Aliases for TDRD12 Gene
External Ids for TDRD12 Gene
Previous GeneCards Identifiers for TDRD12 Gene
GeneCards Summary for TDRD12 Gene
TDRD12 (Tudor Domain Containing 12) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and PIWI-interacting RNA (piRNA) biogenesis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity. An important paralog of this gene is TDRD6.
UniProtKB/Swiss-Prot Summary for TDRD12 Gene
Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.