Aliases for TEN1 Gene
External Ids for TEN1 Gene
Previous HGNC Symbols for TEN1 Gene
Previous GeneCards Identifiers for TEN1 Gene
C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
GeneCards Summary for TEN1 Gene
TEN1 (TEN1 Subunit Of CST Complex) is a Protein Coding gene. Diseases associated with TEN1 include Peroxisomal Acyl-Coa Oxidase Deficiency and Retinal Telangiectasia. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is TEN1-CDK3.
UniProtKB/Swiss-Prot Summary for TEN1 Gene
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097).