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This locus represents naturally occurring read-through transcription between the neighboring TEN1 telomerase capping complex subunit homolog (S. cerevisiae) and cyclin-dependent kinase 3 (CDK3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Oct 2011] See more...
Aliases for TEN1-CDK3 Gene
Data sources for TEN1-CDK3 Gene:
Subcategory (RNA class) for TEN1-CDK3 Gene
lncRNA
Aliases for TEN1-CDK3 Gene
- TEN1-CDK3 Readthrough (NMD Candidate) (HGNC, NCBI Entrez Gene, Ensembl)
- TEN1-CDK3 Readthrough (Non-Protein Coding) (HGNC, NCBI Entrez Gene)
- Telomere Length Regulation Protein TEN1 Homolog (NCBI Entrez Gene)
- Protein Telomeric Pathways With STN1 Homolog (NCBI Entrez Gene)
- CST Complex Subunit TEN1 (NCBI Entrez Gene)
- C17orf106-CDK3 (NCBI Entrez Gene)
- C17orf106 (NCBI Entrez Gene)
- TEN1-CDK3 (Ensembl)
- TEN1 (NCBI Entrez Gene)
External Ids for TEN1-CDK3 Gene
- HGNC: 44420
- NCBI Entrez Gene: 100529145
- Ensembl: ENSG00000261408
Previous GeneCards Identifiers for TEN1-CDK3 Gene
- GC17U901665
- GC17P073981
- GC17P075980
- GC17P075982
Summaries for TEN1-CDK3 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring TEN1 telomerase capping complex subunit homolog (S. cerevisiae) and cyclin-dependent kinase 3 (CDK3) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Oct 2011]
GeneCards Summary for TEN1-CDK3 Gene
TEN1-CDK3 (TEN1-CDK3 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TEN1-CDK3 include Peroxisomal Acyl-Coa Oxidase Deficiency. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TEN1.
Additional gene information for TEN1-CDK3 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEN1-CDK3 Gene
Genomics for TEN1-CDK3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TEN1-CDK3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TEN1-CDK3 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for TEN1-CDK3 Gene
Latest Assembly
- chr17:75,979,217-76,005,999
- (GRCh38/hg38)
- Size:
- 26,783 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:73,975,298-74,002,080
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 26,783 bases
- Orientation:
- Plus strand
- chr17:73,975,312-74,002,080
- (GRCh37/hg19 by Ensembl)
- Size:
- 26,769 bases
- Orientation:
- Plus strand
Genomic View for TEN1-CDK3 Gene
Genes around TEN1-CDK3 on UCSC Golden Path with GeneCards custom track
TEN1-CDK3 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
TEN1-CDK3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TEN1-CDK3 Gene
Proteins for TEN1-CDK3 Gene
Protein Expression for TEN1-CDK3 Gene
Post-translational modifications for TEN1-CDK3 Gene
No Post-translational modifications
Other Protein References for TEN1-CDK3 Gene
- ENSEMBL proteins:
No data available for DME Specific Peptides for TEN1-CDK3 Gene
Domains & Families for TEN1-CDK3 Gene
No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEN1-CDK3 Gene
Function for TEN1-CDK3 Gene
CRISPR products for research
Inhibitory RNAs for research
Clone products for research
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEN1-CDK3 Gene
Localization for TEN1-CDK3 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TEN1-CDK3 Gene
Transcripts for TEN1-CDK3 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for TEN1-CDK3 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000075B1E5_9606 | lncRNA | 3330 | 1 |
RefSeq: NR_037709, |
TEN1-CDK3 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for TEN1-CDK3 Gene
- 2 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000567351 3897 nts (view in UCSC)
- ENST00000569284 3287 nts (view in UCSC)
- ENST00000649294 2259 nts (view in UCSC)
CRISPR products for research
Inhibitory RNAs for research
Clone products for research
Relevant External Links for TEN1-CDK3 Gene
- GeneLoc Exon Structure for
- TEN1-CDK3
Expression for TEN1-CDK3 Gene
This gene is overexpressed in Heart (37.8) and Brain (31.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEN1-CDK3
Evidence on tissue expression from TISSUES for TEN1-CDK3 Gene
- Nervous system(4.3)
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEN1-CDK3 Gene
Orthologs for TEN1-CDK3 Gene
No data available for Orthologs for TEN1-CDK3 Gene
Paralogs for TEN1-CDK3 Gene
Variants for TEN1-CDK3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEN1-CDK3 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs200875806 | Benign: not provided | 75,991,577(+) |
G/A NM_001113324.3(TEN1):c.204G>A (p.Gln68=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs3760132 | Likely Benign: Peroxisomal acyl-CoA oxidase deficiency | 75,979,390(+) |
C/T NM_001113324.3(TEN1):c.-128C>T |
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR | |
| rs543914514 | Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency | 75,979,259(+) |
A/T NM_001113324.3(TEN1):c.-259A>T |
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR | |
| rs575138461 | Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency | 75,979,246(+) |
G/A NM_001113324.3(TEN1):c.-272G>A |
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR | |
| rs74844461 | Benign: not provided | 75,986,292(+) |
C/T NM_001113324.3(TEN1):c.92+8C>T |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for TEN1-CDK3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TEN1-CDK3
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TEN1-CDK3 Gene
Disorders for TEN1-CDK3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| peroxisomal acyl-coa oxidase deficiency |
|
|
Search TEN1-CDK3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TEN1-CDK3
No data available for UniProtKB/Swiss-Prot and Genatlas for TEN1-CDK3 Gene
Publications for TEN1-CDK3 Gene
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
Products for TEN1-CDK3 Gene
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- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for TEN1-CDK3
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- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for TEN1-CDK3
Sources for TEN1-CDK3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB