Aliases for TENM3 Gene
External Ids for TENM3 Gene
Previous HGNC Symbols for TENM3 Gene
Previous GeneCards Identifiers for TENM3 Gene
This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]
GeneCards Summary for TENM3 Gene
TENM3 (Teneurin Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with TENM3 include Microphthalmia, Isolated, With Coloboma 9 and Colobomatous Microphthalmia. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and heme binding. An important paralog of this gene is TENM4.
UniProtKB/Swiss-Prot Summary for TENM3 Gene
Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes.