Aliases for TEKT5 Gene

Aliases for TEKT5 Gene

  • Tektin 5 2 3 5
  • Tektin-5 3 4
  • CT149 2 3
  • FLJ32871 2
  • TEKT5 5

External Ids for TEKT5 Gene

Previous GeneCards Identifiers for TEKT5 Gene

  • GC16M010629
  • GC16M010721
  • GC16M010581

Summaries for TEKT5 Gene

GeneCards Summary for TEKT5 Gene

TEKT5 (Tektin 5) is a Protein Coding gene. Diseases associated with TEKT5 include Bone Leiomyosarcoma and Epilepsy, Myoclonic Juvenile. An important paralog of this gene is TEKT3.

UniProtKB/Swiss-Prot Summary for TEKT5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEKT5 Gene

Genomics for TEKT5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TEKT5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J010694 Promoter 0.4 EPDnew 600.7 0.0 -20 0.1 NFE2 TEKT5 lnc-TEKT5-3 MTCYBP33 NUBP1
GH16J010690 Enhancer 0.4 FANTOM5 71.4 +4.1 4134 0.2 CREB1 ENSG00000263279 LOC105371079 TEKT5 CLEC16A piR-48209-238 EMP2
GH16J010743 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 6.3 -49.2 -49237 3.9 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 SOX13 NFKBIZ ZNF692 POLR2A HSALNG0109549 NUBP1 HNRNPCP4 SOCS1 CIITA ENSG00000256013 TEKT5 piR-50838 TVP23A
GH16J010728 Enhancer 1.1 Ensembl ENCODE 9.3 -34.2 -34186 2.6 CREB1 GATAD2A SOX13 CTCF RCOR2 TARDBP JUND PHB2 ZNF776 ZSCAN4 HNRNPCP4 TEKT5 MTATP6P24 lnc-TEKT5-8 piR-50437-232 NUBP1
GH16J010736 Enhancer 1 ENCODE 7 -43.2 -43189 2.9 SP1 CREB1 GATAD2A CTCF ATF7 ZNF629 LEF1 NFKBIZ RCOR2 POLR2A lnc-NUBP1-2 ENSG00000256013 HNRNPCP4 TEKT5 TVP23A piR-50437-232 NUBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEKT5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEKT5

Top Transcription factor binding sites by QIAGEN in the TEKT5 gene promoter:
  • AREB6
  • Chx10
  • GATA-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • MIF-1
  • SRF
  • SRF (504 AA)
  • XBP-1

Genomic Locations for TEKT5 Gene

Genomic Locations for TEKT5 Gene
chr16:10,627,501-10,694,930
(GRCh38/hg38)
Size:
67,430 bases
Orientation:
Minus strand
chr16:10,721,358-10,788,802
(GRCh37/hg19)
Size:
67,445 bases
Orientation:
Minus strand

Genomic View for TEKT5 Gene

Genes around TEKT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT5 Gene

Proteins for TEKT5 Gene

  • Protein details for TEKT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M29-TEKT5_HUMAN
    Recommended name:
    Tektin-5
    Protein Accession:
    Q96M29
    Secondary Accessions:
    • A1L3Z3

    Protein attributes for TEKT5 Gene

    Size:
    485 amino acids
    Molecular mass:
    56294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT5 Gene

Post-translational modifications for TEKT5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEKT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEKT5 Gene

Domains & Families for TEKT5 Gene

Gene Families for TEKT5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEKT5 Gene

InterPro:
Blocks:
  • Tektin signature
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT5 Gene

GenScript: Design optimal peptide antigens:
  • Tektin-5 (TEKT5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96M29

UniProtKB/Swiss-Prot:

TEKT5_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT5: view

Function for TEKT5 Gene

Molecular function for TEKT5 Gene

UniProtKB/Swiss-Prot Function:
May be a structural component of the sperm flagellum.

Phenotypes From GWAS Catalog for TEKT5 Gene

Gene Ontology (GO) - Molecular Function for TEKT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TEKT5: view
genes like me logo Genes that share phenotypes with TEKT5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEKT5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TEKT5 Gene

Localization for TEKT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT5 Gene

Cell projection, cilium, flagellum. Note=Appears to be associated with flagellar accessory structures and not the axoneme. {ECO:0000250 UniProtKB:G5E8A8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT5 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TEKT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005929 cilium IEA --
GO:0015630 microtubule cytoskeleton IBA 21873635
GO:0031514 motile cilium IEA --
GO:0036126 sperm flagellum IEA,IBA 21873635
genes like me logo Genes that share ontologies with TEKT5: view

Pathways & Interactions for TEKT5 Gene

PathCards logo

SuperPathways for TEKT5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060271 cilium assembly IBA 21873635
GO:0060294 cilium movement involved in cell motility IBA 21873635
genes like me logo Genes that share ontologies with TEKT5: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT5 Gene

Drugs & Compounds for TEKT5 Gene

No Compound Related Data Available

Transcripts for TEKT5 Gene

mRNA/cDNA for TEKT5 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEKT5

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT5 Gene

No ASD Table

Relevant External Links for TEKT5 Gene

GeneLoc Exon Structure for
TEKT5

Expression for TEKT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEKT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for TEKT5 Gene

This gene is overexpressed in Testis (x40.0).

Protein differential expression in normal tissues from HIPED for TEKT5 Gene

This gene is overexpressed in Tlymphocyte (42.1) and Testis (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEKT5 Gene



Protein tissue co-expression partners for TEKT5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEKT5

SOURCE GeneReport for Unigene cluster for TEKT5 Gene:

Hs.143519

Evidence on tissue expression from TISSUES for TEKT5 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TEKT5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT5 Gene

Orthologs for TEKT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TEKT5 30 31
  • 98.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TEKT5 30 31
  • 88.73 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TEKT5 30 31
  • 87.54 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tekt5 30 17 31
  • 82.69 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tekt5 30
  • 82.47 (n)
Oppossum
(Monodelphis domestica)
Mammalia TEKT5 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TEKT5 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TEKT5 30 31
  • 66.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TEKT5 31
  • 69 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG32819 31
  • 29 (a)
ManyToMany
CG17450 31
  • 29 (a)
ManyToMany
CG32820 31
  • 29 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToOne
Species where no ortholog for TEKT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TEKT5 Gene

ENSEMBL:
Gene Tree for TEKT5 (if available)
TreeFam:
Gene Tree for TEKT5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEKT5: view image

Paralogs for TEKT5 Gene

Paralogs for TEKT5 Gene

(4) SIMAP similar genes for TEKT5 Gene using alignment to 2 proteins:

  • TEKT5_HUMAN
  • I3L1F7_HUMAN
genes like me logo Genes that share paralogs with TEKT5: view

Variants for TEKT5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEKT5 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs16957546 - p.His196Arg
rs16957557 - p.Ala59Thr
rs17684500 - p.Met239Thr
rs2719710 - p.Gln315Arg

Additional dbSNP identifiers (rs#s) for TEKT5 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEKT5 Gene

Variant ID Type Subtype PubMed ID
esv1298043 CNV insertion 17803354
esv1434518 CNV insertion 17803354
esv1671601 CNV insertion 17803354
esv2658677 CNV deletion 23128226
esv2674260 CNV deletion 23128226
esv2674786 CNV deletion 23128226
esv2713964 CNV deletion 23290073
esv3351950 CNV insertion 20981092
esv3376019 CNV insertion 20981092
esv3418682 CNV insertion 20981092
esv3582009 CNV loss 25503493
esv3637908 CNV loss 21293372
esv3637909 CNV loss 21293372
esv3637910 CNV loss 21293372
esv3637911 CNV loss 21293372
esv3637912 CNV loss 21293372
esv3892791 CNV loss 25118596
esv5815 CNV loss 19470904
nsv1040428 CNV gain 25217958
nsv1051030 CNV loss 25217958
nsv1071263 CNV deletion 25765185
nsv522111 CNV loss 19592680
nsv827550 CNV loss 20364138
nsv833140 CNV loss 17160897
nsv958203 CNV deletion 24416366

Variation tolerance for TEKT5 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEKT5 Gene

Human Gene Mutation Database (HGMD)
TEKT5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEKT5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT5 Gene

Disorders for TEKT5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TEKT5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bone leiomyosarcoma
epilepsy, myoclonic juvenile
  • ejm
kartagener syndrome
  • kartagener's syndrome
primary ciliary dyskinesia
  • pcd
- elite association - COSMIC cancer census association via MalaCards
Search TEKT5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEKT5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TEKT5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEKT5 Gene

Publications for TEKT5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  5. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. (PMID: 27229929) Daakour S … Twizere JC (BMC cancer 2016) 3

Products for TEKT5 Gene

Sources for TEKT5 Gene