Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed i... See more...

Aliases for TERC Gene

Subcategory (RNA class) for TERC Gene


Number of RNA Genes sources:

4 / 17

Aliases for TERC Gene

  • Telomerase RNA Component 2 3 5
  • Small Cajal Body-Specific RNA 19 2 3
  • SCARNA19 2 3
  • TRC3 2 3
  • TERC 2 5
  • HTR 2 3
  • TR 2 3
  • NONHSAG036615.2 91
  • Lnc-ACTRT3-2 165
  • SNODB171 177
  • SNODB186 177
  • PFBMFT2 3
  • DKCA1 3

External Ids for TERC Gene

Previous GeneCards Identifiers for TERC Gene

  • GC03U990074
  • GC03M170803
  • GC03M170965
  • GC03M169483
  • GC03M166852
  • GC03M169486
  • GC03M169490
  • GC03M169496

Summaries for TERC Gene

Entrez Gene Summary for TERC Gene

  • Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for TERC Gene

TERC (Telomerase RNA Component) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TERC include Pulmonary Fibrosis And/Or Bone Marrow Failure, Telomere-Related, 2 and Dyskeratosis Congenita, Autosomal Dominant 1. Among its related pathways are Gastric cancer and Pathways in cancer.

Gene Wiki entry for TERC Gene

Rfam classification for TERC Gene

  • Vertebrate telomerase RNA

Additional gene information for TERC Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for TERC Gene

Genomics for TERC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TERC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J169762 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.6 578 2.9 BRCA1 ARHGAP35 CREB1 GATAD2A CTCF HNRNPL PRDM10 ZNF629 REST RFX1 AF047386 ENSG00000277925 TERC MYNN SEC62-AS1 PHC3 RPL22P1 PRKCI LRRC34 ACTRT3
GH03J169141 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.1 +618.1 618108 11.3 CREB1 CTCF ATF7 PRDM10 ZNF629 REST RFX1 LEF1 IKZF1 KDM1A MECOM TERC lnc-ACTRT3-6 HSALNG0030569
GH03J169103 Enhancer 0.8 Ensembl ENCODE 5.5 +660.3 660259 2.4 POLR2A GTF2F1 TOE1 HMBOX1 RAD51 ZNF316 MYNN ATF2 GATA3 MAFK TERC lnc-ACTRT3-7 LOC107986051 MECOM
GH03J169115 Enhancer 0.7 VISTA Ensembl ENCODE 5.8 +648.0 647958 3 CTCF JUN POLR2A TERC lnc-ACTRT3-7 LOC107986051 MECOM
GH03J169090 Enhancer 0.2 Ensembl 5.8 +674.7 674659 0.8 TERC LOC107986051 lnc-ACTRT3-7 MECOM GOLIM4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TERC on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the TERC gene promoter:
  • AREB6
  • Arnt
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • HFH-3
  • p53
  • Sp1

Genomic Locations for TERC Gene

Genomic Locations for TERC Gene
598 bases
Minus strand
541 bases
Minus strand

Genomic View for TERC Gene

Genes around TERC on UCSC Golden Path with GeneCards custom track
TERC in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
TERC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TERC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TERC Gene

Proteins for TERC Gene

Post-translational modifications for TERC Gene

No Post-translational modifications

No data available for DME Specific Peptides for TERC Gene

Domains & Families for TERC Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TERC Gene

Function for TERC Gene

Molecular function for TERC Gene

GENATLAS Biochemistry:
telomerase RNA component,involved in telomere maintenance as template in telomeric DNA synthesis,transcription up-regulated by endogeneous TERT,strongly expressed in embryonic tissues (undifferentialed neuroepithelium,epithelium,mesenchymes) absent in differentiated tissues except dividing cells (testis,lymphoid follicles,regenerative epithelia)

Phenotypes From GWAS Catalog for TERC Gene

Gene Ontology (GO) - Molecular Function for TERC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000332 template for synthesis of G-rich strand of telomere DNA activity IDA 9398860
GO:0003720 contributes_to telomerase activity IDA, TAS 23474713
GO:0003721 contributes_to telomerase RNA reverse transcriptase activity IDA, IMP 11313459
GO:0003964 contributes_to RNA-directed DNA polymerase activity IDA 19701182
GO:0005515 protein binding IPI 10757788
genes like me logo Genes that share ontologies with TERC: view

Human Phenotype Ontology for TERC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TERC Gene

Localization for TERC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TERC gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TERC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000333 telomerase catalytic core complex IDA, IMP 11313459
GO:0000781 colocalizes_with chromosome, telomeric region IMP 26950371
GO:0005697 telomerase holoenzyme complex IPI, IC 19701182
GO:0005737 cytoplasm IMP 26950371
GO:0015030 Cajal body IDA, IMP 25467444
genes like me logo Genes that share ontologies with TERC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TERC Gene

Pathways & Interactions for TERC Gene

PathCards logo

SuperPathways for TERC Gene

genes like me logo Genes that share pathways with TERC: view

Pathways by source for TERC Gene

Gene Ontology (GO) - Biological Process for TERC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007004 telomere maintenance via telomerase IDA 9443919
GO:0071456 cellular response to hypoxia IMP 11313459
GO:0071897 DNA biosynthetic process IDA 19701182
GO:2000773 negative regulation of cellular senescence IMP 11313459
genes like me logo Genes that share ontologies with TERC: view

No data available for Interacting Proteins and SIGNOR curated interactions for TERC Gene

Drugs & Compounds for TERC Gene

(15) Drugs for TERC Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BIBR 1532 Pharma Telomerase inhibitor,novel and selective, Selective telomerase inhibitor 0

(18) Additional Compounds for TERC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for TERC Gene

Compound Action Cas Number
BIBR 1532 Telomerase inhibitor,novel and selective 321674-73-1
genes like me logo Genes that share compounds with TERC: view

Drug Products

Transcripts for TERC Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for TERC Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004A7003_9606 telomerase_RNA 451 4

HGNC: 11727,

RefSeq: NR_001566,

snoDB: SNODB186,

ENA: AF221907.1:98..548:misc_RNA,

URS00004416C5_9606 lncRNA 541 3

Ensembl: ENST00000602385 (view in UCSC) ,

LNCipedia: lnc-ACTRT3-2:2,

snoDB: SNODB171,

URS0000593928_9606 lncRNA 598 3

LNCipedia: lnc-ACTRT3-2:1,


ENA: U85256.1:1..598:misc_RNA,

URS0000D5DD7A_9606 lncRNA 540 1

LNCipedia: lnc-ACTRT3-2:3,

URS0000D5A4C0_9606 lncRNA 433 1

LNCipedia: lnc-ACTRT3-2:5,

TERC in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for TERC Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TERC Gene

No ASD Table

Relevant External Links for TERC Gene

GeneLoc Exon Structure for

Expression for TERC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TERC Gene

mRNA differential expression in normal tissues according to GTEx for TERC Gene

This gene is overexpressed in Testis (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TERC

SOURCE GeneReport for Unigene cluster for TERC Gene:


Evidence on tissue expression from TISSUES for TERC Gene

  • Blood(2.3)
  • Skin(2.1)
  • Bone marrow(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TERC Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lacrimal apparatus
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • salivary gland
  • scalp
  • skull
  • tooth
  • breast
  • bronchus
  • chest wall
  • clavicle
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
  • intestine
  • kidney
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
  • anus
  • ovary
  • pelvis
  • penis
  • rectum
  • testicle
  • urethra
  • urinary bladder
  • uterus
  • vagina
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with TERC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TERC Gene

Orthologs for TERC Gene

This gene was present in the common ancestor of chordates.

Orthologs for TERC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia Telomerase-vert 31
  • 99 (a)
(Canis familiaris)
Mammalia Telomerase-vert 31
  • 84 (a)
(Bos Taurus)
Mammalia Telomerase-vert 31 31
  • 83 (a)
(Mus musculus)
Mammalia Terc 31
  • 66 (a)
Gm24413 31
  • 63 (a)
(Monodelphis domestica)
Mammalia Telomerase-vert 31
  • 47 (a)
(Gallus gallus)
Aves Telomerase-vert 31
  • 76 (a)
(Anolis carolinensis)
Reptilia Telomerase-vert 31
  • 48 (a)
(Danio rerio)
Actinopterygii Telomerase-vert 31
  • 48 (a)
Species where no ortholog for TERC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TERC Gene

Gene Tree for TERC (if available)
Gene Tree for TERC (if available)

Paralogs for TERC Gene

No data available for Paralogs for TERC Gene

Variants for TERC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TERC Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
40977 Pathogenic: Dyskeratosis congenita, autosomal dominant 1 169,764,740(-) GGCTGACAGAGCCCAA
636628 Uncertain Significance: Dyskeratosis congenita, autosomal dominant 1; not provided 169,765,043(-) G/A
639725 Uncertain Significance: Dyskeratosis congenita, autosomal dominant 1 169,764,698(-) C/G
639928 Uncertain Significance: Dyskeratosis congenita, autosomal dominant 1 169,764,712(-) A/ACCTCGC NON_CODING_TRANSCRIPT_VARIANT
643046 Uncertain Significance: Dyskeratosis congenita, autosomal dominant 1 169,764,828(-) C/T

Additional dbSNP identifiers (rs#s) for TERC Gene

Structural Variations from Database of Genomic Variants (DGV) for TERC Gene

Variant ID Type Subtype PubMed ID
esv2422204 CNV deletion 17116639
nsv7356 OTHER inversion 18451855

Additional Variant Information for TERC Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TERC Gene

Disorders for TERC Gene

MalaCards: The human disease database

(35) MalaCards diseases for TERC Gene - From: LncRNADisease, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TERC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TERC

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TERC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TERC Gene

Publications for TERC Gene

  1. Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. (PMID: 19147845) Calado RT … Young NS (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 23 41
  2. TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. (PMID: 18931339) Du HY … Bessler M (Blood 2009) 3 23 41
  3. Telomere shortening in familial and sporadic pulmonary fibrosis. (PMID: 18635888) Cronkhite JT … Garcia CK (American journal of respiratory and critical care medicine 2008) 3 23 41
  4. Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres. (PMID: 16319170) Jády BE … Kiss T (Molecular biology of the cell 2006) 2 3 23
  5. Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study. (PMID: 20937264) Zee RY … Chasman DI (Clinica chimica acta; international journal of clinical chemistry 2011) 3 41

Products for TERC Gene

Sources for TERC Gene