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This locus represents naturally occurring read-through transcription between the neighboring TEN1 telomerase capping complex subunit homolog (S. cerevisiae) and cyclin-dependent kinase 3 (CDK3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Oct 2011]
TEN1-CDK3 (TEN1-CDK3 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TEN1-CDK3 include Peroxisomal Acyl-Coa Oxidase Deficiency and Cardiomyopathy, Dilated, 1E. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TEN1.
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
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URS000075B1E5_9606 | lncRNA | 3330 | 1 |
RefSeq: NR_037709, |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
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719572 | Benign: not provided | 75,986,292(+) | C/T | INTRON_VARIANT | |
734747 | Benign: not provided | 75,991,577(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
rs3760132 | Likely Benign: Peroxisomal acyl-CoA oxidase deficiency | 75,979,390(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
rs543914514 | Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency | 75,979,259(+) | A/T | NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
rs575138461 | Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency | 75,979,246(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
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peroxisomal acyl-coa oxidase deficiency |
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cardiomyopathy, dilated, 1e |
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