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C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
TEN1 (TEN1 Subunit Of CST Complex) is a Protein Coding gene. Diseases associated with TEN1 include Peroxisomal Acyl-Coa Oxidase Deficiency and Postpoliomyelitis Syndrome. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is TEN1-CDK3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003697 | single-stranded DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 19854130 |
GO:0010521 | telomerase inhibitor activity | IBA | 21873635 |
GO:0042162 | telomeric DNA binding | IDA | 19854130 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000781 | chromosome, telomeric region | IEA | -- |
GO:0000784 | nuclear chromosome, telomeric region | IDA | 19854130 |
GO:0005634 | nucleus | IEA,IDA | 19854130 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005694 | chromosome | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016233 | telomere capping | TAS | 22763445 |
GO:0032211 | negative regulation of telomere maintenance via telomerase | IBA,IDA | 22763445 |
GO:0051974 | negative regulation of telomerase activity | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TEN1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TEN1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TEN1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ten1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ten1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TEN1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TEN1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | C18H17ORF106 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TEN1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ten1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-89i1.2 30 |
|
||
TEN1 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
719572 | Benign: not provided | 75,986,292(+) | C/T | INTRON_VARIANT | |
734747 | Benign: not provided | 75,991,577(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
rs3760132 | Likely Benign: Peroxisomal acyl-CoA oxidase deficiency | 75,979,390(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
rs543914514 | Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency | 75,979,259(+) | A/T | NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
rs575138461 | Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency | 75,979,246(+) | G/A | NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
peroxisomal acyl-coa oxidase deficiency |
|
|
postpoliomyelitis syndrome |
|
|
leukodystrophy, hypomyelinating, 3 |
|
|
retinal telangiectasia |
|
|
coats disease |
|
|