Aliases for TDRD10 Gene

Aliases for TDRD10 Gene

  • Tudor Domain Containing 10 2 3 5
  • Tudor Domain-Containing Protein 10 3 4

External Ids for TDRD10 Gene

Previous GeneCards Identifiers for TDRD10 Gene

  • GC01P151307
  • GC01P152741
  • GC01P154474
  • GC01P125838

Summaries for TDRD10 Gene

GeneCards Summary for TDRD10 Gene

TDRD10 (Tudor Domain Containing 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TDRD6.

Additional gene information for TDRD10 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TDRD10 Gene

Genomics for TDRD10 Gene

GeneHancer (GH) Regulatory Elements for TDRD10 Gene

Promoters and enhancers for TDRD10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J154499 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 528.8 -1.1 -1119 4.2 MYC USF1 ZFX GABPA HDAC2 EZH2 CEBPB REST CEBPG YY1 TDRD10 SHE IL6R GBA ENSG00000273110
GH01J154935 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +435.5 435482 4.2 FOXK2 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C TCF12 POLR2G USF1 SP1 ENSG00000270361 PMVK TDRD10 ASH1L KCNN3 PBXIP1 SHC1 MTX1 ADAR lnc-CKS1B-3
GH01J154492 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 23.2 -9.0 -9023 2 ZBTB11 NR2F2 MEF2B NBN SPI1 EBF1 IKZF1 FOXP2 ATF2 GATA2 TDRD10 UBE2Q1-AS1 UBE2Q1 RNU7-57P ATP8B2 SHE ADAR C1orf189 GBA ENSG00000273110
GH01J153919 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.3 -580.3 -580283 5.7 HNRNPK ZBTB40 ZNF217 EP300 SIN3A TCF12 POLR2G SP1 PHF8 FOS GATAD2B ENSG00000284738 LOC101928059 UBAP2L ILF2 CREB3L4 DENND4B CRTC2 TDRD10 ENSG00000233222
GH01J154417 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -81.1 -81140 6.7 EP300 FOXK2 ZNF217 TCF12 POLR2G NCOR1 JUND FOS ZNF639 ZIC2 IL6R TDRD10 FAM189B ENSG00000272654 CRTC2 ADAR UBAP2L KRTCAP2 S100A1 GATAD2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TDRD10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TDRD10

Top Transcription factor binding sites by QIAGEN in the TDRD10 gene promoter:
  • AREB6
  • CREB
  • deltaCREB
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Elk-1

Genomic Locations for TDRD10 Gene

Genomic Locations for TDRD10 Gene
chr1:154,502,219-154,548,147
(GRCh38/hg38)
Size:
45,929 bases
Orientation:
Plus strand
chr1:154,474,695-154,520,623
(GRCh37/hg19)
Size:
45,929 bases
Orientation:
Plus strand

Genomic View for TDRD10 Gene

Genes around TDRD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDRD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDRD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRD10 Gene

Proteins for TDRD10 Gene

  • Protein details for TDRD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ19-TDR10_HUMAN
    Recommended name:
    Tudor domain-containing protein 10
    Protein Accession:
    Q5VZ19
    Secondary Accessions:
    • A4FU09
    • B0QZ53
    • B4DXV4
    • Q3ZCP1
    • Q3ZCS7
    • Q5SXY7
    • Q6UXV2
    • Q8TCN3

    Protein attributes for TDRD10 Gene

    Size:
    366 amino acids
    Molecular mass:
    40941 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH44864.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI00896.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI00897.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI00898.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI00899.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88562.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD28538.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for TDRD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRD10 Gene

Post-translational modifications for TDRD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TDRD10 Gene

Domains & Families for TDRD10 Gene

Gene Families for TDRD10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for TDRD10 Gene

Suggested Antigen Peptide Sequences for TDRD10 Gene

GenScript: Design optimal peptide antigens:
  • Tudor domain-containing protein 10 (TDR10_HUMAN)
genes like me logo Genes that share domains with TDRD10: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TDRD10 Gene

Function for TDRD10 Gene

Phenotypes From GWAS Catalog for TDRD10 Gene

Gene Ontology (GO) - Molecular Function for TDRD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with TDRD10: view
genes like me logo Genes that share phenotypes with TDRD10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TDRD10

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TDRD10 Gene

Localization for TDRD10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TDRD10 gene
Compartment Confidence
nucleus 2
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TDRD10 Gene

Pathways & Interactions for TDRD10 Gene

PathCards logo

SuperPathways for TDRD10 Gene

No Data Available

Interacting Proteins for TDRD10 Gene

;

Gene Ontology (GO) - Biological Process for TDRD10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TDRD10 Gene

Drugs & Compounds for TDRD10 Gene

No Compound Related Data Available

Transcripts for TDRD10 Gene

mRNA/cDNA for TDRD10 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TDRD10

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD10 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for TDRD10 Gene

GeneLoc Exon Structure for
TDRD10

Expression for TDRD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TDRD10 Gene

mRNA differential expression in normal tissues according to GTEx for TDRD10 Gene

This gene is overexpressed in Testis (x13.8).

Protein differential expression in normal tissues from HIPED for TDRD10 Gene

This gene is overexpressed in Prostate (58.4) and Ovary (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TDRD10 Gene



Protein tissue co-expression partners for TDRD10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TDRD10

SOURCE GeneReport for Unigene cluster for TDRD10 Gene:

Hs.387671
genes like me logo Genes that share expression patterns with TDRD10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TDRD10 Gene

Orthologs for TDRD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TDRD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TDRD10 31 30
  • 95.1 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TDRD10 31 30
  • 81.73 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TDRD10 31
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490913 30
  • 51.3 (n)
Species where no ortholog for TDRD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TDRD10 Gene

ENSEMBL:
Gene Tree for TDRD10 (if available)
TreeFam:
Gene Tree for TDRD10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TDRD10: view image

Paralogs for TDRD10 Gene

Paralogs for TDRD10 Gene

genes like me logo Genes that share paralogs with TDRD10: view

Variants for TDRD10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TDRD10 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs12750774 - p.Arg181Gln
rs3811448 - p.Val215Ile

Additional dbSNP identifiers (rs#s) for TDRD10 Gene

Structural Variations from Database of Genomic Variants (DGV) for TDRD10 Gene

Variant ID Type Subtype PubMed ID
dgv584n54 CNV gain 21841781
dgv585n54 CNV gain 21841781
esv23279 CNV loss 19812545
nsv160554 CNV deletion 16902084
nsv506960 OTHER sequence alteration 20534489
nsv521887 CNV gain 19592680
nsv547942 CNV gain+loss 21841781
nsv547954 CNV loss 21841781
nsv547957 CNV loss 21841781

Variation tolerance for TDRD10 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TDRD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TDRD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDRD10 Gene

Disorders for TDRD10 Gene

Additional Disease Information for TDRD10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TDRD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TDRD10 Gene

Publications for TDRD10 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3 54

Products for TDRD10 Gene

Sources for TDRD10 Gene