TDRD5 Gene (Protein Coding)

Tudor Domain Containing 5

GC01P179591
GIFtS:
34
See more...

Aliases for TDRD5 Gene

Aliases for TDRD5 Gene

  • Tudor Domain Containing 5 2 3 5
  • TUDOR3 2 3 4
  • Tudor Domain-Containing Protein 5 3 4
  • Testicular Tissue Protein Li 194 3
  • FLJ34823 2
  • TDRD5 5

External Ids for TDRD5 Gene

Previous GeneCards Identifiers for TDRD5 Gene

  • GC01P174993
  • GC01P176085
  • GC01P176814
  • GC01P176800
  • GC01P176292
  • GC01P177827
  • GC01P179560
  • GC01P150787

Summaries for TDRD5 Gene

GeneCards Summary for TDRD5 Gene

TDRD5 (Tudor Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is TDRD6.

UniProtKB/Swiss-Prot Summary for TDRD5 Gene

  • Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).

Additional gene information for TDRD5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TDRD5 Gene

Genomics for TDRD5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TDRD5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TDRD5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TDRD5

Top Transcription factor binding sites by QIAGEN in the TDRD5 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Egr-2
  • HNF-1
  • HNF-1A
  • Ik-2
  • MAZR
  • POU6F1 (c2)

Genomic Locations for TDRD5 Gene

Genomic Locations for TDRD5 Gene
chr1:179,591,613-179,691,272
(GRCh38/hg38)
Size:
99,660 bases
Orientation:
Plus strand
chr1:179,560,748-179,660,407
(GRCh37/hg19)
Size:
99,660 bases
Orientation:
Plus strand

Genomic View for TDRD5 Gene

Genes around TDRD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDRD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDRD5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TDRD5 Gene

Proteins for TDRD5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TDRD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAT2-TDRD5_HUMAN
    Recommended name:
    Tudor domain-containing protein 5
    Protein Accession:
    Q8NAT2
    Secondary Accessions:
    • A1L4G5
    • B7ZLV0
    • Q5EBN4
    • Q5VTV0
    • Q6ZSK2

    Protein attributes for TDRD5 Gene

    Size:
    981 amino acids
    Molecular mass:
    109737 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03815.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TDRD5 Gene

    Alternative splice isoforms for TDRD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRD5 Gene

Protein Expression for TDRD5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TDRD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDRD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TDRD5 Gene

Domains & Families for TDRD5 Gene

Gene Families for TDRD5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TDRD5 Gene

InterPro:
Blocks:
  • Maternal tudor protein
ProtoNet:

Suggested Antigen Peptide Sequences for TDRD5 Gene

GenScript: Design optimal peptide antigens:
  • Tudor domain-containing protein 5 (TDRD5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NAT2

UniProtKB/Swiss-Prot:

TDRD5_HUMAN :
  • Belongs to the TDRD5 family.
Family:
  • Belongs to the TDRD5 family.
genes like me logo Genes that share domains with TDRD5: view

Function for TDRD5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TDRD5 Gene

UniProtKB/Swiss-Prot Function:
Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).

Phenotypes From GWAS Catalog for TDRD5 Gene

genes like me logo Genes that share phenotypes with TDRD5: view

Animal Models for TDRD5 Gene

MGI Knock Outs for TDRD5:
  • Tdrd5 Tdrd5<tm1Sait>
  • Tdrd5 Tdrd5<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for TDRD5 Gene

miRTarBase miRNAs that target TDRD5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TDRD5

Clone Products

  • Addgene plasmids for TDRD5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TDRD5 Gene

Localization for TDRD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRD5 Gene

Cytoplasm. Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TDRD5 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TDRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0033391 chromatoid body IEA,ISS --
GO:0071546 pi-body IEA,ISS --
genes like me logo Genes that share ontologies with TDRD5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TDRD5 Gene

Pathways & Interactions for TDRD5 Gene

PathCards logo

SuperPathways for TDRD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TDRD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007286 spermatid development IEA,ISS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TDRD5: view

No data available for Pathways by source and SIGNOR curated interactions for TDRD5 Gene

Drugs & Compounds for TDRD5 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TDRD5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TDRD5 Gene

6 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TDRD5

Clone Products

  • Addgene plasmids for TDRD5

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD5 Gene

No ASD Table

Relevant External Links for TDRD5 Gene

GeneLoc Exon Structure for
TDRD5

Expression for TDRD5 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TDRD5 Gene

mRNA expression in normal human tissues for TDRD5 Gene
mRNA expression by GTEx for TDRD5 Gene

mRNA differential expression in normal tissues according to GTEx for TDRD5 Gene

This gene is overexpressed in Testis (x18.3).

Protein differential expression in normal tissues from HIPED for TDRD5 Gene

This gene is overexpressed in Liver, secretome (27.2), Heart (18.5), and Skin (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TDRD5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TDRD5

SOURCE GeneReport for Unigene cluster for TDRD5 Gene:

Hs.197354

Evidence on tissue expression from TISSUES for TDRD5 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TDRD5: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TDRD5 Gene

Orthologs for TDRD5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TDRD5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TDRD5 30 31
  • 99.32 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TDRD5 30 31
  • 88.26 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TDRD5 30 31
  • 87.72 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tdrd5 30 17 31
  • 82.6 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tdrd5 30
  • 81.76 (n)
Oppossum
(Monodelphis domestica)
 Mammalia TDRD5 31
  • 66 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia TDRD5 31
  • 63 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves TDRD5 31
  • 45 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TDRD5 31
  • 50 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia tdrd5 30
  • 54.73 (n)
Zebrafish
(Danio rerio)
 Actinopterygii tdrd5 30 31
  • 48.08 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta qin 31
  • 7 (a)
 ManyToMany
tud 31
  • 5 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.10307 31
  • 22 (a)
 OneToOne
Species where no ortholog for TDRD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TDRD5 Gene

ENSEMBL:
Gene Tree for TDRD5 (if available)
TreeFam:
Gene Tree for TDRD5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TDRD5: view image

Paralogs for TDRD5 Gene

Paralogs for TDRD5 Gene

genes like me logo Genes that share paralogs with TDRD5: view

Variants for TDRD5 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TDRD5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
709554 Benign: not provided 179,595,698(+) A/G SYNONYMOUS_VARIANT
767733 Benign: not provided 179,654,294(+) A/G MISSENSE_VARIANT,INTRON_VARIANT
780281 Benign: not provided 179,663,368(+) T/A SYNONYMOUS_VARIANT
rs386352369 Uncertain Significance: not provided 179,593,754(+) T/C MISSENSE_VARIANT
rs12066948 - p.Met104Thr

Additional dbSNP identifiers (rs#s) for TDRD5 Gene

Structural Variations from Database of Genomic Variants (DGV) for TDRD5 Gene

Variant ID Type Subtype PubMed ID
dgv226n106 CNV deletion 24896259
dgv655n54 CNV loss 21841781
esv2244958 CNV deletion 18987734
esv23404 CNV gain+loss 19812545
esv2544242 CNV deletion 19546169
esv2598318 CNV insertion 19546169
esv2677942 CNV deletion 23128226
esv2719895 CNV deletion 23290073
esv3414091 CNV insertion 20981092
esv3417628 CNV duplication 20981092
esv3543200 CNV deletion 23714750
esv3578297 CNV loss 25503493
esv3588056 CNV loss 21293372
esv5000 CNV loss 18987735
esv997488 CNV gain 20482838
nsv1013000 CNV gain 25217958
nsv1068723 CNV deletion 25765185
nsv1119736 CNV deletion 24896259
nsv3732 CNV insertion 18451855
nsv475609 CNV novel sequence insertion 20440878
nsv511147 CNV loss 21212237
nsv511720 CNV loss 21212237
nsv512751 CNV insertion 21212237
nsv548338 CNV loss 21841781
nsv821315 CNV deletion 20802225

Variation tolerance for TDRD5 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.78; 95.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TDRD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TDRD5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDRD5 Gene

Disorders for TDRD5 Gene

Additional Disease Information for TDRD5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for TDRD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TDRD5 Gene

Publications for TDRD5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 41
  3. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl GR … Lerman C (Archives of general psychiatry 2008) 3 41
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

ExternalLinks

View latest publications for TDRD5 gene in Mastermind

Products for TDRD5 Gene

  • Addgene plasmids for TDRD5

Sources for TDRD5 Gene