Aliases for TEPP Gene

Aliases for TEPP Gene

  • Testis, Prostate And Placenta Expressed 2 3 5
  • Testis, Prostate And Placenta-Expressed Protein 3 4
  • Testis/Prostate/Placenta-Expressed Protein 3
  • Testicular Tissue Protein Li 196 3

External Ids for TEPP Gene

Previous GeneCards Identifiers for TEPP Gene

  • GC16P057785
  • GC16P056567
  • GC16P058010
  • GC16P043877

Summaries for TEPP Gene

GeneCards Summary for TEPP Gene

TEPP (Testis, Prostate And Placenta Expressed) is a Protein Coding gene. Diseases associated with TEPP include Heart Sarcoma and Lymphogranuloma Venereum.

Additional gene information for TEPP Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEPP Gene

Genomics for TEPP Gene

GeneHancer (GH) Regulatory Elements for TEPP Gene

Promoters and enhancers for TEPP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J057975 Enhancer 1.1 Ensembl ENCODE 521.8 -0.1 -96 1.1 PHB2 ZNF263 REST MYC CTBP1 JUN NCOR1 NFRKB KDM5B MBD2 TEPP CNGB1 lnc-ZNF319-1
GH16J057984 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 39.3 +8.9 8865 2.2 TCF12 NRF1 ZNF10 GABPA ZBTB26 TARDBP SAP30 MYC EZH2 HDAC2 TEPP CFAP20 CNGB1 piR-42384
GH16J057998 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 19.9 +23.9 23911 4.5 ZBTB40 CTCF SIN3A NRF1 USF1 POLR2G SP1 NCOR1 GTF2E2 PHF8 NONHSAG019587.2 ZNF319 USB1 TEPP
GH16J058021 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13.4 +49.0 49025 7.1 EP300 HNRNPK NRF1 POLR2G NCOR1 TEAD4 ZNF10 ZBTB5 ZIC2 KDM6A MMP15 CNOT1 TEPP CFAP20 CNGB1 RSPRY1 CSNK2A2 ZNF319 piR-38728
GH16J057992 Enhancer 1 Ensembl ENCODE 31.9 +17.9 17934 3.9 ZNF217 CTCF POLR2G ZIC2 REST MYC CTBP1 SMC3 RBM25 KLF9 TEPP ZNF319 piR-42384 CNGB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEPP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEPP

Top Transcription factor binding sites by QIAGEN in the TEPP gene promoter:
  • FOXO4
  • GATA-1
  • GATA-2
  • GATA-3
  • RORalpha1
  • SREBP-1a
  • YY1
  • ZID

Genomic Locations for TEPP Gene

Genomic Locations for TEPP Gene
chr16:57,976,435-57,988,354
(GRCh38/hg38)
Size:
11,920 bases
Orientation:
Plus strand
chr16:58,010,339-58,022,020
(GRCh37/hg19)
Size:
11,682 bases
Orientation:
Plus strand

Genomic View for TEPP Gene

Genes around TEPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEPP Gene

Proteins for TEPP Gene

  • Protein details for TEPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6URK8-TEPP_HUMAN
    Recommended name:
    Testis, prostate and placenta-expressed protein
    Protein Accession:
    Q6URK8
    Secondary Accessions:
    • Q6URK7

    Protein attributes for TEPP Gene

    Size:
    271 amino acids
    Molecular mass:
    30717 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TEPP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEPP Gene

Post-translational modifications for TEPP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEPP Gene

No data available for DME Specific Peptides for TEPP Gene

Domains & Families for TEPP Gene

Gene Families for TEPP Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for TEPP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEPP Gene

GenScript: Design optimal peptide antigens:
  • Testis, prostate and placenta-expressed protein (TEPP_HUMAN)
genes like me logo Genes that share domains with TEPP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEPP Gene

Function for TEPP Gene

Phenotypes From GWAS Catalog for TEPP Gene

genes like me logo Genes that share phenotypes with TEPP: view

Animal Models for TEPP Gene

MGI Knock Outs for TEPP:
  • Tepp Tepp<tm1.1Osb>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEPP

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TEPP Gene

Localization for TEPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEPP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEPP gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TEPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with TEPP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEPP Gene

Pathways & Interactions for TEPP Gene

PathCards logo

SuperPathways for TEPP Gene

No Data Available

Interacting Proteins for TEPP Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000290871 Q6URK8-TEPP_HUMAN for TEPP Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for TEPP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TEPP Gene

Drugs & Compounds for TEPP Gene

No Compound Related Data Available

Transcripts for TEPP Gene

mRNA/cDNA for TEPP Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEPP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEPP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2: -
SP3: - -

Relevant External Links for TEPP Gene

GeneLoc Exon Structure for
TEPP

Expression for TEPP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEPP Gene

This gene is overexpressed in Testis (x21.6) and Thyroid (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEPP Gene



Protein tissue co-expression partners for TEPP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEPP

SOURCE GeneReport for Unigene cluster for TEPP Gene:

Hs.132976

mRNA Expression by UniProt/SwissProt for TEPP Gene:

Q6URK8-TEPP_HUMAN
Tissue specificity: Expressed in testis, prostate and placenta.
genes like me logo Genes that share expression patterns with TEPP: view

No data available for Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEPP Gene

Orthologs for TEPP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEPP 31 30
  • 96.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TEPP 31 30
  • 87.35 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TEPP 31 30
  • 86.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tepp 17 31 30
  • 81.79 (n)
rat
(Rattus norvegicus)
Mammalia Tepp 30
  • 80.86 (n)
oppossum
(Monodelphis domestica)
Mammalia TEPP 31
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEPP 31
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tepp 30
  • 52.79 (n)
Species where no ortholog for TEPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TEPP Gene

ENSEMBL:
Gene Tree for TEPP (if available)
TreeFam:
Gene Tree for TEPP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEPP: view image

Paralogs for TEPP Gene

No data available for Paralogs for TEPP Gene

Variants for TEPP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEPP Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs9934227 - p.Ser260Asn

Additional dbSNP identifiers (rs#s) for TEPP Gene

Structural Variations from Database of Genomic Variants (DGV) for TEPP Gene

Variant ID Type Subtype PubMed ID
nsv1063386 CNV gain 25217958
nsv1816 CNV deletion 18451855
nsv523659 CNV loss 19592680
nsv572759 CNV loss 21841781

Variation tolerance for TEPP Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEPP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEPP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEPP Gene

Disorders for TEPP Gene

MalaCards: The human disease database

(3) MalaCards diseases for TEPP Gene - From: DISEASES

Disorder Aliases PubMed IDs
heart sarcoma
  • cardiac sarcoma
lymphogranuloma venereum
  • climatic or tropical bubo
granuloma inguinale
  • donovanosis
- elite association - COSMIC cancer census association via MalaCards
Search TEPP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEPP

genes like me logo Genes that share disorders with TEPP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEPP Gene

Publications for TEPP Gene

  1. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. (PMID: 14652002) Bera TK … Pastan IH (Biochemical and biophysical research communications 2003) 2 3 4 54
  2. Molecular evolution of TEPP protein genes in metazoans. (PMID: 19548082) Hahn Y (Biochemical genetics 2009) 2 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 54

Products for TEPP Gene

Sources for TEPP Gene