C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009] See more...

Aliases for TEN1 Gene

Aliases for TEN1 Gene

  • TEN1 Subunit Of CST Complex 2 3 5
  • Telomere Length Regulation Protein TEN1 Homolog 3 4
  • Protein Telomeric Pathways With STN1 Homolog 3 4
  • TEN1, CST Complex Subunit 2 3
  • CST Complex Subunit TEN1 3 4
  • C17orf106 3 4
  • TEN1 Telomerase Capping Complex Subunit Homolog (S. Cerevisiae) 2
  • Telomeric Pathways In Association With Stn1, Number 1 3
  • TEN1 Telomerase Capping Complex Subunit Homolog 3
  • Chromosome 17 Open Reading Frame 106 2
  • TEN1 CST Complex Subunit 2
  • FLJ39785 2
  • TEN1 5

External Ids for TEN1 Gene

Previous HGNC Symbols for TEN1 Gene

  • C17orf106

Previous GeneCards Identifiers for TEN1 Gene

  • GC17P073978
  • GC17P075981
  • GC17P075983

Summaries for TEN1 Gene

Entrez Gene Summary for TEN1 Gene

  • C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

GeneCards Summary for TEN1 Gene

TEN1 (TEN1 Subunit Of CST Complex) is a Protein Coding gene. Diseases associated with TEN1 include Peroxisomal Acyl-Coa Oxidase Deficiency and Retinal Telangiectasia. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is TEN1-CDK3.

UniProtKB/Swiss-Prot Summary for TEN1 Gene

  • Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEN1 Gene

Genomics for TEN1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TEN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J075975 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 260.6 +1.0 954 10.1 TBP SP1 ZBTB10 MXD4 CEBPA NR2C1 MNT IKZF1 SMAD5 ETS1 CDK3 ACOX1 TEN1 TEN1-CDK3 lnc-EVPL-3 SRSF2 UNK NUP85 GGA3 ENSG00000266980
GH17J075999 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 36.2 +21.3 21296 1.3 MNT CTCF THAP11 FOXA2 SMAD4 RXRA GABPB1 RAD21 RARA TEAD3 CDK3 ACOX1 TEN1 RF00017-2555 TEN1-CDK3 lnc-SRP68-1
GH17J076002 Enhancer 1.3 Ensembl ENCODE dbSUPER 36.6 +25.2 25226 3.5 MXD4 CEBPA FOXA1 IKZF1 CTCF ZIC2 HOMEZ KDM6A THAP11 REST TEN1 ACOX1 CDK3 TRIM65 RF00017-2556 EVPL TEN1-CDK3 lnc-SRP68-1
GH17J075995 Enhancer 1.1 ENCODE dbSUPER 36.4 +18.0 18025 4.1 CEBPA ZFP64 KDM6A THAP11 FOXA2 ZNF511 SMAD4 SAP130 GABPA RXRA RF00017-2555 TEN1 UNK NUP85 GGA3 SRSF2 NT5C ENSG00000266980 CDK3 TRIM65
GH17J076025 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.3 +48.7 48749 4.8 ZSCAN16 ZBTB10 MXD4 FEZF1 MNT ETS1 HES1 ZFP64 ZNF217 BHLHE40 EVPL UNK NUP85 SRSF2 NT5C GGA3 ENSG00000266980 CDK3 METTL23 MFSD11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEN1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEN1

Genomic Locations for TEN1 Gene

Latest Assembly
chr17:75,979,240-76,000,586
(GRCh38/hg38)
Size:
21,347 bases
Orientation:
Plus strand

Previous Assembly
chr17:73,975,321-73,996,667
(GRCh37/hg19 by Entrez Gene)
Size:
21,347 bases
Orientation:
Plus strand

chr17:73,975,301-73,996,667
(GRCh37/hg19 by Ensembl)
Size:
21,367 bases
Orientation:
Plus strand

Genomic View for TEN1 Gene

Genes around TEN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEN1 Gene

Proteins for TEN1 Gene

  • Protein details for TEN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WV5-TEN1L_HUMAN
    Recommended name:
    CST complex subunit TEN1
    Protein Accession:
    Q86WV5
    Secondary Accessions:
    • I3L0C7

    Protein attributes for TEN1 Gene

    Size:
    123 amino acids
    Molecular mass:
    13856 Da
    Quaternary structure:
    • Component of the CST complex, composed of TEN1/C17orf106, CTC1/C17orf68 and STN1; in the complex interacts directly with STN1.
    SequenceCaution:
    • Sequence=AAH47782.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TEN1 Gene

neXtProt entry for TEN1 Gene

Post-translational modifications for TEN1 Gene

No Post-translational modifications

Other Protein References for TEN1 Gene

No data available for DME Specific Peptides for TEN1 Gene

Domains & Families for TEN1 Gene

Gene Families for TEN1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEN1 Gene

GenScript: Design optimal peptide antigens:
  • Telomeric pathways in association with Stn1 number 1 (D3U720_HUMAN)
  • Telomere length regulation protein TEN1 homolog (TEN1L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86WV5

UniProtKB/Swiss-Prot:

TEN1L_HUMAN :
  • Belongs to the TEN1 family.
Family:
  • Belongs to the TEN1 family.
genes like me logo Genes that share domains with TEN1: view

Function for TEN1 Gene

Molecular function for TEN1 Gene

UniProtKB/Swiss-Prot Function:
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097).

Phenotypes From GWAS Catalog for TEN1 Gene

Gene Ontology (GO) - Molecular Function for TEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0005515 protein binding IPI 19854130
GO:0010521 telomerase inhibitor activity IBA 21873635
GO:0042162 telomeric DNA binding IDA 19854130
genes like me logo Genes that share ontologies with TEN1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEN1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEN1 Gene

Localization for TEN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEN1 Gene

Nucleus. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEN1 gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA,IDA 19854130
GO:0005634 nucleus IEA,IDA 19854130
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:1990879 CST complex IEA,ISS --
genes like me logo Genes that share ontologies with TEN1: view

Pathways & Interactions for TEN1 Gene

PathCards logo

SuperPathways for TEN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016233 telomere capping TAS 22763445
GO:0032211 negative regulation of telomere maintenance via telomerase IBA,IDA 22763445
GO:0051974 negative regulation of telomerase activity IEA --
genes like me logo Genes that share ontologies with TEN1: view

No data available for Pathways by source and SIGNOR curated interactions for TEN1 Gene

Drugs & Compounds for TEN1 Gene

No Compound Related Data Available

Transcripts for TEN1 Gene

mRNA/cDNA for TEN1 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEN1

Alternative Splicing Database (ASD) splice patterns (SP) for TEN1 Gene

No ASD Table

Relevant External Links for TEN1 Gene

GeneLoc Exon Structure for
TEN1

Expression for TEN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEN1 Gene

Protein differential expression in normal tissues from HIPED for TEN1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TEN1 Gene



Protein tissue co-expression partners for TEN1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEN1

SOURCE GeneReport for Unigene cluster for TEN1 Gene:

Hs.593566

Evidence on tissue expression from TISSUES for TEN1 Gene

  • Eye(4)
  • Spleen(4)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with TEN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEN1 Gene

Orthologs for TEN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEN1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TEN1 30 31
  • 98.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TEN1 30 31
  • 82.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TEN1 31
  • 81 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ten1 30
  • 77.12 (n)
Mouse
(Mus musculus)
Mammalia Ten1 30 17 31
  • 72.6 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TEN1 31
  • 59 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TEN1 31
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C18H17ORF106 30 31
  • 65.81 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TEN1 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ten1 30
  • 59.44 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-89i1.2 30
  • 50.71 (n)
TEN1 31
  • 32 (a)
OneToOne
Species where no ortholog for TEN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TEN1 Gene

ENSEMBL:
Gene Tree for TEN1 (if available)
TreeFam:
Gene Tree for TEN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEN1: view image

Paralogs for TEN1 Gene

Paralogs for TEN1 Gene

(1) SIMAP similar genes for TEN1 Gene using alignment to 5 proteins:

  • TEN1L_HUMAN
  • D3U720_HUMAN
  • K7EIL0_HUMAN
  • K7EJS2_HUMAN
  • K7EL09_HUMAN

Pseudogenes.org Pseudogenes for TEN1 Gene

genes like me logo Genes that share paralogs with TEN1: view

Variants for TEN1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEN1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs200875806 Benign: not provided 75,991,577(+) G/A
NM_001113324.3(TEN1):c.204G>A (p.Gln68=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs3760132 Likely Benign: Peroxisomal acyl-CoA oxidase deficiency 75,979,390(+) C/T
NM_001113324.3(TEN1):c.-128C>T
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs543914514 Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency 75,979,259(+) A/T
NM_001113324.3(TEN1):c.-259A>T
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs575138461 Uncertain Significance: Peroxisomal acyl-CoA oxidase deficiency 75,979,246(+) G/A
NM_001113324.3(TEN1):c.-272G>A
NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs74844461 Benign: not provided 75,986,292(+) C/T
NM_001113324.3(TEN1):c.92+8C>T
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TEN1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for TEN1 Gene

Gene Damage Index Score: 1.51; 29.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEN1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TEN1 Gene

Disorders for TEN1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TEN1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
peroxisomal acyl-coa oxidase deficiency
  • straight-chain acyl-coa oxidase deficiency
retinal telangiectasia
dyskeratosis congenita
  • zinsser-cole-engman syndrome
melanoma, cutaneous malignant 1
  • melanoma, cutaneous malignant, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search TEN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEN1

genes like me logo Genes that share disorders with TEN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEN1 Gene

Publications for TEN1 Gene

  1. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. (PMID: 19854130) Miyake Y … Ishikawa F (Molecular cell 2009) 2 3 4
  2. Structure of the human telomeric Stn1-Ten1 capping complex. (PMID: 23826127) Bryan C … Skordalakes E (PloS one 2013) 3 4
  3. The human CST complex is a terminator of telomerase activity. (PMID: 22763445) Chen LY … Lingner J (Nature 2012) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3

Products for TEN1 Gene

Sources for TEN1 Gene