Aliases for TDRP Gene
Aliases for TDRP Gene
External Ids for TDRP Gene
- HGNC: 26951
- Entrez Gene: 157695
- Ensembl: ENSG00000180190
- UniProtKB: Q86YL5
Previous HGNC Symbols for TDRP Gene
- C8orf42
Previous GeneCards Identifiers for TDRP Gene
- GC08M000440
- GC08M000443
Summaries for TDRP Gene
GeneCards Summary for TDRP Gene
TDRP (Testis Development Related Protein) is a Protein Coding gene.
Additional gene information for TDRP Gene
- Monarch Initiative
- Search for TDRP at DataMed
- Search for TDRP at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRP Gene
Genomics for TDRP Gene
GeneHancer (GH) Regulatory Elements for TDRP Gene
Promoters and enhancers for TDRP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TDRP on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TDRP Gene
Genomic Locations for TDRP Gene
- chr8:457,018-545,781
- (GRCh38/hg38)
- Size:
- 88,764 bases
- Orientation:
- Minus strand
- chr8:439,803-495,781
- (GRCh37/hg19)
Genomic View for TDRP Gene
Genes around TDRP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p23.3 by Ensembl
- 8p23.3 by Entrez Gene
- 8p23.3 by HGNC
TDRP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TDRP Gene
Proteins for TDRP Gene
-
Protein details for TDRP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86YL5-TDRP_HUMAN
- Recommended name:
- Testis development-related protein
- Protein Accession:
- Q86YL5
- B6VF03
- B9EG53
Protein attributes for TDRP Gene
- Size:
- 185 amino acids
- Molecular mass:
- 20403 Da
- Quaternary structure:
- No Data Available
Protein Expression for TDRP Gene
Post-translational modifications for TDRP Gene
Other Protein References for TDRP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TDRP
- Novus Biologicals Antibodies for TDRP
- Invitrogen Antibodies for TDRP
- antibodies-online: Search results for available TDRP related products ranked by validation data
- Search GeneTex for Antibodies for TDRP
Protein Products
-
OriGene Purified Proteins for TDRP
- Search Origene for MassSpec and Protein Over-expression Lysates for TDRP
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- antibodies-online: Search results for available TDRP related products ranked by validation data
- Search GeneTex for Proteins for TDRP
Assay Products
- antibodies-online: Search results for available TDRP related products ranked by validation data
No data available for DME Specific Peptides for TDRP Gene
Domains & Families for TDRP Gene
Gene Families for TDRP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for TDRP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TDRP Gene
Function for TDRP Gene
Phenotypes From GWAS Catalog for TDRP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for TDRP Gene
- MGI mutant phenotypes for TDRP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TDRP:
Animal Models for TDRP Gene
- MGI Knock Outs for TDRP:
-
- Tdrp tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TDRP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TDRP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TDRP gene
- Search ViGene Biosciences for TDRP
CRISPR Products
-
OriGene CRISPR knockouts for TDRP
- genomics-online: gRNA clones - Search results for available TDRP gene related products
- Applied Biological Materials CRISPR for TDRP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TDRP
- GenScript: Design CRISPR guide RNA sequences for TDRP
miRNA for TDRP Gene
- miRTarBase miRNAs that target TDRP
miRNA Products
- Search ViGene Biosciences for TDRP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TDRP
- Browse OriGene Inhibitory RNA Products For TDRP
- genomics-online: shRNA clones - Search results for available TDRP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TDRP gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TDRP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TDRP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TDRP gene related products
- orf clones - Search results for available TDRP gene related products
- Applied Biological Materials Clones for TDRP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TDRP
-
ViGene Biosciences adenoviral particle packaged cDNA for TDRP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TDRP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TDRP gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TDRP Gene
Localization for TDRP Gene
Subcellular locations from UniProtKB/Swiss-Prot for TDRP Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
- Cytosol (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 20170638 |
| GO:0005737 | cytoplasm | IDA,IEA | 20170638 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for TDRP Gene
No Data Available
Interacting Proteins for TDRP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007283 | spermatogenesis | IDA | 20170638 |
No data available for Pathways by source and SIGNOR curated interactions for TDRP Gene
Transcripts for TDRP Gene
mRNA/cDNA for TDRP Gene
- (4) REFSEQ mRNAs :
- (124) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TDRP
- genomics-online: gRNA clones - Search results for available TDRP gene related products
- Applied Biological Materials CRISPR for TDRP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TDRP
- GenScript: Design CRISPR guide RNA sequences for TDRP
miRNA Products
- Search ViGene Biosciences for TDRP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TDRP
- Browse OriGene Inhibitory RNA Products For TDRP
- genomics-online: shRNA clones - Search results for available TDRP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TDRP gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TDRP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TDRP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TDRP gene related products
- orf clones - Search results for available TDRP gene related products
- Applied Biological Materials Clones for TDRP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TDRP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
-
Testis (Reproductive System)
This gene is overexpressed in Peripheral blood mononuclear cells (29.7), Platelet (21.4), and Placenta (11.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TDRP Gene
NURSA nuclear receptor signaling pathways regulating expression of TDRP Gene:
TDRPmRNA Expression by UniProt/SwissProt for TDRP Gene:
Q86YL5-TDRP_HUMAN
Tissue specificity:
Expressed in spermatogenic cells, especially in spermatocytes (at protein level).
Evidence on tissue expression from TISSUES for TDRP Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for TDRP
-
OriGene qPCR primer pairs and template standards for TDRP
- genomics-online: primer clones - Search results for available TDRP gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TDRP Gene
Orthologs for TDRP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C8H8orf42 33 |
|
||
| TDRP 34 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C25H8orf42 33 |
|
||
| TDRP 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C1H8orf42 33 |
|
||
| TDRP 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Tdrp 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tdrp 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TDRP 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TDRP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C8ORF42 33 |
|
||
| TDRP 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | TDRP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tdrp 33 |
|
||
| Str.15789 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2936 33 |
|
- Species where no ortholog for TDRP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TDRP Gene
No data available for Paralogs for TDRP Gene
Variants for TDRP Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for TDRP Gene
- TDRP_HUMAN-Q86YL5
- The poly-Ala region seems to be polymorphic and the number of Ala varies between 4 and 6.
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000007205 | -- | 512,861(-) | A/C | intron_variant | |
| rs1000016748 | -- | 535,845(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000043496 | -- | 490,490(-) | C/T | 3_prime_UTR_variant | |
| rs1000072190 | -- | 490,830(-) | T/A/C | 3_prime_UTR_variant | |
| rs1000078600 | -- | 512,969(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.80;
16.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TDRP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TDRP
SNP Genotyping and Copy Number Assay Products
Disorders for TDRP Gene
Additional Disease Information for TDRP
No disorders were found for TDRP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TDRP Gene
Publications for TDRP Gene
- Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells of testis and its relationship with spermatogenesis. (PMID: 20170638) Wang X … Hu R (Biochemical and biophysical research communications 2010) 2 3 4 58
- Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population. (PMID: 24667176) Kan M … Liu Y (Diagnostic pathology 2014) 3 58
- Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PMID: 21646302) Bielinski SJ … Chute CG (Mayo Clinic proceedings 2011) 3 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
- DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58
Products for TDRP Gene
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- Custom Antibody ServicesOriGene Antibodies for TDRP
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- Cyagen custom Knockout/knockin (KOKI) mouse models for TDRP
- VectorBuilder custom plasmid, inducible vectors for TDRP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TDRP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available TDRP related products ranked by validation data
- antibodies-online: Search results for available TDRP related products ranked by validation data
- antibodies-online: Search results for available TDRP related products ranked by validation data
- Search GeneTex for Antibodies for TDRP
- Search GeneTex for Proteins for TDRP
- ViGene Biosciences adenoviral particle packaged cDNA for TDRP gene
- ViGene Biosciences lentiviral particle packaged cDNA for TDRP gene
- ViGene Biosciences ready-to-package AAV shRNAs for TDRP gene
- Search ViGene Biosciences for TDRP
- Horizon Cell Lines for TDRP
- genomics-online: cdna clones - Search results for available TDRP gene related products
- orf clones - Search results for available TDRP gene related products
- genomics-online: gRNA clones - Search results for available TDRP gene related products
- genomics-online: primer clones - Search results for available TDRP gene related products
- genomics-online: shRNA clones - Search results for available TDRP gene related products
Sources for TDRP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
