TEAD4 Gene (Protein Coding)

TEA Domain Transcription Factor 4

GC12P002959
GIFtS:
41
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct... See more...

Aliases for TEAD4 Gene

Aliases for TEAD4 Gene

  • TEA Domain Transcription Factor 4 2 3 5
  • TEA Domain Family Member 4 2 3 4
  • Transcriptional Enhancer Factor TEF-3 3 4
  • Transcription Factor 13-Like 1 3 4
  • Transcription Factor RTEF-1 3 4
  • TCF13L1 3 4
  • RTEF1 3 4
  • TEF3 3 4
  • Transcriptional Enhancer Factor 1-Related 3
  • Related Transcription Enhancer Factor 1B 3
  • Transcriptional Enhancer Factor 3 3
  • HRTEF-1B 3
  • EFTR-2 3
  • TEFR-1 3
  • TEAD-4 4
  • TEF-3 3

External Ids for TEAD4 Gene

Previous HGNC Symbols for TEAD4 Gene

  • TCF13L1

Previous GeneCards Identifiers for TEAD4 Gene

  • GC12U990098
  • GC12M123588
  • GC12P002947
  • GC12P002938
  • GC12P003068

Summaries for TEAD4 Gene

Entrez Gene Summary for TEAD4 Gene

  • This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEAD4 Gene

TEAD4 (TEA Domain Transcription Factor 4) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is TEAD1.

UniProtKB/Swiss-Prot Summary for TEAD4 Gene

  • Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

Gene Wiki entry for TEAD4 Gene

Additional gene information for TEAD4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEAD4 Gene

Genomics for TEAD4 Gene

GeneHancer (GH) Regulatory Elements for TEAD4 Gene

Promoters and enhancers for TEAD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J002957 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.7 689 4.4 SIN3A POLR2A CTBP1 L3MBTL2 MNT ELF3 AHR TFE3 SP7 ELF1 lnc-FOXM1-2 TEAD4 TULP3 ENSG00000250899
GH12J002997 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +40.2 40186 3.3 SMARCE1 TEAD4 CBFA2T2 SP7 SMARCA4 EGR1 IKZF1 DPF2 GLIS2 ZIC2 TEAD4 RNU6-1315P ITFG2 lnc-FOXM1-2 ENSG00000250899
GH12J003001 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.5 +44.4 44355 3.4 POLR2A ZFHX2 CTCF ZNF146 TEAD4 RNU6-1315P NRIP2 ITFG2 ENSG00000250899 lnc-FOXM1-2
GH12J002980 Enhancer 0.8 Ensembl ENCODE dbSUPER 7 +23.0 23005 2.9 DACH1 ZNF10 ZFHX2 CTCF NRIP2 FOXM1 RHNO1 TULP3 ITFG2 ENSG00000250899 TEAD4 lnc-FOXM1-2
GH12J002974 Enhancer 0.6 ENCODE dbSUPER 6.3 +15.4 15423 1.1 ZBTB6 SP2 SIN3A POLR2A KLF1 ENSG00000250899 TEAD4 lnc-FOXM1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEAD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TEAD4 gene promoter:
  • FOXL1
  • HNF-4alpha1
  • IRF-7A
  • NRSF form 1
  • Pax-2
  • Pax-2a

Genomic Locations for TEAD4 Gene

Genomic Locations for TEAD4 Gene
chr12:2,959,312-3,040,676
(GRCh38/hg38)
Size:
81,365 bases
Orientation:
Plus strand
chr12:3,068,478-3,149,842
(GRCh37/hg19)
Size:
81,365 bases
Orientation:
Plus strand

Genomic View for TEAD4 Gene

Genes around TEAD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEAD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEAD4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TEAD4 Gene

Proteins for TEAD4 Gene

Products:

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  • Protein details for TEAD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15561-TEAD4_HUMAN
    Recommended name:
    Transcriptional enhancer factor TEF-3
    Protein Accession:
    Q15561
    Secondary Accessions:
    • H0Y308
    • Q6MZR9
    • Q8NEV5
    • Q92883
    • Q96BK2

    Protein attributes for TEAD4 Gene

    Size:
    434 amino acids
    Molecular mass:
    48329 Da
    Quaternary structure:
    • Interacts with YAP1 and WWTR1/TAZ.
    SequenceCaution:
    • Sequence=CAA64212.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TEAD4 Gene

    Alternative splice isoforms for TEAD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEAD4 Gene

Protein Expression for TEAD4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TEAD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEAD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEAD4 Gene

Domains & Families for TEAD4 Gene

Gene Families for TEAD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TEAD4 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TEAD4 Gene

GenScript: Design optimal peptide antigens:
  • TEA domain family member 4, isoform CRA_b (D3DUQ6_HUMAN)
  • Transcription factor RTEF-1 (TEAD4_HUMAN)
genes like me logo Genes that share domains with TEAD4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEAD4 Gene

Function for TEAD4 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TEAD4 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
GENATLAS Biochemistry:
SV40-transcriptional enhancer factor 4 (TEF4)

Phenotypes From GWAS Catalog for TEAD4 Gene

Gene Ontology (GO) - Molecular Function for TEAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001085 RNA polymerase II transcription factor binding IBA 21873635
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,IDA 18579750
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TEAD4: view
genes like me logo Genes that share phenotypes with TEAD4: view

Animal Models for TEAD4 Gene

MGI Knock Outs for TEAD4:

Animal Model Products

CRISPR Products

miRNA for TEAD4 Gene

miRTarBase miRNAs that target TEAD4
Targeted motifs for TEAD4 Gene
HOMER Transcription Factor Regulatory Elements motif TEAD4
  • Consensus sequence: CCWGGAATGY Submotif: canonical Cell Type: Tropoblast GEO ID: GSE37350

Clone Products

  • Addgene plasmids for TEAD4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TEAD4 Gene

Localization for TEAD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEAD4 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEAD4 gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TEAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 25796446
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IBA 21873635
genes like me logo Genes that share ontologies with TEAD4: view

Pathways & Interactions for TEAD4 Gene

genes like me logo Genes that share pathways with TEAD4: view

Pathways by source for TEAD4 Gene

1 BioSystems pathway for TEAD4 Gene
7 Qiagen pathways for TEAD4 Gene
  • Epithelial Adherens Junctions
  • Factors Promoting Cardiogenesis in Vertebrates
  • Human Embryonic Stem Cell Pluripotency
  • ILK Signaling
  • JNK Pathway
1 Cell Signaling Technology pathway for TEAD4 Gene

SIGNOR curated interactions for TEAD4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TEAD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8662936
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 8921372
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TEAD4: view

Drugs & Compounds for TEAD4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TEAD4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TEAD4 Gene

(3) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(144) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for TEAD4

Alternative Splicing Database (ASD) splice patterns (SP) for TEAD4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - - -
SP6:
SP7: -
SP8: - -

Relevant External Links for TEAD4 Gene

GeneLoc Exon Structure for
TEAD4
ECgene alternative splicing isoforms for
TEAD4

Expression for TEAD4 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TEAD4 Gene

mRNA expression in normal human tissues for TEAD4 Gene
mRNA expression by BioGPS for TEAD4 GenemRNA expression by GTEx for TEAD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TEAD4 Gene

This gene is overexpressed in Muscle - Skeletal (x10.7) and Pancreas (x5.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TEAD4 Gene



NURSA nuclear receptor signaling pathways regulating expression of TEAD4 Gene:

TEAD4

SOURCE GeneReport for Unigene cluster for TEAD4 Gene:

Hs.94865

mRNA Expression by UniProt/SwissProt for TEAD4 Gene:

Q15561-TEAD4_HUMAN
Tissue specificity: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Evidence on tissue expression from TISSUES for TEAD4 Gene

  • Heart(4.4)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with TEAD4: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEAD4 Gene

Orthologs for TEAD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEAD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TEAD4 33 32
  • 99.35 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia TEAD4 33
  • 94 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia TEAD4 33 32
  • 93.26 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia TEAD4 33 32
  • 90.19 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tead4 32
  • 88.86 (n)
mouse
(Mus musculus)
 Mammalia Tead4 17 33 32
  • 88.84 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia TEAD4 33
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TEAD4 33 32
  • 78.6 (n)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tead4 32
  • 70.25 (n)
zebrafish
(Danio rerio)
 Actinopterygii CABZ01090021.1 33
  • 81 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.5943 32
fruit fly
(Drosophila melanogaster)
 Insecta sd 33 34
  • 43 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea egl-44 33 34
  • 37 (a)
 OneToMany
Species where no ortholog for TEAD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEAD4 Gene

ENSEMBL:
Gene Tree for TEAD4 (if available)
TreeFam:
Gene Tree for TEAD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEAD4: view image

Paralogs for TEAD4 Gene

Paralogs for TEAD4 Gene

(3) SIMAP similar genes for TEAD4 Gene using alignment to 8 proteins:

  • TEAD4_HUMAN
  • D3DUQ6_HUMAN
  • H0Y7B0_HUMAN
  • H0YFF9_HUMAN
  • H0YFK0_HUMAN
  • H0YG62_HUMAN
  • H0YGS2_HUMAN
  • Q53GI4_HUMAN
genes like me logo Genes that share paralogs with TEAD4: view

Variants for TEAD4 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for TEAD4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000012605 -- 2,999,293(+) C/G/T intron_variant
rs1000128262 -- 3,039,217(+) A/G intron_variant
rs1000140991 -- 2,969,344(+) G/A/T intron_variant
rs1000142410 -- 3,026,988(+) C/T intron_variant
rs1000148523 -- 2,974,056(+) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TEAD4 Gene

Variant ID Type Subtype PubMed ID
dgv440e212 CNV loss 25503493
dgv441e212 CNV gain 25503493
dgv442e212 CNV gain 25503493
esv2662595 CNV deletion 23128226
esv2673655 CNV deletion 23128226
esv275406 CNV gain+loss 21479260
esv3548643 CNV deletion 23714750
esv3580073 CNV loss 25503493
esv3628329 CNV gain 21293372
esv3628331 CNV gain 21293372
esv3628332 CNV gain 21293372
esv3628333 CNV loss 21293372
esv3628334 CNV loss 21293372
esv3628335 CNV loss 21293372
esv3628336 CNV loss 21293372
nsv1036000 CNV gain 25217958
nsv1136146 CNV deletion 24896259
nsv468974 CNV loss 19166990
nsv468975 CNV loss 19166990
nsv470261 CNV loss 18288195
nsv523615 CNV loss 19592680
nsv528500 CNV loss 19592680
nsv557082 CNV loss 21841781
nsv557083 CNV loss 21841781
nsv832311 CNV loss 17160897

Variation tolerance for TEAD4 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEAD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEAD4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEAD4 Gene

Disorders for TEAD4 Gene

Additional Disease Information for TEAD4

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TEAD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEAD4 Gene

Publications for TEAD4 Gene

  1. Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family. (PMID: 8921372) Stewart AF … Adra CN (Genomics 1996) 2 3 4 56
  2. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PMID: 19324877) Zhang H … Guan KL (The Journal of biological chemistry 2009) 3 4 56
  3. Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells. (PMID: 18840614) Liu X … Zeng H (The Journal of biological chemistry 2008) 3 23 56
  4. TEAD mediates YAP-dependent gene induction and growth control. (PMID: 18579750) Zhao B … Guan KL (Genes & development 2008) 3 4 56
  5. Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation. (PMID: 15520314) Chen HH … Stewart AF (Circulation 2004) 3 23 56

ExternalLinks

View latest publications for TEAD4 gene in Mastermind

Products for TEAD4 Gene

  • Addgene plasmids for TEAD4

Sources for TEAD4 Gene