The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010] See more...

Aliases for TENT4A Gene

Aliases for TENT4A Gene

  • Terminal Nucleotidyltransferase 4A 2 3 4 5
  • Topoisomerase-Related Function Protein 4-1 2 3 4
  • TRF4-1 2 3 4
  • LAK-1 2 3 4
  • TRF4 2 3 4
  • TRAMP-Like Complex Polyadenylate Polymerase 3 4
  • PAP-Associated Domain-Containing Protein 7 3 4
  • Non-Canonical Poly(A) RNA Polymerase PAPD7 3 4
  • Poly(A) RNA Polymerase D7, Non-Canonical 2 3
  • Polymerase (DNA Directed) Sigma 2 3
  • Terminal Uridylyltransferase 5 3 4
  • Terminal Guanylyltransferase 3 4
  • DNA Polymerase Kappa 2 3
  • DNA Polymerase Sigma 3 4
  • PAPD7 3 4
  • POLK 2 3
  • POLS 3 4
  • PAP Associated Domain Containing 7 2
  • Polymerase (DNA-Directed) Sigma 2
  • EC 2.7.7.19 4
  • EC 2.7.7.- 4
  • TUTase 5 4
  • TUTase5 2
  • TUTASE5 3
  • TENT4A 5
  • TRF41 3
  • LAK1 3

External Ids for TENT4A Gene

Previous HGNC Symbols for TENT4A Gene

  • POLS
  • PAPD7

Summaries for TENT4A Gene

Entrez Gene Summary for TENT4A Gene

  • The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]

GeneCards Summary for TENT4A Gene

TENT4A (Terminal Nucleotidyltransferase 4A) is a Protein Coding gene. Diseases associated with TENT4A include Aids Phobia and Nemaline Myopathy 3. Among its related pathways are Chks in Checkpoint Regulation and Oncogenic MAPK signaling. An important paralog of this gene is TENT4B.

UniProtKB/Swiss-Prot Summary for TENT4A Gene

  • Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TENT4A Gene

Genomics for TENT4A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TENT4A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J006711 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 634.9 +0.7 653 5.4 ZNF221 CREB1 PRDM10 ZNF629 REST TFE3 RFX1 KDM1A POLR2A ZNF692 LINC02102 TENT4A LINC02145 NSUN2 SRD5A1 piR-34234 ADCY2
GH05J006448 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl 60.8 -262.9 -262931 4.2 PRDM10 ZNF629 ZNF512 ZNF300 LARP7 PRDM1 PHB2 ZIC2 ZSCAN4 POLR2A UBE2QL1 TENT4A NSUN2 LINC02102 MED10 LINC02145 LOC105374639
GH05J006631 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 33.5 -78.3 -78295 7.9 ZNF221 HNRNPL PRDM10 ZNF629 ZNF692 POLR2A BACH1 LARP7 GABPA MTA2 NSUN2 SRD5A1 lnc-PAPD7-7 LINC02102 TENT4A LINC02145 LINC01018 MED10
GH05J006731 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 24.9 +20.0 20022 4 ZIC2 RXRB SP1 ZNF600 CEBPB RUNX3 ZNF316 MAFF MAFK MAFG TENT4A SRD5A1 LINC02102 NSUN2 piR-34234 ADCY2
GH05J006376 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 13.8 -335.1 -335133 2.6 CREB1 PRDM10 ZNF629 RFX1 POLR2A BACH1 ETV6 GABPA ZIC2 RBFOX2 MED10 ENSG00000287031 lnc-NSUN2-5 LINC02145 LINC02102 TENT4A ICE1 lnc-NSUN2-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TENT4A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TENT4A

Genomic Locations for TENT4A Gene

Genomic Locations for TENT4A Gene
chr5:6,713,432-6,757,045
(GRCh38/hg38)
Size:
43,614 bases
Orientation:
Plus strand
chr5:6,714,718-6,757,161
(GRCh37/hg19)
Size:
42,444 bases
Orientation:
Plus strand

Genomic View for TENT4A Gene

Genes around TENT4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENT4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENT4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENT4A Gene

Proteins for TENT4A Gene

  • Protein details for TENT4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XG87-PAPD7_HUMAN
    Recommended name:
    Terminal nucleotidyltransferase 4A
    Protein Accession:
    Q5XG87
    Secondary Accessions:
    • A8K1E2
    • M1JCE6
    • O43289
    • Q17RZ1
    • Q9Y6C1

    Protein attributes for TENT4A Gene

    Size:
    772 amino acids
    Molecular mass:
    82360 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.
    SequenceCaution:
    • Sequence=AAD45198.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Exhibits poor nucleotidyl transferase activity.

    Alternative splice isoforms for TENT4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TENT4A Gene

Post-translational modifications for TENT4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TENT4A Gene

Domains & Families for TENT4A Gene

Gene Families for TENT4A Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TENT4A Gene

InterPro:
Blocks:
  • DNA polymerase, beta-like region
  • PAP/25A-associated domain
ProtoNet:

Suggested Antigen Peptide Sequences for TENT4A Gene

GenScript: Design optimal peptide antigens:
  • POLS protein (B7ZLL4_HUMAN)
  • Topoisomerase-related function protein 4-1 (PAPD7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5XG87

UniProtKB/Swiss-Prot:

PAPD7_HUMAN :
  • Belongs to the DNA polymerase type-B-like family.
Family:
  • Belongs to the DNA polymerase type-B-like family.
genes like me logo Genes that share domains with TENT4A: view

Function for TENT4A Gene

Molecular function for TENT4A Gene

UniProtKB/Swiss-Prot Function:
Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:11128, Rhea:RHEA-COMP:14647, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:83400, ChEBI:CHEBI:140626; EC=2.7.7.19;.

Enzyme Numbers (IUBMB) for TENT4A Gene

Phenotypes From GWAS Catalog for TENT4A Gene

Gene Ontology (GO) - Molecular Function for TENT4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004652 polynucleotide adenylyltransferase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with TENT4A: view
genes like me logo Genes that share phenotypes with TENT4A: view

Animal Models for TENT4A Gene

MGI Knock Outs for TENT4A:
  • Tent4a Tent4a<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for TENT4A Gene

miRTarBase miRNAs that target TENT4A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TENT4A

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TENT4A Gene

Localization for TENT4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENT4A Gene

Cytoplasm. Nucleus, nucleoplasm. Note=Excluded from nucleolus, weak staining detected in the cytoplasm. {ECO:0000269 PubMed:23376078}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TENT4A gene
Compartment Confidence
nucleus 5
golgi apparatus 4
extracellular 2
mitochondrion 2
cytosol 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TENT4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10066793
GO:0005654 nucleoplasm IEA,IDA --
GO:0005730 nucleolus IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with TENT4A: view

Pathways & Interactions for TENT4A Gene

PathCards logo

SuperPathways for TENT4A Gene

genes like me logo Genes that share pathways with TENT4A: view

Pathways by source for TENT4A Gene

2 Qiagen pathways for TENT4A Gene
  • Cell Cycle Control of Chromosomal Replication
  • DNA Repair Mechanisms

Gene Ontology (GO) - Biological Process for TENT4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair NAS 10066793
GO:0006397 mRNA processing IEA --
GO:0007062 sister chromatid cohesion TAS 10066793
GO:0007076 mitotic chromosome condensation NAS 10066793
GO:0042493 response to drug IDA 10066793
genes like me logo Genes that share ontologies with TENT4A: view

No data available for SIGNOR curated interactions for TENT4A Gene

Drugs & Compounds for TENT4A Gene

(1) Drugs for TENT4A Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2451

(1) Additional Compounds for TENT4A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with TENT4A: view

Transcripts for TENT4A Gene

mRNA/cDNA for TENT4A Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TENT4A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TENT4A Gene

No ASD Table

Relevant External Links for TENT4A Gene

GeneLoc Exon Structure for
TENT4A

Expression for TENT4A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TENT4A

Evidence on tissue expression from TISSUES for TENT4A Gene

  • Nervous system(4.6)
  • Lung(4.6)
  • Skin(3.4)
  • Kidney(3.2)
  • Intestine(3.2)
  • Stomach(2.9)
  • Pancreas(2.9)
  • Muscle(2.9)
  • Thyroid gland(2.8)
  • Heart(2.8)
  • Gall bladder(2.8)
  • Liver(2.6)
  • Adrenal gland(2.5)
  • Bone marrow(2.5)
  • Lymph node(2.5)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TENT4A Gene

Orthologs for TENT4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TENT4A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PAPD7 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PAPD7 30 31
  • 88.5 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Papd7 30 31
  • 86.72 (n)
OneToOne
Tent4a 17
Rat
(Rattus norvegicus)
Mammalia Papd7 30
  • 86.69 (n)
Cow
(Bos Taurus)
Mammalia PAPD7 30 31
  • 85.03 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PAPD7 31
  • 70 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PAPD7 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PAPD7 30 31
  • 78.04 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PAPD7 31
  • 73 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii papd7 30 31
  • 65.82 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Trf4-2 31
  • 34 (a)
ManyToMany
Trf4-1 31
  • 23 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea gld-4 31
  • 18 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAP2 31
  • 20 (a)
ManyToMany
TRF5 31 33
  • 18 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9243 31
  • 29 (a)
OneToMany
Species where no ortholog for TENT4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TENT4A Gene

ENSEMBL:
Gene Tree for TENT4A (if available)
TreeFam:
Gene Tree for TENT4A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TENT4A: view image

Paralogs for TENT4A Gene

Paralogs for TENT4A Gene

Pseudogenes.org Pseudogenes for TENT4A Gene

genes like me logo Genes that share paralogs with TENT4A: view

Variants for TENT4A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TENT4A Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs28381415 - p.Asn556Ser
rs28381418 - p.Gly626Ser

Additional dbSNP identifiers (rs#s) for TENT4A Gene

Structural Variations from Database of Genomic Variants (DGV) for TENT4A Gene

Variant ID Type Subtype PubMed ID
dgv9556n54 CNV gain 21841781
dgv9558n54 CNV loss 21841781
dgv9559n54 CNV gain 21841781
esv23095 CNV gain+loss 19812545
esv3603920 CNV loss 21293372
nsv1074806 CNV deletion 25765185
nsv1122100 CNV deletion 24896259
nsv1144100 CNV deletion 24896259
nsv461922 CNV loss 19166990
nsv476053 CNV novel sequence insertion 20440878
nsv596947 CNV loss 21841781
nsv596949 CNV loss 21841781
nsv596950 CNV loss 21841781
nsv596958 CNV gain+loss 21841781
nsv596965 CNV loss 21841781
nsv596974 CNV gain+loss 21841781
nsv596976 CNV loss 21841781
nsv822993 CNV loss 20364138
nsv822994 CNV gain 20364138
nsv822995 CNV gain 20364138
nsv822996 CNV gain 20364138
nsv830196 CNV gain 17160897

Variation tolerance for TENT4A Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TENT4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TENT4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TENT4A Gene

Disorders for TENT4A Gene

MalaCards: The human disease database

(5) MalaCards diseases for TENT4A Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TENT4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TENT4A Gene

Publications for TENT4A Gene

  1. The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin. (PMID: 10066793) Walowsky C … Christman MF (The Journal of biological chemistry 1999) 2 3 4 23
  2. Molecular cloning and characterization of a novel isoform of the non-canonical poly(A) polymerase PAPD7. (PMID: 23376078) Ogami K … Hoshino S (Biochemical and biophysical research communications 2013) 2 3 4
  3. Pol kappa: A DNA polymerase required for sister chromatid cohesion. (PMID: 10926539) Wang Z … Christman MF (Science (New York, N.Y.) 2000) 2 3 4
  4. Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation. (PMID: 30026317) Lim J … Kim VN (Science (New York, N.Y.) 2018) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for TENT4A Gene

Sources for TENT4A Gene