Aliases for TDO2 Gene
External Ids for TDO2 Gene
Previous GeneCards Identifiers for TDO2 Gene
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
GeneCards Summary for TDO2 Gene
TDO2 (Tryptophan 2,3-Dioxygenase) is a Protein Coding gene. Diseases associated with TDO2 include Hypertryptophanemia and Porphyria. Among its related pathways are Monoamine Transport and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. Gene Ontology (GO) annotations related to this gene include heme binding and amino acid binding.
UniProtKB/Swiss-Prot Summary for TDO2 Gene
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.