Aliases for TEAD2 Gene
External Ids for TEAD2 Gene
Previous GeneCards Identifiers for TEAD2 Gene
GeneCards Summary for TEAD2 Gene
TEAD2 (TEA Domain Transcription Factor 2) is a Protein Coding gene. Diseases associated with TEAD2 include Multiple Acyl-Coa Dehydrogenase Deficiency and Sveinsson Chorioretinal Atrophy. Among its related pathways are Mesodermal Commitment Pathway and Hippo signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is TEAD1.
UniProtKB/Swiss-Prot Summary for TEAD2 Gene
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.