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Aliases for TENM2 Gene

Aliases for TENM2 Gene

  • Teneurin Transmembrane Protein 2 2 3 4 5
  • Protein Odd Oz/Ten-M Homolog 2 3 4
  • Tenascin-M2 3 4
  • Ten-2 3 4
  • ODZ2 3 4
  • TNM2 3 4
  • Odz, Odd Oz/Ten-M Homolog 2 (Drosophila) 2
  • Odz, Odd Oz/Ten-M Homolog 2 3
  • Odd Oz/Ten-M Homolog 2 3
  • Neurestin Alpha 3
  • Teneurin-2 3
  • KIAA1127 4
  • TEN-M2 3
  • Ten-M2 4

External Ids for TENM2 Gene

Previous HGNC Symbols for TENM2 Gene

  • ODZ2

Previous GeneCards Identifiers for TENM2 Gene

  • GC05P166711

Summaries for TENM2 Gene

GeneCards Summary for TENM2 Gene

TENM2 (Teneurin Transmembrane Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is TENM3.

UniProtKB/Swiss-Prot for TENM2 Gene

  • Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer.

  • Isoform 2: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion.

  • Ten-2 intracellular domain: Induces gene transcription inhibition.

Gene Wiki entry for TENM2 Gene

Additional gene information for TENM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TENM2 Gene

Genomics for TENM2 Gene

GeneHancer (GH) Regulatory Elements for TENM2 Gene

Promoters and enhancers for TENM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J167754 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 657.7 +776.1 776124 1.9 POLR2A FOXP2 TENM2 ENSG00000253357 GC05P167933
GH05J166978 Enhancer 0.7 Ensembl ENCODE 650.7 +0.0 23 1.8 MXI1 POLR2A ZSCAN4 ZBTB26 TENM2 GC05P167003
GH05J167813 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 6.7 +836.9 836898 4.3 ATF4 POLR2A FOXP2 SPI1 TENM2 ENSG00000253357 GC05P167933
GH05J167358 Enhancer 0.4 ENCODE 10.6 +380.1 380050 0.7 SP1 ATF7 ATF2 ENSG00000253527 TENM2 GC05M167377
GH05J167383 Enhancer 0.2 FANTOM5 9 +404.8 404760 0.2 TENM2 GC05M167377 ENSG00000253527
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TENM2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TENM2 Gene

Genomic Locations for TENM2 Gene
chr5:166,979,078-168,264,157
(GRCh38/hg38)
Size:
1,285,080 bases
Orientation:
Plus strand
chr5:166,711,804-167,691,162
(GRCh37/hg19)
Size:
979,359 bases
Orientation:
Plus strand

Genomic View for TENM2 Gene

Genes around TENM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TENM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TENM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TENM2 Gene

Proteins for TENM2 Gene

  • Protein details for TENM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NT68-TEN2_HUMAN
    Recommended name:
    Teneurin-2
    Protein Accession:
    Q9NT68
    Secondary Accessions:
    • Q9ULU2

    Protein attributes for TENM2 Gene

    Size:
    2774 amino acids
    Molecular mass:
    307787 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (Probable). Heterodimer with either TENM1 or TENM3. May also form heterodimer with TENM4 (By similarity). Isoform 2 (C-terminal globular domain) interacts with ADGRL1 isoform 2.

    Alternative splice isoforms for TENM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TENM2 Gene

Post-translational modifications for TENM2 Gene

  • Ten-2, soluble form: Derives from the membrane form by proteolytic processing.
  • Ten-2 intracellular domain: Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway (By similarity).
  • Glycosylation at posLast=26482648, isoforms=22337, posLast=21972197, posLast=19931993, posLast=18921892, posLast=18071807, isoforms=21773, isoforms=21749, posLast=17121712, isoforms=21616, isoforms=21267, posLast=948948, posLast=925925, isoforms=2482, and posLast=443443
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TENM2 Gene

Domains & Families for TENM2 Gene

Gene Families for TENM2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TENM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NT68

UniProtKB/Swiss-Prot:

TEN2_HUMAN :
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Belongs to the tenascin family. Teneurin subfamily.
Domain:
  • EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
  • Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.
Family:
  • Belongs to the tenascin family. Teneurin subfamily.
genes like me logo Genes that share domains with TENM2: view

Function for TENM2 Gene

Molecular function for TENM2 Gene

UniProtKB/Swiss-Prot Function:
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer.
UniProtKB/Swiss-Prot Function:
Isoform 2: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion.
UniProtKB/Swiss-Prot Function:
Ten-2 intracellular domain: Induces gene transcription inhibition.

Phenotypes From GWAS Catalog for TENM2 Gene

Gene Ontology (GO) - Molecular Function for TENM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0042803 protein homodimerization activity IBA,ISS --
GO:0046982 protein heterodimerization activity IBA,ISS --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with TENM2: view

Phenotypes for TENM2 Gene

genes like me logo Genes that share phenotypes with TENM2: view

Animal Models for TENM2 Gene

MGI Knock Outs for TENM2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TENM2 Gene

Localization for TENM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TENM2 Gene

Cell membrane; Single-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, filopodium. Cell projection, growth cone. Cell junction, synapse, postsynaptic cell membrane; Single-pass membrane protein. Cell junction, synapse, synaptosome. Note=Colocalizes with ADGRL1 across intercellular junctions. {ECO:0000250}.
Isoform 2: Cell membrane. Note=Colocalizes with ADGRL1 across intercellular junctions.
Ten-2 intracellular domain: Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TENM2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endoplasmic reticulum 4
golgi apparatus 4
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TENM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA,IEA --
genes like me logo Genes that share ontologies with TENM2: view

Pathways & Interactions for TENM2 Gene

SuperPathways for TENM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TENM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0000902 cell morphogenesis IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with TENM2: view

No data available for Pathways by source and SIGNOR curated interactions for TENM2 Gene

Drugs & Compounds for TENM2 Gene

No Compound Related Data Available

Transcripts for TENM2 Gene

mRNA/cDNA for TENM2 Gene

(16) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TENM2 Gene

Teneurin transmembrane protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TENM2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2:

Relevant External Links for TENM2 Gene

GeneLoc Exon Structure for
TENM2
ECgene alternative splicing isoforms for
TENM2

Expression for TENM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TENM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TENM2 Gene

This gene is overexpressed in Heart - Left Ventricle (x16.4) and Heart - Atrial Appendage (x6.8).

Protein differential expression in normal tissues from HIPED for TENM2 Gene

This gene is overexpressed in Fetal Brain (30.0), Amniocyte (17.2), and Heart (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TENM2 Gene



Protein tissue co-expression partners for TENM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TENM2 Gene:

TENM2

SOURCE GeneReport for Unigene cluster for TENM2 Gene:

Hs.631957

mRNA Expression by UniProt/SwissProt for TENM2 Gene:

Q9NT68-TEN2_HUMAN
Tissue specificity: Highly expressed in heart, followed by brain, liver, kidney and fetal brain and weakly expressed in lung and testis. No expression was detected in skeletal muscle, pancreas, spleen, ovary and fetal liver.

Evidence on tissue expression from TISSUES for TENM2 Gene

  • Nervous system(4.7)
  • Heart(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with TENM2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TENM2 Gene

Orthologs for TENM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TENM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TENM2 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TENM2 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TENM2 34 33
  • 93.35 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
OneToMany
-- 34
  • 93 (a)
OneToMany
-- 34
  • 93 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TENM2 34 33
  • 92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tenm2 16 34 33
  • 90.58 (n)
rat
(Rattus norvegicus)
Mammalia Tenm2 33
  • 90.1 (n)
chicken
(Gallus gallus)
Aves ODZ2 34 33
  • 81.01 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TENM2 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tenm2 33
  • 76.8 (n)
zebrafish
(Danio rerio)
Actinopterygii TENM2 (2 of 2) 34
  • 80 (a)
OneToMany
TENM2 (1 of 2) 34
  • 75 (a)
OneToMany
odz2 33
  • 71.89 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011034 33
  • 48.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ten-m 33
  • 48.19 (n)
worm
(Caenorhabditis elegans)
Secernentea ten-1 33
  • 41.22 (n)
Species where no ortholog for TENM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TENM2 Gene

ENSEMBL:
Gene Tree for TENM2 (if available)
TreeFam:
Gene Tree for TENM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TENM2: view image

Paralogs for TENM2 Gene

Paralogs for TENM2 Gene

(10) SIMAP similar genes for TENM2 Gene using alignment to 5 proteins:

  • TEN2_HUMAN
  • F5H2D1_HUMAN
  • F8VNQ3_HUMAN
  • G3V106_HUMAN
  • H7BYZ1_HUMAN
genes like me logo Genes that share paralogs with TENM2: view

Variants for TENM2 Gene

Sequence variations from dbSNP and Humsavar for TENM2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs11411759 benign, not specified 168,062,045(+) TTTTTTTTTTTT/TTTTTTTTT/TTTTTTTTTT/TTTTTTTTTTT/TTTTTTTTTTTTT/TTTTTTTTTTTTTT/TTTTTTTTTTTTTTT intron_variant
rs1000001159 -- 167,974,430(+) G/A/T intron_variant
rs1000001570 -- 167,824,305(+) T/C/G genic_upstream_transcript_variant, intron_variant
rs1000001761 -- 167,951,543(+) G/A intron_variant
rs1000003976 -- 167,683,572(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TENM2 Gene

Variant ID Type Subtype PubMed ID
dgv10168n54 CNV loss 21841781
dgv1665e212 CNV loss 25503493
dgv219n6 CNV deletion 16902084
dgv3419e59 CNV tandem duplication 20981092
dgv371e215 CNV deletion 23714750
esv1093097 CNV deletion 17803354
esv1674597 CNV deletion 17803354
esv1773187 CNV insertion 17803354
esv1994221 CNV deletion 18987734
esv22564 CNV loss 19812545
esv2320159 CNV deletion 18987734
esv2424408 CNV deletion 19546169
esv2474493 CNV deletion 19546169
esv25479 CNV loss 19812545
esv2658414 CNV deletion 23128226
esv2662434 CNV deletion 23128226
esv2665401 CNV deletion 23128226
esv2677611 CNV deletion 23128226
esv2731037 CNV deletion 23290073
esv2731038 CNV deletion 23290073
esv2731039 CNV deletion 23290073
esv2731041 CNV deletion 23290073
esv2731042 CNV deletion 23290073
esv2731043 CNV deletion 23290073
esv2763517 CNV loss 21179565
esv2763892 CNV loss 21179565
esv3394005 CNV insertion 20981092
esv3445032 CNV duplication 20981092
esv3566967 CNV deletion 23714750
esv3566968 CNV deletion 23714750
esv3566969 CNV deletion 23714750
esv3570538 CNV loss 25503493
esv3570541 CNV loss 25503493
esv3607518 CNV loss 21293372
esv3607520 CNV loss 21293372
esv3607522 CNV loss 21293372
esv3607523 CNV loss 21293372
esv3607525 CNV loss 21293372
esv3607526 CNV loss 21293372
esv3607527 CNV loss 21293372
esv3607528 CNV loss 21293372
esv3607529 CNV loss 21293372
esv3607530 CNV loss 21293372
esv3607531 CNV loss 21293372
nsv1027805 CNV loss 25217958
nsv1032183 CNV loss 25217958
nsv1032559 CNV loss 25217958
nsv1074341 CNV deletion 25765185
nsv1074342 CNV deletion 25765185
nsv1114754 CNV deletion 24896259
nsv1114755 CNV deletion 24896259
nsv1117423 CNV tandem duplication 24896259
nsv1117424 CNV tandem duplication 24896259
nsv1128207 CNV deletion 24896259
nsv1137045 CNV deletion 24896259
nsv1146048 CNV insertion 26484159
nsv327594 CNV deletion 16902084
nsv328697 CNV deletion 16902084
nsv462511 CNV loss 19166990
nsv462512 CNV loss 19166990
nsv472343 CNV novel sequence insertion 20440878
nsv473721 CNV novel sequence insertion 20440878
nsv475985 CNV novel sequence insertion 20440878
nsv507305 OTHER sequence alteration 20534489
nsv507306 OTHER sequence alteration 20534489
nsv510002 OTHER sequence alteration 20534489
nsv510003 OTHER sequence alteration 20534489
nsv510004 OTHER sequence alteration 20534489
nsv5114 CNV insertion 18451855
nsv5115 CNV deletion 18451855
nsv5116 CNV insertion 18451855
nsv5117 CNV deletion 18451855
nsv517414 CNV loss 19592680
nsv527385 CNV gain 19592680
nsv600254 CNV loss 21841781
nsv600257 CNV loss 21841781
nsv823339 CNV gain 20364138
nsv830546 CNV loss 17160897
nsv955865 CNV deletion 24416366

Variation tolerance for TENM2 Gene

Gene Damage Index Score: 5.24; 70.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TENM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TENM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TENM2 Gene

Disorders for TENM2 Gene

Additional Disease Information for TENM2

No disorders were found for TENM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TENM2 Gene

Publications for TENM2 Gene

  1. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. (PMID: 21724987) Silva JP … Ushkaryov YA (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58
  3. The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription. (PMID: 12783990) Bagutti C … Chiquet-Ehrismann R (Journal of cell science 2003) 3 22 58
  4. The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles. (PMID: 10625539) Ben-Zur T … Wides R (Developmental biology 2000) 2 3 58
  5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58

Products for TENM2 Gene

Sources for TENM2 Gene

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