This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct... See more...

Aliases for TEAD4 Gene

Aliases for TEAD4 Gene

  • TEA Domain Transcription Factor 4 2 3 5
  • TEA Domain Family Member 4 2 3 4
  • Transcriptional Enhancer Factor TEF-3 3 4
  • Transcription Factor 13-Like 1 3 4
  • Transcription Factor RTEF-1 3 4
  • TCF13L1 3 4
  • EFTR-2 2 3
  • TEFR-1 2 3
  • RTEF1 3 4
  • TEF-3 2 3
  • TEF3 3 4
  • Transcriptional Enhancer Factor 1-Related 3
  • Related Transcription Enhancer Factor 1B 3
  • Transcriptional Enhancer Factor 3 3
  • HRTEF-1B 3
  • RTEF-1 2
  • TEAD-4 4
  • TEAD4 5

External Ids for TEAD4 Gene

Previous HGNC Symbols for TEAD4 Gene

  • TCF13L1

Previous GeneCards Identifiers for TEAD4 Gene

  • GC12U990098
  • GC12M123588
  • GC12P002947
  • GC12P002938
  • GC12P003068

Summaries for TEAD4 Gene

Entrez Gene Summary for TEAD4 Gene

  • This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEAD4 Gene

TEAD4 (TEA Domain Transcription Factor 4) is a Protein Coding gene. Diseases associated with TEAD4 include Sveinsson Chorioretinal Atrophy and Atypical Teratoid Rhabdoid Tumor. Among its related pathways are Preimplantation Embryo and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is TEAD1.

UniProtKB/Swiss-Prot Summary for TEAD4 Gene

  • Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

Gene Wiki entry for TEAD4 Gene

Additional gene information for TEAD4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEAD4 Gene

Genomics for TEAD4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TEAD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J002957 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +0.7 671 4.4 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 TFE3 IKZF1 ZNF692 ZNF7 FOXA1 TEAD4 lnc-FOXM1-2 ITFG2 DCP1B TULP3 ENSG00000250899 TSPAN9
GH12J002997 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +40.2 40168 3.3 CTCF PRDM10 IKZF1 ZNF692 JUND ZIC2 PKNOX1 PATZ1 POLR2A DPF2 TEAD4 RNU6-1315P ITFG2 lnc-FOXM1-2 ENSG00000250899 TSPAN9
GH12J003001 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.5 +44.3 44337 3.4 CTCF ZFHX2 POLR2A ZNF146 SMARCA4 EGR2 TEAD4 RNU6-1315P NRIP2 ITFG2 ENSG00000250899 lnc-FOXM1-2 TSPAN9
GH12J002980 Enhancer 0.8 Ensembl ENCODE dbSUPER 7 +23.0 22987 2.9 ZNF10 RBM22 ZFHX2 CTCF DACH1 NRIP2 FOXM1 RHNO1 TULP3 ITFG2 ENSG00000250899 TEAD4 lnc-FOXM1-2 TSPAN9
GH12J002990 Enhancer 0.4 dbSUPER 12 +32.7 32747 3.6 SCRT2 RBM22 ESRRA TEAD4 RNU6-1315P NRIP2 TSPAN9 TULP3 FOXM1 RHNO1 ITFG2 lnc-FOXM1-2 ENSG00000250899
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEAD4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEAD4

Top Transcription factor binding sites by QIAGEN in the TEAD4 gene promoter:
  • FOXL1
  • HNF-4alpha1
  • IRF-7A
  • NRSF form 1
  • Pax-2
  • Pax-2a

Genomic Locations for TEAD4 Gene

Genomic Locations for TEAD4 Gene
chr12:2,959,330-3,040,676
(GRCh38/hg38)
Size:
81,347 bases
Orientation:
Plus strand
chr12:3,068,478-3,149,842
(GRCh37/hg19)
Size:
81,365 bases
Orientation:
Plus strand

Genomic View for TEAD4 Gene

Genes around TEAD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEAD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEAD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEAD4 Gene

Proteins for TEAD4 Gene

  • Protein details for TEAD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15561-TEAD4_HUMAN
    Recommended name:
    Transcriptional enhancer factor TEF-3
    Protein Accession:
    Q15561
    Secondary Accessions:
    • H0Y308
    • Q6MZR9
    • Q8NEV5
    • Q92883
    • Q96BK2

    Protein attributes for TEAD4 Gene

    Size:
    434 amino acids
    Molecular mass:
    48329 Da
    Quaternary structure:
    • Interacts with YAP1 and WWTR1/TAZ.
    SequenceCaution:
    • Sequence=CAA64212.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TEAD4 Gene

    Alternative splice isoforms for TEAD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEAD4 Gene

Post-translational modifications for TEAD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEAD4 Gene

Domains & Families for TEAD4 Gene

Gene Families for TEAD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TEAD4 Gene

InterPro:
Blocks:
  • TEA/ATTS family
ProtoNet:

Suggested Antigen Peptide Sequences for TEAD4 Gene

GenScript: Design optimal peptide antigens:
  • TEA domain family member 4, isoform CRA_b (D3DUQ6_HUMAN)
  • Transcription factor RTEF-1 (TEAD4_HUMAN)
genes like me logo Genes that share domains with TEAD4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEAD4 Gene

Function for TEAD4 Gene

Molecular function for TEAD4 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
GENATLAS Biochemistry:
SV40-transcriptional enhancer factor 4 (TEF4)

Phenotypes From GWAS Catalog for TEAD4 Gene

Gene Ontology (GO) - Molecular Function for TEAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001085 RNA polymerase II transcription factor binding IBA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TEAD4: view
genes like me logo Genes that share phenotypes with TEAD4: view

Animal Models for TEAD4 Gene

MGI Knock Outs for TEAD4:

Animal Model Products

CRISPR Products

Targeted motifs for TEAD4 Gene
HOMER Transcription Factor Regulatory Elements motif TEAD4
  • Consensus sequence: CCWGGAATGY Submotif: canonical Cell Type: Tropoblast GEO ID: GSE37350

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEAD4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TEAD4 Gene

Localization for TEAD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEAD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEAD4 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TEAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IDA 25796446
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IBA 21873635
genes like me logo Genes that share ontologies with TEAD4: view

Pathways & Interactions for TEAD4 Gene

genes like me logo Genes that share pathways with TEAD4: view

Pathways by source for TEAD4 Gene

7 Qiagen pathways for TEAD4 Gene
  • Epithelial Adherens Junctions
  • Factors Promoting Cardiogenesis in Vertebrates
  • Human Embryonic Stem Cell Pluripotency
  • ILK Signaling
  • JNK Pathway
1 Cell Signaling Technology pathway for TEAD4 Gene

SIGNOR curated interactions for TEAD4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TEAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 8921372
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TEAD4: view

Drugs & Compounds for TEAD4 Gene

No Compound Related Data Available

Transcripts for TEAD4 Gene

mRNA/cDNA for TEAD4 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEAD4

Alternative Splicing Database (ASD) splice patterns (SP) for TEAD4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - - -
SP6:
SP7: -
SP8: - -

Relevant External Links for TEAD4 Gene

GeneLoc Exon Structure for
TEAD4

Expression for TEAD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEAD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEAD4 Gene

This gene is overexpressed in Muscle - Skeletal (x10.7) and Pancreas (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TEAD4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEAD4

SOURCE GeneReport for Unigene cluster for TEAD4 Gene:

Hs.94865

mRNA Expression by UniProt/SwissProt for TEAD4 Gene:

Q15561-TEAD4_HUMAN
Tissue specificity: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Evidence on tissue expression from TISSUES for TEAD4 Gene

  • Heart(4.4)
  • Muscle(2.9)
  • Lung(2.3)
  • Skin(2.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with TEAD4: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEAD4 Gene

Orthologs for TEAD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEAD4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TEAD4 30 31
  • 99.35 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TEAD4 31
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TEAD4 30 31
  • 93.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TEAD4 30 31
  • 90.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tead4 30
  • 88.86 (n)
Mouse
(Mus musculus)
Mammalia Tead4 30 17 31
  • 88.84 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TEAD4 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TEAD4 30 31
  • 78.6 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tead4 30
  • 70.25 (n)
Zebrafish
(Danio rerio)
Actinopterygii CABZ01090021.1 31
  • 81 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5943 30
Fruit Fly
(Drosophila melanogaster)
Insecta sd 31 32
  • 43 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea egl-44 31 32
  • 37 (a)
OneToMany
Species where no ortholog for TEAD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TEAD4 Gene

ENSEMBL:
Gene Tree for TEAD4 (if available)
TreeFam:
Gene Tree for TEAD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEAD4: view image

Paralogs for TEAD4 Gene

Paralogs for TEAD4 Gene

(3) SIMAP similar genes for TEAD4 Gene using alignment to 8 proteins:

  • TEAD4_HUMAN
  • D3DUQ6_HUMAN
  • H0Y7B0_HUMAN
  • H0YFF9_HUMAN
  • H0YFK0_HUMAN
  • H0YG62_HUMAN
  • H0YGS2_HUMAN
  • Q53GI4_HUMAN
genes like me logo Genes that share paralogs with TEAD4: view

Variants for TEAD4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEAD4 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs11550887 - p.Pro323Ser

Additional dbSNP identifiers (rs#s) for TEAD4 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEAD4 Gene

Variant ID Type Subtype PubMed ID
dgv440e212 CNV loss 25503493
dgv441e212 CNV gain 25503493
dgv442e212 CNV gain 25503493
esv2662595 CNV deletion 23128226
esv2673655 CNV deletion 23128226
esv275406 CNV gain+loss 21479260
esv3548643 CNV deletion 23714750
esv3580073 CNV loss 25503493
esv3628329 CNV gain 21293372
esv3628331 CNV gain 21293372
esv3628332 CNV gain 21293372
esv3628333 CNV loss 21293372
esv3628334 CNV loss 21293372
esv3628335 CNV loss 21293372
esv3628336 CNV loss 21293372
nsv1036000 CNV gain 25217958
nsv1136146 CNV deletion 24896259
nsv468974 CNV loss 19166990
nsv468975 CNV loss 19166990
nsv470261 CNV loss 18288195
nsv523615 CNV loss 19592680
nsv528500 CNV loss 19592680
nsv557082 CNV loss 21841781
nsv557083 CNV loss 21841781
nsv832311 CNV loss 17160897

Variation tolerance for TEAD4 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEAD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEAD4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEAD4 Gene

Disorders for TEAD4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TEAD4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sveinsson chorioretinal atrophy
  • scra
atypical teratoid rhabdoid tumor
  • at/rt
narcolepsy
  • narcolepsy, without cataplexy
wilson-turner x-linked mental retardation syndrome
  • wts
meningioma, familial
  • meningioma, familial, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search TEAD4 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TEAD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEAD4 Gene

Publications for TEAD4 Gene

  1. Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family. (PMID: 8921372) Stewart AF … Adra CN (Genomics 1996) 2 3 4
  2. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PMID: 19324877) Zhang H … Guan KL (The Journal of biological chemistry 2009) 3 4
  3. TEAD mediates YAP-dependent gene induction and growth control. (PMID: 18579750) Zhao B … Guan KL (Genes & development 2008) 3 4
  4. Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells. (PMID: 18840614) Liu X … Zeng H (The Journal of biological chemistry 2008) 3 23
  5. Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation. (PMID: 15520314) Chen HH … Stewart AF (Circulation 2004) 3 23

Products for TEAD4 Gene

Sources for TEAD4 Gene