Aliases for TEAD2 Gene
External Ids for TEAD2 Gene
Previous GeneCards Identifiers for TEAD2 Gene
GeneCards Summary for TEAD2 Gene
TEAD2 (TEA Domain Transcription Factor 2) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is TEAD1.
UniProtKB/Swiss-Prot for TEAD2 Gene
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC enhansons (5-GTGGAATGT-3). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.