This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by Re... See more...

Aliases for TEAD3 Gene

Aliases for TEAD3 Gene

  • TEA Domain Transcription Factor 3 2 3 5
  • TEA Domain Family Member 3 2 3 4
  • Transcriptional Enhancer Factor TEF-5 3 4
  • DTEF-1 3 4
  • ETFR-1 2 3
  • TEAD-3 3 4
  • TEAD5 3 4
  • TEF-5 2 3
  • TEF5 3 4
  • Transcriptional Enhancer Factor TEF-5 (DTEF-1) 3
  • Transcriptional Enhancer Factor 5 3
  • TEA Domain Family Member 5 3
  • TEAD3 5

External Ids for TEAD3 Gene

Previous HGNC Symbols for TEAD3 Gene

  • TEAD5

Previous GeneCards Identifiers for TEAD3 Gene

  • GC06M035443
  • GC06M035488
  • GC06M035549
  • GC06M035162
  • GC06M035441
  • GC06M035615
  • GC06M035622
  • GC06M038956
  • GC06M039648
  • GC06M039951
  • GC06M041287
  • GC06M036297
  • GC06M036666
  • GC06M037019
  • GC06M037369
  • GC06M037725
  • GC06M038071
  • GC06M038461
  • GC06M038806

Summaries for TEAD3 Gene

Entrez Gene Summary for TEAD3 Gene

  • This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEAD3 Gene

TEAD3 (TEA Domain Transcription Factor 3) is a Protein Coding gene. Diseases associated with TEAD3 include Fallopian Tube Carcinoma. Among its related pathways are Hippo signaling pathway - multiple species and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II transcription factor binding. An important paralog of this gene is TEAD4.

UniProtKB/Swiss-Prot Summary for TEAD3 Gene

  • Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Gene Wiki entry for TEAD3 Gene

Additional gene information for TEAD3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEAD3 Gene

Genomics for TEAD3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TEAD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEAD3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEAD3

Top Transcription factor binding sites by QIAGEN in the TEAD3 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5

Genomic Locations for TEAD3 Gene

Genomic Locations for TEAD3 Gene
chr6:35,473,597-35,497,079
(GRCh38/hg38)
Size:
23,483 bases
Orientation:
Minus strand
chr6:35,441,374-35,464,861
(GRCh37/hg19)
Size:
23,488 bases
Orientation:
Minus strand

Genomic View for TEAD3 Gene

Genes around TEAD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEAD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEAD3 Gene

Proteins for TEAD3 Gene

  • Protein details for TEAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99594-TEAD3_HUMAN
    Recommended name:
    Transcriptional enhancer factor TEF-5
    Protein Accession:
    Q99594
    Secondary Accessions:
    • O95910
    • Q5BJG7
    • Q8N6Y4

    Protein attributes for TEAD3 Gene

    Size:
    435 amino acids
    Molecular mass:
    48676 Da
    Quaternary structure:
    • Interacts with YAP1 and WWTR1/TAZ.
    SequenceCaution:
    • Sequence=AAH27877.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305}; Sequence=AAH91488.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305}; Sequence=CAA64213.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TEAD3 Gene

neXtProt entry for TEAD3 Gene

Post-translational modifications for TEAD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEAD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TEAD3 Gene

Domains & Families for TEAD3 Gene

Gene Families for TEAD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TEAD3 Gene

InterPro:
Blocks:
  • TEA/ATTS family
ProtoNet:

Suggested Antigen Peptide Sequences for TEAD3 Gene

GenScript: Design optimal peptide antigens:
  • TEA domain family member 3 (Q7Z6U7_HUMAN)
  • TEA domain family member 3 (Q7Z6U8_HUMAN)
  • TEA domain family member 3 (Q7Z6U9_HUMAN)
  • TEA domain family member 3 (Q7Z6V0_HUMAN)
  • TEAD3 protein (Q96G15_HUMAN)
genes like me logo Genes that share domains with TEAD3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEAD3 Gene

Function for TEAD3 Gene

Molecular function for TEAD3 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
GENATLAS Biochemistry:
SV40-transcriptional enhancer factor 3 (TEF5),expressed in syncytiotrophoblast,where it binds to CSH2 enhancer

Phenotypes From GWAS Catalog for TEAD3 Gene

Gene Ontology (GO) - Molecular Function for TEAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001085 RNA polymerase II transcription factor binding IPI 23946438
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TEAD3: view
genes like me logo Genes that share phenotypes with TEAD3: view

Animal Models for TEAD3 Gene

MGI Knock Outs for TEAD3:
  • Tead3 Tead3<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEAD3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TEAD3 Gene

Localization for TEAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEAD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEAD3 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TEAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA 21873635
genes like me logo Genes that share ontologies with TEAD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TEAD3 Gene

Pathways & Interactions for TEAD3 Gene

genes like me logo Genes that share pathways with TEAD3: view

Pathways by source for TEAD3 Gene

SIGNOR curated interactions for TEAD3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TEAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 9148898
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007565 female pregnancy TAS 9148898
GO:0035329 hippo signaling IDA 18579750
genes like me logo Genes that share ontologies with TEAD3: view

Drugs & Compounds for TEAD3 Gene

No Compound Related Data Available

Transcripts for TEAD3 Gene

mRNA/cDNA for TEAD3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEAD3

Alternative Splicing Database (ASD) splice patterns (SP) for TEAD3 Gene

No ASD Table

Relevant External Links for TEAD3 Gene

GeneLoc Exon Structure for
TEAD3

Expression for TEAD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEAD3 Gene

Protein differential expression in normal tissues from HIPED for TEAD3 Gene

This gene is overexpressed in Placenta (34.4), Pancreatic juice (8.8), and Bone marrow mesenchymal stem cell (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TEAD3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEAD3

SOURCE GeneReport for Unigene cluster for TEAD3 Gene:

Hs.485205

mRNA Expression by UniProt/SwissProt for TEAD3 Gene:

Q99594-TEAD3_HUMAN
Tissue specificity: Preferentially expressed in the placenta.

Evidence on tissue expression from TISSUES for TEAD3 Gene

  • Nervous system(4.4)
  • Lung(4.3)
  • Muscle(2.6)
  • Heart(2.5)
  • Liver(2.3)
  • Kidney(2.3)
  • Skin(2.2)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with TEAD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEAD3 Gene

Orthologs for TEAD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEAD3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TEAD3 31
  • 99 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TEAD3 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TEAD3 30 31
  • 92.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TEAD3 30 31
  • 92.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tead3 30
  • 90.94 (n)
Mouse
(Mus musculus)
Mammalia Tead3 30 17 31
  • 90.33 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TEAD3 31
  • 90 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TEAD3 30 31
  • 80.86 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TEAD3 31
  • 84 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tead3a 31
  • 76 (a)
OneToMany
tead3b 30 31
  • 74.58 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta sd 31 32
  • 41 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea egl-44 31 32
  • 36 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 64 (a)
OneToOne
Species where no ortholog for TEAD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TEAD3 Gene

ENSEMBL:
Gene Tree for TEAD3 (if available)
TreeFam:
Gene Tree for TEAD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEAD3: view image

Paralogs for TEAD3 Gene

Paralogs for TEAD3 Gene

(3) SIMAP similar genes for TEAD3 Gene using alignment to 4 proteins:

  • TEAD3_HUMAN
  • B5MCM0_HUMAN
  • H7C4A7_HUMAN
  • Q96G15_HUMAN
genes like me logo Genes that share paralogs with TEAD3: view

Variants for TEAD3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEAD3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs35080860 - p.Thr254Met

Additional dbSNP identifiers (rs#s) for TEAD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TEAD3 Gene

Variant ID Type Subtype PubMed ID
dgv10624n54 CNV loss 21841781
dgv10625n54 CNV gain 21841781
dgv3299n106 CNV deletion 24896259
esv23268 CNV loss 19812545
esv2759420 CNV gain 17122850
nsv1073547 CNV deletion 25765185
nsv462909 CNV loss 19166990
nsv519370 CNV loss 19592680
nsv528351 CNV loss 19592680
nsv602910 CNV loss 21841781
nsv602912 CNV loss 21841781
nsv602914 CNV loss 21841781
nsv602915 CNV gain 21841781
nsv602916 CNV loss 21841781

Variation tolerance for TEAD3 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEAD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEAD3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEAD3 Gene

Disorders for TEAD3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TEAD3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fallopian tube carcinoma
  • cancer of the fallopian tube
- elite association - COSMIC cancer census association via MalaCards
Search TEAD3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEAD3

genes like me logo Genes that share disorders with TEAD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEAD3 Gene

Publications for TEAD3 Gene

  1. Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. (PMID: 9148898) Jacquemin P … Davidson I (The Journal of biological chemistry 1997) 2 3 4 23
  2. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PMID: 9889009) Jacquemin P … Davidson I (Genomics 1999) 2 3 23
  3. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PMID: 19324877) Zhang H … Guan KL (The Journal of biological chemistry 2009) 3 4
  4. TEAD mediates YAP-dependent gene induction and growth control. (PMID: 18579750) Zhao B … Guan KL (Genes & development 2008) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for TEAD3 Gene

Sources for TEAD3 Gene