This locus represents naturally occurring read-through transcription between the neighboring TEN1 telomerase capping complex subunit homolog (S. cerevisiae) and cyclin-dependent kinase 3 (CDK3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Oct 2011] See more...

Aliases for TEN1-CDK3 Gene

Subcategory (RNA class) for TEN1-CDK3 Gene

lncRNA

Aliases for TEN1-CDK3 Gene

  • TEN1-CDK3 Readthrough (NMD Candidate) 2 3 5
  • TEN1-CDK3 Readthrough (Non-Protein Coding) 2 3
  • Telomere Length Regulation Protein TEN1 Homolog 3
  • Protein Telomeric Pathways With STN1 Homolog 3
  • CST Complex Subunit TEN1 3
  • C17orf106-CDK3 3
  • C17orf106 3
  • TEN1-CDK3 5
  • TEN1 3

External Ids for TEN1-CDK3 Gene

Previous GeneCards Identifiers for TEN1-CDK3 Gene

  • GC17U901665
  • GC17P073981
  • GC17P075980

Summaries for TEN1-CDK3 Gene

Entrez Gene Summary for TEN1-CDK3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring TEN1 telomerase capping complex subunit homolog (S. cerevisiae) and cyclin-dependent kinase 3 (CDK3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Oct 2011]

GeneCards Summary for TEN1-CDK3 Gene

TEN1-CDK3 (TEN1-CDK3 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TEN1-CDK3 include Peroxisomal Acyl-Coa Oxidase Deficiency and Cardiomyopathy, Dilated, 1E. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TEN1.

Additional gene information for TEN1-CDK3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEN1-CDK3 Gene

Genomics for TEN1-CDK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TEN1-CDK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J075975 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.0 977 10.1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 TFE3 CDK3 ACOX1 TEN1 TEN1-CDK3 lnc-EVPL-3 SRSF2 NT5C NUP85 UNK TRIM65
GH17J075995 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 0.4 +19.0 18972 6 HNRNPL GATAD2A CTCF ATF7 PRDM10 REST TFE3 RCOR2 PRDM1 RELA CDK3 RF00017-2557 ACOX1 TEN1 UNK NUP85 GGA3 SRSF2 NT5C ENSG00000266980
GH17J076002 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.3 +25.2 25249 3.5 HNRNPL GATAD2A CTCF REST TFE3 SOX13 IKZF1 NFKBIZ RCOR2 ZNF143 TEN1 ACOX1 CDK3 TRIM65 RF00017-2558 EVPL TEN1-CDK3 lnc-SRP68-1
GH17J075988 Enhancer 0.7 Ensembl 0.4 +9.5 9484 1 GATAD2A ATF7 PRDM10 PATZ1 SOX6 CEBPA SOX13 CEBPB FOXA2 ATF2 NUP85 SRSF2 UNK NT5C ENSG00000266980 TRIM65 GGA3 ENSG00000267546 CDK3 MRPS7
GH17J075992 Enhancer 0.7 Ensembl ENCODE 0.4 +12.9 12884 1 PKNOX1 RUNX3 BCLAF1 TCF12 BCL11A SPI1 IRF4 EBF1 TARDBP ZNF362 TEN1 CDK3 RF00017-2557 TEN1-CDK3 lnc-SRP68-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEN1-CDK3 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TEN1-CDK3 Gene

Genomic Locations for TEN1-CDK3 Gene
chr17:75,979,217-76,005,999
(GRCh38/hg38)
Size:
26,783 bases
Orientation:
Plus strand
chr17:73,975,298-74,002,080
(GRCh37/hg19)
Size:
26,783 bases
Orientation:
Plus strand

Genomic View for TEN1-CDK3 Gene

Genes around TEN1-CDK3 on UCSC Golden Path with GeneCards custom track
TEN1-CDK3 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
TEN1-CDK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEN1-CDK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEN1-CDK3 Gene

Proteins for TEN1-CDK3 Gene

Post-translational modifications for TEN1-CDK3 Gene

No Post-translational modifications

Other Protein References for TEN1-CDK3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TEN1-CDK3 Gene

Domains & Families for TEN1-CDK3 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEN1-CDK3 Gene

Function for TEN1-CDK3 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEN1-CDK3 Gene

Localization for TEN1-CDK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEN1-CDK3 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TEN1-CDK3 Gene

Pathways & Interactions for TEN1-CDK3 Gene

PathCards logo

SuperPathways for TEN1-CDK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEN1-CDK3 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for TEN1-CDK3 Gene

Drugs & Compounds for TEN1-CDK3 Gene

No Compound Related Data Available

Transcripts for TEN1-CDK3 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for TEN1-CDK3 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B1E5_9606 lncRNA 3330 1

RefSeq: NR_037709,

TEN1-CDK3 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for TEN1-CDK3 Gene

2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TEN1-CDK3 Gene

No ASD Table

Relevant External Links for TEN1-CDK3 Gene

GeneLoc Exon Structure for
TEN1-CDK3

Expression for TEN1-CDK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEN1-CDK3 Gene

Protein differential expression in normal tissues from HIPED for TEN1-CDK3 Gene

This gene is overexpressed in Heart (37.8) and Brain (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for TEN1-CDK3 Gene



Protein tissue co-expression partners for TEN1-CDK3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEN1-CDK3

Evidence on tissue expression from TISSUES for TEN1-CDK3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TEN1-CDK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEN1-CDK3 Gene

Orthologs for TEN1-CDK3 Gene

Evolution for TEN1-CDK3 Gene

ENSEMBL:
Gene Tree for TEN1-CDK3 (if available)
TreeFam:
Gene Tree for TEN1-CDK3 (if available)

No data available for Orthologs for TEN1-CDK3 Gene

Paralogs for TEN1-CDK3 Gene

Paralogs for TEN1-CDK3 Gene

genes like me logo Genes that share paralogs with TEN1-CDK3: view

Variants for TEN1-CDK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEN1-CDK3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
719572 Benign: not provided 75,986,292(+) C/T INTRON_VARIANT
734747 Benign: not provided 75,991,577(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs3760132 Likely Benign: Peroxisomal acyl-CoA oxidase deficiency 75,979,390(+) C/T NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
rs543914514 Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency 75,979,259(+) A/T NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
rs575138461 Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency 75,979,246(+) G/A NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for TEN1-CDK3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEN1-CDK3 Gene

Variant ID Type Subtype PubMed ID
nsv833546 CNV loss 17160897

Additional Variant Information for TEN1-CDK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEN1-CDK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TEN1-CDK3 Gene

Disorders for TEN1-CDK3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TEN1-CDK3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
peroxisomal acyl-coa oxidase deficiency
  • straight-chain acyl-coa oxidase deficiency
cardiomyopathy, dilated, 1e
  • cmd1e
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TEN1-CDK3

genes like me logo Genes that share disorders with TEN1-CDK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEN1-CDK3 Gene

Publications for TEN1-CDK3 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3

Products for TEN1-CDK3 Gene

Sources for TEN1-CDK3 Gene