Antibodies against the protein encoded by this gene were found only in plasma from cancer patients. While it may be a target for immunotherapy, the function of this gene is unknown. [provided by RefSeq, Dec 2009] See more...

Aliases for TENT5D Gene

Aliases for TENT5D Gene

  • Terminal Nucleotidyltransferase 5D 2 3 4 5
  • Family With Sequence Similarity 46 Member D 2 3
  • Non-Canonical Poly(A) Polymerase FAM46D 3 4
  • Cancer/Testis Antigen 112 2 3
  • CT1.26 2 3
  • FAM46D 3 4
  • CT112 2 3
  • Family With Sequence Similarity 46, Member D 2
  • Putative Nucleotidyltransferase FAM46D 3
  • Protein FAM46D 3
  • EC 4
  • MGC26999 2
  • TENT5D 5

External Ids for TENT5D Gene

Previous HGNC Symbols for TENT5D Gene

  • FAM46D

Summaries for TENT5D Gene

Entrez Gene Summary for TENT5D Gene

  • Antibodies against the protein encoded by this gene were found only in plasma from cancer patients. While it may be a target for immunotherapy, the function of this gene is unknown. [provided by RefSeq, Dec 2009]

GeneCards Summary for TENT5D Gene

TENT5D (Terminal Nucleotidyltransferase 5D) is a Protein Coding gene. Diseases associated with TENT5D include Punctate Epithelial Keratoconjunctivitis and Recurrent Corneal Erosion. An important paralog of this gene is TENT5A.

UniProtKB/Swiss-Prot Summary for TENT5D Gene

  • Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase.

Additional gene information for TENT5D Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TENT5D Gene

Genomics for TENT5D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TENT5D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ080334 Promoter/Enhancer 0.9 Ensembl ENCODE 600.7 -0.4 -438 2 POLR2A CTCF YY1 CHAMP1 NRF1 ZBTB33 TAF1 TBP CHMP1B2P lnc-BRWD3-2 TENT5D piR-55194-446 TBX22
GH0XJ080420 Promoter 0.6 EPDnew 600.2 +85.0 85023 0.1 RFX1 ATF4 ATF3 TENT5D piR-52079-222 piR-36393-558 BRWD3
GH0XJ080423 Enhancer 0.8 ENCODE 0.2 +88.4 88358 0.2 LEF1 DDX20 PHF21A ZNF24 MTA1 BRD9 DPF2 HDAC1 SOX6 GATAD2B piR-52079-222 piR-36393-558 TENT5D BRWD3
GH0XJ080223 Enhancer 0.6 FANTOM5 Ensembl 0.1 -111.0 -111038 2.4 CTCF SPI1 ATF4 POLR2A RAD21 TBX22 VDAC1P1 piR-56451-111 RF00017-8551 TENT5D
GH0XJ080511 Enhancer 0.9 ENCODE 0.1 +177.2 177197 1.6 RFX1 LEF1 IKZF1 JUND DDX20 MTA1 DPF2 HDAC1 SOX6 FOXJ2 BRWD3 piR-60885-181 piR-38257-016 TENT5D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TENT5D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TENT5D

Genomic Locations for TENT5D Gene

Genomic Locations for TENT5D Gene
111,447 bases
Plus strand
109,808 bases
Plus strand

Genomic View for TENT5D Gene

Genes around TENT5D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENT5D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENT5D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENT5D Gene

Proteins for TENT5D Gene

  • Protein details for TENT5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Terminal nucleotidyltransferase 5D
    Protein Accession:
    Secondary Accessions:
    • B2R9Q6
    • Q7Z3F6
    • Q8NHU1

    Protein attributes for TENT5D Gene

    389 amino acids
    Molecular mass:
    44500 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TENT5D Gene

Post-translational modifications for TENT5D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TENT5D Gene

No data available for DME Specific Peptides for TENT5D Gene

Domains & Families for TENT5D Gene

Gene Families for TENT5D Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TENT5D Gene

  • Protein of unknown function DUF1693

Suggested Antigen Peptide Sequences for TENT5D Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94508 (B2R9Q6_HUMAN)
  • Protein FAM46D (FA46D_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TENT family.
  • Belongs to the TENT family.
genes like me logo Genes that share domains with TENT5D: view

Function for TENT5D Gene

Molecular function for TENT5D Gene

UniProtKB/Swiss-Prot Function:
Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:11128, Rhea:RHEA-COMP:14647, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:83400, ChEBI:CHEBI:140626; EC=; Evidence={ECO:0000269|PubMed:28931820};.

Enzyme Numbers (IUBMB) for TENT5D Gene

Gene Ontology (GO) - Molecular Function for TENT5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004652 polynucleotide adenylyltransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
GO:1990817 RNA adenylyltransferase activity IDA 28931820
genes like me logo Genes that share ontologies with TENT5D: view
genes like me logo Genes that share phenotypes with TENT5D: view

Animal Model Products

CRISPR Products

miRNA for TENT5D Gene

miRTarBase miRNAs that target TENT5D

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TENT5D

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TENT5D Gene

Localization for TENT5D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TENT5D gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 0
cytoskeleton 0
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TENT5D Gene

Pathways & Interactions for TENT5D Gene

PathCards logo

SuperPathways for TENT5D Gene

No Data Available

Gene Ontology (GO) - Biological Process for TENT5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048255 mRNA stabilization IBA 21873635
genes like me logo Genes that share ontologies with TENT5D: view

No data available for Pathways by source and SIGNOR curated interactions for TENT5D Gene

Drugs & Compounds for TENT5D Gene

No Compound Related Data Available

Transcripts for TENT5D Gene

mRNA/cDNA for TENT5D Gene

7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TENT5D

Alternative Splicing Database (ASD) splice patterns (SP) for TENT5D Gene

No ASD Table

Relevant External Links for TENT5D Gene

GeneLoc Exon Structure for

Expression for TENT5D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TENT5D

mRNA Expression by UniProt/SwissProt for TENT5D Gene:

Tissue specificity: restricted to testis.

Evidence on tissue expression from TISSUES for TENT5D Gene

  • Eye(2.1)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TENT5D Gene

Orthologs for TENT5D Gene

This gene was present in the common ancestor of animals.

Orthologs for TENT5D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM46D 30 31
  • 98.8 (n)
(Canis familiaris)
Mammalia FAM46D 30 31
  • 87.54 (n)
(Bos Taurus)
Mammalia FAM46D 30 31
  • 86.68 (n)
(Rattus norvegicus)
Mammalia Fam46d 30
  • 83.16 (n)
(Mus musculus)
Mammalia Fam46d 30 31
  • 82.47 (n)
Tent5d 17
(Monodelphis domestica)
Mammalia FAM46D 31
  • 65 (a)
(Gallus gallus)
Aves FAM46D 30 31
  • 70.67 (n)
(Anolis carolinensis)
Reptilia FAM46D 31
  • 67 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam46d 30
  • 69.02 (n)
(Danio rerio)
Actinopterygii LOC100149701 30
  • 64.74 (n)
FAM46D 31
  • 64 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG30497 31
  • 23 (a)
(Caenorhabditis elegans)
Secernentea pqn-44 31
  • 33 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
Species where no ortholog for TENT5D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TENT5D Gene

Gene Tree for TENT5D (if available)
Gene Tree for TENT5D (if available)
Evolutionary constrained regions (ECRs) for TENT5D: view image

Paralogs for TENT5D Gene

Paralogs for TENT5D Gene

genes like me logo Genes that share paralogs with TENT5D: view

Variants for TENT5D Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TENT5D Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs1113265 - p.Asp185Glu

Additional dbSNP identifiers (rs#s) for TENT5D Gene

Structural Variations from Database of Genomic Variants (DGV) for TENT5D Gene

Variant ID Type Subtype PubMed ID
esv1341044 CNV insertion 17803354
nsv1115875 CNV duplication 24896259
nsv6972 CNV insertion 18451855

Variation tolerance for TENT5D Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TENT5D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TENT5D Gene

Disorders for TENT5D Gene

MalaCards: The human disease database

(4) MalaCards diseases for TENT5D Gene - From: DISEASES

Disorder Aliases PubMed IDs
punctate epithelial keratoconjunctivitis
  • punctate keratitis
recurrent corneal erosion
  • recurrent erosion of cornea
retinitis pigmentosa 25
  • rp25
corneal degeneration
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TENT5D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TENT5D Gene

Publications for TENT5D Gene

  1. 3' RNA Uridylation in Epitranscriptomics, Gene Regulation, and Disease. (PMID: 30057901) Menezes MR … Hagan JP (Frontiers in molecular biosciences 2018) 2 3
  2. The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. (PMID: 28931820) Mroczek S … Dziembowski A (Nature communications 2017) 3 4
  3. Identification of FAM46D as a novel cancer/testis antigen using EST data and serological analysis. (PMID: 19540335) Bettoni F … Camargo AA (Genomics 2009) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for TENT5D Gene

Sources for TENT5D Gene