Aliases for TENT5C Gene
Aliases for TENT5C Gene
External Ids for TENT5C Gene
- HGNC: 24712
- Entrez Gene: 54855
- Ensembl: ENSG00000183508
- OMIM: 613952
- UniProtKB: Q5VWP2
Previous HGNC Symbols for TENT5C Gene
- FAM46C
Summaries for TENT5C Gene
GeneCards Summary for TENT5C Gene
TENT5C (Terminal Nucleotidyltransferase 5C) is a Protein Coding gene. Diseases associated with TENT5C include Myeloma, Multiple. An important paralog of this gene is TENT5A.
UniProtKB/Swiss-Prot for TENT5C Gene
-
Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.
-
(Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
Additional gene information for TENT5C Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TENT5C Gene
Genomics for TENT5C Gene
GeneHancer (GH) Regulatory Elements for TENT5C Gene
Promoters and enhancers for TENT5C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around TENT5C on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TENT5C Gene
Genomic Locations for TENT5C Gene
- chr1:117,605,934-117,628,389
- (GRCh38/hg38)
- Size:
- 22,456 bases
- Orientation:
- Plus strand
- chr1:118,148,556-118,171,011
- (GRCh37/hg19)
- Size:
- 22,456 bases
- Orientation:
- Plus strand
Genomic View for TENT5C Gene
Genes around TENT5C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p12 by Entrez Gene
- 1p12 by HGNC
- 1p12 by Ensembl
TENT5C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TENT5C Gene
Proteins for TENT5C Gene
-
Protein details for TENT5C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VWP2-FA46C_HUMAN
- Recommended name:
- Putative nucleotidyltransferase FAM46C
- Protein Accession:
- Q5VWP2
- A3KMG2
- Q8NE25
- Q9NXK0
Protein attributes for TENT5C Gene
- Size:
- 391 amino acids
- Molecular mass:
- 44944 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for TENT5C Gene
Other Protein References for TENT5C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TENT5C
- Novus Biologicals Antibodies for TENT5C
-
Abcam antibodies for TENT5C
- Invitrogen Antibodies for TENT5C (AFLGC-FAM46C)
- GeneTex FAM46C Antibody for TENT5C
-
Boster Bio Antibodies for TENT5C
Protein Products
-
OriGene Purified Proteins for TENT5C
- Search Origene for MassSpec and Protein Over-expression Lysates for TENT5C
- Origene Custom Protein Services for TENT5C
- antibodies-online: Search results for 6 available FAM46C Proteins ranked by validation data
- Compare Top FAM46C Proteins
-
Quality Products:
- Search GeneTex for Proteins for TENT5C
-
Abcam proteins for TENT5C
Assay Products
No data available for DME Specific Peptides for TENT5C Gene
Domains & Families for TENT5C Gene
Gene Families for TENT5C Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for TENT5C Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TENT5C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q5VWP2- Family:
-
- Belongs to the FAM46 family.
Function for TENT5C Gene
Molecular function for TENT5C Gene
- UniProtKB/Swiss-Prot Function:
- Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
- UniProtKB/Swiss-Prot Induction:
- By type I interferons.
Enzyme Numbers (IUBMB) for TENT5C Gene
Phenotypes From GWAS Catalog for TENT5C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016779 | nucleotidyltransferase activity | IEA | -- |
Phenotypes for TENT5C Gene
- MGI mutant phenotypes for TENT5C:
-
inferred from 2 alleles
- cardiovascular system phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- craniofacial phenotype
- liver/biliary system phenotype
- skeleton phenotype
- embryo phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for TENT5C:
Animal Models for TENT5C Gene
- MGI Knock Outs for TENT5C:
-
- Tent5c Tent5c<tm1b(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TENT5C
-
CRISPR Products
-
OriGene CRISPR knockouts for TENT5C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TENT5C
- genomics-online: gRNA clones - Search results for 105 available FAM46C gene related products
- Overview of 105 available FAM46C gene related products
- Applied Biological Materials CRISPR for TENT5C
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for TENT5C
miRNA for TENT5C Gene
- miRTarBase miRNAs that target TENT5C
-
- hsa-mir-335-5p (MIRT018630)
- hsa-mir-98-5p (MIRT027756)
- hsa-mir-17-5p (MIRT058911)
- hsa-mir-20a-5p (MIRT058912)
- hsa-mir-93-5p (MIRT058913)
- hsa-mir-106b-5p (MIRT058915)
- hsa-mir-20b-5p (MIRT058916)
- hsa-mir-519d-3p (MIRT058920)
- hsa-mir-33a-5p (MIRT058929)
- hsa-mir-507 (MIRT058930)
- hsa-mir-557 (MIRT058931)
- hsa-mir-33b-5p (MIRT058932)
- hsa-mir-450b-5p (MIRT058933)
- hsa-mir-3680-3p (MIRT058936)
- hsa-mir-8062 (MIRT058938)
- hsa-mir-19a-3p (MIRT129779)
- hsa-mir-19b-3p (MIRT129780)
- hsa-mir-8485 (MIRT540194)
- hsa-mir-20a-3p (MIRT557940)
- hsa-mir-4686 (MIRT557941)
- hsa-mir-7152-5p (MIRT616568)
- hsa-mir-3074-5p (MIRT616569)
- hsa-mir-1200 (MIRT616570)
- hsa-mir-378a-5p (MIRT616571)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TENT5C
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- genomics-online: shRNA clones - Search results for 105 available FAM46C gene related products
- Overview of 105 available FAM46C gene related products
Clone Products
- Sino Biological Human cDNA Clone for TENT5C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TENT5C
- Applied Biological Materials Clones for TENT5C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TENT5C
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TENT5C Gene
Localization for TENT5C Gene
| Compartment | Confidence |
|---|---|
| cytoskeleton | 2 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
- Nucleoplasm (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TENT5C Gene
Pathways & Interactions for TENT5C Gene
No Data Available
Interacting Proteins for TENT5C Gene
Selected Interacting proteins:
Q5VWP2-FA46C_HUMAN
ENSP00000358458
for TENT5C Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TENT5C
No data available for Pathways by source and SIGNOR curated interactions for TENT5C Gene
Transcripts for TENT5C Gene
mRNA/cDNA for TENT5C Gene
- (1) REFSEQ mRNAs :
- (108) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000369448 5751 bps (uc001ehe.4)
CRISPR Products
-
OriGene CRISPR knockouts for TENT5C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TENT5C
- genomics-online: gRNA clones - Search results for 105 available FAM46C gene related products
- Overview of 105 available FAM46C gene related products
- Applied Biological Materials CRISPR for TENT5C
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for TENT5C
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TENT5C
- Browse OriGene Inhibitory RNA Products For TENT5C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TENT5C
- genomics-online: shRNA clones - Search results for 105 available FAM46C gene related products
- Overview of 105 available FAM46C gene related products
Clone Products
- Sino Biological Human cDNA Clone for TENT5C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TENT5C
- Applied Biological Materials Clones for TENT5C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TENT5C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
NURSA nuclear receptor signaling pathways regulating expression of TENT5C Gene:
TENT5CEvidence on tissue expression from TISSUES for TENT5C Gene
- Intestine(4.2)
Primer Products
-
OriGene qPCR primer pairs for TENT5C
-
OriGene qPCR primer pairs and template standards for TENT5C
- genomics-online: primer clones - Search results for 105 available FAM46C gene related products
- Overview of 105 available FAM46C gene related products
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TENT5C Gene
Orthologs for TENT5C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FAM46C 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FAM46C 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fam46c 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Fam46c 34 33 |
|
OneToOne | |
| Tent5c 16 |
|
||||
| dog (Canis familiaris) |
Mammalia | FAM46C 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FAM46C 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FAM46C 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FAM46C 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fam46c 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fam46c 34 33 |
|
OneToOne | |
| zgc66197 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005088 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG30497 34 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | pqn-44 34 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for TENT5C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for TENT5C Gene
- ENSEMBL:
- Gene Tree for TENT5C (if available)
- TreeFam:
- Gene Tree for TENT5C (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TENT5C: view image
Paralogs for TENT5C Gene
Variants for TENT5C Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs145471785 | not-provided, not specified | 117,623,763(+) | G/A | coding_sequence_variant, missense_variant | |
| rs149654076 | not-provided, not specified | 117,623,757(+) | G/A/C | coding_sequence_variant, missense_variant | |
| rs1630312 | not-provided, not specified | 117,623,069(+) | C/G/T | coding_sequence_variant, missense_variant, synonymous_variant | |
| rs34495780 | not-provided, not specified | 117,622,914(+) | G/A | coding_sequence_variant, missense_variant | |
| rs587778306 | not-provided, not specified | 117,623,641(+) | C/T | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.39;
27.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TENT5C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TENT5C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TENT5C Gene
Disorders for TENT5C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myeloma, multiple |
|
|
Search TENT5C in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TENT5C
No data available for UniProtKB/Swiss-Prot and Genatlas for TENT5C Gene
Publications for TENT5C Gene
- A diverse range of gene products are effectors of the type I interferon antiviral response. (PMID: 21478870) Schoggins JW … Rice CM (Nature 2011) 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
Products for TENT5C Gene
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- Custom Antibody ServicesOriGene Antibodies for TENT5C
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- CloneReady with Over 120,000 Genes
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- antibodies-online: Search results for 22 available FAM46C Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Search results for available FAM46C related products ranked by validation data
- antibodies-online: Search results for 6 available FAM46C Proteins ranked by validation data
- Compare Top FAM46C Proteins
- Quality Products:
- GeneTex FAM46C Antibody for TENT5C
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- genomics-online: cdna clones - Search results for 105 available FAM46C gene related products
- Overview of 105 available FAM46C gene related products
- orf clones - Search results for 105 available FAM46C gene related products
- Overview of 105 available FAM46C gene related products
- genomics-online: gRNA clones - Search results for 105 available FAM46C gene related products
- Overview of 105 available FAM46C gene related products
- genomics-online: primer clones - Search results for 105 available FAM46C gene related products
- Overview of 105 available FAM46C gene related products
- genomics-online: shRNA clones - Search results for 105 available FAM46C gene related products
- Overview of 105 available FAM46C gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TENT5C
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Sources for TENT5C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
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- (148) abm
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- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
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- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt