The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation o... See more...

Aliases for TEC Gene

Aliases for TEC Gene

  • Tec Protein Tyrosine Kinase 2 3 5
  • Tyrosine-Protein Kinase Tec 3 4
  • EC 2.7.10.2 4 54
  • PSCTK4 3 4
  • EC 2.7.10 54

External Ids for TEC Gene

Previous GeneCards Identifiers for TEC Gene

  • GC04M048214
  • GC04M048447
  • GC04M047987
  • GC04M048053
  • GC04M047978
  • GC04M047832
  • GC04M047457

Summaries for TEC Gene

Entrez Gene Summary for TEC Gene

  • The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEC Gene

TEC (Tec Protein Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TEC include Transient Erythroblastopenia Of Childhood and Agammaglobulinemia. Among its related pathways are Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway and Prolactin Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ITK.

UniProtKB/Swiss-Prot Summary for TEC Gene

  • Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.

Gene Wiki entry for TEC Gene

Additional gene information for TEC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEC Gene

Genomics for TEC Gene

GeneHancer (GH) Regulatory Elements for TEC Gene

Promoters and enhancers for TEC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J048267 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 767.2 +0.3 281 4.1 ZBTB40 CTCF RBPJ SMARCE1 POLR2A USF2 MYC CC2D1A ETV6 ELF1 TEC SLAIN2 HSALNG0034277 LOC105374445 piR-46391-006
GH04J048336 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 14.1 -71.0 -70963 8 ZNF785 SP1 ZBTB40 CTCF FOXA1 SMARCE1 POLR2A NR2F6 ZNF362 MYC SLAIN2 lnc-TEC-2 TEC ZAR1 TXK SLC10A4 lnc-TEC-1
GH04J048225 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 25.2 +43.2 43237 6.8 SMARCE1 HLF MAX TEAD4 CBFA2T2 ZNF687 SMARCA4 POLR2A CTBP1 RUNX3 TEC TXK SLAIN2 NFXL1 CNGA1 piR-46391-006
GH04J048242 Enhancer 1 Ensembl dbSUPER 27.1 +27.2 27237 4.4 SMARCE1 CC2D1A L3MBTL2 DACH1 TEAD4 ZNF148 GTF2F1 MAFK CBFA2T2 SMARCA4 TEC TXK OCIAD1 ATP10D piR-46391-006
GH04J048830 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.9 -561.9 -561916 3.1 SP1 ZBTB40 FOXA1 SMARCE1 POLR2A ATF1 CREB1 HCFC1 CC2D1A L3MBTL2 OCIAD1 NONHSAG037899.2 NFXL1 TEC SLAIN2 OCIAD2 OCIAD1-AS1 piR-56497-119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEC gene promoter:
  • Arnt
  • E47
  • FOXD3
  • HNF-3beta
  • MRF-2
  • POU2F1
  • POU2F1a
  • PPAR-alpha
  • SEF-1 (1)
  • SRY

Genomic Locations for TEC Gene

Genomic Locations for TEC Gene
chr4:48,135,783-48,269,838
(GRCh38/hg38)
Size:
134,056 bases
Orientation:
Minus strand
chr4:48,137,800-48,271,881
(GRCh37/hg19)
Size:
134,082 bases
Orientation:
Minus strand

Genomic View for TEC Gene

Genes around TEC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEC Gene

Proteins for TEC Gene

  • Protein details for TEC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42680-TEC_HUMAN
    Recommended name:
    Tyrosine-protein kinase Tec
    Protein Accession:
    P42680
    Secondary Accessions:
    • B7ZKZ6
    • Q3MIS5

    Protein attributes for TEC Gene

    Size:
    631 amino acids
    Molecular mass:
    73581 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with CD28, FASLG, FGF2, GRB10, LYN and KIT. Interacts with VAV1 and JAK2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for TEC Gene

neXtProt entry for TEC Gene

Selected DME Specific Peptides for TEC Gene

P42680:
  • SSKSDVWSFGVLMWE
  • RDLAARN
  • SDVWSFGVLMWE
  • PIYIVTE
  • LVQLYGVC
  • KSDVWSFG
  • YYLAEKH

Post-translational modifications for TEC Gene

  • Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-519. Undergoes also tyrosine phosphorylation during platelet activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEC Gene

Domains & Families for TEC Gene

Gene Families for TEC Gene

Suggested Antigen Peptide Sequences for TEC Gene

GenScript: Design optimal peptide antigens:
  • Protein tyrosine kinase (Q14219_HUMAN)
  • Tyrosine-protein kinase Tec (TEC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42680

UniProtKB/Swiss-Prot:

TEC_HUMAN :
  • The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its targeting to the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Domain:
  • The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its targeting to the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain.
  • The SH3 domain is essential for its targeting to activated CD28 costimulatory molecule.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
genes like me logo Genes that share domains with TEC: view

Function for TEC Gene

Molecular function for TEC Gene

UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by tyrosine phosphorylation by a wide range of cytokine stimulations. When T-cells or B-cells receptors are activated, a series of phosphorylation leads to the recruitment of TEC to the cell membrane, where it is phosphorylated at Tyr-519. Also activated in response to SCF. Integrin engagement induces tyrosine phosphorylation of TEC in platelets. STAP1 participates in a positive feedback loop by increasing the activity of TEC. SOCS1 is an inhibitor of TEC kinase activity.
GENATLAS Biochemistry:
Tec non receptor protein tyrosine kinase,73.6kDa

Enzyme Numbers (IUBMB) for TEC Gene

Phenotypes From GWAS Catalog for TEC Gene

Gene Ontology (GO) - Molecular Function for TEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA,TAS 10518561
GO:0005515 protein binding IPI 8892607
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TEC: view
genes like me logo Genes that share phenotypes with TEC: view

Animal Models for TEC Gene

MGI Knock Outs for TEC:
  • Tec Tec<tm1Welm>

Animal Model Products

CRISPR Products

miRNA for TEC Gene

miRTarBase miRNAs that target TEC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEC

Clone Products

  • Addgene plasmids for TEC

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEC Gene

Localization for TEC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEC Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEC gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 2
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA,IDA 9299487
GO:0005886 plasma membrane IDA,IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TEC: view

Pathways & Interactions for TEC Gene

genes like me logo Genes that share pathways with TEC: view

Pathways by source for TEC Gene

1 GeneGo (Thomson Reuters) pathway for TEC Gene
6 Qiagen pathways for TEC Gene
  • CD28 Signaling in T-Helper Cell
  • G12-G13 in Cellular Signaling
  • ICos-ICosL Pathway in T-Helper Cell
  • PI3K Signaling in B-Lymphocyte
  • Tec Kinases Signaling
2 Cell Signaling Technology pathways for TEC Gene

SIGNOR curated interactions for TEC Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation TAS,IEA 7934162
GO:0007229 integrin-mediated signaling pathway IDA,IBA 9652744
GO:0010543 regulation of platelet activation IBA,IDA 9299487
genes like me logo Genes that share ontologies with TEC: view

Drugs & Compounds for TEC Gene

(8) Drugs for TEC Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(5) Additional Compounds for TEC Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with TEC: view

Transcripts for TEC Gene

mRNA/cDNA for TEC Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEC

Clone Products

  • Addgene plasmids for TEC

Alternative Splicing Database (ASD) splice patterns (SP) for TEC Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - -
SP2:
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for TEC Gene

GeneLoc Exon Structure for
TEC
ECgene alternative splicing isoforms for
TEC

Expression for TEC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TEC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TEC Gene



Protein tissue co-expression partners for TEC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TEC Gene:

TEC

SOURCE GeneReport for Unigene cluster for TEC Gene:

Hs.479670

mRNA Expression by UniProt/SwissProt for TEC Gene:

P42680-TEC_HUMAN
Tissue specificity: Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages.

Evidence on tissue expression from TISSUES for TEC Gene

  • Blood(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TEC: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEC Gene

Orthologs for TEC Gene

This gene was present in the common ancestor of animals.

Orthologs for TEC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEC 33 32
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TEC 33 32
  • 92.02 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TEC 33 32
  • 91.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tec 17 33 32
  • 88.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TEC 33
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tec 32
  • 87.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TEC 33
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TEC 33 32
  • 78.72 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEC 33
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tec 32
  • 73.6 (n)
zebrafish
(Danio rerio)
Actinopterygii tec 33 32
  • 65.99 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13650 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008317 32
  • 55.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta Btk29A 33 34 32
  • 52.72 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spe-8 34
  • 32 (a)
F22B3.8 34
  • 28 (a)
kin-24 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1818 33
  • 43 (a)
ManyToMany
-- 33
  • 34 (a)
ManyToMany
Species where no ortholog for TEC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEC Gene

ENSEMBL:
Gene Tree for TEC (if available)
TreeFam:
Gene Tree for TEC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEC: view image

Paralogs for TEC Gene

(24) SIMAP similar genes for TEC Gene using alignment to 3 proteins:

  • TEC_HUMAN
  • D6RB05_HUMAN
  • D6RB75_HUMAN

Pseudogenes.org Pseudogenes for TEC Gene

genes like me logo Genes that share paralogs with TEC: view

Variants for TEC Gene

Sequence variations from dbSNP and Humsavar for TEC Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
VAR_041851 A lung adenocarcinoma sample p.Arg563Lys
rs1000047218 -- 48,248,700(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000050915 -- 48,148,519(-) T/G intron_variant
rs10000735 -- 48,186,953(-) C/T intron_variant
rs1000169638 -- 48,148,898(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TEC Gene

Variant ID Type Subtype PubMed ID
dgv5203n100 CNV loss 25217958
esv275189 CNV loss 21479260
esv2763359 CNV gain 21179565
nsv1006853 CNV gain 25217958
nsv1114520 CNV deletion 24896259
nsv4329 CNV deletion 18451855
nsv461357 CNV gain 19166990
nsv461358 CNV loss 19166990
nsv470032 CNV gain 18288195
nsv509003 CNV insertion 20534489
nsv594119 CNV gain 21841781
nsv594120 CNV loss 21841781
nsv819666 CNV loss 19587683
nsv819982 CNV loss 19587683
nsv820308 CNV loss 19587683

Variation tolerance for TEC Gene

Residual Variation Intolerance Score: 10.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEC Gene

Disorders for TEC Gene

MalaCards: The human disease database

(2) MalaCards diseases for TEC Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
transient erythroblastopenia of childhood
  • tec
agammaglobulinemia
  • hypogammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards
Search TEC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
genes like me logo Genes that share disorders with TEC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEC Gene

Publications for TEC Gene

  1. Molecular cloning and analysis of the human Tec protein-tyrosine kinase. (PMID: 7934162) Sato K … Hirai H (Leukemia 1994) 2 3 4 23 56
  2. Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte. (PMID: 19883687) Susaki K … Ishida T (Immunology letters 2010) 3 4 23 56
  3. SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. (PMID: 15492005) Tomlinson MG … Weiss A (The Journal of biological chemistry 2004) 3 4 23 56
  4. Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. (PMID: 12573241) Nore BF … Smith CI (Biochimica et biophysica acta 2003) 3 4 23 56
  5. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. (PMID: 10518561) Ohya K … Mano H (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 23 56

Products for TEC Gene

Sources for TEC Gene