This locus represents naturally occurring read-through transcription between the neighboring TEN1 telomerase capping complex subunit homolog (S. cerevisiae) and cyclin-dependent kinase 3 (CDK3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Oct 2011] See more...

Aliases for TEN1-CDK3 Gene

Data sources for TEN1-CDK3 Gene:

Subcategory (RNA class) for TEN1-CDK3 Gene

lncRNA

Aliases for TEN1-CDK3 Gene

External Ids for TEN1-CDK3 Gene

Previous GeneCards Identifiers for TEN1-CDK3 Gene

  • GC17U901665
  • GC17P073981
  • GC17P075980
  • GC17P075982

Summaries for TEN1-CDK3 Gene

Entrez Gene Summary for TEN1-CDK3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring TEN1 telomerase capping complex subunit homolog (S. cerevisiae) and cyclin-dependent kinase 3 (CDK3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Oct 2011]

GeneCards Summary for TEN1-CDK3 Gene

TEN1-CDK3 (TEN1-CDK3 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TEN1-CDK3 include Peroxisomal Acyl-Coa Oxidase Deficiency. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TEN1.

Additional gene information for TEN1-CDK3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEN1-CDK3 Gene

Genomics for TEN1-CDK3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TEN1-CDK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J075975 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.0 977 10.1 TBP SP1 ZBTB10 MXD4 CEBPA NR2C1 MNT IKZF1 SMAD5 ETS1 CDK3 ACOX1 TEN1 TEN1-CDK3 lnc-EVPL-3 SRSF2 UNK NUP85 GGA3 ENSG00000266980
GH17J075999 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 0.3 +21.3 21319 1.3 MNT CTCF THAP11 FOXA2 SMAD4 RXRA GABPB1 RAD21 RARA TEAD3 CDK3 ACOX1 TEN1 RF00017-2555 TEN1-CDK3 lnc-SRP68-1
GH17J076002 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.3 +25.2 25249 3.5 MXD4 CEBPA FOXA1 IKZF1 CTCF ZIC2 HOMEZ KDM6A THAP11 REST TEN1 ACOX1 CDK3 TRIM65 RF00017-2556 EVPL TEN1-CDK3 lnc-SRP68-1
GH17J075995 Enhancer 1.1 ENCODE dbSUPER 0.4 +18.0 18048 4.1 CEBPA ZFP64 KDM6A THAP11 FOXA2 ZNF511 SMAD4 SAP130 GABPA RXRA RF00017-2555 TEN1 UNK NUP85 GGA3 SRSF2 NT5C ENSG00000266980 CDK3 TRIM65
GH17J075988 Enhancer 0.7 Ensembl 0.4 +9.5 9484 1 CEBPA CEBPB FOXA2 JUND IRF9 SOX5 FOXA1 ZNF24 ZBTB33 ZNF664 NUP85 SRSF2 UNK NT5C ENSG00000266980 TRIM65 GGA3 ENSG00000267546 CDK3 MRPS7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEN1-CDK3 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for TEN1-CDK3 Gene

Latest Assembly
chr17:75,979,217-76,005,999
(GRCh38/hg38)
Size:
26,783 bases
Orientation:
Plus strand

Previous Assembly
chr17:73,975,298-74,002,080
(GRCh37/hg19 by Entrez Gene)
Size:
26,783 bases
Orientation:
Plus strand

chr17:73,975,312-74,002,080
(GRCh37/hg19 by Ensembl)
Size:
26,769 bases
Orientation:
Plus strand

Genomic View for TEN1-CDK3 Gene

Genes around TEN1-CDK3 on UCSC Golden Path with GeneCards custom track
TEN1-CDK3 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
TEN1-CDK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEN1-CDK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEN1-CDK3 Gene

Proteins for TEN1-CDK3 Gene

Post-translational modifications for TEN1-CDK3 Gene

No Post-translational modifications

Other Protein References for TEN1-CDK3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TEN1-CDK3 Gene

Domains & Families for TEN1-CDK3 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEN1-CDK3 Gene

Function for TEN1-CDK3 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEN1-CDK3 Gene

Localization for TEN1-CDK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEN1-CDK3 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TEN1-CDK3 Gene

Pathways & Interactions for TEN1-CDK3 Gene

PathCards logo

SuperPathways for TEN1-CDK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEN1-CDK3 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for TEN1-CDK3 Gene

Drugs & Compounds for TEN1-CDK3 Gene

No Compound Related Data Available

Transcripts for TEN1-CDK3 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for TEN1-CDK3 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B1E5_9606 lncRNA 3330 1

RefSeq: NR_037709,

TEN1-CDK3 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for TEN1-CDK3 Gene

2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TEN1-CDK3 Gene

No ASD Table

Relevant External Links for TEN1-CDK3 Gene

GeneLoc Exon Structure for
TEN1-CDK3

Expression for TEN1-CDK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEN1-CDK3 Gene

Protein differential expression in normal tissues from HIPED for TEN1-CDK3 Gene

This gene is overexpressed in Heart (37.8) and Brain (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for TEN1-CDK3 Gene



Protein tissue co-expression partners for TEN1-CDK3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEN1-CDK3

Evidence on tissue expression from TISSUES for TEN1-CDK3 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TEN1-CDK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEN1-CDK3 Gene

Orthologs for TEN1-CDK3 Gene

Evolution for TEN1-CDK3 Gene

ENSEMBL:
Gene Tree for TEN1-CDK3 (if available)
TreeFam:
Gene Tree for TEN1-CDK3 (if available)

No data available for Orthologs for TEN1-CDK3 Gene

Paralogs for TEN1-CDK3 Gene

Paralogs for TEN1-CDK3 Gene

genes like me logo Genes that share paralogs with TEN1-CDK3: view

Variants for TEN1-CDK3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEN1-CDK3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs200875806 Benign: not provided 75,991,577(+) G/A
NM_001113324.3(TEN1):c.204G>A (p.Gln68=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs3760132 Likely Benign: Peroxisomal acyl-CoA oxidase deficiency 75,979,390(+) C/T
NM_001113324.3(TEN1):c.-128C>T
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs543914514 Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency 75,979,259(+) A/T
NM_001113324.3(TEN1):c.-259A>T
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs575138461 Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency 75,979,246(+) G/A
NM_001113324.3(TEN1):c.-272G>A
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs74844461 Benign: not provided 75,986,292(+) C/T
NM_001113324.3(TEN1):c.92+8C>T
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TEN1-CDK3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TEN1-CDK3 Gene

Variant ID Type Subtype PubMed ID
nsv833546 CNV loss 17160897

Additional Variant Information for TEN1-CDK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEN1-CDK3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TEN1-CDK3 Gene

Disorders for TEN1-CDK3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TEN1-CDK3 Gene - From: GCD

Disorder Aliases PubMed IDs
peroxisomal acyl-coa oxidase deficiency
  • straight-chain acyl-coa oxidase deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TEN1-CDK3

genes like me logo Genes that share disorders with TEN1-CDK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEN1-CDK3 Gene

Publications for TEN1-CDK3 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3

Products for TEN1-CDK3 Gene

Sources for TEN1-CDK3 Gene