Aliases for TEAD3 Gene
External Ids for TEAD3 Gene
Previous HGNC Symbols for TEAD3 Gene
Previous GeneCards Identifiers for TEAD3 Gene
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]
GeneCards Summary for TEAD3 Gene
TEAD3 (TEA Domain Transcription Factor 3) is a Protein Coding gene. Diseases associated with TEAD3 include Retinitis Pigmentosa 14 and Leber Congenital Amaurosis. Among its related pathways are Gene Expression and BMAL1-CLOCK,NPAS2 activates circadian gene expression. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor binding. An important paralog of this gene is TEAD1.
UniProtKB/Swiss-Prot for TEAD3 Gene
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.