TDP2 Gene (Protein Coding)

Tyrosyl-DNA Phosphodiesterase 2

GC06M024651
GIFtS:
41
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repa... See more...

Aliases for TDP2 Gene

Aliases for TDP2 Gene

  • Tyrosyl-DNA Phosphodiesterase 2 2 3 4 5
  • TRAF And TNF Receptor-Associated Protein 3 4
  • 5'-Tyrosyl-DNA Phosphodiesterase 3 4
  • Tyrosyl-RNA Phosphodiesterase 3 4
  • 5'-Tyr-DNA Phosphodiesterase 3 4
  • Tyr-DNA Phosphodiesterase 2 3 4
  • ETS1-Associated Protein II 3 4
  • ETS1-Associated Protein 2 3 4
  • VPg Unlinkase 3 4
  • TTRAP 3 4
  • EAPII 3 4
  • HTDP2 3 4
  • EAP2 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • TRAF And TNF Receptor Associated Protein 2
  • EC 3.1.4.- 4
  • DJ30M3.3 3
  • AD022 3

External Ids for TDP2 Gene

Previous HGNC Symbols for TDP2 Gene

  • TTRAP

Summaries for TDP2 Gene

Entrez Gene Summary for TDP2 Gene

  • This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]

GeneCards Summary for TDP2 Gene

TDP2 (Tyrosyl-DNA Phosphodiesterase 2) is a Protein Coding gene. Diseases associated with TDP2 include Spinocerebellar Ataxia, Autosomal Recessive 23 and Paralytic Poliomyelitis. Among its related pathways are DNA Double Strand Break Response and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and single-stranded DNA binding.

UniProtKB/Swiss-Prot Summary for TDP2 Gene

  • DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27099339, PubMed:27060144). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation.
  • (Microbial infection) Also acts as a 5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA.

Gene Wiki entry for TDP2 Gene

Additional gene information for TDP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TDP2 Gene

Genomics for TDP2 Gene

GeneHancer (GH) Regulatory Elements for TDP2 Gene

Promoters and enhancers for TDP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TDP2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TDP2 Gene

Genomic Locations for TDP2 Gene
chr6:24,649,977-24,666,989
(GRCh38/hg38)
Size:
17,013 bases
Orientation:
Minus strand
chr6:24,650,205-24,667,261
(GRCh37/hg19)
Size:
17,057 bases
Orientation:
Minus strand

Genomic View for TDP2 Gene

Genes around TDP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TDP2 Gene

Proteins for TDP2 Gene

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  • Protein details for TDP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95551-TYDP2_HUMAN
    Recommended name:
    Tyrosyl-DNA phosphodiesterase 2
    Protein Accession:
    O95551
    Secondary Accessions:
    • B4DKL8
    • B4DQ95
    • Q2TBE2
    • Q5JYM0
    • Q7Z6U5
    • Q9NUK5
    • Q9NYY9

    Protein attributes for TDP2 Gene

    Size:
    362 amino acids
    Molecular mass:
    40930 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1, SMAD3 and ACVR1B/ALK4.
    SequenceCaution:
    • Sequence=BAG59230.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TDP2 Gene

    Alternative splice isoforms for TDP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDP2 Gene

Protein Expression for TDP2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TDP2 Gene

  • Ubiquitinated by TRAF6.
  • Ubiquitination at Lys23, Lys82, Lys192, Lys203, Lys242, Lys247, and Lys341
  • Modification sites at PhosphoSitePlus

Other Protein References for TDP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TDP2 Gene

Domains & Families for TDP2 Gene

Gene Families for TDP2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TDP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TDP2 Gene

GenScript: Design optimal peptide antigens:
  • TRAF and TNF receptor-associated protein (TYDP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95551

UniProtKB/Swiss-Prot:

TYDP2_HUMAN :
  • Belongs to the CCR4/nocturin family.
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with TDP2: view

Function for TDP2 Gene

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Molecular function for TDP2 Gene

UniProtKB/Swiss-Prot Function:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (PubMed:27099339, PubMed:27060144). Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Also acts as a 5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8 uM for single-stranded 5'-tyrosyl DNA {ECO:0000269 PubMed:22822062}; Note=kcat is 3 sec(-1) with single-stranded 5'-tyrosyl DNA as substrate.;

Enzyme Numbers (IUBMB) for TDP2 Gene

Phenotypes From GWAS Catalog for TDP2 Gene

Gene Ontology (GO) - Molecular Function for TDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding TAS 19794497
GO:0003697 single-stranded DNA binding IBA,IDA 22822062
GO:0003714 transcription corepressor activity TAS 10764746
GO:0004518 nuclease activity IEA --
GO:0005515 protein binding IPI 18039968
genes like me logo Genes that share ontologies with TDP2: view
genes like me logo Genes that share phenotypes with TDP2: view

Human Phenotype Ontology for TDP2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TDP2 Gene

MGI Knock Outs for TDP2:
  • Tdp2 Tdp2<tm1.1Huy>

Animal Model Products

CRISPR Products

Clone Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for TDP2 Gene

Localization for TDP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDP2 Gene

Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. {ECO:0000269 PubMed:21921940}.
Cytoplasm. Note=(Microbial infection) In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation. {ECO:0000269 PubMed:22908287}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TDP2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 22908287
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA,IBA 22908287
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with TDP2: view

Pathways & Interactions for TDP2 Gene

genes like me logo Genes that share pathways with TDP2: view

Pathways by source for TDP2 Gene

1 BioSystems pathway for TDP2 Gene

Gene Ontology (GO) - Biological Process for TDP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006302 double-strand break repair IBA,IMP 21030584
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007166 cell surface receptor signaling pathway TAS 10764746
GO:0048666 neuron development IMP 24658003
genes like me logo Genes that share ontologies with TDP2: view

No data available for SIGNOR curated interactions for TDP2 Gene

Drugs & Compounds for TDP2 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for TDP2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TDP2 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(313) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TDP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5: -

Relevant External Links for TDP2 Gene

GeneLoc Exon Structure for
TDP2
ECgene alternative splicing isoforms for
TDP2

Expression for TDP2 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TDP2 Gene

mRNA expression in normal human tissues for TDP2 Gene
mRNA expression by GTEx for TDP2 GenemRNA expression by BioGPS for TDP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TDP2 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for TDP2 Gene

This gene is overexpressed in Cervix (15.7), CD4 Tcells (11.9), and Breast (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TDP2 Gene



Protein tissue co-expression partners for TDP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TDP2 Gene:

TDP2

SOURCE GeneReport for Unigene cluster for TDP2 Gene:

Hs.403010

mRNA Expression by UniProt/SwissProt for TDP2 Gene:

O95551-TYDP2_HUMAN
Tissue specificity: Widely expressed (PubMed:10764746). Highly expressed in various brain regions, including the frontal and occipital lobes, the hippocampus, the striatum and the cerebellum (PubMed:24658003).

Evidence on tissue expression from TISSUES for TDP2 Gene

  • Intestine(4.7)
  • Adrenal gland(4.2)
  • Skin(4.2)
  • Nervous system(3.9)
  • Lung(2.4)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with TDP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TDP2 Gene

Orthologs for TDP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TDP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TDP2 33 32
  • 99.36 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia TDP2 33 32
  • 89.35 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia TDP2 33 32
  • 87.07 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tdp2 32
  • 79.59 (n)
mouse
(Mus musculus)
 Mammalia Tdp2 17 33 32
  • 79.39 (n)
oppossum
(Monodelphis domestica)
 Mammalia TDP2 33
  • 60 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TDP2 33 32
  • 67.94 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TDP2 33
  • 61 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tdp2 32
  • 64.22 (n)
Str.3755 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.8025 32
zebrafish
(Danio rerio)
 Actinopterygii tdp2b 33 32
  • 59.54 (n)
 OneToMany
TDP2 (2 of 2) 33
  • 30 (a)
 OneToMany
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.7216 32
worm
(Caenorhabditis elegans)
 Secernentea CELE_Y63D3A.4 32
  • 44.74 (n)
Y63D3A.4 33
  • 29 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.2731 33
  • 34 (a)
 OneToOne
Species where no ortholog for TDP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TDP2 Gene

ENSEMBL:
Gene Tree for TDP2 (if available)
TreeFam:
Gene Tree for TDP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TDP2: view image

Paralogs for TDP2 Gene

No data available for Paralogs for TDP2 Gene

Variants for TDP2 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for TDP2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs372245668 pathogenic, Spinocerebellar ataxia, autosomal recessive 23 24,658,560(-) C/T splice_donor_variant
rs879255601 pathogenic, Spinocerebellar ataxia, autosomal recessive 23 24,658,572(-) GG/TT coding_sequence_variant, stop_gained
rs1562148727 pathogenic, not provided 24,658,597(-) G/C coding_sequence_variant, stop_gained
rs1209809150 uncertain-significance, not provided 24,654,488(-) G/A coding_sequence_variant, missense_variant
rs758350133 uncertain-significance, not specified 24,651,017(-) A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TDP2 Gene

Variant ID Type Subtype PubMed ID
nsv601164 CNV gain 21841781
nsv601165 CNV loss 21841781

Variation tolerance for TDP2 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.97; 87.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TDP2 Gene

Human Gene Mutation Database (HGMD)
TDP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TDP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDP2 Gene

Disorders for TDP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TDP2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia, autosomal recessive 23
  • scar23
paralytic poliomyelitis
  • poliomyelitis, paralytic
reading disorder
  • dyslexia
- elite association - COSMIC cancer census association via MalaCards
Search TDP2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TYDP2_HUMAN
  • Spinocerebellar ataxia, autosomal recessive, 23 (SCAR23) [MIM:616949]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR23 patients manifest epilepsy, intellectual disability, and gait ataxia. {ECO:0000269 PubMed:24658003}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TDP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TDP2: view

No data available for Genatlas for TDP2 Gene

Publications for TDP2 Gene

  1. TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. (PMID: 10764746) Pype S … Remacle JE (The Journal of biological chemistry 2000) 3 4 23 56
  2. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. (PMID: 24658003) Gómez-Herreros F … Caldecott KW (Nature genetics 2014) 3 4 56
  3. The PML nuclear bodies-associated protein TTRAP regulates ribosome biogenesis in nucleolar cavities upon proteasome inhibition. (PMID: 21921940) Vilotti S … Gustincich S (Cell death and differentiation 2012) 3 4 56
  4. An RNA virus hijacks an incognito function of a DNA repair enzyme. (PMID: 22908287) Virgen-Slane R … Semler BL (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4 56
  5. Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes. (PMID: 22822062) Gao R … Pommier Y (The Journal of biological chemistry 2012) 3 4 56

ExternalLinks

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