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Aliases for TECPR1 Gene

Aliases for TECPR1 Gene

  • Tectonin Beta-Propeller Repeat Containing 1 2 3 5
  • KIAA1358 4

External Ids for TECPR1 Gene

Previous GeneCards Identifiers for TECPR1 Gene

  • GC07M097684
  • GC07M097843
  • GC07M092446

Summaries for TECPR1 Gene

Entrez Gene Summary for TECPR1 Gene

  • This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]

GeneCards Summary for TECPR1 Gene

TECPR1 (Tectonin Beta-Propeller Repeat Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot for TECPR1 Gene

  • Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.

Additional gene information for TECPR1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TECPR1 Gene

Genomics for TECPR1 Gene

GeneHancer (GH) Regulatory Elements for TECPR1 Gene

Promoters and enhancers for TECPR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I098248 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.5 1517 4.7 PKNOX1 CLOCK ARID4B SIN3A DMAP1 ZNF2 ZBTB7B E2F8 ZNF143 FOS BRI3 TECPR1 ENSG00000272950 BHLHA15 BAIAP2L1 LOC100419643 TRRAP PIR62558
GH07I098210 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 7.5 +39.3 39300 4.7 MLX ARID4B DMAP1 ZNF48 TCF12 ZNF121 GLIS2 FOS RXRA SP5 BHLHA15 GC07P098214 PIR48900 PIR62558 ENSG00000272950 TECPR1 LMTK2
GH07I098163 Enhancer 1 Ensembl ENCODE 13 +88.0 87993 2.3 PKNOX1 INSM2 MZF1 FEZF1 RAD21 ZNF366 ZSCAN5C SCRT2 RCOR1 IKZF2 LMTK2 TECPR1 GC07M098146 PIR34704
GH07I098293 Enhancer 1 ENCODE dbSUPER 11.6 -42.6 -42599 3 HDGF RB1 ARID4B KLF17 SIN3A GLI4 ZNF2 RAD21 GLIS2 ARID2 ENSG00000272950 BRI3 TECPR1 BHLHA15 BAIAP2L1
GH07I098202 Enhancer 1 Ensembl ENCODE 11.5 +49.3 49313 1.5 BMI1 BATF KLF5 IRF4 SCRT2 ZNF207 ZNF143 ATF7 ETV6 BCLAF1 LMTK2 TECPR1 BRI3 BHLHA15 PIR34704
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TECPR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TECPR1 gene promoter:

Genomic Locations for TECPR1 Gene

Genomic Locations for TECPR1 Gene
chr7:98,214,624-98,252,251
(GRCh38/hg38)
Size:
37,628 bases
Orientation:
Minus strand
chr7:97,843,936-97,881,563
(GRCh37/hg19)

Genomic View for TECPR1 Gene

Genes around TECPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TECPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TECPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TECPR1 Gene

Proteins for TECPR1 Gene

  • Protein details for TECPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6L1-TCPR1_HUMAN
    Recommended name:
    Tectonin beta-propeller repeat-containing protein 1
    Protein Accession:
    Q7Z6L1
    Secondary Accessions:
    • A8KAD1
    • B3KPZ1
    • C9J024
    • F5GX57
    • Q96EB0
    • Q9P2I9
    • Q9UFR6

    Protein attributes for TECPR1 Gene

    Size:
    1165 amino acids
    Molecular mass:
    129696 Da
    Quaternary structure:
    • Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.

    Three dimensional structures from OCA and Proteopedia for TECPR1 Gene

    Alternative splice isoforms for TECPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TECPR1 Gene

Post-translational modifications for TECPR1 Gene

No Post-translational modifications

Other Protein References for TECPR1 Gene

No data available for DME Specific Peptides for TECPR1 Gene

Domains & Families for TECPR1 Gene

Gene Families for TECPR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TECPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6L1

UniProtKB/Swiss-Prot:

TCPR1_HUMAN :
  • The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). While full-length protein is unable to bind PtdIns(3)P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns(3)P (PubMed:22342342).
  • Belongs to the TECPR1 family.
Domain:
  • The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). While full-length protein is unable to bind PtdIns(3)P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns(3)P (PubMed:22342342).
Family:
  • Belongs to the TECPR1 family.
genes like me logo Genes that share domains with TECPR1: view

Function for TECPR1 Gene

Molecular function for TECPR1 Gene

UniProtKB/Swiss-Prot Function:
Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.

Phenotypes From GWAS Catalog for TECPR1 Gene

Gene Ontology (GO) - Molecular Function for TECPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
GO:0008289 lipid binding IEA --
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 22342342
genes like me logo Genes that share ontologies with TECPR1: view

Phenotypes for TECPR1 Gene

genes like me logo Genes that share phenotypes with TECPR1: view

Animal Models for TECPR1 Gene

MGI Knock Outs for TECPR1:

Animal Model Products

miRNA for TECPR1 Gene

miRTarBase miRNAs that target TECPR1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TECPR1 Gene

Localization for TECPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TECPR1 Gene

Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TECPR1 gene
Compartment Confidence
nucleus 5
lysosome 5
plasma membrane 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TECPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IDA 21575909
GO:0005654 nucleoplasm IDA --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IDA,IEA 22342342
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TECPR1: view

Pathways & Interactions for TECPR1 Gene

SuperPathways for TECPR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TECPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IDA,IEA 21575909
GO:0097352 autophagosome maturation IMP 22342342
genes like me logo Genes that share ontologies with TECPR1: view

No data available for Pathways by source and SIGNOR curated interactions for TECPR1 Gene

Drugs & Compounds for TECPR1 Gene

No Compound Related Data Available

Transcripts for TECPR1 Gene

Unigene Clusters for TECPR1 Gene

Tectonin beta-propeller repeat containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TECPR1 Gene

No ASD Table

Relevant External Links for TECPR1 Gene

GeneLoc Exon Structure for
TECPR1
ECgene alternative splicing isoforms for
TECPR1

Expression for TECPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TECPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TECPR1 Gene

This gene is overexpressed in Pancreas (x8.3).

Protein differential expression in normal tissues from HIPED for TECPR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2), Frontal cortex (9.4), Liver, secretome (9.3), and Lymph node (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TECPR1 Gene



Protein tissue co-expression partners for TECPR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TECPR1 Gene:

TECPR1

SOURCE GeneReport for Unigene cluster for TECPR1 Gene:

Hs.592281

Evidence on tissue expression from TISSUES for TECPR1 Gene

  • Nervous system(4.6)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with TECPR1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TECPR1 Gene

Orthologs for TECPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TECPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TECPR1 33 34
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia TECPR1 33 34
  • 87.43 (n)
cow
(Bos Taurus)
Mammalia TECPR1 33
  • 86.61 (n)
mouse
(Mus musculus)
Mammalia Tecpr1 33 16 34
  • 84.7 (n)
rat
(Rattus norvegicus)
Mammalia Tecpr1 33
  • 84.41 (n)
oppossum
(Monodelphis domestica)
Mammalia TECPR1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TECPR1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TECPR1 33 34
  • 71.08 (n)
lizard
(Anolis carolinensis)
Reptilia TECPR1 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tecpr1 33
  • 67.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9912 33
zebrafish
(Danio rerio)
Actinopterygii tecpr1a 33 34
  • 66.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pex23 33 34
  • 52.43 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GALE3 33
  • 51.15 (n)
worm
(Caenorhabditis elegans)
Secernentea T01H3.2 34
  • 23 (a)
OneToOne
Species where no ortholog for TECPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TECPR1 Gene

ENSEMBL:
Gene Tree for TECPR1 (if available)
TreeFam:
Gene Tree for TECPR1 (if available)

Paralogs for TECPR1 Gene

No data available for Paralogs for TECPR1 Gene

Variants for TECPR1 Gene

Sequence variations from dbSNP and Humsavar for TECPR1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000104157 -- 98,245,239(-) A/C intron_variant
rs1000189366 -- 98,242,028(-) T/C intron_variant
rs1000191248 -- 98,230,065(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000272864 -- 98,245,019(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000360363 -- 98,215,339(-) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TECPR1 Gene

Variant ID Type Subtype PubMed ID
nsv951376 CNV deletion 24416366
nsv831067 CNV loss 17160897
nsv831066 CNV loss 17160897
nsv525934 CNV loss 19592680
nsv512916 CNV insertion 21212237
esv3614252 CNV loss 21293372
esv3614250 CNV gain 21293372
esv3614249 CNV loss 21293372

Variation tolerance for TECPR1 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TECPR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TECPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TECPR1 Gene

Disorders for TECPR1 Gene

Additional Disease Information for TECPR1

No disorders were found for TECPR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TECPR1 Gene

Publications for TECPR1 Gene

  1. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. (PMID: 22342342) Chen D … Zhong Q (Molecular cell 2012) 3 4 58
  2. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. (PMID: 21575909) Ogawa M … Sasakawa C (Cell host & microbe 2011) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58

Products for TECPR1 Gene

Sources for TECPR1 Gene

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