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This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
TEAD1 (TEA Domain Transcription Factor 1) is a Protein Coding gene. Diseases associated with TEAD1 include Sveinsson Chorioretinal Atrophy and Aicardi Syndrome. Among its related pathways are ERK Signaling and Hippo signaling pathway - multiple species. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is TEAD4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IMP,ISM | 19274049 |
GO:0000987 | proximal promoter sequence-specific DNA binding | IMP | 26045994 |
GO:0001085 | RNA polymerase II transcription factor binding | IBA | -- |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005667 | transcription factor complex | IBA | 21873635 |
GO:0071148 | TEAD-1-YAP complex | IDA | 20123905 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
2 | Human Embryonic Stem Cell Pluripotency |
Factors Promoting Cardiogenesis in Vertebrates
.50
|
Human Embryonic Stem Cell Pluripotency
.50
|
3 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
4 | Gene Expression |
.48
|
|
5 | Metabolism |
.40
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006367 | transcription initiation from RNA polymerase II promoter | TAS | -- |
GO:0035329 | hippo signaling | IBA,IDA | 18579750 |
GO:0045893 | positive regulation of transcription, DNA-templated | IMP | 20123905 |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IMP | 25796446 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||
SP2: | |||||||||||||||||||||
SP3: | |||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TEAD1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TEAD1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TEAD1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TEAD1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TEAD1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tead1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tead1 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TEAD1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TEAD1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tead1 30 |
|
||
Str.6996 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.29088 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tead1b 31 |
|
OneToMany | |
TEAD1 (3 of 3) 31 |
|
OneToMany | |||
tead1a 31 |
|
OneToMany | |||
LOC100537467 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000512 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | sd 30 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | egl-44 30 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5470 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
737324 | Likely Benign: not provided | 12,883,076(+) | G/A | MISSENSE_VARIANT | |
737332 | Likely Benign: not provided | 12,862,299(+) | G/A | SYNONYMOUS_VARIANT | |
802657 | Benign: Sveinsson chorioretinal atrophy | 12,878,800(+) | CAT/C | INTRON_VARIANT | |
834736 | Uncertain Significance: not provided | 12,901,944(+) | A/G | MISSENSE_VARIANT | |
836948 | Uncertain Significance: not provided | 12,764,308(+) | C/T | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
sveinsson chorioretinal atrophy |
|
|
aicardi syndrome |
|
|
spindle cell rhabdomyosarcoma |
|
|
fallopian tube carcinoma |
|
|
gastric fundus cancer |
|
|