This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyro... See more...

Aliases for TEF Gene

Aliases for TEF Gene

  • TEF Transcription Factor, PAR BZIP Family Member 2 3 5
  • Thyrotroph Embryonic Factor 2 3 4
  • TEF, PAR BZIP Transcription Factor 2 3
  • Thyrotrophic Embryonic Factor 2 3
  • KIAA1655 4

External Ids for TEF Gene

Previous GeneCards Identifiers for TEF Gene

  • GC22P038392
  • GC22P040006
  • GC22P040021
  • GC22P040102
  • GC22P041763
  • GC22P024729

Summaries for TEF Gene

Entrez Gene Summary for TEF Gene

  • This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for TEF Gene

TEF (TEF Transcription Factor, PAR BZIP Family Member) is a Protein Coding gene. Diseases associated with TEF include Esophageal Atresia/Tracheoesophageal Fistula and Tracheomalacia. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HLF.

UniProtKB/Swiss-Prot Summary for TEF Gene

  • Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.

Gene Wiki entry for TEF Gene

Additional gene information for TEF Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEF Gene

Genomics for TEF Gene

GeneHancer (GH) Regulatory Elements for TEF Gene

Promoters and enhancers for TEF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEF on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEF

Top Transcription factor binding sites by QIAGEN in the TEF gene promoter:
  • AhR
  • AP-1
  • C/EBPalpha
  • CREB
  • p53

Genomic Locations for TEF Gene

Genomic Locations for TEF Gene
chr22:41,367,333-41,399,328
(GRCh38/hg38)
Size:
31,996 bases
Orientation:
Plus strand
chr22:41,763,337-41,795,330
(GRCh37/hg19)
Size:
31,994 bases
Orientation:
Plus strand

Genomic View for TEF Gene

Genes around TEF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEF Gene

Proteins for TEF Gene

  • Protein details for TEF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10587-TEF_HUMAN
    Recommended name:
    Thyrotroph embryonic factor
    Protein Accession:
    Q10587
    Secondary Accessions:
    • B0QYS8
    • B2RC22
    • Q15729
    • Q7Z3J7
    • Q8IU94
    • Q96TG4

    Protein attributes for TEF Gene

    Size:
    303 amino acids
    Molecular mass:
    33248 Da
    Quaternary structure:
    • Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP.
    SequenceCaution:
    • Sequence=AAA81373.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TEF Gene

    Alternative splice isoforms for TEF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEF Gene

Post-translational modifications for TEF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEF Gene

No data available for DME Specific Peptides for TEF Gene

Domains & Families for TEF Gene

Gene Families for TEF Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TEF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEF Gene

GenScript: Design optimal peptide antigens:
  • Thyrotrophic embryonic factor (B0QYS9_HUMAN)
  • Thyrotrophic embryonic factor (E0ZS57_HUMAN)
  • Thyrotroph embryonic factor (TEF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q10587

UniProtKB/Swiss-Prot:

TEF_HUMAN :
  • Belongs to the bZIP family. PAR subfamily.
Family:
  • Belongs to the bZIP family. PAR subfamily.
genes like me logo Genes that share domains with TEF: view

Function for TEF Gene

Molecular function for TEF Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.
UniProtKB/Swiss-Prot Induction:
Accumulates according to a robust circadian rhythm.
GENATLAS Biochemistry:
thyrotroph embryonic factor,accumulating in liver and kidney,according to a robust circadian rythm

Phenotypes From GWAS Catalog for TEF Gene

Gene Ontology (GO) - Molecular Function for TEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with TEF: view
genes like me logo Genes that share phenotypes with TEF: view

Animal Models for TEF Gene

MGI Knock Outs for TEF:
  • Tef Tef<tm1Schb>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEF Gene

Localization for TEF Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEF Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEF gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,IEA 21873635
genes like me logo Genes that share ontologies with TEF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEF Gene

Pathways & Interactions for TEF Gene

PathCards logo

SuperPathways for TEF Gene

No Data Available

SIGNOR curated interactions for TEF Gene

Other effect:

Gene Ontology (GO) - Biological Process for TEF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS,IEA 7835883
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with TEF: view

No data available for Pathways by source for TEF Gene

Drugs & Compounds for TEF Gene

(1) Drugs for TEF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TEF: view

Transcripts for TEF Gene

mRNA/cDNA for TEF Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEF Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for TEF Gene

GeneLoc Exon Structure for
TEF

Expression for TEF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TEF Gene

This gene is overexpressed in Heart (62.0) and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TEF Gene



Protein tissue co-expression partners for TEF Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEF

SOURCE GeneReport for Unigene cluster for TEF Gene:

Hs.181159

Evidence on tissue expression from TISSUES for TEF Gene

  • Nervous system(4.9)
  • Kidney(4.4)
  • Eye(4.2)
  • Muscle(2.5)
  • Lung(2.4)
  • Heart(2.1)
  • Thyroid gland(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with TEF: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEF Gene

Orthologs for TEF Gene

This gene was present in the common ancestor of animals.

Orthologs for TEF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEF 31 30
  • 99.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TEF 31 30
  • 92.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TEF 31 30
  • 92.3 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEF 31
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tef 17 31 30
  • 91.14 (n)
rat
(Rattus norvegicus)
Mammalia Tef 30
  • 90.7 (n)
oppossum
(Monodelphis domestica)
Mammalia TEF 31
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEF 31 30
  • 76.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEF 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tef 30
  • 66.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia tef-prov 30
zebrafish
(Danio rerio)
Actinopterygii tefb 31 30
  • 63.45 (n)
OneToMany
tefa 31
  • 55 (a)
OneToMany
tef 30
fruit fly
(Drosophila melanogaster)
Insecta Pdp1 31
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6834 31
  • 10 (a)
OneToMany
Species where no ortholog for TEF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEF Gene

ENSEMBL:
Gene Tree for TEF (if available)
TreeFam:
Gene Tree for TEF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEF: view image

Paralogs for TEF Gene

Paralogs for TEF Gene

(2) SIMAP similar genes for TEF Gene using alignment to 4 proteins:

  • TEF_HUMAN
  • E0ZS57_HUMAN
  • H0Y797_HUMAN
  • L8E7U2_HUMAN
genes like me logo Genes that share paralogs with TEF: view

Variants for TEF Gene

Additional dbSNP identifiers (rs#s) for TEF Gene

Structural Variations from Database of Genomic Variants (DGV) for TEF Gene

Variant ID Type Subtype PubMed ID
esv3647796 CNV loss 21293372
nsv459888 CNV gain 19166990
nsv516925 CNV loss 19592680
nsv524585 CNV loss 19592680
nsv589050 CNV gain 21841781
nsv834207 CNV loss 17160897
nsv834208 CNV loss 17160897

Variation tolerance for TEF Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEF Gene

Human Gene Mutation Database (HGMD)
TEF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEF Gene

Disorders for TEF Gene

MalaCards: The human disease database

(37) MalaCards diseases for TEF Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
esophageal atresia/tracheoesophageal fistula
  • esophageal atresia with or without tracheoesophageal fistula
tracheomalacia
  • congenital tracheomalacia
tracheal disease
  • tracheal anomaly
fusariosis
  • fusarium infection
pancreas, annular
  • annular pancreas
- elite association - COSMIC cancer census association via MalaCards
Search TEF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEF

genes like me logo Genes that share disorders with TEF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEF Gene

Publications for TEF Gene

  1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PMID: 7835883) Khatib ZA … Look AT (Genomics 1994) 2 3 4 23 54
  2. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. (PMID: 8639829) Hunger SP … Cleary ML (Blood 1996) 3 4 23 54
  3. TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors. (PMID: 15665112) Inukai T … Nakazawa S (Blood 2005) 2 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for TEF Gene

Sources for TEF Gene