This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may... See more...

Aliases for TEKT1 Gene

Aliases for TEKT1 Gene

  • Tektin 1 2 3 5
  • Tektin-1 3 4

External Ids for TEKT1 Gene

Previous GeneCards Identifiers for TEKT1 Gene

  • GC17M007092
  • GC17M007432
  • GC17M006645
  • GC17M006901
  • GC17M006644
  • GC17M006692

Summaries for TEKT1 Gene

Entrez Gene Summary for TEKT1 Gene

  • This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEKT1 Gene

TEKT1 (Tektin 1) is a Protein Coding gene. Diseases associated with TEKT1 include Kartagener Syndrome and Epilepsy, Myoclonic Juvenile. An important paralog of this gene is TEKT4.

UniProtKB/Swiss-Prot Summary for TEKT1 Gene

  • Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.

Gene Wiki entry for TEKT1 Gene

Additional gene information for TEKT1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEKT1 Gene

Genomics for TEKT1 Gene

GeneHancer (GH) Regulatory Elements for TEKT1 Gene

Promoters and enhancers for TEKT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J006831 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 500.7 -0.1 -139 1 EP300 NRF1 SAP30 RFX1 U2AF2 FOXA2 EZH2 SIN3A MYNN CREB1 TEKT1 FBXO39 lnc-ALOX12-1
GH17J006853 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 11.5 -22.7 -22701 2.3 ZBTB40 CTCF POLR2G ZFX ZIC2 POLR2A TGIF2 TEAD1 ZKSCAN8 GABPA ALOX12P2 TEKT1 FBXO39 SLC13A5 lnc-TEKT1-3 lnc-ALOX12-1
GH17J006867 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.4 -37.4 -37405 3.7 TCF12 ZNF10 EP300 CTBP1 WT1 BRCA1 FOS FOSL2 CEBPB CHD2 piR-48759-116 TEKT1 ALOX12P2 FBXO39 lnc-TEKT1-3 lnc-ALOX12-1
GH17J006799 Enhancer 0.7 Ensembl ENCODE 17 +31.7 31660 1.4 TEAD4 CTCF YY1 RAD21 SP1 SMC3 CREB1 FBXO39 TEKT1 piR-48209-266 piR-51878-013
GH17J006871 Enhancer 0.8 Ensembl ENCODE 11.1 -40.8 -40840 2.8 TCF12 JUND EP300 DEK FOS FOSL2 CEBPB CHD2 JUN NFE2 TEKT1 SLC13A5 MIR195 piR-48759-116 piR-48209-267 ALOX12P2 lnc-ALOX12-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEKT1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEKT1

Top Transcription factor binding sites by QIAGEN in the TEKT1 gene promoter:
  • AML1a
  • FOXO4
  • ISGF-3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • S8

Genomic Locations for TEKT1 Gene

Genomic Locations for TEKT1 Gene
chr17:6,789,133-6,831,761
(GRCh38/hg38)
Size:
42,629 bases
Orientation:
Minus strand
chr17:6,692,452-6,735,080
(GRCh37/hg19)
Size:
42,629 bases
Orientation:
Minus strand

Genomic View for TEKT1 Gene

Genes around TEKT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEKT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEKT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEKT1 Gene

Proteins for TEKT1 Gene

  • Protein details for TEKT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969V4-TEKT1_HUMAN
    Recommended name:
    Tektin-1
    Protein Accession:
    Q969V4
    Secondary Accessions:
    • D3DTM7

    Protein attributes for TEKT1 Gene

    Size:
    418 amino acids
    Molecular mass:
    48283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TEKT1 Gene

Post-translational modifications for TEKT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEKT1 Gene

No data available for DME Specific Peptides for TEKT1 Gene

Domains & Families for TEKT1 Gene

Gene Families for TEKT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TEKT1 Gene

Blocks:
  • Tektin signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEKT1 Gene

GenScript: Design optimal peptide antigens:
  • Tektin-1 (TEKT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969V4

UniProtKB/Swiss-Prot:

TEKT1_HUMAN :
  • Belongs to the tektin family.
Family:
  • Belongs to the tektin family.
genes like me logo Genes that share domains with TEKT1: view

Function for TEKT1 Gene

Molecular function for TEKT1 Gene

UniProtKB/Swiss-Prot Function:
Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.

Phenotypes From GWAS Catalog for TEKT1 Gene

Gene Ontology (GO) - Molecular Function for TEKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TEKT1: view
genes like me logo Genes that share phenotypes with TEKT1: view

Animal Model Products

CRISPR Products

miRNA for TEKT1 Gene

miRTarBase miRNAs that target TEKT1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TEKT1 Gene

Localization for TEKT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEKT1 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEKT1 gene
Compartment Confidence
cytoskeleton 4
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for TEKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with TEKT1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEKT1 Gene

Pathways & Interactions for TEKT1 Gene

PathCards logo

SuperPathways for TEKT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEKT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060271 cilium assembly IBA 21873635
GO:0060294 cilium movement involved in cell motility IBA 21873635
genes like me logo Genes that share ontologies with TEKT1: view

No data available for Pathways by source and SIGNOR curated interactions for TEKT1 Gene

Drugs & Compounds for TEKT1 Gene

No Compound Related Data Available

Transcripts for TEKT1 Gene

mRNA/cDNA for TEKT1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEKT1 Gene

No ASD Table

Relevant External Links for TEKT1 Gene

GeneLoc Exon Structure for
TEKT1

Expression for TEKT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEKT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEKT1 Gene

This gene is overexpressed in Testis (x16.4), Fallopian Tube (x7.4), Brain - Hypothalamus (x4.8), and Cervix - Endocervix (x4.7).

Protein differential expression in normal tissues from HIPED for TEKT1 Gene

This gene is overexpressed in Esophagus (47.0), Heart (8.3), and Tlymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEKT1 Gene



Protein tissue co-expression partners for TEKT1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEKT1

SOURCE GeneReport for Unigene cluster for TEKT1 Gene:

Hs.462108

mRNA Expression by UniProt/SwissProt for TEKT1 Gene:

Q969V4-TEKT1_HUMAN
Tissue specificity: Predominantly expressed in testis.

Evidence on tissue expression from TISSUES for TEKT1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TEKT1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TEKT1 Gene

Orthologs for TEKT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEKT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEKT1 31 30
  • 99.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TEKT1 31 30
  • 87.08 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tekt1 30
  • 81.82 (n)
mouse
(Mus musculus)
Mammalia Tekt1 17 31 30
  • 81.74 (n)
dog
(Canis familiaris)
Mammalia TEKT1 31 30
  • 81.64 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEKT1 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEKT1 31 30
  • 66.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEKT1 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tekt1 30
  • 65.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30012 30
zebrafish
(Danio rerio)
Actinopterygii tekt1 31 30
  • 57.74 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tektin-C 32 30
  • 46.8 (n)
Tektin-A 32
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007334 30
  • 46.8 (n)
worm
(Caenorhabditis elegans)
Secernentea R02E12.4 30
  • 41.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9917 31
  • 56 (a)
OneToOne
Species where no ortholog for TEKT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEKT1 Gene

ENSEMBL:
Gene Tree for TEKT1 (if available)
TreeFam:
Gene Tree for TEKT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEKT1: view image

Paralogs for TEKT1 Gene

Paralogs for TEKT1 Gene

(5) SIMAP similar genes for TEKT1 Gene using alignment to 5 proteins:

  • TEKT1_HUMAN
  • F5GZX2_HUMAN
  • I3L122_HUMAN
  • I3L357_HUMAN
  • I3L3D4_HUMAN
genes like me logo Genes that share paralogs with TEKT1: view

Variants for TEKT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEKT1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs2271233 - p.Val332Ile
rs34431552 - p.Ile146Val
rs3744395 - p.Arg254Cys

Additional dbSNP identifiers (rs#s) for TEKT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEKT1 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2761942 CNV gain 21179565
esv3572387 CNV gain 25503493
esv3639846 CNV loss 21293372
nsv1059072 CNV loss 25217958

Variation tolerance for TEKT1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.48; 88.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEKT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEKT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEKT1 Gene

Disorders for TEKT1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TEKT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kartagener syndrome
  • kartagener's syndrome
epilepsy, myoclonic juvenile
  • ejm
primary ciliary dyskinesia
  • pcd
- elite association - COSMIC cancer census association via MalaCards
Search TEKT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEKT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TEKT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEKT1 Gene

Publications for TEKT1 Gene

  1. Cloning and characterization of a novel human TEKTIN1 gene. (PMID: 11606253) Xu M … Mao Y (The international journal of biochemistry & cell biology 2001) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. (PMID: 20442750) Newby PR … Gough SC (European journal of human genetics : EJHG 2010) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 54

Products for TEKT1 Gene

Sources for TEKT1 Gene