33 34
  • 90.82 (n)
mouse
(Mus musculus)
Mammalia Tesk1 33 16 34
  • 89.38 (n)
dog
(Canis familiaris)
Mammalia TESK1 33 34
  • 89.07 (n)
rat
(Rattus norvegicus)
Mammalia Tesk1 33
  • 89 (n)
oppossum
(Monodelphis domestica)
Mammalia TESK1 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TESK1 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves TESK1 33 34
  • 67.25 (n)
lizard
(Anolis carolinensis)
Reptilia TESK1 34
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-113e8.3 33
  • 64.24 (n)
TESK1 (1 of 2) 34
  • 46 (a)
OneToMany
TESK1 (2 of 2) 34
  • 44 (a)
OneToMany
Dr.12054 33
fruit fly
(Drosophila melanogaster)
Insecta cdi 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K09B11.5 34
  • 17 (a)
ManyToMany
T25B9.5 34
  • 17 (a)
ManyToMany
Y69E1A.3 34
  • 17 (a)
ManyToMany
kin-21 34
  • 16 (a)
ManyToMany
Y52D5A.2 34
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToMany
Species where no ortholog for TESK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TESK1 Gene

ENSEMBL:
Gene Tree for TESK1 (if available)
TreeFam:
Gene Tree for TESK1 (if available)

Paralogs for TESK1 Gene

Paralogs for TESK1 Gene

(1) SIMAP similar genes for TESK1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TESK1: view

Variants for TESK1 Gene

Sequence variations from dbSNP and Humsavar for TESK1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
VAR_035638 Breast cancer samples p.His539Tyr
rs1000160337 -- 35,606,114(+) C/A intron_variant
rs1000208275 -- 35,605,028(+) G/A upstream_transcript_variant
rs1000513122 -- 35,610,046(+) G/A downstream_transcript_variant
rs1000566923 -- 35,610,234(+) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TESK1 Gene

Variant ID Type Subtype PubMed ID
nsv614165 CNV gain 21841781
nsv614164 CNV gain 21841781
nsv528256 CNV loss 19592680
nsv1125318 OTHER inversion 24896259
nsv1119196 CNV deletion 24896259
esv25703 CNV loss 19812545

Variation tolerance for TESK1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TESK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TESK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESK1 Gene

Disorders for TESK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TESK1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
wilson-turner x-linked mental retardation syndrome
  • wts
- elite association - COSMIC cancer census association via MalaCards
Search TESK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TESK1

genes like me logo Genes that share disorders with TESK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TESK1 Gene

Publications for TESK1 Gene

  1. Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells. (PMID: 8537404) Toshima J … Mizuno K (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. (PMID: 12027893) Leeksma OC … de Vries CJ (European journal of biochemistry 2002) 3 4 22 58
  3. Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. (PMID: 15817463) LaLonde DP … Turner CE (The Journal of biological chemistry 2005) 3 22 58
  4. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. (PMID: 11418599) Toshima J … Mizuno K (The Journal of biological chemistry 2001) 3 22 58
  5. Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. (PMID: 11294912) Toshima J … Mizuno K (Molecular biology of the cell 2001) 3 22 58

Products for TESK1 Gene

Sources for TESK1 Gene

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