Aliases for TEAD3 Gene
External Ids for TEAD3 Gene
Previous HGNC Symbols for TEAD3 Gene
Previous GeneCards Identifiers for TEAD3 Gene
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]
GeneCards Summary for TEAD3 Gene
TEAD3 (TEA Domain Transcription Factor 3) is a Protein Coding gene. Diseases associated with TEAD3 include Leber Congenital Amaurosis and Retinitis Pigmentosa. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II transcription factor binding. An important paralog of this gene is TEAD4.
UniProtKB/Swiss-Prot Summary for TEAD3 Gene
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.