Aliases for TDRKH Gene
External Ids for TDRKH Gene
Previous GeneCards Identifiers for TDRKH Gene
GeneCards Summary for TDRKH Gene
TDRKH (Tudor And KH Domain Containing) is a Protein Coding gene. Diseases associated with TDRKH include Ewing Sarcoma. Among its related pathways are Gene Expression and PIWI-interacting RNA (piRNA) biogenesis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TDRD6.
UniProtKB/Swiss-Prot Summary for TDRKH Gene
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.