Aliases for TENT5C Gene

Aliases for TENT5C Gene

  • Terminal Nucleotidyltransferase 5C 2 3 4 5
  • Family With Sequence Similarity 46 Member C 2 3
  • Non-Canonical Poly(A) Polymerase FAM46C 3 4
  • FAM46C 3 4
  • Family With Sequence Similarity 46, Member C 2
  • Putative Nucleotidyltransferase FAM46C 3
  • Protein FAM46C 3
  • EC 2.7.7.19 4

External Ids for TENT5C Gene

Previous HGNC Symbols for TENT5C Gene

  • FAM46C

Summaries for TENT5C Gene

GeneCards Summary for TENT5C Gene

TENT5C (Terminal Nucleotidyltransferase 5C) is a Protein Coding gene. Diseases associated with TENT5C include Smoldering Myeloma and Monoclonal Gammopathy Of Uncertain Significance. An important paralog of this gene is TENT5A.

UniProtKB/Swiss-Prot Summary for TENT5C Gene

  • Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.
  • (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.

Additional gene information for TENT5C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TENT5C Gene

Genomics for TENT5C Gene

GeneHancer (GH) Regulatory Elements for TENT5C Gene

Promoters and enhancers for TENT5C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J117604 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 508.5 +1.6 1631 5.6 ZNF217 SIN3A NRF1 POLR2G GTF2E2 PHF8 ZNF639 ZNF10 ZBTB5 ZIC2 TENT5C LOC100996263 piR-56716 ENSG00000271427 ENSG00000212266
GH01J117662 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 19.4 +58.6 58615 4.1 SP1 EP300 RELA MEF2C TOE1 RCOR1 CTBP1 TRIM22 EZH2 BCL11A TENT5C ENSG00000212266 LOC100996263 MAN1A2 lnc-GDAP2-9 HSALNG0006398
GH01J117675 Enhancer 1.1 Ensembl ENCODE dbSUPER 16.3 +68.2 68230 2 CTCF JUND FOS REST MYC RAD21 CTBP1 SMC3 RBM25 NFIC TENT5C LOC100996263 VTCN1 HSALNG0006398 lnc-GDAP2-9
GH01J117644 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.8 +39.0 38981 1.1 PHB2 ZBTB11 AFF1 TARDBP REST HES1 MYC RUNX1 CTBP1 HDAC3 ENSG00000212266 LOC100996263 TENT5C VDAC2P3 lnc-GDAP2-9
GH01J117708 Enhancer 0.9 Ensembl ENCODE 15.6 +102.8 102819 2 REST MYC ZNF316 TRIM24 ZNF592 E2F6 TAL1 MAFK CUX1 HDAC2 TENT5C ENSG00000212266 LOC100996263 LOC100192389 piR-45012-031
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TENT5C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TENT5C

Genomic Locations for TENT5C Gene

Genomic Locations for TENT5C Gene
chr1:117,605,982-117,628,389
(GRCh38/hg38)
Size:
22,408 bases
Orientation:
Plus strand
chr1:118,148,556-118,171,011
(GRCh37/hg19)
Size:
22,456 bases
Orientation:
Plus strand

Genomic View for TENT5C Gene

Genes around TENT5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENT5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENT5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENT5C Gene

Proteins for TENT5C Gene

  • Protein details for TENT5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWP2-TET5C_HUMAN
    Recommended name:
    Terminal nucleotidyltransferase 5C
    Protein Accession:
    Q5VWP2
    Secondary Accessions:
    • A3KMG2
    • Q8NE25
    • Q9NXK0

    Protein attributes for TENT5C Gene

    Size:
    391 amino acids
    Molecular mass:
    44944 Da
    Quaternary structure:
    • Interacts with BCCIP and PABPC1; the interaction has no effect on TENT5C poly(A) polymerase function.

neXtProt entry for TENT5C Gene

Post-translational modifications for TENT5C Gene

  • Ubiquitination at Lys65, Lys234, Lys246, and Lys264
  • Modification sites at PhosphoSitePlus

Other Protein References for TENT5C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TENT5C Gene

Domains & Families for TENT5C Gene

Gene Families for TENT5C Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for TENT5C Gene

Blocks:
  • Protein of unknown function DUF1693
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TENT5C Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM46C (FA46C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VWP2

UniProtKB/Swiss-Prot:

TET5C_HUMAN :
  • Belongs to the TENT family.
Family:
  • Belongs to the TENT family.
genes like me logo Genes that share domains with TENT5C: view

Function for TENT5C Gene

Molecular function for TENT5C Gene

UniProtKB/Swiss-Prot Function:
Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:11128, Rhea:RHEA-COMP:14647, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:83400, ChEBI:CHEBI:140626; EC=2.7.7.19; Evidence=. ;.
UniProtKB/Swiss-Prot Induction:
By type I interferons.

Enzyme Numbers (IUBMB) for TENT5C Gene

Phenotypes From GWAS Catalog for TENT5C Gene

Gene Ontology (GO) - Molecular Function for TENT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004652 polynucleotide adenylyltransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with TENT5C: view
genes like me logo Genes that share phenotypes with TENT5C: view

Animal Models for TENT5C Gene

MGI Knock Outs for TENT5C:
  • Tent5c Tent5c<tm1b(KOMP)Wtsi>

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TENT5C Gene

Localization for TENT5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENT5C Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TENT5C gene
Compartment Confidence
nucleus 5
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TENT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 28931820
GO:0005737 cytoplasm IEA,IDA 28931820
genes like me logo Genes that share ontologies with TENT5C: view

Pathways & Interactions for TENT5C Gene

PathCards logo

SuperPathways for TENT5C Gene

No Data Available

Gene Ontology (GO) - Biological Process for TENT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0048255 mRNA stabilization IEA,IDA 28931820
genes like me logo Genes that share ontologies with TENT5C: view

No data available for Pathways by source and SIGNOR curated interactions for TENT5C Gene

Drugs & Compounds for TENT5C Gene

No Compound Related Data Available

Transcripts for TENT5C Gene

mRNA/cDNA for TENT5C Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TENT5C Gene

No ASD Table

Relevant External Links for TENT5C Gene

GeneLoc Exon Structure for
TENT5C

Expression for TENT5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TENT5C

Evidence on tissue expression from TISSUES for TENT5C Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with TENT5C: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TENT5C Gene

Orthologs for TENT5C Gene

This gene was present in the common ancestor of animals.

Orthologs for TENT5C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM46C 31 30
  • 98.89 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM46C 31
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam46c 30
  • 90.28 (n)
mouse
(Mus musculus)
Mammalia Fam46c 31 30
  • 89.94 (n)
OneToOne
Tent5c 17
dog
(Canis familiaris)
Mammalia FAM46C 31 30
  • 88.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM46C 31 30
  • 85.39 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM46C 31
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM46C 31 30
  • 78.8 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam46c 30
  • 77.58 (n)
zebrafish
(Danio rerio)
Actinopterygii fam46c 31 30
  • 71.85 (n)
OneToOne
zgc66197 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005088 30
  • 64.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG30497 31 30
  • 62.91 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pqn-44 31 30
  • 52.3 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
OneToMany
Species where no ortholog for TENT5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TENT5C Gene

ENSEMBL:
Gene Tree for TENT5C (if available)
TreeFam:
Gene Tree for TENT5C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TENT5C: view image

Paralogs for TENT5C Gene

Paralogs for TENT5C Gene

genes like me logo Genes that share paralogs with TENT5C: view

Variants for TENT5C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TENT5C Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs145471785 Not Provided: not specified 117,623,763(+) G/A MISSENSE_VARIANT
rs149654076 Not Provided: not specified 117,623,757(+) G/A MISSENSE_VARIANT
rs1630312 Not Provided: not specified. - 117,623,069(+) C/Gp.His67Gln MISSENSE_VARIANT
rs34495780 Not Provided: not specified 117,622,914(+) G/A MISSENSE_VARIANT
rs587778306 Not Provided: not specified 117,623,641(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TENT5C Gene

Structural Variations from Database of Genomic Variants (DGV) for TENT5C Gene

Variant ID Type Subtype PubMed ID
nsv1007736 CNV gain 25217958
nsv819506 CNV gain 19587683
nsv831170 CNV gain 17160897

Variation tolerance for TENT5C Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TENT5C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TENT5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TENT5C Gene

Disorders for TENT5C Gene

MalaCards: The human disease database

(5) MalaCards diseases for TENT5C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smoldering myeloma
monoclonal gammopathy of uncertain significance
  • mgus
yellow fever
  • jungle yellow fever
blood protein disease
  • blood protein disorder
myeloma, multiple
  • multiple myeloma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TENT5C

genes like me logo Genes that share disorders with TENT5C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TENT5C Gene

Publications for TENT5C Gene

  1. 3' RNA Uridylation in Epitranscriptomics, Gene Regulation, and Disease. (PMID: 30057901) Menezes MR … Hagan JP (Frontiers in molecular biosciences 2018) 2 3 54
  2. The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. (PMID: 28931820) Mroczek S … Dziembowski A (Nature communications 2017) 3 4 54
  3. A diverse range of gene products are effectors of the type I interferon antiviral response. (PMID: 21478870) Schoggins JW … Rice CM (Nature 2011) 3 4 54
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for TENT5C Gene

Sources for TENT5C Gene