Aliases for TEAD2 Gene

Aliases for TEAD2 Gene

  • TEA Domain Transcription Factor 2 2 3 5
  • TEA Domain Family Member 2 2 3 4
  • TEF4 2 3 4
  • Transcriptional Enhancer Factor TEF-4 3 4
  • TEAD-2 3 4
  • TEF-4 2 3
  • ETF 2 3
  • TEAD2 5

External Ids for TEAD2 Gene

Previous GeneCards Identifiers for TEAD2 Gene

  • GC19M050502
  • GC19M050211
  • GC19M054519
  • GC19M054535
  • GC19M049843
  • GC19M046220

Summaries for TEAD2 Gene

GeneCards Summary for TEAD2 Gene

TEAD2 (TEA Domain Transcription Factor 2) is a Protein Coding gene. Diseases associated with TEAD2 include Multiple Acyl-Coa Dehydrogenase Deficiency and Sveinsson Chorioretinal Atrophy. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is TEAD1.

UniProtKB/Swiss-Prot Summary for TEAD2 Gene

  • Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Gene Wiki entry for TEAD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TEAD2 Gene

Genomics for TEAD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TEAD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049359 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.1 91 4.9 SP1 MYC IKZF1 POLR2A ZIC2 NFIC ZBTB10 YY1 MXD4 SMAD5 DKKL1 TEAD2 KASH5 LOC400710
GH19J049369 Promoter 0.3 EPDnew 250.4 -7.4 -7421 0.1 piR-52474 TEAD2 PTH2 SLC17A7 CD37 SLC6A16 DKKL1 KASH5 LOC101928295
GH19J048644 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.1 +716.7 716656 3.2 BCLAF1 ZNF654 MYC IKZF1 ZNF600 SIX5 SSRP1 ZNF580 ZNF592 ZNF10 CA11 SNORD35A SNORD35B PRR12 GRWD1 NOP53-AS1 ALDH16A1 SNRNP70 NOP53 RPS11
GH19J048988 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11 +370.4 370404 7.2 BCLAF1 SP1 MYC NCOR1 ZNF600 IKZF1 POLR2A CEBPA ZIC2 YY1 RUVBL2 GYS1 HSALNG0126941-001 HSALNG0126941-002 lnc-LHB-2 NUP62 GRWD1 PTOV1-AS2 SNORD35A IRF3
GH19J048395 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas 12.1 +963.7 963738 6.3 NCOR1 MYC ZNF600 IKZF1 SIX5 ZNF580 ZNF592 POLR2A CEBPA ZNF223 lnc-KDELR1-2 NOP53-AS1 BICRA GRWD1 KDELR1 CYTH2 SNRNP70 NOP53 SNORD23 ENSG00000268746
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TEAD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TEAD2

Top Transcription factor binding sites by QIAGEN in the TEAD2 gene promoter:
  • FAC1
  • HSF1 (long)
  • HSF1short
  • MyoD
  • MZF-1
  • RREB-1
  • TBP

Genomic Locations for TEAD2 Gene

Latest Assembly
chr19:49,340,595-49,362,457
(GRCh38/hg38)
Size:
21,863 bases
Orientation:
Minus strand

Previous Assembly
chr19:49,843,852-49,865,673
(GRCh37/hg19 by Entrez Gene)
Size:
21,822 bases
Orientation:
Minus strand

chr19:49,843,852-49,865,714
(GRCh37/hg19 by Ensembl)
Size:
21,863 bases
Orientation:
Minus strand

Genomic View for TEAD2 Gene

Genes around TEAD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEAD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEAD2 Gene

Proteins for TEAD2 Gene

  • Protein details for TEAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15562-TEAD2_HUMAN
    Recommended name:
    Transcriptional enhancer factor TEF-4
    Protein Accession:
    Q15562
    Secondary Accessions:
    • B4DTJ6
    • M0R1T9
    • Q8NA25
    • Q96IG3

    Protein attributes for TEAD2 Gene

    Size:
    447 amino acids
    Molecular mass:
    49243 Da
    Quaternary structure:
    • Interacts with YAP1 and WWTR1/TAZ.

    Three dimensional structures from OCA and Proteopedia for TEAD2 Gene

    Alternative splice isoforms for TEAD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TEAD2 Gene

Post-translational modifications for TEAD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEAD2 Gene

Domains & Families for TEAD2 Gene

Gene Families for TEAD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TEAD2 Gene

InterPro:
Blocks:
  • TEA/ATTS family

Suggested Antigen Peptide Sequences for TEAD2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57003, highly similar to Transcriptional enhancer factor TEF-4 (B4DTJ6_HUMAN)
  • cDNA FLJ77886, highly similar to Homo sapiens TEA domain family member 2, mRNA (Q8NA25_HUMAN)
  • TEA domain family member 2 (TEAD2_HUMAN)
genes like me logo Genes that share domains with TEAD2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TEAD2 Gene

Function for TEAD2 Gene

Molecular function for TEAD2 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
GENATLAS Biochemistry:
SV40-transcriptional enhancer factor 4 (TEF4),expressed throughout the embryo from the onset of gene expression,required for cardiac muscle and skeletal muscle specific genes

Phenotypes From GWAS Catalog for TEAD2 Gene

Gene Ontology (GO) - Molecular Function for TEAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001223 transcription coactivator binding IPI 20368466
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IMP,NAS 8702974
genes like me logo Genes that share ontologies with TEAD2: view
genes like me logo Genes that share phenotypes with TEAD2: view

Animal Models for TEAD2 Gene

MGI Knock Outs for TEAD2:

miRNA for TEAD2 Gene

miRTarBase miRNAs that target TEAD2
Targeted motifs for TEAD2 Gene
HOMER Transcription Factor Regulatory Elements motif TEAD2
  • Consensus sequence: CCWGGAATGY Submotif: canonical Cell Type: Py2T GEO ID: GSE55709

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEAD2

Clone products for research

  • Addgene plasmids for TEAD2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TEAD2 Gene

Localization for TEAD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEAD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEAD2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TEAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus NAS 8702974
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IBA 21873635
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TEAD2: view

Pathways & Interactions for TEAD2 Gene

genes like me logo Genes that share pathways with TEAD2: view

Pathways by source for TEAD2 Gene

SIGNOR curated interactions for TEAD2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TEAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001843 neural tube closure IEA --
GO:0003143 embryonic heart tube morphogenesis IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8702974
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with TEAD2: view

Drugs & Compounds for TEAD2 Gene

No Compound Related Data Available

Transcripts for TEAD2 Gene

mRNA/cDNA for TEAD2 Gene

6 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TEAD2

Clone products for research

  • Addgene plasmids for TEAD2

Alternative Splicing Database (ASD) splice patterns (SP) for TEAD2 Gene

No ASD Table

Relevant External Links for TEAD2 Gene

GeneLoc Exon Structure for
TEAD2

Expression for TEAD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TEAD2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TEAD2

SOURCE GeneReport for Unigene cluster for TEAD2 Gene:

Hs.515534

Evidence on tissue expression from TISSUES for TEAD2 Gene

  • Skin(4.4)
  • Nervous system(4.4)
  • Eye(4.2)
  • Heart(2.2)
  • Muscle(2.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with TEAD2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEAD2 Gene

Orthologs for TEAD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TEAD2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TEAD2 29 30
  • 96.3 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TEAD2 29 30
  • 91.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TEAD2 29 30
  • 91.17 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tead2 29
  • 86.67 (n)
Mouse
(Mus musculus)
Mammalia Tead2 29 16 30
  • 86.14 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TEAD2 30
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TEAD2 30
  • 63 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta sd 30 31
  • 39 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea egl-44 30 31
  • 36 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TEC1 32
Species where no ortholog for TEAD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for TEAD2 Gene

ENSEMBL:
Gene Tree for TEAD2 (if available)
TreeFam:
Gene Tree for TEAD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TEAD2: view image
Alliance of Genome Resources:
Additional Orthologs for TEAD2

Paralogs for TEAD2 Gene

Paralogs for TEAD2 Gene

(3) SIMAP similar genes for TEAD2 Gene using alignment to 4 proteins:

  • TEAD2_HUMAN
  • M0R1A5_HUMAN
  • M0R1T9_HUMAN
  • M0R290_HUMAN
genes like me logo Genes that share paralogs with TEAD2: view

Variants for TEAD2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TEAD2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs201393859 Benign: not provided 49,348,813(-) G/A
NM_001256660.2(TEAD2):c.637C>T (p.Pro213Ser)
MISSENSE
rs75100029 Benign: not provided 49,348,773(-) C/G
NM_001256660.2(TEAD2):c.677G>C (p.Gly226Ala)
MISSENSE
rs80095365 Benign: not provided 49,357,264(-) C/A
NM_001256660.2(TEAD2):c.348G>T (p.Gln116His)
MISSENSE_VARIANT,FIVE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TEAD2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TEAD2 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
nsv1138716 CNV deletion 24896259
nsv476353 CNV novel sequence insertion 20440878
nsv9739 CNV gain+loss 18304495

Variation tolerance for TEAD2 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TEAD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEAD2
Leiden Open Variation Database (LOVD)
TEAD2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEAD2 Gene

Disorders for TEAD2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TEAD2 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search TEAD2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TEAD2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TEAD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TEAD2 Gene

Publications for TEAD2 Gene

  1. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PMID: 9889009) Jacquemin P … Davidson I (Genomics 1999) 2 3 22
  2. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. (PMID: 8702974) Jacquemin P … Davidson I (The Journal of biological chemistry 1996) 2 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  4. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PMID: 19324877) Zhang H … Guan KL (The Journal of biological chemistry 2009) 3 4
  5. TEAD mediates YAP-dependent gene induction and growth control. (PMID: 18579750) Zhao B … Guan KL (Genes & development 2008) 3 4

Products for TEAD2 Gene

Sources for TEAD2 Gene