Aliases for TENT2 Gene

Aliases for TENT2 Gene

  • Terminal Nucleotidyltransferase 2 2 3 4 5
  • PAP-Associated Domain-Containing Protein 4 3 4
  • Poly(A) RNA Polymerase D4, Non-Canonical 2 3
  • PAP Associated Domain Containing 4 2 3
  • Terminal Uridylyltransferase 2 3 4
  • Poly(A) RNA Polymerase GLD2 3 4
  • EC 2.7.7.19 4 52
  • TUTase 2 3 4
  • HGLD-2 3 4
  • PAPD4 3 4
  • GLD2 3 4
  • TUTase2 2
  • APD4 3
  • TUT2 3

External Ids for TENT2 Gene

Previous HGNC Symbols for TENT2 Gene

  • PAPD4

Summaries for TENT2 Gene

GeneCards Summary for TENT2 Gene

TENT2 (Terminal Nucleotidyltransferase 2) is a Protein Coding gene. Diseases associated with TENT2 include Perlman Syndrome. An important paralog of this gene is TUT4.

UniProtKB/Swiss-Prot Summary for TENT2 Gene

  • Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856).

Additional gene information for TENT2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TENT2 Gene

Genomics for TENT2 Gene

GeneHancer (GH) Regulatory Elements for TENT2 Gene

Promoters and enhancers for TENT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TENT2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TENT2

Genomic Locations for TENT2 Gene

Genomic Locations for TENT2 Gene
chr5:79,612,120-79,686,648
(GRCh38/hg38)
Size:
74,529 bases
Orientation:
Plus strand
chr5:78,907,943-78,982,471
(GRCh37/hg19)
Size:
74,529 bases
Orientation:
Plus strand

Genomic View for TENT2 Gene

Genes around TENT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENT2 Gene

Proteins for TENT2 Gene

  • Protein details for TENT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIY7-GLD2_HUMAN
    Recommended name:
    Poly(A) RNA polymerase GLD2
    Protein Accession:
    Q6PIY7
    Secondary Accessions:
    • Q86WZ2
    • Q8N927

    Protein attributes for TENT2 Gene

    Size:
    484 amino acids
    Molecular mass:
    56028 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with CPEB1, CPEB2, CPSF1 and PABPC1.

    Alternative splice isoforms for TENT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TENT2 Gene

Selected DME Specific Peptides for TENT2 Gene

Q6PIY7:
  • KRQRFHSP
  • RVRPLVLVIKKWA
  • DKLSQQIL
  • PPYLSKNE
  • NDASRGTLSSY
  • EFDLNVNN
  • AKVPIVK
  • SSYSLVLMVLHYLQ
  • VGIRNTFLLRTYA

Post-translational modifications for TENT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TENT2 Gene

Gene Families for TENT2 Gene

Protein Domains for TENT2 Gene

Blocks:
  • PAP/25A-associated domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TENT2 Gene

GenScript: Design optimal peptide antigens:
  • Terminal uridylyltransferase 2 (GLD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6PIY7

UniProtKB/Swiss-Prot:

GLD2_HUMAN :
  • Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
Family:
  • Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
genes like me logo Genes that share domains with TENT2: view

Function for TENT2 Gene

Molecular function for TENT2 Gene

UniProtKB/Swiss-Prot Function:
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:11128, Rhea:RHEA-COMP:14647, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:83400, ChEBI:CHEBI:140626; EC=2.7.7.19; Evidence=. ;.

Enzyme Numbers (IUBMB) for TENT2 Gene

Phenotypes From GWAS Catalog for TENT2 Gene

Gene Ontology (GO) - Molecular Function for TENT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004652 polynucleotide adenylyltransferase activity IEA,IDA 15070731
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0034062 5'-3' RNA polymerase activity IDA 23200856
genes like me logo Genes that share ontologies with TENT2: view
genes like me logo Genes that share phenotypes with TENT2: view

Animal Models for TENT2 Gene

MGI Knock Outs for TENT2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TENT2

Clone Products

  • Addgene plasmids for TENT2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TENT2 Gene

Localization for TENT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENT2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TENT2 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TENT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0031380 nuclear RNA-directed RNA polymerase complex IC 15070731
genes like me logo Genes that share ontologies with TENT2: view

Pathways & Interactions for TENT2 Gene

PathCards logo

SuperPathways for TENT2 Gene

No Data Available

SIGNOR curated interactions for TENT2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TENT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006397 mRNA processing IEA --
GO:0021766 hippocampus development IEA --
GO:0030182 neuron differentiation IEA --
GO:0043489 RNA stabilization IDA 23200856
genes like me logo Genes that share ontologies with TENT2: view

No data available for Pathways by source for TENT2 Gene

Drugs & Compounds for TENT2 Gene

(1) Drugs for TENT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for TENT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with TENT2: view

Transcripts for TENT2 Gene

mRNA/cDNA for TENT2 Gene

12 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TENT2

Clone Products

  • Addgene plasmids for TENT2

Alternative Splicing Database (ASD) splice patterns (SP) for TENT2 Gene

No ASD Table

Relevant External Links for TENT2 Gene

GeneLoc Exon Structure for
TENT2

Expression for TENT2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TENT2

mRNA Expression by UniProt/SwissProt for TENT2 Gene:

Q6PIY7-GLD2_HUMAN
Tissue specificity: Expressed in brain. Within brain, it is expressed in cerebellum, hippocampus and medulla.

Evidence on tissue expression from TISSUES for TENT2 Gene

  • Muscle(4.2)
  • Pancreas(4.1)
  • Nervous system(3.5)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TENT2 Gene

Orthologs for TENT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TENT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PAPD4 31 30
  • 99.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PAPD4 31 30
  • 96.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PAPD4 31 30
  • 94.9 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Papd4 30
  • 91.53 (n)
mouse
(Mus musculus)
Mammalia Papd4 31 30
  • 91.46 (n)
OneToOne
Tent2 17
oppossum
(Monodelphis domestica)
Mammalia PAPD4 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAPD4 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAPD4 31 30
  • 78.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAPD4 31
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia papd4 30
  • 71.81 (n)
Str.3513 30
zebrafish
(Danio rerio)
Actinopterygii papd4 31 31 30
  • 59.65 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001130 30
  • 49.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta wisp 31
  • 13 (a)
OneToMany
Gld2 31
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gld-2 31
  • 13 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
OneToOne
Species where no ortholog for TENT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TENT2 Gene

ENSEMBL:
Gene Tree for TENT2 (if available)
TreeFam:
Gene Tree for TENT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TENT2: view image

Paralogs for TENT2 Gene

Paralogs for TENT2 Gene

genes like me logo Genes that share paralogs with TENT2: view

Variants for TENT2 Gene

Additional dbSNP identifiers (rs#s) for TENT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TENT2 Gene

Variant ID Type Subtype PubMed ID
dgv1620e212 CNV loss 25503493
esv2660209 CNV deletion 23128226
esv2665951 CNV deletion 23128226
esv2730355 CNV deletion 23290073
esv3605534 CNV loss 21293372
esv3605535 CNV gain 21293372
esv3605540 CNV loss 21293372
esv3605541 CNV gain 21293372
esv3605542 CNV loss 21293372
esv3605543 CNV loss 21293372
esv3605544 CNV loss 21293372
esv3605545 CNV gain 21293372
esv3605546 CNV loss 21293372
nsv1141999 OTHER inversion 24896259
nsv462218 CNV gain 19166990
nsv598742 CNV gain 21841781
nsv830357 CNV gain 17160897

Variation tolerance for TENT2 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TENT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TENT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TENT2 Gene

Disorders for TENT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TENT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
perlman syndrome
  • nephroblastoma
- elite association - COSMIC cancer census association via MalaCards
Search TENT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TENT2

genes like me logo Genes that share disorders with TENT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TENT2 Gene

Publications for TENT2 Gene

  1. The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs. (PMID: 26926106) Yamagishi R … Hoshino S (Nucleic acids research 2016) 2 3 54
  2. Specific miRNA stabilization by Gld2-catalyzed monoadenylation. (PMID: 23200856) D'Ambrogio A … Richter JD (Cell reports 2012) 3 4 54
  3. Post-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity. (PMID: 21813625) Wyman SK … Tewari M (Genome research 2011) 2 3 54
  4. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PMID: 18172165) Mullen TE … Marzluff WF (Genes & development 2008) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for TENT2 Gene

Sources for TENT2 Gene