Aliases for TDRP Gene

Aliases for TDRP Gene

  • Testis Development Related Protein 2 3 5
  • Testis Development-Related Protein 3 4
  • C8orf42 3 4
  • Chromosome 8 Open Reading Frame 42 2
  • Protein INM01 4
  • Inm01 3
  • TDRP1 3
  • TDRP2 3

External Ids for TDRP Gene

Previous HGNC Symbols for TDRP Gene

  • C8orf42

Previous GeneCards Identifiers for TDRP Gene

  • GC08M000440
  • GC08M000443

Summaries for TDRP Gene

GeneCards Summary for TDRP Gene

TDRP (Testis Development Related Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for TDRP Gene

  • Contributes to normal sperm motility, but not essential for male fertility.

Additional gene information for TDRP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TDRP Gene

Genomics for TDRP Gene

GeneHancer (GH) Regulatory Elements for TDRP Gene

Promoters and enhancers for TDRP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TDRP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TDRP

Genomic Locations for TDRP Gene

Genomic Locations for TDRP Gene
chr8:457,018-545,781
(GRCh38/hg38)
Size:
88,764 bases
Orientation:
Minus strand
chr8:439,803-495,781
(GRCh37/hg19)
Size:
55,979 bases
Orientation:
Minus strand

Genomic View for TDRP Gene

Genes around TDRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRP Gene

Proteins for TDRP Gene

  • Protein details for TDRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YL5-TDRP_HUMAN
    Recommended name:
    Testis development-related protein
    Protein Accession:
    Q86YL5
    Secondary Accessions:
    • B6VF03
    • B9EG53

    Protein attributes for TDRP Gene

    Size:
    185 amino acids
    Molecular mass:
    20403 Da
    Quaternary structure:
    • Interacts with PRM2.

    Alternative splice isoforms for TDRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRP Gene

Post-translational modifications for TDRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDRP Gene

No data available for DME Specific Peptides for TDRP Gene

Domains & Families for TDRP Gene

Gene Families for TDRP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TDRP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TDRP Gene

GenScript: Design optimal peptide antigens:
  • Protein TDRP (CH042_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86YL5

UniProtKB/Swiss-Prot:

TDRP_HUMAN :
  • Belongs to the TDRP family.
Family:
  • Belongs to the TDRP family.
genes like me logo Genes that share domains with TDRP: view

Function for TDRP Gene

Molecular function for TDRP Gene

UniProtKB/Swiss-Prot Function:
Contributes to normal sperm motility, but not essential for male fertility.

Phenotypes From GWAS Catalog for TDRP Gene

Gene Ontology (GO) - Molecular Function for TDRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TDRP: view
genes like me logo Genes that share phenotypes with TDRP: view

Animal Models for TDRP Gene

MGI Knock Outs for TDRP:
  • Tdrp Tdrp<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for TDRP Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TDRP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TDRP Gene

Localization for TDRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRP Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. Also detected in cytoplasm near the midpiece of the flagellum. {ECO:0000269 PubMed:27069551}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TDRP gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TDRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 20170638
GO:0005737 cytoplasm IEA,IDA 20170638
GO:0005829 cytosol IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TDRP: view

Pathways & Interactions for TDRP Gene

PathCards logo

SuperPathways for TDRP Gene

No Data Available

Interacting Proteins for TDRP Gene

;

Gene Ontology (GO) - Biological Process for TDRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IDA 20170638
genes like me logo Genes that share ontologies with TDRP: view

No data available for Pathways by source and SIGNOR curated interactions for TDRP Gene

Drugs & Compounds for TDRP Gene

No Compound Related Data Available

Transcripts for TDRP Gene

mRNA/cDNA for TDRP Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TDRP

Alternative Splicing Database (ASD) splice patterns (SP) for TDRP Gene

No ASD Table

Relevant External Links for TDRP Gene

GeneLoc Exon Structure for
TDRP

Expression for TDRP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TDRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TDRP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.7), Platelet (21.4), and Placenta (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TDRP Gene



Protein tissue co-expression partners for TDRP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TDRP

mRNA Expression by UniProt/SwissProt for TDRP Gene:

Q86YL5-TDRP_HUMAN
Tissue specificity: Expressed in spermatogenic cells, especially in spermatocytes (at protein level).

Evidence on tissue expression from TISSUES for TDRP Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TDRP: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TDRP Gene

Orthologs for TDRP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TDRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf42 30
  • 99.46 (n)
TDRP 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C25H8orf42 30
  • 84.68 (n)
TDRP 31
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H8orf42 30
  • 82.43 (n)
TDRP 31
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tdrp 17 31 30
  • 78.45 (n)
rat
(Rattus norvegicus)
Mammalia Tdrp 30
  • 77.9 (n)
oppossum
(Monodelphis domestica)
Mammalia TDRP 31
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TDRP 31
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8ORF42 30
  • 72.41 (n)
TDRP 31
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TDRP 31
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tdrp 30
  • 64.68 (n)
Str.15789 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.2936 30
Species where no ortholog for TDRP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TDRP Gene

ENSEMBL:
Gene Tree for TDRP (if available)
TreeFam:
Gene Tree for TDRP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TDRP: view image

Paralogs for TDRP Gene

No data available for Paralogs for TDRP Gene

Variants for TDRP Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TDRP Gene

TDRP_HUMAN-Q86YL5
The poly-Ala region seems to be polymorphic and the number of Ala varies between 4 and 6.

Additional dbSNP identifiers (rs#s) for TDRP Gene

Structural Variations from Database of Genomic Variants (DGV) for TDRP Gene

Variant ID Type Subtype PubMed ID
dgv11809n54 CNV loss 21841781
dgv1353e214 CNV gain 21293372
esv2670416 CNV deletion 23128226
esv2677525 CNV deletion 23128226
esv2759581 CNV gain+loss 17122850
esv2761228 CNV gain+loss 21179565
esv2761393 CNV loss 21179565
esv3542848 CNV deletion 23714750
esv3542849 CNV deletion 23714750
esv3572374 CNV loss 25503493
esv3572375 CNV loss 25503493
esv3572377 CNV loss 25503493
esv3615771 CNV gain 21293372
esv3615787 CNV gain 21293372
esv5525 CNV loss 19470904
nsv1020142 CNV loss 25217958
nsv1023046 CNV loss 25217958
nsv1027283 CNV gain 25217958
nsv1027731 CNV gain 25217958
nsv1030422 CNV gain 25217958
nsv1073317 CNV deletion 25765185
nsv1075500 CNV deletion 25765185
nsv1075501 CNV deletion 25765185
nsv465264 CNV loss 19166990
nsv465265 CNV loss 19166990
nsv470163 CNV loss 18288195
nsv519615 CNV loss 19592680
nsv524542 CNV gain 19592680
nsv609451 CNV loss 21841781
nsv609452 CNV loss 21841781
nsv609457 CNV gain 21841781
nsv609458 CNV gain 21841781
nsv824434 CNV gain 20364138

Variation tolerance for TDRP Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TDRP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TDRP

SNP Genotyping and Copy Number Assay Products

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TDRP Gene

Disorders for TDRP Gene

Additional Disease Information for TDRP

No disorders were found for TDRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TDRP Gene

Publications for TDRP Gene

  1. Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells of testis and its relationship with spermatogenesis. (PMID: 20170638) Wang X … Hu R (Biochemical and biophysical research communications 2010) 2 3 4 54
  2. Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes. (PMID: 31682009) Wang Y … Tatakis DN (Journal of periodontology 2019) 3 54
  3. TDRP deficiency contributes to low sperm motility and is a potential risk factor for male infertility. (PMID: 27069551) Mao S … Wang X (American journal of translational research 2016) 4 54
  4. Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population. (PMID: 24667176) Kan M … Liu Y (Diagnostic pathology 2014) 3 54
  5. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PMID: 21646302) Bielinski SJ … Chute CG (Mayo Clinic proceedings 2011) 3 54

Products for TDRP Gene

Sources for TDRP Gene