This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008] See more...

Aliases for TEKT3 Gene

Aliases for TEKT3 Gene

  • Tektin 3 2 3 5
  • Tektin-3 3 4
  • Testicular Microtubules-Related Protein 3

External Ids for TEKT3 Gene

Previous GeneCards Identifiers for TEKT3 Gene

  • GC17M015573
  • GC17M016322
  • GC17M015150
  • GC17M015407
  • GC17M015147
  • GC17M015207
  • GC17M015100

Summaries for TEKT3 Gene

Entrez Gene Summary for TEKT3 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT3 Gene

TEKT3 (Tektin 3) is a Protein Coding gene. Diseases associated with TEKT3 include Charcot-Marie-Tooth Disease, Dominant Intermediate D and Charcot-Marie-Tooth Disease And Deafness. An important paralog of this gene is TEKT5.

UniProtKB/Swiss-Prot Summary for TEKT3 Gene

  • May be a structural component of the sperm flagellum. Required for normal sperm mobility.

Additional gene information for TEKT3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEKT3 Gene

Genomics for TEKT3 Gene

GeneHancer (GH) Regulatory Elements for TEKT3 Gene

Promoters and enhancers for TEKT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J015341 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 505.3 +0.4 388 1.4 ZIC2 SAP30 RFX1 HDAC2 MXI1 ZNF341 SIN3A KLF9 SP2 ZBTB17 TEKT3 RNU6-799P ENSG00000237377 RF00026-416
GH17J015342 Enhancer 0.3 ENCODE 500.7 -0.8 -779 0 ZNF189 TEKT3 piR-33605-195
GH17J016212 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 10.6 -873.9 -873855 6.1 HNRNPK ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A NRF1 TCF12 POLR2G SP1 PIGL HSALNG0114839 NCOR1 lnc-CENPV-4 ZSWIM7 ZNF286A UPF3AP1 MPRIP-AS1 PPIAP53 TVP23C
GH17J015998 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -658.1 -658112 4 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 MYC USF1 POLR2G ZSWIM7 TTC19 lnc-ZSWIM7-2 ZNF286A UPF3AP1 ADORA2B MEIS3P1 ENSG00000265519 RPLP1P11 ENSG00000227782
GH17J015429 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 -92.9 -92937 10 CTCF ZSCAN5C POLR2G NCOR1 FOS KDM6A TCF7 SKI TEAD1 FOXA2 CDRT4 piR-33392 TEKT3 RNU6-799P PPIAP53 lnc-CDRT4-3 RPL9P2 TVP23C-CDRT4 lnc-CDRT4-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEKT3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEKT3

Top Transcription factor binding sites by QIAGEN in the TEKT3 gene promoter:
  • AP-1
  • Bach1
  • FOXI1
  • GR
  • GR-alpha
  • HFH-3
  • Ik-3
  • RFX1
  • S8

Genomic Locations for TEKT3 Gene

Genomic Locations for TEKT3 Gene
chr17:15,303,811-15,341,889
(GRCh38/hg38)
Size:
38,079 bases
Orientation:
Minus strand
chr17:15,207,128-15,244,958
(GRCh37/hg19)
Size:
37,831 bases
Orientation:
Minus strand

Genomic View for TEKT3 Gene

Genes around TEKT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT3 Gene

Proteins for TEKT3 Gene

  • Protein details for TEKT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXF9-TEKT3_HUMAN
    Recommended name:
    Tektin-3
    Protein Accession:
    Q9BXF9
    Secondary Accessions:
    • B2RAS7
    • D3DTT0
    • Q8N5R5
    • Q96M48

    Protein attributes for TEKT3 Gene

    Size:
    490 amino acids
    Molecular mass:
    56636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT3 Gene

Post-translational modifications for TEKT3 Gene

  • N- and O-glycosylated.
  • May be proteolytically processed during the epididymal transit of spermatozoa.
  • Glycosylation at Thr7, Thr9, Thr10, Asn41, Asn86, Asn103, Asn111, Asn276, and Asn344
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TEKT3 Gene

Domains & Families for TEKT3 Gene

Gene Families for TEKT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEKT3 Gene

Blocks:
  • Tektin signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT3 Gene

GenScript: Design optimal peptide antigens:
  • Tektin-3 (TEKT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BXF9

UniProtKB/Swiss-Prot:

TEKT3_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT3: view

Function for TEKT3 Gene

Molecular function for TEKT3 Gene

UniProtKB/Swiss-Prot Function:
May be a structural component of the sperm flagellum. Required for normal sperm mobility.

Phenotypes From GWAS Catalog for TEKT3 Gene

Gene Ontology (GO) - Molecular Function for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TEKT3: view
genes like me logo Genes that share phenotypes with TEKT3: view

Animal Models for TEKT3 Gene

MGI Knock Outs for TEKT3:

Animal Model Products

CRISPR Products

miRNA for TEKT3 Gene

miRTarBase miRNAs that target TEKT3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEKT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEKT3 Gene

Localization for TEKT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT3 Gene

Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane; Peripheral membrane protein. Note=In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (By similarity). Not detected in the central axonemal region of the flagellum (By similarity). Associates with the acrosome membrane in the equatorial segment of the sperm head (By similarity). Also detected just below the plasma membrane in the post-acrosomal region where it might localize to the postacrosomal dense lamina (By similarity). However, other studies report little or no expression in the postacrosomal region (By similarity). Translocates from the postacrosomal region to the equatorial segment after sperm activation (By similarity). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (By similarity). Some studies report strong expression in the anterior cap region (By similarity). However, other studies report little or no expression in the acrosomal cap (By similarity). {ECO:0000250 UniProtKB:A6H782, ECO:0000250 UniProtKB:Q4V8G8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT3 gene
Compartment Confidence
cytoskeleton 4
mitochondrion 3
plasma membrane 1
extracellular 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane ISS --
GO:0002081 outer acrosomal membrane IEA --
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TEKT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEKT3 Gene

Pathways & Interactions for TEKT3 Gene

PathCards logo

SuperPathways for TEKT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030317 flagellated sperm motility ISS --
GO:0060271 cilium assembly IBA,ISS --
GO:0060294 cilium movement involved in cell motility IBA 21873635
GO:0060378 regulation of brood size ISS --
genes like me logo Genes that share ontologies with TEKT3: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT3 Gene

Drugs & Compounds for TEKT3 Gene

No Compound Related Data Available

Transcripts for TEKT3 Gene

mRNA/cDNA for TEKT3 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEKT3

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for TEKT3 Gene

GeneLoc Exon Structure for
TEKT3

Expression for TEKT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEKT3 Gene

mRNA differential expression in normal tissues according to GTEx for TEKT3 Gene

This gene is overexpressed in Testis (x26.2).

Protein differential expression in normal tissues from HIPED for TEKT3 Gene

This gene is overexpressed in Plasma (55.8) and Testis (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEKT3 Gene



Protein tissue co-expression partners for TEKT3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEKT3

SOURCE GeneReport for Unigene cluster for TEKT3 Gene:

Hs.414648

Evidence on tissue expression from TISSUES for TEKT3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TEKT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT3 Gene

Orthologs for TEKT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT3 31 30
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TEKT3 31 30
  • 89.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TEKT3 31 30
  • 87.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tekt3 17 31 30
  • 83.47 (n)
rat
(Rattus norvegicus)
Mammalia Tekt3 30
  • 82.79 (n)
oppossum
(Monodelphis domestica)
Mammalia TEKT3 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT3 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEKT3 31 30
  • 73.01 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEKT3 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt3 30
  • 67.76 (n)
Str.15141 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68964 30
zebrafish
(Danio rerio)
Actinopterygii tekt3 31 30
  • 62.77 (n)
OneToOne
wufc88h09 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000219 30
  • 52.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32819 31 30
  • 50.58 (n)
ManyToMany
CG32820 31
  • 30 (a)
ManyToMany
CG17450 31 32
  • 30 (a)
ManyToMany
Tektin-A 32
  • 30 (a)
Tektin-C 32
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1706 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1706 30
Species where no ortholog for TEKT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEKT3 Gene

ENSEMBL:
Gene Tree for TEKT3 (if available)
TreeFam:
Gene Tree for TEKT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEKT3: view image

Paralogs for TEKT3 Gene

Paralogs for TEKT3 Gene

(4) SIMAP similar genes for TEKT3 Gene using alignment to 6 proteins:

  • TEKT3_HUMAN
  • F5GZV8_HUMAN
  • F5H115_HUMAN
  • F5H4K1_HUMAN
  • F5H5M8_HUMAN
  • J3KPT7_HUMAN
genes like me logo Genes that share paralogs with TEKT3: view

Variants for TEKT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEKT3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs230898 - p.Gly282Ala
rs35855709 - p.Glu410Asp
rs6502446 - p.Val296Ala
rs7226363 - p.Arg3His

Additional dbSNP identifiers (rs#s) for TEKT3 Gene

Variation tolerance for TEKT3 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.82; 93.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEKT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEKT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TEKT3 Gene

Disorders for TEKT3 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TEKT3 Gene - From: DISEASES

Additional Disease Information for TEKT3

genes like me logo Genes that share disorders with TEKT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEKT3 Gene

Publications for TEKT3 Gene

  1. Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells. (PMID: 14735490) Roy A … Matzuk MM (Molecular reproduction and development 2004) 2 3 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. The 1.4-Mb CMT1A duplication/HNPP deletion genomic region reveals unique genome architectural features and provides insights into the recent evolution of new genes. (PMID: 11381029) Inoue K … Birren B (Genome research 2001) 2 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for TEKT3 Gene

Sources for TEKT3 Gene