The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016] See more...

Aliases for TENM4 Gene

Aliases for TENM4 Gene

  • Teneurin Transmembrane Protein 4 2 3 4 5
  • Protein Odd Oz/Ten-M Homolog 4 3 4
  • Tenascin-M4 3 4
  • Teneurin-4 3 4
  • Ten-M4 3 4
  • Ten-4 3 4
  • ODZ4 3 4
  • TNM4 3 4
  • Odz, Odd Oz/Ten-M Homolog 4 (Drosophila) 2
  • Odz, Odd Oz/Ten-M Homolog 4 3
  • KIAA1302 4
  • Doc4 3
  • ETM5 3

External Ids for TENM4 Gene

Previous HGNC Symbols for TENM4 Gene

  • ODZ4

Previous GeneCards Identifiers for TENM4 Gene

  • GC11M078363

Summaries for TENM4 Gene

Entrez Gene Summary for TENM4 Gene

  • The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]

GeneCards Summary for TENM4 Gene

TENM4 (Teneurin Transmembrane Protein 4) is a Protein Coding gene. Diseases associated with TENM4 include Tremor, Hereditary Essential, 5 and Tremor. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is TENM3.

UniProtKB/Swiss-Prot Summary for TENM4 Gene

  • Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity).

Additional gene information for TENM4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TENM4 Gene

Genomics for TENM4 Gene

GeneHancer (GH) Regulatory Elements for TENM4 Gene

Promoters and enhancers for TENM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J079436 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 759.8 +1.5 1466 5.4 ZNF785 ZNF24 CTCF ZBTB6 SP7 ZSCAN21 ZNF687 PRDM1 ZNF704 IKZF1 TENM4 lnc-TENM4-3 MIR5579
GH11J079412 Enhancer 0.8 Ensembl ENCODE dbSUPER 39.3 +26.7 26674 3.8 POLR2A SCRT2 ZSCAN5C BATF JUND ZNF146 TENM4 MIR5579 MIR708 lnc-TENM4-3
GH11J079417 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 20.4 +22.2 22207 2.5 ZNF133 MNT FOSL2 CREB1 CTBP1 ATF7 FOS DPF2 ZNF217 JUND TENM4 MIR5579 MIR708 lnc-TENM4-3
GH11J079420 Enhancer 0.7 Ensembl ENCODE dbSUPER 27.8 +19.1 19088 3.4 PRDM1 ZIC2 GLIS1 MIR5579 TENM4 lnc-TENM4-3 MIR708
GH11J079431 Enhancer 0.7 Ensembl ENCODE dbSUPER 28.5 +9.3 9289 1.4 POLR2A JUND TENM4 MIR5579 lnc-TENM4-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TENM4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TENM4 Gene

Genomic Locations for TENM4 Gene
chr11:78,652,831-79,440,989
(GRCh38/hg38)
Size:
788,159 bases
Orientation:
Minus strand
chr11:78,363,876-79,151,992
(GRCh37/hg19)
Size:
788,117 bases
Orientation:
Minus strand

Genomic View for TENM4 Gene

Genes around TENM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENM4 Gene

Proteins for TENM4 Gene

  • Protein details for TENM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N022-TEN4_HUMAN
    Recommended name:
    Teneurin-4
    Protein Accession:
    Q6N022
    Secondary Accessions:
    • A6ND26
    • Q7Z3C7
    • Q96MS6
    • Q9P2P4
    • Q9Y4S2

    Protein attributes for TENM4 Gene

    Size:
    2769 amino acids
    Molecular mass:
    307957 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (Probable). May also form heterodimer with either TENM1 or TENM2 or TENM3 (By similarity).
    SequenceCaution:
    • Sequence=BAB71206.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TENM4 Gene

Post-translational modifications for TENM4 Gene

  • Glycosylation at Asn467, Asn940, Asn1259, Asn1609, Asn1705, Asn1741, Asn1799, Asn1884, Asn1985, Asn2188, Asn2328, and Asn2646
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TENM4 Gene

Domains & Families for TENM4 Gene

Gene Families for TENM4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TENM4 Gene

GenScript: Design optimal peptide antigens:
  • Tenascin-M4 (TEN4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6N022

UniProtKB/Swiss-Prot:

TEN4_HUMAN :
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Belongs to the tenascin family. Teneurin subfamily.
Domain:
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.
Family:
  • Belongs to the tenascin family. Teneurin subfamily.
genes like me logo Genes that share domains with TENM4: view

Function for TENM4 Gene

Molecular function for TENM4 Gene

UniProtKB/Swiss-Prot Function:
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity).

Phenotypes From GWAS Catalog for TENM4 Gene

Gene Ontology (GO) - Molecular Function for TENM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA,ISS --
GO:0046982 protein heterodimerization activity IBA 21873635
GO:0050839 cell adhesion molecule binding IBA 21873635
genes like me logo Genes that share ontologies with TENM4: view
genes like me logo Genes that share phenotypes with TENM4: view

Human Phenotype Ontology for TENM4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for TENM4

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TENM4 Gene

Localization for TENM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENM4 Gene

Cell membrane; Single-pass membrane protein. Cell projection. Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TENM4 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 1
mitochondrion 1
cytosol 1
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for TENM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane IDA,IEA 26188006
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TENM4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TENM4 Gene

Pathways & Interactions for TENM4 Gene

PathCards logo

SuperPathways for TENM4 Gene

No Data Available

Interacting Proteins for TENM4 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000278550 Q6N022-TEN4_HUMAN for TENM4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TENM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001702 gastrulation with mouth forming second IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TENM4: view

No data available for Pathways by source and SIGNOR curated interactions for TENM4 Gene

Drugs & Compounds for TENM4 Gene

No Compound Related Data Available

Transcripts for TENM4 Gene

mRNA/cDNA for TENM4 Gene

(1) REFSEQ mRNAs :
(22) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TENM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:
SP2: - -

Relevant External Links for TENM4 Gene

GeneLoc Exon Structure for
TENM4
ECgene alternative splicing isoforms for
TENM4

Expression for TENM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TENM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TENM4 Gene

This gene is overexpressed in Ovary (x6.4) and Pituitary (x4.9).

Protein differential expression in normal tissues from HIPED for TENM4 Gene

This gene is overexpressed in Adipocyte (26.9), Fetal Brain (21.6), and Platelet (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TENM4 Gene



Protein tissue co-expression partners for TENM4 Gene

NURSA nuclear receptor signaling pathways regulating expression of TENM4 Gene:

TENM4

SOURCE GeneReport for Unigene cluster for TENM4 Gene:

Hs.213087

Evidence on tissue expression from TISSUES for TENM4 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TENM4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TENM4 Gene

Orthologs for TENM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TENM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TENM4 33
  • 100 (a)
OneToOne
ODZ4 32
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia TENM4 33
  • 97 (a)
OneToOne
ODZ4 32
  • 91.25 (n)
dog
(Canis familiaris)
Mammalia TENM4 33 32
  • 92.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tenm4 17 33 32
  • 90.01 (n)
rat
(Rattus norvegicus)
Mammalia Tenm4 32
  • 89.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 67 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 62 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 33
  • 93 (a)
ManyToMany
ODZ4 32
  • 81.92 (n)
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 87 (a)
ManyToMany
-- 33
  • 65 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tenm4 32
  • 78.31 (n)
zebrafish
(Danio rerio)
Actinopterygii odz4 33 32 32
  • 72.57 (n)
ManyToMany
Species where no ortholog for TENM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TENM4 Gene

ENSEMBL:
Gene Tree for TENM4 (if available)
TreeFam:
Gene Tree for TENM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TENM4: view image

Paralogs for TENM4 Gene

Paralogs for TENM4 Gene

(8) SIMAP similar genes for TENM4 Gene using alignment to 4 proteins:

  • TEN4_HUMAN
  • E9PPG4_HUMAN
  • H0YCJ4_HUMAN
  • H0YCW4_HUMAN
genes like me logo Genes that share paralogs with TENM4: view

Variants for TENM4 Gene

Sequence variations from dbSNP and Humsavar for TENM4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs199687168 Tremor, hereditary essential 5 (ETM5) [MIM:616736] 78,701,718(-) C/T coding_sequence_variant, missense_variant
rs201191369 Tremor, hereditary essential 5 (ETM5) [MIM:616736] 78,854,232(-) C/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs201769315 Tremor, hereditary essential 5 (ETM5) [MIM:616736] 78,668,992(-) C/T coding_sequence_variant, missense_variant
rs201995608 Tremor, hereditary essential 5 (ETM5) [MIM:616736] 78,676,361(-) C/T coding_sequence_variant, missense_variant
rs375681722 pathogenic, Tremor, hereditary essential, 5, Tremor, hereditary essential 5 (ETM5) [MIM:616736] 78,702,289(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TENM4 Gene

Variant ID Type Subtype PubMed ID
dgv2013n54 CNV loss 21841781
dgv2014n54 CNV loss 21841781
dgv2015n54 CNV loss 21841781
dgv2016n54 CNV loss 21841781
dgv211e214 CNV gain 21293372
dgv677n106 CNV deletion 24896259
dgv69e215 CNV deletion 23714750
esv1011297 CNV deletion 20482838
esv1231369 CNV insertion 17803354
esv2649079 CNV deletion 19546169
esv2668533 CNV deletion 23128226
esv2671586 CNV deletion 23128226
esv2674028 CNV deletion 23128226
esv2676593 CNV deletion 23128226
esv2744813 CNV deletion 23290073
esv2744814 CNV deletion 23290073
esv2744815 CNV deletion 23290073
esv2744816 CNV deletion 23290073
esv274997 CNV loss 21479260
esv2761683 CNV loss 21179565
esv2761684 CNV gain 21179565
esv2761685 CNV loss 21179565
esv2762918 CNV loss 21179565
esv28740 CNV loss 19812545
esv3303123 CNV mobile element insertion 20981092
esv3335828 CNV insertion 20981092
esv3337161 CNV insertion 20981092
esv33883 CNV loss 17666407
esv3401724 CNV insertion 20981092
esv34127 CNV loss 18971310
esv3430090 CNV insertion 20981092
esv3548040 CNV deletion 23714750
esv3626908 CNV loss 21293372
esv3626913 CNV loss 21293372
esv3626914 CNV loss 21293372
esv3626915 CNV gain 21293372
esv3626916 CNV gain 21293372
esv3892028 CNV loss 25118596
esv3892029 CNV loss 25118596
esv6428 CNV gain 19470904
esv998787 CNV insertion 20482838
nsv1044745 CNV loss 25217958
nsv1053433 CNV gain 25217958
nsv1070056 CNV deletion 25765185
nsv1070057 CNV deletion 25765185
nsv1070472 CNV deletion 25765185
nsv1126301 CNV deletion 24896259
nsv1132347 CNV duplication 24896259
nsv1139522 CNV deletion 24896259
nsv1144580 CNV deletion 24896259
nsv401 CNV insertion 18451855
nsv468643 CNV gain 19166990
nsv476007 CNV novel sequence insertion 20440878
nsv476042 CNV novel sequence insertion 20440878
nsv483084 CNV loss 15286789
nsv507602 OTHER sequence alteration 20534489
nsv509436 CNV insertion 20534489
nsv516542 CNV loss 19592680
nsv519911 CNV loss 19592680
nsv525230 CNV loss 19592680
nsv555455 CNV gain 21841781
nsv555456 CNV loss 21841781
nsv555457 CNV loss 21841781
nsv555458 CNV loss 21841781
nsv555459 CNV loss 21841781
nsv555471 CNV loss 21841781
nsv555472 CNV gain 21841781
nsv820315 CNV gain 19587683
nsv832213 CNV gain 17160897
nsv832214 CNV gain 17160897
nsv832216 CNV gain 17160897
nsv951047 CNV deletion 24416366

Variation tolerance for TENM4 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.52; 77.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TENM4 Gene

Human Gene Mutation Database (HGMD)
TENM4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TENM4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TENM4 Gene

Disorders for TENM4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TENM4 Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
tremor, hereditary essential, 5
  • etm5
tremor
  • tremors
essential tremor
  • tremor, hereditary essential, 1
schizophrenia 2
  • sczd2
severe cutaneous adverse reaction
  • sjs
- elite association - COSMIC cancer census association via MalaCards
Search TENM4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TEN4_HUMAN
  • Tremor, hereditary essential 5 (ETM5) [MIM:616736]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269 PubMed:26188006}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TENM4

genes like me logo Genes that share disorders with TENM4: view

No data available for Genatlas for TENM4 Gene

Publications for TENM4 Gene

  1. Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor. (PMID: 26188006) Hor H … Estivill X (Human molecular genetics 2015) 3 4 56
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 56
  5. All four members of the Ten-m/Odz family of transmembrane proteins form dimers. (PMID: 12000766) Feng K … Fässler R (The Journal of biological chemistry 2002) 2 3 56

Products for TENM4 Gene

Sources for TENM4 Gene