Aliases for TDP2 Gene
Aliases for TDP2 Gene
External Ids for TDP2 Gene
- HGNC: 17768
- Entrez Gene: 51567
- Ensembl: ENSG00000111802
- OMIM: 605764
- UniProtKB: O95551
Previous HGNC Symbols for TDP2 Gene
- TTRAP
Summaries for TDP2 Gene
-
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
GeneCards Summary for TDP2 Gene
TDP2 (Tyrosyl-DNA Phosphodiesterase 2) is a Protein Coding gene. Diseases associated with TDP2 include Spinocerebellar Ataxia, Autosomal Recessive 23 and Paralytic Poliomyelitis. Among its related pathways are DNA Double-Strand Break Repair and CD40/CD40L signaling. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and single-stranded DNA binding.
UniProtKB/Swiss-Prot for TDP2 Gene
-
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5-phosphodiester bond, giving rise to DNA with a free 5 phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a clean DSB with 5-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5-phosphoglycolates on protruding 5 ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation.
-
(Microbial infection) Also acts as a 5-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA.
Additional gene information for TDP2 Gene
- Monarch Initiative
- Search for TDP2 at DataMed
- Search for TDP2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDP2 Gene
Genomics for TDP2 Gene
GeneHancer (GH) Regulatory Elements for TDP2 Gene
Promoters and enhancers for TDP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TDP2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TDP2 Gene
Genomic Locations for TDP2 Gene
- chr6:24,649,977-24,667,033
- (GRCh38/hg38)
- Size:
- 17,057 bases
- Orientation:
- Minus strand
- chr6:24,650,205-24,667,261
- (GRCh37/hg19)
Genomic View for TDP2 Gene
Genes around TDP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.3 by Ensembl
- 6p22.3 by Entrez Gene
- 6p22.3 by HGNC
TDP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TDP2 Gene
Proteins for TDP2 Gene
-
Protein details for TDP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95551-TYDP2_HUMAN
- Recommended name:
- Tyrosyl-DNA phosphodiesterase 2
- Protein Accession:
- O95551
- B4DKL8
- B4DQ95
- Q2TBE2
- Q5JYM0
- Q7Z6U5
- Q9NUK5
- Q9NYY9
Protein attributes for TDP2 Gene
- Size:
- 362 amino acids
- Molecular mass:
- 40930 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1, SMAD3 and ACVR1B/ALK4.
- SequenceCaution:
-
- Sequence=BAG59230.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD92510.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for TDP2 Gene
Post-translational modifications for TDP2 Gene
- Ubiquitinated by TRAF6.
- Ubiquitination at posLast=2323, posLast=8282, posLast=192192, isoforms=2, 3203, posLast=242242, posLast=247247, and posLast=341341
- Modification sites at PhosphoSitePlus
Other Protein References for TDP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam proteins for TDP2
Assay Products
- antibodies-online: Search results for available TDP2 related products ranked by validation data
No data available for DME Specific Peptides for TDP2 Gene
Domains & Families for TDP2 Gene
Gene Families for TDP2 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for TDP2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TDP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95551- Family:
-
- Belongs to the CCR4/nocturin family.
Function for TDP2 Gene
Molecular function for TDP2 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=8 uM for single-stranded 5-tyrosyl DNA {ECO:0000269 PubMed:22822062}; Note=kcat is 3 sec(-1) with single-stranded 5-tyrosyl DNA as substrate.;
- UniProtKB/Swiss-Prot Function:
- DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5-phosphodiester bond, giving rise to DNA with a free 5 phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a clean DSB with 5-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5-phosphoglycolates on protruding 5 ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Also acts as a 5-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA.
Enzyme Numbers (IUBMB) for TDP2 Gene
Phenotypes From GWAS Catalog for TDP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | TAS | 19794497 |
| GO:0003697 | single-stranded DNA binding | IDA | 22822062 |
| GO:0003714 | transcription corepressor activity | TAS | 10764746 |
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 18039968 |
Phenotypes for TDP2 Gene
- MGI mutant phenotypes for TDP2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TDP2:
Animal Models for TDP2 Gene
- MGI Knock Outs for TDP2:
-
- Tdp2 tm1.1Huy
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for TDP2 gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TDP2
-
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No data available for miRNA , Transcription Factor Targets and HOMER Transcription for TDP2 Gene
Localization for TDP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TDP2 Gene
- Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein.
- Cytoplasm. Note=(Microbial infection) In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation. {ECO:0000269 PubMed:22908287}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 22908287 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IEA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 22908287 |
| GO:0016235 | aggresome | IDA | -- |
Pathways & Interactions for TDP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Double-Strand Break Repair |
.53
|
|
| 2 | DNA Double Strand Break Response | ||
| 3 | CD40/CD40L signaling | ||
Pathways by source for TDP2 Gene
1 BioSystems pathway for TDP2 Gene
3 Reactome pathways for TDP2 Gene
Interacting Proteins for TDP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006302 | double-strand break repair | IMP | 21030584 |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | TAS | 10764746 |
| GO:0048666 | neuron development | IMP | 24658003 |
No data available for SIGNOR curated interactions for TDP2 Gene
Transcripts for TDP2 Gene
mRNA/cDNA for TDP2 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (313) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TDP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TDP2
- genomics-online: gRNA clones - Search results for 108 available TDP2 gene related products
- Overview of 108 available TDP2 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TDP2
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miRNA Products
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Inhibitory RNA Products
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- Overview of 108 available TDP2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TDP2 gene
Clone Products
- Sino Biological Human cDNA Clone for TDP2
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TDP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TDP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: | - |
Expression for TDP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Brain (Nervous System)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for TDP2 Gene
This gene is overexpressed in Whole Blood (x4.3).
This gene is overexpressed in Cervix (15.7), CD4 Tcells (11.9), and Breast (10.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TDP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of TDP2 Gene:
TDP2SOURCE GeneReport for Unigene cluster for TDP2 Gene:
Hs.403010mRNA Expression by UniProt/SwissProt for TDP2 Gene:
O95551-TYDP2_HUMAN
Tissue specificity:
Widely expressed (PubMed:10764746). Highly expressed in various brain regions, including the frontal and occipital lobes, the hippocampus, the striatum and the cerebellum (PubMed:24658003).
Evidence on tissue expression from TISSUES for TDP2 Gene
- Intestine(4.7)
- Adrenal gland(4.2)
- Skin(4.2)
- Nervous system(3.9)
- Lung(2.4)
- Kidney(2.1)
Primer Products
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OriGene qPCR primer pairs for TDP2
-
OriGene qPCR primer pairs and template standards for TDP2
- genomics-online: primer clones - Search results for 108 available TDP2 gene related products
- Overview of 108 available TDP2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TDP2 Gene
Orthologs for TDP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TDP2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TDP2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TDP2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tdp2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tdp2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TDP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TDP2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TDP2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tdp2 33 |
|
||
| Str.3755 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8025 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tdp2b 33 34 |
|
||
| TDP2 (2 of 2) 34 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7216 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_Y63D3A.4 33 |
|
||
| Y63D3A.4 34 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2731 34 |
|
OneToOne |
- Species where no ortholog for TDP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TDP2 Gene
No data available for Paralogs for TDP2 Gene
Variants for TDP2 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs372245668 | pathogenic, Spinocerebellar ataxia, autosomal recessive 23 | 24,658,560(-) | C/T | splice_donor_variant | |
| rs879255601 | pathogenic, Spinocerebellar ataxia, autosomal recessive 23 | 24,658,572(-) | GG/TT | coding_sequence_variant, stop_gained | |
| rs758350133 | uncertain-significance, not specified | 24,651,017(-) | A/C | coding_sequence_variant, missense_variant | |
| rs1000050028 | -- | 24,658,266(-) | T/A | intron_variant | |
| rs1000101888 | -- | 24,658,091(-) | G/C | intron_variant |
Residual Variation Intolerance Score:
31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.97;
87.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TDP2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDP2 Gene
Disorders for TDP2 Gene
(3) MalaCards diseases for TDP2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinocerebellar ataxia, autosomal recessive 23 |
|
|
| paralytic poliomyelitis |
|
|
| reading disorder |
|
|
Search TDP2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TYDP2_HUMAN- Spinocerebellar ataxia, autosomal recessive, 23 (SCAR23) [MIM:616949]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR23 patients manifest epilepsy, intellectual disability, and gait ataxia. {ECO:0000269 PubMed:24658003}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for TDP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for TDP2 Gene
Publications for TDP2 Gene
- TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. (PMID: 10764746) Pype S … Remacle JE (The Journal of biological chemistry 2000) 3 4 22 58
- TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. (PMID: 24658003) Gómez-Herreros F … Caldecott KW (Nature genetics 2014) 3 4 58
- The PML nuclear bodies-associated protein TTRAP regulates ribosome biogenesis in nucleolar cavities upon proteasome inhibition. (PMID: 21921940) Vilotti S … Gustincich S (Cell death and differentiation 2012) 3 4 58
- Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction. (PMID: 22405347) Adhikari S … Uren A (BMC research notes 2012) 3 4 58
- Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes. (PMID: 22822062) Gao R … Pommier Y (The Journal of biological chemistry 2012) 3 4 58
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- Abcam proteins for TDP2
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- ProSpec Recombinant Proteins for TDP2
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for TDP2
- VectorBuilder custom plasmid, inducible vectors for TDP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TDP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 88 available TDP2 Antibodies ranked by validation data
- Compare Top TDP2 Antibodies
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- antibodies-online: Search results for available TDP2 related products ranked by validation data
- antibodies-online: Search results for 12 available TDP2 Proteins ranked by validation data
- Compare Top TDP2 Proteins
- GeneTex TDP2 antibody for TDP2
- Search GeneTex for Proteins for TDP2
- ViGene Biosciences adenoviral particle packaged cDNA for TDP2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TDP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TDP2 gene
- Search ViGene Biosciences for TDP2
- Santa Cruz Biotechnology (SCBT) Antibodies for TDP2
- Search Santa Cruz Biotechnology (SCBT) for TDP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TDP2
- Horizon Cell Lines for TDP2
- genomics-online: cdna clones - Search results for 108 available TDP2 gene related products
- Overview of 108 available TDP2 gene related products
- orf clones - Search results for 108 available TDP2 gene related products
- Overview of 108 available TDP2 gene related products
- genomics-online: gRNA clones - Search results for 108 available TDP2 gene related products
- Overview of 108 available TDP2 gene related products
- genomics-online: primer clones - Search results for 108 available TDP2 gene related products
- Overview of 108 available TDP2 gene related products
- genomics-online: shRNA clones - Search results for 108 available TDP2 gene related products
- Overview of 108 available TDP2 gene related products
Sources for TDP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems