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This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]
TDP2 (Tyrosyl-DNA Phosphodiesterase 2) is a Protein Coding gene. Diseases associated with TDP2 include Spinocerebellar Ataxia, Autosomal Recessive 23 and Paralytic Poliomyelitis. Among its related pathways are DNA Double Strand Break Response and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and single-stranded DNA binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000287 | magnesium ion binding | TAS | 19794497 |
GO:0003697 | single-stranded DNA binding | IBA,IDA | 22822062 |
GO:0003714 | transcription corepressor activity | TAS | 10764746 |
GO:0004518 | nuclease activity | IEA | -- |
GO:0005515 | protein binding | IPI | 18039968 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA,IEA | 22908287 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005730 | nucleolus | IEA | -- |
GO:0005737 | cytoplasm | IDA,IBA | 22908287 |
GO:0016235 | aggresome | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | DNA Double-Strand Break Repair |
.53
|
|
2 | DNA Double Strand Break Response | ||
3 | CD40/CD40L signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006281 | DNA repair | IEA | -- |
GO:0006302 | double-strand break repair | IBA,IMP | 21030584 |
GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
GO:0007166 | cell surface receptor signaling pathway | TAS | 10764746 |
GO:0048666 | neuron development | IMP | 24658003 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TDP2 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | TDP2 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | TDP2 33 32 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Tdp2 32 |
|
||
mouse (Mus musculus) |
Mammalia | Tdp2 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | TDP2 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | TDP2 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | TDP2 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | tdp2 32 |
|
||
Str.3755 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8025 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | tdp2b 33 32 |
|
OneToMany | |
TDP2 (2 of 2) 33 |
|
OneToMany | |||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7216 32 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | CELE_Y63D3A.4 32 |
|
||
Y63D3A.4 33 |
|
OneToOne | |||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2731 33 |
|
OneToOne |
SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs372245668 | pathogenic, Spinocerebellar ataxia, autosomal recessive 23 | 24,658,560(-) | C/T | splice_donor_variant | |
rs879255601 | pathogenic, Spinocerebellar ataxia, autosomal recessive 23 | 24,658,572(-) | GG/TT | coding_sequence_variant, stop_gained | |
rs1562148727 | pathogenic, not provided | 24,658,597(-) | G/C | coding_sequence_variant, stop_gained | |
rs1209809150 | uncertain-significance, not provided | 24,654,488(-) | G/A | coding_sequence_variant, missense_variant | |
rs758350133 | uncertain-significance, not specified | 24,651,017(-) | A/C | coding_sequence_variant, missense_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
spinocerebellar ataxia, autosomal recessive 23 |
|
|
paralytic poliomyelitis |
|
|
reading disorder |
|
|