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Aliases for TENT5B Gene

Aliases for TENT5B Gene

  • Terminal Nucleotidyltransferase 5B 2 3
  • Family With Sequence Similarity 46 Member B 2 3 5
  • FAM46B 3 5
  • Family With Sequence Similarity 46, Member B 2
  • Putative Nucleotidyltransferase FAM46B 3
  • Protein FAM46B 3
  • EC 2.7.7.- 4

External Ids for TENT5B Gene

Previous HGNC Symbols for TENT5B Gene

  • FAM46B

Summaries for TENT5B Gene

GeneCards Summary for TENT5B Gene

TENT5B (Terminal Nucleotidyltransferase 5B) is a Protein Coding gene. An important paralog of this gene is TENT5A.

UniProtKB/Swiss-Prot for TENT5B Gene

  • Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.

Additional gene information for TENT5B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TENT5B Gene

Genomics for TENT5B Gene

GeneHancer (GH) Regulatory Elements for TENT5B Gene

Promoters and enhancers for TENT5B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J027003 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 +4.0 3957 10.5 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A YY1 POLR2B E2F8 TENT5B ARID1A LOC101928324 HMGN2 LOC101928728 GPN2 ACTG1P20 RPL17P9 FAM76A RPA2
GH01J026958 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11.4 +52.0 52000 3.9 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 ZNF121 GLIS2 ELK1 GC01P026960 KDF1 TRNP1 PIGV NR0B2 NUDC TENT5B GPATCH3 ENSG00000226698 SFN
GH01J027614 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -613.0 -612996 23.4 HDGF PKNOX1 FOXA2 SMAD1 SIN3A YBX1 IRF4 ZNF207 ZNF143 MCM3 FGR ACTG1P20 ARID1A EYA3 FAM76A TRNAU1AP NPM1P39 THEMIS2 PTAFR SNHG12
GH01J027487 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 -477.9 -477854 5.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 MCM3 WASF2 ARID1A ACTG1P20 GPN2 FAM76A PHACTR4 NPM1P39 MAP3K6 PPP1R8 ENSG00000231344
GH01J027516 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -511.0 -510971 13.7 ZFP64 DMAP1 YY1 ZNF548 ZNF263 MCM3 SP3 MEF2D SSRP1 GLIS1 LOC105376892 ARID1A ACTG1P20 MAP3K6 FAM76A PHACTR4 NPM1P39 EYA3 GPN2 WASF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TENT5B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TENT5B Gene

Genomic Locations for TENT5B Gene
7,823 bases
Minus strand
7,823 bases
Minus strand

Genomic View for TENT5B Gene

Genes around TENT5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENT5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENT5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENT5B Gene

Proteins for TENT5B Gene

  • Protein details for TENT5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative nucleotidyltransferase FAM46B
    Protein Accession:

    Protein attributes for TENT5B Gene

    425 amino acids
    Molecular mass:
    46688 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH12790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH14160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13555.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TENT5B Gene

Post-translational modifications for TENT5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TENT5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TENT5B Gene

Domains & Families for TENT5B Gene

Gene Families for TENT5B Gene

Protein Domains for TENT5B Gene


Suggested Antigen Peptide Sequences for TENT5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM46 family.
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with TENT5B: view

Function for TENT5B Gene

Molecular function for TENT5B Gene

UniProtKB/Swiss-Prot Function:
Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.

Enzyme Numbers (IUBMB) for TENT5B Gene

Phenotypes From GWAS Catalog for TENT5B Gene

Gene Ontology (GO) - Molecular Function for TENT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with TENT5B: view
genes like me logo Genes that share phenotypes with TENT5B: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TENT5B Gene

Localization for TENT5B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TENT5B gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TENT5B Gene

Pathways & Interactions for TENT5B Gene

SuperPathways for TENT5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TENT5B Gene


No data available for Pathways by source and SIGNOR curated interactions for TENT5B Gene

Drugs & Compounds for TENT5B Gene

No Compound Related Data Available

Transcripts for TENT5B Gene

mRNA/cDNA for TENT5B Gene

(1) REFSEQ mRNAs :
(51) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TENT5B Gene

No ASD Table

Relevant External Links for TENT5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TENT5B Gene

NURSA nuclear receptor signaling pathways regulating expression of TENT5B Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TENT5B Gene

Orthologs for TENT5B Gene

This gene was present in the common ancestor of animals.

Orthologs for TENT5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM46B 34 33
  • 99.45 (n)
(Bos Taurus)
Mammalia FAM46B 34 33
  • 89.57 (n)
(Canis familiaris)
Mammalia FAM46B 34 33
  • 89.25 (n)
(Mus musculus)
Mammalia Fam46b 34 33
  • 87.22 (n)
Tent5b 16
(Rattus norvegicus)
Mammalia Fam46b 33
  • 86.51 (n)
(Monodelphis domestica)
Mammalia FAM46B 34
  • 65 (a)
(Gallus gallus)
Aves FAM46B 34
  • 68 (a)
(Anolis carolinensis)
Reptilia FAM46B 34
  • 63 (a)
(Danio rerio)
Actinopterygii fam46ba 34
  • 67 (a)
fam46bb 34
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3131 33
fruit fly
(Drosophila melanogaster)
Insecta CG30497 34
  • 25 (a)
(Caenorhabditis elegans)
Secernentea pqn-44 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for TENT5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TENT5B Gene

Gene Tree for TENT5B (if available)
Gene Tree for TENT5B (if available)
Evolutionary constrained regions (ECRs) for TENT5B: view image

Paralogs for TENT5B Gene

Paralogs for TENT5B Gene

genes like me logo Genes that share paralogs with TENT5B: view

Variants for TENT5B Gene

Sequence variations from dbSNP and Humsavar for TENT5B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000029318 -- 27,005,050(-) T/G 3_prime_UTR_variant
rs1000072607 -- 27,009,632(-) C/G intron_variant
rs1001668955 -- 27,005,703(-) A/G 3_prime_UTR_variant
rs1001747447 -- 27,008,189(-) G/A intron_variant
rs1001763769 -- 27,005,467(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TENT5B Gene

Variant ID Type Subtype PubMed ID
esv3585551 CNV gain 21293372
nsv1000012 CNV gain 25217958
nsv834535 CNV gain+loss 17160897

Variation tolerance for TENT5B Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TENT5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TENT5B Gene

Disorders for TENT5B Gene

Additional Disease Information for TENT5B

No disorders were found for TENT5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TENT5B Gene

Publications for TENT5B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases. (PMID: 27060136) Kuchta K … Ginalski K (Nucleic acids research 2016) 4 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for TENT5B Gene

Sources for TENT5B Gene

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