TDP1 Gene (Protein Coding)

Tyrosyl-DNA Phosphodiesterase 1

GC14P089954
GIFtS:
44
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical m... See more...

Aliases for TDP1 Gene

Aliases for TDP1 Gene

  • Tyrosyl-DNA Phosphodiesterase 1 2 3 4 5
  • Tyr-DNA Phosphodiesterase 1 3 4
  • EC 3.1.4.- 4
  • FLJ11090 2
  • EC 3.1.4 51
  • SCAN1 2
  • TDP1 5

External Ids for TDP1 Gene

Previous GeneCards Identifiers for TDP1 Gene

  • GC14P087927
  • GC14P084237
  • GC14P088411
  • GC14P088412
  • GC14P089492
  • GC14P090422
  • GC14P070596

Summaries for TDP1 Gene

Entrez Gene Summary for TDP1 Gene

  • The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]

GeneCards Summary for TDP1 Gene

TDP1 (Tyrosyl-DNA Phosphodiesterase 1) is a Protein Coding gene. Diseases associated with TDP1 include Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1 and Axonal Neuropathy. Among its related pathways are DNA Double Strand Break Response and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include double-stranded DNA binding and phosphoric diester hydrolase activity.

UniProtKB/Swiss-Prot Summary for TDP1 Gene

  • DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.

Gene Wiki entry for TDP1 Gene

Additional gene information for TDP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TDP1 Gene

Genomics for TDP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TDP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TDP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TDP1

Top Transcription factor binding sites by QIAGEN in the TDP1 gene promoter:
  • AML1a
  • CBF(2)
  • CBF-A
  • CBF-C
  • CUTL1
  • HSF1 (long)
  • HSF1short
  • MyoD
  • Nkx2-5

Genomic Locations for TDP1 Gene

Genomic Locations for TDP1 Gene
chr14:89,954,923-90,044,768
(GRCh38/hg38)
Size:
89,846 bases
Orientation:
Plus strand
chr14:90,421,283-90,511,108
(GRCh37/hg19)
Size:
89,826 bases
Orientation:
Plus strand

Genomic View for TDP1 Gene

Genes around TDP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TDP1 Gene

Proteins for TDP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TDP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUW8-TYDP1_HUMAN
    Recommended name:
    Tyrosyl-DNA phosphodiesterase 1
    Protein Accession:
    Q9NUW8
    Secondary Accessions:
    • Q2HXX4
    • Q86TV8
    • Q96BK7
    • Q9NZM7
    • Q9NZM8

    Protein attributes for TDP1 Gene

    Size:
    608 amino acids
    Molecular mass:
    68420 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for TDP1 Gene

    Alternative splice isoforms for TDP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDP1 Gene

Protein Expression for TDP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for TDP1 Gene

Q9NUW8:
  • FGTHHTKM
  • PHIKTYMR

Post-translational modifications for TDP1 Gene

  • Phosphorylated on serine and/or threonine residues, but not on tyrosine residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TDP1 Gene

Gene Families for TDP1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TDP1 Gene

InterPro:
Blocks:
  • Tyrosyl-DNA phosphodiesterase
ProtoNet:

Suggested Antigen Peptide Sequences for TDP1 Gene

GenScript: Design optimal peptide antigens:
  • TDP1 protein (Q32Q25_HUMAN)
  • Tyrosyl-DNA phosphodiesterase 1 (TYDP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NUW8

UniProtKB/Swiss-Prot:

TYDP1_HUMAN :
  • Belongs to the tyrosyl-DNA phosphodiesterase family.
Family:
  • Belongs to the tyrosyl-DNA phosphodiesterase family.
genes like me logo Genes that share domains with TDP1: view

Function for TDP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TDP1 Gene

UniProtKB/Swiss-Prot Function:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.08 uM for 14-mer single-stranded oligo with a 3'-phosphotyrosine {ECO:0000269|PubMed:22822062}; Note=kcat is 7 sec(-1) with single-stranded 5'-tyrosyl DNA as substrate.;

Enzyme Numbers (IUBMB) for TDP1 Gene

Phenotypes From GWAS Catalog for TDP1 Gene

Gene Ontology (GO) - Molecular Function for TDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IBA,IDA 15811850
GO:0003697 single-stranded DNA binding IBA,IDA 15811850
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0005515 protein binding IPI 15744309
genes like me logo Genes that share ontologies with TDP1: view
genes like me logo Genes that share phenotypes with TDP1: view

Human Phenotype Ontology for TDP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for TDP1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TDP1

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TDP1 Gene

Localization for TDP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDP1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TDP1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
mitochondrion 2
cytosol 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 17948061
GO:0005886 plasma membrane IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TDP1: view

Pathways & Interactions for TDP1 Gene

genes like me logo Genes that share pathways with TDP1: view

Pathways by source for TDP1 Gene

1 Cell Signaling Technology pathway for TDP1 Gene

SIGNOR curated interactions for TDP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TDP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000012 single strand break repair IBA,IMP 17600775
GO:0006281 DNA repair IEA,IDA 17948061
GO:0006302 double-strand break repair IBA,IDA 12023295
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with TDP1: view

Drugs & Compounds for TDP1 Gene

Products:

  1. Drug

(2) Drugs for TDP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for TDP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TDP1: view

Transcripts for TDP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TDP1 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TDP1

Alternative Splicing Database (ASD) splice patterns (SP) for TDP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: -
SP7: - - - - -
SP8: - - -
SP9: -
SP10:

ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TDP1 Gene

GeneLoc Exon Structure for
TDP1

Expression for TDP1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TDP1 Gene

mRNA expression in normal human tissues for TDP1 Gene
mRNA expression by BioGPS for TDP1 GenemRNA expression by GTEx for TDP1 Gene

Protein differential expression in normal tissues from HIPED for TDP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (39.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TDP1 Gene



Protein tissue co-expression partners for TDP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TDP1

SOURCE GeneReport for Unigene cluster for TDP1 Gene:

Hs.209945

mRNA Expression by UniProt/SwissProt for TDP1 Gene:

Q9NUW8-TYDP1_HUMAN
Tissue specificity: Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus.

Evidence on tissue expression from TISSUES for TDP1 Gene

  • Pancreas(4.2)
  • Nervous system(3.3)
  • Lung(2.6)
  • Blood(2.3)
  • Intestine(2.2)
  • Skin(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TDP1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • head
Limb:
  • foot
  • hand
  • lower limb
  • upper limb
General:
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with TDP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TDP1 Gene

Orthologs for TDP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TDP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TDP1 30 31
  • 99.34 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TDP1 30 31
  • 87.55 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TDP1 30 31
  • 84.07 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tdp1 30
  • 82.24 (n)
Mouse
(Mus musculus)
 Mammalia Tdp1 30 17 31
  • 81.25 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia TDP1 31
  • 75 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TDP1 31
  • 73 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves TDP1 30 31
  • 68.94 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TDP1 31
  • 64 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia tdp1 30
  • 66.44 (n)
Str.15945 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.16878 30
Zebrafish
(Danio rerio)
 Actinopterygii tdp1 30 31
  • 61.71 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta gkt 30 31
  • 48.05 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP010577 30
  • 47.97 (n)
Worm
(Caenorhabditis elegans)
 Secernentea F52C12.1 30 31 32
  • 46.93 (n)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TDP1 33
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons TDP1 30
  • 48.85 (n)
Rice
(Oryza sativa)
 Liliopsida Os07g0530100 30
  • 47.96 (n)
Os.9987 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 52 (a)
 OneToOne
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.1071 30
Species where no ortholog for TDP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TDP1 Gene

ENSEMBL:
Gene Tree for TDP1 (if available)
TreeFam:
Gene Tree for TDP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TDP1: view image

Paralogs for TDP1 Gene

No data available for Paralogs for TDP1 Gene

Variants for TDP1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TDP1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
716009 Benign: not provided 89,993,478(+) C/T SYNONYMOUS_VARIANT
726721 Likely Benign: not provided 89,963,351(+) C/T SYNONYMOUS_VARIANT
739951 Likely Benign: not provided 89,967,363(+) C/G INTRON_VARIANT
777244 Likely Benign: not provided 89,975,798(+) G/A SYNONYMOUS_VARIANT
805646 Uncertain Significance: not provided 89,989,022(+) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TDP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TDP1 Gene

Variant ID Type Subtype PubMed ID
esv3635305 CNV loss 21293372
nsv1045864 CNV loss 25217958
nsv1392 CNV deletion 18451855
nsv521779 CNV loss 19592680
nsv832853 CNV gain 17160897
nsv832854 CNV gain 17160897

Variation tolerance for TDP1 Gene

Residual Variation Intolerance Score: 47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TDP1 Gene

Human Gene Mutation Database (HGMD)
TDP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TDP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDP1 Gene

Disorders for TDP1 Gene

MalaCards: The human disease database

(15) MalaCards diseases for TDP1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TDP1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TYDP1_HUMAN
  • Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 (SCAN1) [MIM:607250]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence. {ECO:0000269 PubMed:12244316, ECO:0000269 PubMed:15647511, ECO:0000269 PubMed:15920477, ECO:0000269 PubMed:16141202, ECO:0000269 PubMed:17948061}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TDP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TDP1: view

No data available for Genatlas for TDP1 Gene

Publications for TDP1 Gene

  1. The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1. (PMID: 11839309) Davies DR … Hol WG (Structure (London, England : 1993) 2002) 2 3 4 23
  2. Irinotecan pharmacogenetics: influence of pharmacodynamic genes. (PMID: 18347181) Hoskins JM … Baiget M (Clinical cancer research : an official journal of the American Association for Cancer Research 2008) 3 23 41
  3. Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages. (PMID: 16141202) Interthal H … Champoux JJ (The Journal of biological chemistry 2005) 3 4 23
  4. Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1). (PMID: 15811850) Raymond AC … Burgin AB (The Journal of biological chemistry 2005) 3 4 23
  5. Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1). (PMID: 15647511) Zhou T … Povirk LF (Nucleic acids research 2005) 3 4 23

ExternalLinks

View latest publications for TDP1 gene in Mastermind

Products for TDP1 Gene

Sources for TDP1 Gene