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This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
TEAD4 (TEA Domain Transcription Factor 4) is a Protein Coding gene. Diseases associated with TEAD4 include Sveinsson Chorioretinal Atrophy and Atypical Teratoid Rhabdoid Tumor. Among its related pathways are Preimplantation Embryo and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is TEAD1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001085 | RNA polymerase II transcription factor binding | IBA | -- |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IBA | 21873635 |
GO:0003677 | DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IDA | 25796446 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005667 | transcription factor complex | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
2 | Human Embryonic Stem Cell Pluripotency |
Factors Promoting Cardiogenesis in Vertebrates
.50
|
Human Embryonic Stem Cell Pluripotency
.50
|
3 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
4 | Gene Expression |
.48
|
|
5 | Metabolism |
.40
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001501 | skeletal system development | TAS | -- |
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 8921372 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TEAD4 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TEAD4 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TEAD4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TEAD4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tead4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tead4 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TEAD4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TEAD4 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tead4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CABZ01090021.1 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5943 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | sd 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | egl-44 31 32 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11550887 | - | p.Pro323Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv440e212 | CNV | loss | 25503493 |
dgv441e212 | CNV | gain | 25503493 |
dgv442e212 | CNV | gain | 25503493 |
esv2662595 | CNV | deletion | 23128226 |
esv2673655 | CNV | deletion | 23128226 |
esv275406 | CNV | gain+loss | 21479260 |
esv3548643 | CNV | deletion | 23714750 |
esv3580073 | CNV | loss | 25503493 |
esv3628329 | CNV | gain | 21293372 |
esv3628331 | CNV | gain | 21293372 |
esv3628332 | CNV | gain | 21293372 |
esv3628333 | CNV | loss | 21293372 |
esv3628334 | CNV | loss | 21293372 |
esv3628335 | CNV | loss | 21293372 |
esv3628336 | CNV | loss | 21293372 |
nsv1036000 | CNV | gain | 25217958 |
nsv1136146 | CNV | deletion | 24896259 |
nsv468974 | CNV | loss | 19166990 |
nsv468975 | CNV | loss | 19166990 |
nsv470261 | CNV | loss | 18288195 |
nsv523615 | CNV | loss | 19592680 |
nsv528500 | CNV | loss | 19592680 |
nsv557082 | CNV | loss | 21841781 |
nsv557083 | CNV | loss | 21841781 |
nsv832311 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
sveinsson chorioretinal atrophy |
|
|
atypical teratoid rhabdoid tumor |
|
|
narcolepsy |
|
|
wilson-turner x-linked mental retardation syndrome |
|
|
meningioma, familial |
|
|