This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be a... See more...

Aliases for TDO2 Gene

Aliases for TDO2 Gene

  • Tryptophan 2,3-Dioxygenase 2 3 4 5
  • TDO 2 3 4
  • Tryptamin 2,3-Dioxygenase 3 4
  • Tryptophan Oxygenase 3 4
  • Tryptophan Pyrrolase 3 4
  • Tryptophanase 3 4
  • EC 1.13.11.11 4 50
  • TPH2 2 3
  • TRPO 3 4
  • TO 3 4
  • HYPTRP 3
  • TDO2 5

External Ids for TDO2 Gene

Previous GeneCards Identifiers for TDO2 Gene

  • GC04P157712
  • GC04P157252
  • GC04P157402
  • GC04P157182
  • GC04P157044
  • GC04P156824
  • GC04P152563

Summaries for TDO2 Gene

Entrez Gene Summary for TDO2 Gene

  • This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

GeneCards Summary for TDO2 Gene

TDO2 (Tryptophan 2,3-Dioxygenase) is a Protein Coding gene. Diseases associated with TDO2 include Hypertryptophanemia and Porphyria. Among its related pathways are superpathway of tryptophan utilization and Tryptophan metabolism. Gene Ontology (GO) annotations related to this gene include heme binding and amino acid binding.

UniProtKB/Swiss-Prot Summary for TDO2 Gene

  • Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Tocris Summary for TDO2 Gene

Gene Wiki entry for TDO2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TDO2 Gene

Genomics for TDO2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TDO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J155854 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 250.7 +0.3 278 1.2 RXRA TBP NFE2 ZNF143 IKZF1 RAD21 POLR2A TAF1 MAFK YY1 LOC105377507 TDO2 lnc-GUCY1B1-3 ASIC5
GH04J155903 Promoter 0.8 EPDnew 250.3 +48.9 48939 0.1 ATF3 YY1 FOXA2 RXRA ZBTB33 JUND HNF4A FOXA1 RAD21 REST TDO2 piR-46847-193 HSALNG0038049 ASIC5 lnc-GUCY1B1-3 CTSO
GH04J155906 Enhancer 0.9 Ensembl ENCODE 10.5 +52.9 52930 2.3 YY1 FEZF1 ZNF341 RXRA ZBTB33 ZNF843 PRDM6 INSM2 HNF4A ZNF664 CTSO TDO2 HSALNG0038049 piR-46847-193 ASIC5 lnc-GUCY1B1-3
GH04J155809 Enhancer 0.7 Ensembl 11.1 -44.3 -44338 0.4 YY1 RXRA GABPB1 ZBTB40 CTCF HNF4A RB1 RAD21 ZNF362 REST TDO2 HSALNG0038044 HSALNG0038045 GUCY1B1
GH04J155940 Enhancer 0.6 ENCODE 10.6 +88.2 88159 3.8 ATF3 FOXA2 RXRA ZBTB33 JUND HNF4A FOXA1 RAD21 REST MAX HSALNG0038052-001 HSALNG0038052-002 TDO2 CTSO piR-45035-143 ASIC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TDO2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TDO2

Top Transcription factor binding sites by QIAGEN in the TDO2 gene promoter:
  • Bach1
  • CUTL1
  • FOXJ2 (long isoform)
  • GATA-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Pbx1a
  • STAT3
  • TBP

Genomic Locations for TDO2 Gene

Latest Assembly
chr4:155,854,738-155,920,406
(GRCh38/hg38)
Size:
65,669 bases
Orientation:
Plus strand

Previous Assembly
chr4:156,824,848-156,841,558
(GRCh37/hg19 by Entrez Gene)
Size:
16,711 bases
Orientation:
Plus strand

chr4:156,775,890-156,841,558
(GRCh37/hg19 by Ensembl)
Size:
65,669 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr4(ALT_REF_LOCI_1):68,319-85,029 (+)

Genomic View for TDO2 Gene

Genes around TDO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDO2 Gene

Proteins for TDO2 Gene

  • Protein details for TDO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48775-T23O_HUMAN
    Recommended name:
    Tryptophan 2,3-dioxygenase
    Protein Accession:
    P48775
    Secondary Accessions:
    • A8K053

    Protein attributes for TDO2 Gene

    Size:
    406 amino acids
    Molecular mass:
    47872 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • Homotetramer. Dimer of dimers.

    Three dimensional structures from OCA and Proteopedia for TDO2 Gene

neXtProt entry for TDO2 Gene

Selected DME Specific Peptides for TDO2 Gene

P48775:
  • ASKGGLIYG
  • TKWRYNHV
  • SDRYKVF
  • FYREEPRFQVPFQLLT
  • YELWFKQ
  • GTGGSSGY
  • LLSKGERRLSY
  • LMDIDSL
  • WLERTPGLE
  • ASGFQSLQFR
  • HDEHLFI
  • PASGFQS
  • IHKFLYTAE
  • HVRDERNMLKV
  • GFNFWGK
  • LNAQELQSE
  • DLFNLST

Post-translational modifications for TDO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDO2 Gene

Domains & Families for TDO2 Gene

Gene Families for TDO2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for TDO2 Gene

InterPro:
Blocks:
  • Tryptophan 2,3-dioxygenase

Suggested Antigen Peptide Sequences for TDO2 Gene

GenScript: Design optimal peptide antigens:
  • Tryptophanase (T23O_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48775

UniProtKB/Swiss-Prot:

T23O_HUMAN :
  • Belongs to the tryptophan 2,3-dioxygenase family.
Family:
  • Belongs to the tryptophan 2,3-dioxygenase family.
genes like me logo Genes that share domains with TDO2: view

Function for TDO2 Gene

Molecular function for TDO2 Gene

UniProtKB/Swiss-Prot Function:
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, ChEBI:CHEBI:58629; EC=1.13.11.11; Evidence={ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:25066423, ECO:0000269|PubMed:27762317, ECO:0000269|PubMed:28285122};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.135 mM for L-tryptophan {ECO:0000269|PubMed:25066423}; KM=0.132 mM for L-tryptophan {ECO:0000269|PubMed:28285122}; Note=Kcat is 0.54 sec(-1) with L-tryptophan as substrate. {ECO:0000269|PubMed:28285122};
GENATLAS Biochemistry:
tryptophan 2-3 dioxygenase

Enzyme Numbers (IUBMB) for TDO2 Gene

Phenotypes From GWAS Catalog for TDO2 Gene

Gene Ontology (GO) - Molecular Function for TDO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004833 tryptophan 2,3-dioxygenase activity TAS,IDA 27762317
GO:0005515 protein binding IPI 16189514
GO:0016491 oxidoreductase activity IEA --
GO:0016597 amino acid binding IEA --
GO:0019825 oxygen binding IEA --
genes like me logo Genes that share ontologies with TDO2: view
genes like me logo Genes that share phenotypes with TDO2: view

Animal Models for TDO2 Gene

MGI Knock Outs for TDO2:
  • Tdo2 Tdo2<tm1Tnak>
  • Tdo2 Tdo2<tm1b(KOMP)Mbp>

Animal Models for research

  • Taconic Biosciences Mouse Models for TDO2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TDO2

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TDO2 Gene

Localization for TDO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TDO2 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TDO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TDO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TDO2 Gene

Pathways & Interactions for TDO2 Gene

genes like me logo Genes that share pathways with TDO2: view

UniProtKB/Swiss-Prot P48775-T23O_HUMAN

  • Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.

Gene Ontology (GO) - Biological Process for TDO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006568 tryptophan metabolic process IEA --
GO:0006569 tryptophan catabolic process TAS --
GO:0019441 tryptophan catabolic process to kynurenine IDA,IEA --
GO:0019442 tryptophan catabolic process to acetyl-CoA IBA 21873635
GO:0051289 protein homotetramerization IDA 27762317
genes like me logo Genes that share ontologies with TDO2: view

No data available for SIGNOR curated interactions for TDO2 Gene

Drugs & Compounds for TDO2 Gene

(23) Drugs for TDO2 Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tryptophan Approved, Withdrawn Nutra Enzyme, substrate 106
Nalidixic Acid Approved, Investigational Pharma Enzyme, inhibitor 2
Oxygen Approved, Vet_approved Pharma 0
Tolmetin Approved Pharma Enzyme, inhibitor 0
Febuxostat Approved Pharma Xanthine oxidase inhibitor 79

(14) Additional Compounds for TDO2 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-Formylkynurenine
  • 3-(2-Formamidobenzoyl)-L-alanine
  • N'-formylkynurenine
  • N-Formylkynurenine
  • N-Formyl-L-kynurenine
  • L-Formylkynurenine
1-Methyl-D-tryptophan
110117-83-4
LM 10
1316695-35-8

(5) Tocris Compounds for TDO2 Gene

Compound Action Cas Number
1-Methyl-D-tryptophan Indoleamine 2,3-dioxygenase (IDO) inhibitor 110117-83-4
680C91 Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor 163239-22-3
Febuxostat Xanthine oxidase inhibitor 144060-53-7
LM 10 Selective tryptophan 2,3-dioxygenase (TDO) inhibitor 1316695-35-8
MDL 72527 Polyamine oxidase (PAO) inhibitor 93565-01-6
genes like me logo Genes that share compounds with TDO2: view

Transcripts for TDO2 Gene

mRNA/cDNA for TDO2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TDO2

Alternative Splicing Database (ASD) splice patterns (SP) for TDO2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - -
SP3: -
SP4: - - -
SP5: - - - -

Relevant External Links for TDO2 Gene

GeneLoc Exon Structure for
TDO2

Expression for TDO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TDO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TDO2 Gene

This gene is overexpressed in Liver (x49.4).

Protein differential expression in normal tissues from HIPED for TDO2 Gene

This gene is overexpressed in Liver (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TDO2 Gene



Protein tissue co-expression partners for TDO2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TDO2

SOURCE GeneReport for Unigene cluster for TDO2 Gene:

Hs.183671

Evidence on tissue expression from TISSUES for TDO2 Gene

  • Liver(4.9)
  • Nervous system(4.5)
  • Intestine(2.5)
  • Adrenal gland(2.3)
  • Spleen(2.1)
  • Blood(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with TDO2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TDO2 Gene

Orthologs for TDO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TDO2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TDO2 29 30
  • 99.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TDO2 29 30
  • 91.87 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TDO2 30
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 89 (a)
OneToMany
-- 30
  • 85 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TDO2 29 30
  • 86.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tdo2 29
  • 83.99 (n)
Mouse
(Mus musculus)
Mammalia Tdo2 29 16 30
  • 83.58 (n)
OneToOne
Chicken
(Gallus gallus)
Aves TDO2 29
  • 78.33 (n)
Lizard
(Anolis carolinensis)
Reptilia TDO2 30
  • 83 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tdo2 29
  • 75.78 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30711 29
Zebrafish
(Danio rerio)
Actinopterygii tdo2a 30
  • 75 (a)
OneToMany
tdo2b 29 30
  • 67.57 (n)
OneToMany
wufi30d08 29
Fruit Fly
(Drosophila melanogaster)
Insecta v 29 30 31
  • 60.11 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta T23O_ANOGA 29
  • 55.64 (n)
Worm
(Caenorhabditis elegans)
Secernentea C28H8.11 29
  • 56.28 (n)
tdo-2 30
  • 51 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 47 (a)
OneToMany
-- 30
  • 41 (a)
OneToMany
Species where no ortholog for TDO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TDO2 Gene

ENSEMBL:
Gene Tree for TDO2 (if available)
TreeFam:
Gene Tree for TDO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TDO2: view image
Alliance of Genome Resources:
Additional Orthologs for TDO2

Paralogs for TDO2 Gene

No data available for Paralogs for TDO2 Gene

Variants for TDO2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TDO2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs144382797 Benign: not provided 155,917,416(+) G/A
NM_005651.4(TDO2):c.918G>A (p.Val306=)
SYNONYMOUS
rs155395799 Hypertryptophanemia (HYPTRP) [MIM:600627] p.Met108Ile
rs1553957997 Pathogenic: Hypertryptophanemia, familial 155,908,907(+) G/C
NM_005651.4(TDO2):c.324G>C (p.Met108Ile)
MISSENSE
rs201248688 Benign: not provided 155,908,938(+) T/C
NM_005651.4(TDO2):c.355T>C (p.Ser119Pro)
MISSENSE
rs767123432 Pathogenic: Hypertryptophanemia, familial 155,910,082(+) C/CA
NM_005651.4(TDO2):c.491dup (p.Ile165fs)
FRAMESHIFT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TDO2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TDO2 Gene

Variant ID Type Subtype PubMed ID
esv3575777 CNV gain 25503493
nsv1029122 CNV gain 25217958
nsv480989 CNV novel sequence insertion 20440878
nsv481477 CNV novel sequence insertion 20440878
nsv830121 CNV gain 17160897

Variation tolerance for TDO2 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TDO2 Gene

Human Gene Mutation Database (HGMD)
TDO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TDO2
Leiden Open Variation Database (LOVD)
TDO2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDO2 Gene

Disorders for TDO2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for TDO2 Gene - From: OMI, CVR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
hypertryptophanemia
  • hyptrp
porphyria
  • disorder of porphyrin and hem metabolism
pervasive developmental disorder
  • pervasive development disorder
substance abuse
  • substance-related disorders
autism
  • autistic disorder
- elite association - COSMIC cancer census association via MalaCards
Search TDO2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

T23O_HUMAN
  • Hypertryptophanemia (HYPTRP) [MIM:600627]: An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia. {ECO:0000269 PubMed:28285122}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for TDO2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TDO2: view

No data available for Genatlas for TDO2 Gene

Publications for TDO2 Gene

  1. Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency. (PMID: 28285122) Ferreira P … Liu A (Molecular genetics and metabolism 2017) 3 4 72
  2. Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat. (PMID: 8666386) Comings DE … Forest GL (Genomics 1995) 3 4 22
  3. Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. (PMID: 27762317) Lewis-Ballester A … Tong L (Scientific reports 2016) 3 4
  4. Structural and functional analyses of human tryptophan 2,3-dioxygenase. (PMID: 25066423) Meng B … Liu ZJ (Proteins 2014) 3 4
  5. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. (PMID: 19786962) Roeske D … Schulte-Körne G (Molecular psychiatry 2011) 3 40

Products for TDO2 Gene

Sources for TDO2 Gene